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Protein

Rho GTPase-activating protein 39

Gene

Arhgap39

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 39
Gene namesi
Name:Arhgap39
Synonyms:D15Wsu169e, Kiaa1688
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107858. Arhgap39.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 11071106Rho GTPase-activating protein 39PRO_0000076093Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei380 – 3801PhosphoserineCombined sources
Modified residuei384 – 3841PhosphoserineBy similarity
Modified residuei402 – 4021PhosphoserineBy similarity
Modified residuei403 – 4031PhosphoserineBy similarity
Modified residuei597 – 5971PhosphoserineCombined sources
Modified residuei708 – 7081PhosphoserineCombined sources
Modified residuei719 – 7191PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP59281.
PaxDbiP59281.
PRIDEiP59281.

PTM databases

iPTMnetiP59281.
PhosphoSiteiP59281.

Expressioni

Gene expression databases

BgeeiP59281.

Interactioni

Protein-protein interaction databases

IntActiP59281. 2 interactions.
STRINGi10090.ENSMUSP00000036697.

Structurei

3D structure databases

ProteinModelPortaliP59281.
SMRiP59281. Positions 68-96, 772-823, 912-1098.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 5834WW 1PROSITE-ProRule annotationAdd
BLAST
Domaini63 – 9735WW 2PROSITE-ProRule annotationAdd
BLAST
Domaini715 – 867153MyTH4PROSITE-ProRule annotationAdd
BLAST
Domaini914 – 1102189Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MyTH4 domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IG4K. Eukaryota.
ENOG410XQ23. LUCA.
HOGENOMiHOG000290162.
HOVERGENiHBG052205.
InParanoidiP59281.
PhylomeDBiP59281.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR000857. MyTH4_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00784. MyTH4. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00139. MyTH4. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS51016. MYTH4. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P59281-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQAQDYECR SHHVDEQEPR IPGSSTRLEW VEIIEPRTRE RMYANLVTGE
60 70 80 90 100
CVWDPPAGVR IKRTSEDQWW ELFDPNTSRF YYYSAASQRT VWHRPQNCDI
110 120 130 140 150
IPLAKLQTLK QNTESPRASA DNSPGRGSRD GSTGSSLEPE LEERTQELPV
160 170 180 190 200
RSGRATTLVT SKEDTSSCSP PGVLLEKDYE VYRDYSADGQ LLHYRTSSLR
210 220 230 240 250
WNSGNKERML IKVADREPSF LTPQGNGYPA DNQPGGHHRR PSGSQHSPNL
260 270 280 290 300
QTFVPDTDGT VFFPERRPSP FLRRAELSGN CSPLLIQPRK PSSDSQPSSP
310 320 330 340 350
RYGYEPPLYE EPPVEYQAPI YDEPPMDVQF EANSPYQTGS PQRSPGRKPH
360 370 380 390 400
PFLQTTKQTP TSPCQQLMRT KQKCPERFLS LEYSPVGKEY VRQLVYVEQA
410 420 430 440 450
GSSPKLRAGP RHKYAPNPGG GTYSLQPSPC LLRDQRLGVR SGDYSTMEGP
460 470 480 490 500
ESRPSQPPTP LPQAQEDAMS WSSQQDTMSS TGYSPGTRKR KNRKPSLCQV
510 520 530 540 550
PSTSSTDGAG GLLGEQPLTE ERSPCRASLT PVKAEADLVR GTPEPFLAQA
560 570 580 590 600
RLAWEAQQAH FHMKQRGSWD SQQDGSGYES DGAVPLPMPG PVVRAFSEDE
610 620 630 640 650
ALAQQDSKHW KRSTFDKLGF PQILLEKSVS VQTNLASPEP HLHPSQSEDL
660 670 680 690 700
GACAQFESSR QNRSAMPSSS CVFPTFTLRK PSSETDIENW ASKHFNKHTQ
710 720 730 740 750
GLFRRKVSIA NMLAWSSESI KKPMIVTSDR HVKKEACEIF KLIQMYMGDR
760 770 780 790 800
RAKADPLHVA LEIATKGWSA QGLRDELYIQ LCRQTTENFR LESLARGWEL
810 820 830 840 850
MAICLAFFPP TPKFHSYLEG YIYRHMDPVN DTKVTQHIKE LLERNSKKKS
860 870 880 890 900
KLRKKPKPYV EEPDGVAIST YAKYCYHKLQ KAALTGAKKG LKKPNVEEIR
910 920 930 940 950
HAKNAVFSPS MFGSALQEVM SMQKERYPDR QLPWVQTRLS EEVLALNGDQ
960 970 980 990 1000
TEGIFRVPGD IDEVNALKLQ VDQWKVPTGL EDPHVPASLL KLWYRELEEP
1010 1020 1030 1040 1050
LIPHEFYEQC IAHYESPEAA VAVVHALPRI NRMVLCYLIR FLQVFVQPAN
1060 1070 1080 1090 1100
VAITKMDVSN LAMVMAPNCL RCQSDDPRVI FENTRKEMSF LRVLIQHLDT

SFMEGVL
Length:1,107
Mass (Da):125,206
Last modified:May 10, 2005 - v2
Checksum:iBCEF3C200664DF31
GO
Isoform 2 (identifier: P59281-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     834-864: Missing.

Show »
Length:1,076
Mass (Da):121,477
Checksum:i2451E2E35AF838C6
GO

Sequence cautioni

The sequence BAD32510.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1032 – 10321R → Q in AAH60637 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei834 – 86431Missing in isoform 2. 2 PublicationsVSP_013707Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173232 mRNA. Translation: BAD32510.1. Different initiation.
BC060637 mRNA. Translation: AAH60637.1.
AK035479 mRNA. Translation: BAC29074.1.
RefSeqiNP_001161760.1. NM_001168288.1.
NP_940812.2. NM_198420.2.
UniGeneiMm.322931.

Genome annotation databases

GeneIDi223666.
KEGGimmu:223666.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173232 mRNA. Translation: BAD32510.1. Different initiation.
BC060637 mRNA. Translation: AAH60637.1.
AK035479 mRNA. Translation: BAC29074.1.
RefSeqiNP_001161760.1. NM_001168288.1.
NP_940812.2. NM_198420.2.
UniGeneiMm.322931.

3D structure databases

ProteinModelPortaliP59281.
SMRiP59281. Positions 68-96, 772-823, 912-1098.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP59281. 2 interactions.
STRINGi10090.ENSMUSP00000036697.

PTM databases

iPTMnetiP59281.
PhosphoSiteiP59281.

Proteomic databases

MaxQBiP59281.
PaxDbiP59281.
PRIDEiP59281.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi223666.
KEGGimmu:223666.

Organism-specific databases

CTDi80728.
MGIiMGI:107858. Arhgap39.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IG4K. Eukaryota.
ENOG410XQ23. LUCA.
HOGENOMiHOG000290162.
HOVERGENiHBG052205.
InParanoidiP59281.
PhylomeDBiP59281.

Miscellaneous databases

PROiP59281.
SOURCEiSearch...

Gene expression databases

BgeeiP59281.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR000857. MyTH4_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00784. MyTH4. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00139. MyTH4. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS51016. MYTH4. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Fetal brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 11-1107 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Urinary bladder.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-597, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  5. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-597, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380; SER-597; SER-708 AND SER-719, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Spleen and Testis.

Entry informationi

Entry nameiRHG39_MOUSE
AccessioniPrimary (citable) accession number: P59281
Secondary accession number(s): Q69ZD4, Q6P9R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: May 10, 2005
Last modified: June 8, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.