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Protein

Palmitoyltransferase ZDHHC2

Gene

Zdhhc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Palmitoyltransferase specific for GAP43 and DLG4/PSD95.1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

GO - Biological processi

  • protein palmitoylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-5683826. Surfactant metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC2 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 2
Short name:
DHHC-2
Gene namesi
Name:Zdhhc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1923452. Zdhhc2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence analysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence analysisAdd
BLAST
Transmembranei170 – 19021HelicalSequence analysisAdd
BLAST
Transmembranei208 – 22821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: MGI
  • Golgi apparatus Source: MGI
  • integral component of plasma membrane Source: MGI
  • recycling endosome membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Palmitoyltransferase ZDHHC2PRO_0000212860Add
BLAST

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiP59267.
MaxQBiP59267.
PaxDbiP59267.
PRIDEiP59267.

PTM databases

iPTMnetiP59267.
PhosphoSiteiP59267.

Expressioni

Tissue specificityi

Expressed in all brain regions.1 Publication

Gene expression databases

BgeeiENSMUSG00000039470.
CleanExiMM_ZDHHC2.
GenevisibleiP59267. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041727.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini126 – 17651DHHCPROSITE-ProRule annotationAdd
BLAST

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1315. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129766.
HOGENOMiHOG000234777.
HOVERGENiHBG055108.
InParanoidiP59267.
KOiK20028.
OMAiVCLIAYH.
OrthoDBiEOG091G0AXR.
PhylomeDBiP59267.
TreeFamiTF316044.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59267-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSGSGGVR RRCRRVLYWI PVVFISLLLG WSYYAYAIQL CIVSMENIGE
60 70 80 90 100
QVVCLMAYHL LFAMFVWSYW KTIFTLPMNP SKEFHLSYAE KELLEREPRG
110 120 130 140 150
EAHQEVLRRA AKDLPIYTRT MSGAIRYCDR CQLIKPDRCH HCSVCDKCIL
160 170 180 190 200
KMDHHCPWVN NCVGFSNYKF FLLFLAYSLL YCLFIAATDL QYFIRFWTNG
210 220 230 240 250
LPDTQAKFHI MFLFFAAAMF SVSLSSLFGY HCWLVSKNKS TLEAFRNPVF
260 270 280 290 300
RHGTDKNGFS LGFSKNMRQV FGDEKKYWLL PVFSSQGDGC SFPTCLVNQD
310 320 330 340 350
PEQPSTPAGL NSTVKNPENH QFPAKPLRES QSHLLKDSQT WTESSANPGK
360
GKAGMSNPAL TMENET
Length:366
Mass (Da):41,982
Last modified:February 1, 2003 - v1
Checksum:i05DC0FCC7D786278
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030662 mRNA. Translation: BAC27068.1.
CCDSiCCDS22252.1.
RefSeqiNP_848482.1. NM_178395.3.
XP_006509548.1. XM_006509485.2.
UniGeneiMm.34326.

Genome annotation databases

EnsembliENSMUST00000049389; ENSMUSP00000041727; ENSMUSG00000039470.
ENSMUST00000128166; ENSMUSP00000123070; ENSMUSG00000039470.
ENSMUST00000167766; ENSMUSP00000129996; ENSMUSG00000039470.
GeneIDi70546.
KEGGimmu:70546.
UCSCiuc009lmn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030662 mRNA. Translation: BAC27068.1.
CCDSiCCDS22252.1.
RefSeqiNP_848482.1. NM_178395.3.
XP_006509548.1. XM_006509485.2.
UniGeneiMm.34326.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041727.

PTM databases

iPTMnetiP59267.
PhosphoSiteiP59267.

Proteomic databases

EPDiP59267.
MaxQBiP59267.
PaxDbiP59267.
PRIDEiP59267.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049389; ENSMUSP00000041727; ENSMUSG00000039470.
ENSMUST00000128166; ENSMUSP00000123070; ENSMUSG00000039470.
ENSMUST00000167766; ENSMUSP00000129996; ENSMUSG00000039470.
GeneIDi70546.
KEGGimmu:70546.
UCSCiuc009lmn.1. mouse.

Organism-specific databases

CTDi51201.
MGIiMGI:1923452. Zdhhc2.

Phylogenomic databases

eggNOGiKOG1315. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129766.
HOGENOMiHOG000234777.
HOVERGENiHBG055108.
InParanoidiP59267.
KOiK20028.
OMAiVCLIAYH.
OrthoDBiEOG091G0AXR.
PhylomeDBiP59267.
TreeFamiTF316044.

Enzyme and pathway databases

ReactomeiR-MMU-5683826. Surfactant metabolism.

Miscellaneous databases

ChiTaRSiZdhhc2. mouse.
PROiP59267.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039470.
CleanExiMM_ZDHHC2.
GenevisibleiP59267. MM.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDHC2_MOUSE
AccessioniPrimary (citable) accession number: P59267
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: February 1, 2003
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.