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Protein

Palmitoyltransferase ZDHHC9

Gene

Zdhhc9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei169S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC9 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 9
Short name:
DHHC-9
Short name:
DHHC9
Gene namesi
Name:Zdhhc9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2444393. Zdhhc9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Topological domaini57 – 63LumenalSequence analysis7
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 183CytoplasmicSequence analysisAdd BLAST99
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 228LumenalSequence analysisAdd BLAST24
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 364CytoplasmicSequence analysisAdd BLAST115

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128811 – 364Palmitoyltransferase ZDHHC9Add BLAST364

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP59268.
PRIDEiP59268.

PTM databases

iPTMnetiP59268.
PhosphoSitePlusiP59268.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036985.
CleanExiMM_ZDHHC9.
GenevisibleiP59268. MM.

Interactioni

Subunit structurei

Interacts with GOLGA7.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044734.

Structurei

3D structure databases

ProteinModelPortaliP59268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 189DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000242943.
HOVERGENiHBG056239.
InParanoidiP59268.
KOiK16675.
OMAiSPNEMPE.
OrthoDBiEOG091G0BOW.
PhylomeDBiP59268.
TreeFamiTF312923.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVMVVRKKV TRKWEKLPGR NTFCCDGRVM MARQKGIFYL TLFLILGTCT
60 70 80 90 100
LFFAFECRYL AVQLSPAIPV FAAMLFLFSM ATLLRTSFSD PGVIPRALPD
110 120 130 140 150
EAAFIEMEIE ATNGAVPQGQ RPPPRIKNFQ INNQIVKLKY CYTCKIFRPP
160 170 180 190 200
RASHCSICDN CVERFDHHCP WVGNCVGKRN YRYFYLFILS LSLLTIYVFA
210 220 230 240 250
FNIVYVALKS LKIGFLETLK ETPGTVLEVL ICFFTLWSVV GLTGFHTFLV
260 270 280 290 300
ALNQTTNEDI KGSWTGKNRV QNPYSHGNIV KNCCEVLCGP LPPSVLDRRG
310 320 330 340 350
ILPLEESGSR PPSTQETSSS LLPQSPASTE HMNSNEMAED TSIPEEMPPP
360
EPPEPPQEAS EAEK
Length:364
Mass (Da):40,940
Last modified:February 1, 2003 - v1
Checksum:iD035759B8844B67A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032233 mRNA. Translation: BAC27774.1.
BC042618 mRNA. Translation: AAH42618.1.
BC090832 mRNA. Translation: AAH90832.1.
CCDSiCCDS40960.1.
RefSeqiNP_766053.1. NM_172465.4.
XP_006541517.1. XM_006541454.3.
UniGeneiMm.207367.

Genome annotation databases

EnsembliENSMUST00000037960; ENSMUSP00000044734; ENSMUSG00000036985.
ENSMUST00000088935; ENSMUSP00000086325; ENSMUSG00000036985.
GeneIDi208884.
KEGGimmu:208884.
UCSCiuc009tbx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032233 mRNA. Translation: BAC27774.1.
BC042618 mRNA. Translation: AAH42618.1.
BC090832 mRNA. Translation: AAH90832.1.
CCDSiCCDS40960.1.
RefSeqiNP_766053.1. NM_172465.4.
XP_006541517.1. XM_006541454.3.
UniGeneiMm.207367.

3D structure databases

ProteinModelPortaliP59268.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044734.

PTM databases

iPTMnetiP59268.
PhosphoSitePlusiP59268.

Proteomic databases

PaxDbiP59268.
PRIDEiP59268.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037960; ENSMUSP00000044734; ENSMUSG00000036985.
ENSMUST00000088935; ENSMUSP00000086325; ENSMUSG00000036985.
GeneIDi208884.
KEGGimmu:208884.
UCSCiuc009tbx.2. mouse.

Organism-specific databases

CTDi51114.
MGIiMGI:2444393. Zdhhc9.

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
HOGENOMiHOG000242943.
HOVERGENiHBG056239.
InParanoidiP59268.
KOiK16675.
OMAiSPNEMPE.
OrthoDBiEOG091G0BOW.
PhylomeDBiP59268.
TreeFamiTF312923.

Miscellaneous databases

PROiP59268.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036985.
CleanExiMM_ZDHHC9.
GenevisibleiP59268. MM.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDHC9_MOUSE
AccessioniPrimary (citable) accession number: P59268
Secondary accession number(s): Q5BL19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: February 1, 2003
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.