Reviewed, UniProtKB/Swiss-Prot P59305 (ARGC_BIFLO)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	BL1064

Organism

Bifidobacterium longum [Complete proteome] [HAMAP]

Taxonomic identifier

216816 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_0000112387
Sites
	Active site	157	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P59305-1 [UniParc]. Last modified February 12, 2003. Version 1. Checksum: FC46B36409321F0C	FASTA	364	38,017
	10 20 30 40 50 60 MAKYTVAVAG ATGYAGGEAL RILAAHPDFD ITCVAGHSSV GESMAKHMPH IPQLANLVVE 70 80 90 100 110 120 DTAPEVLNGH DVIILALPHG ASGKLASQLD PNAVVVDLGA DHRLEEQAAW DEFYGGDFYE 130 140 150 160 170 180 HWTYGMPELI TGKAADGSYT RQRAALPGTK RIAGPGCNVT ATTLALQPGI AEGLVESQDI 190 200 210 220 230 240 VADLVVGYSG AGKNLKRTNL LAAEALQSAL PYSVGGKHRH IPEILQNFAH AAGKSAAEAS 250 260 270 280 290 300 EFTLGFTPIL APMSRGILAT VSARMTDKAK TLSDEEIRAV WSKAYEGQDF MVLLPEGTLP 310 320 330 340 350 360 ATGNIIGSNA AHLQVVTDRK AGRIYAFAAI DNLNRGTAGQ AVQSLNIALG LPEDAGLTKI GVAP

References

[1]

"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract." Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F. Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed: 12381787] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCC 2705.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014295 Genomic DNA. Translation: AAN24872.1.
RefSeq	NP_696236.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1022596.
GenomeReviews	Gene locus BL1064 in contig AE014295_GR.
KEGG	blo:BL1064.
NMPDR	fig|206672.1.peg.1003.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P59305.
OMA	VCRIAVH.
Enzyme and pathway databases
BioCyc	BLON206672:BL1064-MON.
BRENDA	1.2.1.38. 39917.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_BIFLO

Accession

Primary (citable) accession number: P59305

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	February 12, 2003
Last modified:	November 3, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)