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P59290 (KAX39_BUTOC) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin alpha-KTx 3.9
Alternative name(s):
Kaliotoxin-3
Short name=KTX-3
Gene names
Name:KTX3
OrganismButhus occitanus tunetanus (Common European scorpion)
Taxonomic identifier6871 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeButhus

Protein attributes

Sequence length37 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds and inhibits potassium channels. Intracerebroventricular injection into mice induces paralyzing symptoms followed by death. Its binding affinity to rat brain synaptosomes is 5-fold lower than this of KTX 1.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Toxic dose

LD50 is 5.5 µg/kg by intracerebroventricular injection. Ref.1

Sequence similarities

Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 3 subfamily.

Mass spectrometry

Molecular mass is 4376.27 Da from positions 1 - 37. Determined by ESI. Ref.1

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionIon channel impairing toxin
Neurotoxin
Potassium channel impairing toxin
Toxin
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processdefense response

Inferred from electronic annotation. Source: InterPro

pathogenesis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionion channel inhibitor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3737Potassium channel toxin alpha-KTx 3.9
PRO_0000044897

Regions

Region25 – 328Interaction with Ca(2+)-activated K(+) channels Potential

Amino acid modifications

Disulfide bond7 ↔ 27 By similarity
Disulfide bond13 ↔ 32 By similarity
Disulfide bond17 ↔ 34 By similarity

Sequences

Sequence LengthMass (Da)Tools
P59290 [UniParc].

Last modified February 12, 2003. Version 1.
Checksum: D3A9805D5B55D8CB

FASTA374,028
        10         20         30 
VGIPVSCKHS GQCIKPCKDA GMRFGKCMNR KCDCTPK 

« Hide

References

[1]"KTX3, the kaliotoxin from Buthus occitanus tunetanus scorpion venom: one of an extensive family of peptidyl ligands of potassium channels."
Meki A., Mansuelle P., Laraba-Djebari F., Oughideni R., Rochat H., Martin-Eauclaire M.-F.
Toxicon 38:105-111(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, LETHAL DOSE, MASS SPECTROMETRY.
Tissue: Venom.

Cross-references

3D structure databases

ProteinModelPortalP59290.
SMRP59290. Positions 1-37.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.30.10. 1 hit.
InterProIPR003614. Scorpion_toxin-like.
IPR001947. Scorpion_toxinS_K_inh.
[Graphical view]
PfamPF00451. Toxin_2. 1 hit.
[Graphical view]
PRINTSPR00286. CHARYBDTOXIN.
ProDomPD003586. Scorpion_toxinS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF57095. SSF57095. 1 hit.
PROSITEPS01138. SCORP_SHORT_TOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKAX39_BUTOC
AccessionPrimary (citable) accession number: P59290
Entry history
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: February 12, 2003
Last modified: October 16, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries