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Protein

Histone H4

Gene

At1g07660

more
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi17 – 215

GO - Molecular functioni

  • DNA binding Source: TAIR
  • histone binding Source: GO_Central
  • protein heterodimerization activity Source: InterPro

GO - Biological processi

  • nucleosome assembly Source: GO_Central
  • response to water deprivation Source: TAIR

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-ATH-212300 PRC2 methylates histones and DNA
R-ATH-2299718 Condensation of Prophase Chromosomes
R-ATH-2559580 Oxidative Stress Induced Senescence
R-ATH-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-ATH-3214842 HDMs demethylate histones
R-ATH-3214847 HATs acetylate histones
R-ATH-3214858 RMTs methylate histone arginines
R-ATH-5578749 Transcriptional regulation by small RNAs
R-ATH-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4
Gene namesi
Ordered Locus Names:At1g07660
ORF Names:F24B9.25
AND
Ordered Locus Names:At1g07820
ORF Names:F24B9.8
AND
Ordered Locus Names:At2g28740
ORF Names:F8N16.2, T11P11.4
AND
Ordered Locus Names:At3g45930
ORF Names:F16L2_140
AND
Ordered Locus Names:At3g46320
ORF Names:F18L15.40
AND
Ordered Locus Names:At3g53730
ORF Names:F5K20_30
AND
Ordered Locus Names:At5g59690
ORF Names:MTH12.10
AND
Ordered Locus Names:At5g59970
ORF Names:MMN10.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componentsi: Chromosome 1, Chromosome 2, Chromosome 3, Chromosome 5

Organism-specific databases

AraportiAT1G07660
AT1G07820
AT2G28740
AT3G45930
AT3G46320
AT3G53730
AT5G59690
AT5G59970
TAIRilocus:2026565 AT1G07820
locus:2026570 AT1G07660
locus:2053195 AT2G28740
locus:2077127 AT3G45930
locus:2078166 AT3G46320
locus:2084380 AT3G53730
locus:2168037 AT5G59970
locus:2174314 AT5G59690

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001582781 – 103Histone H4Add BLAST103

Post-translational modificationi

May be acetylated by MBD9.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP59259
PRIDEiP59259

Expressioni

Gene expression databases

ExpressionAtlasiP59259 baseline and differential
GenevisibleiP59259 AT

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with ORTH2 (PubMed:17242155). Interacts with AHL27 (PubMed:24218605).2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213631 interactor.
225204 interactors.
277312 interactors.
90971 interactor.
98571 interactor.
IntActiP59259 9 interactors.
STRINGi3702.AT5G59970.1

Structurei

3D structure databases

ProteinModelPortaliP59259
SMRiP59259
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

eggNOGiKOG3467 Eukaryota
COG2036 LUCA
HOGENOMiHOG000234654
KOiK11254
OMAiHINGITK
OrthoDBiEOG09360XKI
PhylomeDBiP59259

Family and domain databases

CDDicd00076 H4, 1 hit
Gene3Di1.10.20.101 hit
InterProiView protein in InterPro
IPR035425 CENP-T/H4_C
IPR009072 Histone-fold
IPR001951 Histone_H4
IPR019809 Histone_H4_CS
PfamiView protein in Pfam
PF15511 CENP-T_C, 1 hit
PRINTSiPR00623 HISTONEH4
SMARTiView protein in SMART
SM00417 H4, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00047 HISTONE_H4, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: P59259-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
60 70 80 90 100
IYEETRGVLK IFLENVIRDA VTYTEHARRK TVTAMDVVYA LKRQGRTLYG

