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Protein

Ras-related protein Rab-2B

Gene

Rab2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for protein transport from the endoplasmic reticulum to the Golgi complex.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 21GTPBy similarity9
Nucleotide bindingi61 – 65GTPBy similarity5
Nucleotide bindingi119 – 122GTPBy similarity4
Nucleotide bindingi149 – 151GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-2B
Gene namesi
Name:Rab2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1923588. Rab2b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210721 – 216Ras-related protein Rab-2BAdd BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi215S-geranylgeranyl cysteineBy similarity1
Lipidationi216S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

EPDiP59279.
PaxDbiP59279.
PeptideAtlasiP59279.
PRIDEiP59279.

PTM databases

iPTMnetiP59279.
PhosphoSitePlusiP59279.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022159.
CleanExiMM_RAB2B.
ExpressionAtlasiP59279. baseline and differential.
GenevisibleiP59279. MM.

Interactioni

Protein-protein interaction databases

BioGridi218074. 1 interactor.
IntActiP59279. 6 interactors.
STRINGi10090.ENSMUSP00000022765.

Structurei

3D structure databases

ProteinModelPortaliP59279.
SMRiP59279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 43Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0098. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP59279.
KOiK07878.
OMAiEGEMFAR.
OrthoDBiEOG091G0QOB.
PhylomeDBiP59279.
TreeFamiTF300032.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59279-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMVNI
60 70 80 90 100
DGKQIKLQIW DTAGQESFRS ITRSYYRGAA GALLVYDITR RETFNHLTSW
110 120 130 140 150
LEDARQHSSS NMVIMLIGNK SDLESRRDVK REEGEAFARE HGLIFMETSA
160 170 180 190 200
KTACNVEEAY INTAKEIYRK IQQGLFDVHN EANGIKIGPQ QSITSSVGPC
210
SPQQNVSDIG PDSGCC
Length:216
Mass (Da):24,198
Last modified:February 12, 2003 - v1
Checksum:i54EE7E2337BFD751
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038393 mRNA. Translation: BAC29983.1.
AK044202 mRNA. Translation: BAC31814.1.
AK160249 mRNA. Translation: BAE35713.1.
AK160351 mRNA. Translation: BAE35753.1.
BC046334 mRNA. Translation: AAH46334.1.
CCDSiCCDS27052.1.
RefSeqiNP_766189.1. NM_172601.3.
UniGeneiMm.32870.

Genome annotation databases

EnsembliENSMUST00000022765; ENSMUSP00000022765; ENSMUSG00000022159.
ENSMUST00000167116; ENSMUSP00000131145; ENSMUSG00000022159.
GeneIDi76338.
KEGGimmu:76338.
UCSCiuc007tox.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038393 mRNA. Translation: BAC29983.1.
AK044202 mRNA. Translation: BAC31814.1.
AK160249 mRNA. Translation: BAE35713.1.
AK160351 mRNA. Translation: BAE35753.1.
BC046334 mRNA. Translation: AAH46334.1.
CCDSiCCDS27052.1.
RefSeqiNP_766189.1. NM_172601.3.
UniGeneiMm.32870.

3D structure databases

ProteinModelPortaliP59279.
SMRiP59279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218074. 1 interactor.
IntActiP59279. 6 interactors.
STRINGi10090.ENSMUSP00000022765.

PTM databases

iPTMnetiP59279.
PhosphoSitePlusiP59279.

Proteomic databases

EPDiP59279.
PaxDbiP59279.
PeptideAtlasiP59279.
PRIDEiP59279.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022765; ENSMUSP00000022765; ENSMUSG00000022159.
ENSMUST00000167116; ENSMUSP00000131145; ENSMUSG00000022159.
GeneIDi76338.
KEGGimmu:76338.
UCSCiuc007tox.2. mouse.

Organism-specific databases

CTDi84932.
MGIiMGI:1923588. Rab2b.

Phylogenomic databases

eggNOGiKOG0098. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP59279.
KOiK07878.
OMAiEGEMFAR.
OrthoDBiEOG091G0QOB.
PhylomeDBiP59279.
TreeFamiTF300032.

Miscellaneous databases

ChiTaRSiRab2b. mouse.
PROiP59279.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022159.
CleanExiMM_RAB2B.
ExpressionAtlasiP59279. baseline and differential.
GenevisibleiP59279. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB2B_MOUSE
AccessioniPrimary (citable) accession number: P59279
Secondary accession number(s): Q3TV67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: February 12, 2003
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.