FGG
Length:103
Mass (Da):11,409
Last modified:January 23, 2007 - v2
Checksum:iA9FD57725A2A7598
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17132 Genomic DNA Translation: AAA32810.1
M17133 Genomic DNA Translation: AAA32811.1
AC007583 Genomic DNA Translation: AAF75089.1
AC007583 Genomic DNA Translation: AAF75072.1
AC005727 Genomic DNA Translation: AAC79580.1
AC007184 Genomic DNA Translation: AAM15445.1
AL162459 Genomic DNA Translation: CAB82817.1
AL133298 Genomic DNA Translation: CAB62023.1
AL132960 Genomic DNA Translation: CAB88335.1
AB006705 Genomic DNA Translation: BAB09507.1
AB015475 Genomic DNA Translation: BAB08365.1
CP002684 Genomic DNA Translation: AEE28158.1
CP002684 Genomic DNA Translation: AEE28187.1
CP002684 Genomic DNA Translation: AEE28188.1
CP002685 Genomic DNA Translation: AEC08165.1
CP002686 Genomic DNA Translation: AEE78091.1
CP002686 Genomic DNA Translation: AEE78146.1
CP002686 Genomic DNA Translation: AEE79133.1
CP002688 Genomic DNA Translation: AED97220.1
CP002688 Genomic DNA Translation: AED97260.1
CP002688 Genomic DNA Translation: ANM70482.1
AF325058 mRNA Translation: AAG40410.1
AF334729 mRNA Translation: AAG50107.1
AY057609 mRNA Translation: AAL14404.1
AY062717 mRNA Translation: AAL32795.1
AY063857 mRNA Translation: AAL36213.1
AY093353 mRNA Translation: AAM13352.1
AY099675 mRNA Translation: AAM20526.1
AY124836 mRNA Translation: AAM70545.1
AY128855 mRNA Translation: AAM91255.1
AY142651 mRNA Translation: AAN13189.1
AY085175 mRNA Translation: AAM61726.1
AY085495 mRNA Translation: AAM62721.1
AY085965 mRNA Translation: AAM63175.1
AY086789 mRNA Translation: AAM63839.1
AY086185 mRNA Translation: AAM64264.1
AY087061 mRNA Translation: AAM64622.1
AY087188 mRNA Translation: AAM64744.1
PIRiE84688
S06904
RefSeqiNP_001332089.1, NM_001345379.1 [P59259-1]
NP_180441.1, NM_128434.4 [P59259-1]
NP_190179.1, NM_114462.5 [P59259-1]
NP_190941.1, NM_115233.3 [P59259-1]
NP_563793.1, NM_100639.3 [P59259-1]
NP_563797.1, NM_100656.6 [P59259-1]
NP_568911.1, NM_125361.3 [P59259-1]
NP_568918.1, NM_125390.4 [P59259-1]
NP_850660.1, NM_180329.3 [P59259-1]
NP_850939.1, NM_180608.3 [P59259-1]
UniGeneiAt.25388
At.27255
At.27457
At.43267
At.48166
At.49195
At.66138
At.68113
At.71937
At.71990
At.72015
At.75642
At.75657

Genome annotation databases

EnsemblPlantsiAT1G07660.1; AT1G07660.1; AT1G07660 [P59259-1]
AT1G07820.1; AT1G07820.1; AT1G07820 [P59259-1]
AT1G07820.2; AT1G07820.2; AT1G07820 [P59259-1]
AT2G28740.1; AT2G28740.1; AT2G28740 [P59259-1]
AT3G45930.1; AT3G45930.1; AT3G45930 [P59259-1]
AT3G46320.1; AT3G46320.1; AT3G46320 [P59259-1]
AT3G53730.1; AT3G53730.1; AT3G53730 [P59259-1]
AT5G59690.1; AT5G59690.1; AT5G59690 [P59259-1]
AT5G59970.1; AT5G59970.1; AT5G59970 [P59259-1]
AT5G59970.2; AT5G59970.2; AT5G59970 [P59259-1]
GeneIDi817423
823736
823777
824540
836090
836119
837279
837297
GrameneiAT1G07660.1; AT1G07660.1; AT1G07660 [P59259-1]
AT1G07820.1; AT1G07820.1; AT1G07820 [P59259-1]
AT1G07820.2; AT1G07820.2; AT1G07820 [P59259-1]
AT2G28740.1; AT2G28740.1; AT2G28740 [P59259-1]
AT3G45930.1; AT3G45930.1; AT3G45930 [P59259-1]
AT3G46320.1; AT3G46320.1; AT3G46320 [P59259-1]
AT3G53730.1; AT3G53730.1; AT3G53730 [P59259-1]
AT5G59690.1; AT5G59690.1; AT5G59690 [P59259-1]
AT5G59970.1; AT5G59970.1; AT5G59970 [P59259-1]
AT5G59970.2; AT5G59970.2; AT5G59970 [P59259-1]
KEGGiath:AT1G07660
ath:AT1G07820
ath:AT2G28740
ath:AT3G45930
ath:AT3G46320
ath:AT3G53730
ath:AT5G59690
ath:AT5G59970

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiH4_ARATH
AccessioniPrimary (citable) accession number: P59259
Secondary accession number(s): P02308
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome