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Protein

Histone H4

Gene

At1g07660

more
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi17 – 215

GO - Molecular functioni

  • DNA binding Source: TAIR

GO - Biological processi

  • nucleosome assembly Source: InterPro
  • response to water deprivation Source: TAIR
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4
Gene namesi
Ordered Locus Names:At1g07660
ORF Names:F24B9.25
AND
Ordered Locus Names:At1g07820
ORF Names:F24B9.8
AND
Ordered Locus Names:At2g28740
ORF Names:F8N16.2, T11P11.4
AND
Ordered Locus Names:At3g45930
ORF Names:F16L2_140
AND
Ordered Locus Names:At3g46320
ORF Names:F18L15.40
AND
Ordered Locus Names:At3g53730
ORF Names:F5K20_30
AND
Ordered Locus Names:At5g59690
ORF Names:MTH12.10
AND
Ordered Locus Names:At5g59970
ORF Names:MMN10.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componentsi: Chromosome 1, Chromosome 2, Chromosome 3, Chromosome 5

Organism-specific databases

TAIRiAT1G07660.
AT1G07820.
AT2G28740.
AT3G45930.
AT3G46320.
AT3G53730.
AT5G59690.
AT5G59970.

Subcellular locationi

GO - Cellular componenti

  • chloroplast Source: TAIR
  • cytosol Source: TAIR
  • nucleolus Source: TAIR
  • nucleosome Source: TAIR
  • plasma membrane Source: TAIR
  • plasmodesma Source: TAIR
  • thylakoid Source: TAIR
  • vacuolar membrane Source: TAIR
  • vacuole Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 103103Histone H4PRO_0000158278Add
BLAST

Post-translational modificationi

May be acetylated by MBD9.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP59259.
PRIDEiP59259.

Expressioni

Gene expression databases

ExpressionAtlasiP59259. baseline and differential.
GenevisibleiP59259. AT.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with ORTH2 (PubMed:17242155). Interacts with AHL27 (PubMed:24218605).2 Publications

Protein-protein interaction databases

BioGridi21363. 1 interaction.
22520. 4 interactions.
2773. 12 interactions.
9097. 1 interaction.
9857. 1 interaction.
IntActiP59259. 9 interactions.
STRINGi3702.AT5G59970.1.

Structurei

3D structure databases

ProteinModelPortaliP59259.
SMRiP59259. Positions 2-103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

eggNOGiKOG3467. Eukaryota.
COG2036. LUCA.
HOGENOMiHOG000234654.
KOiK11254.
OMAiSTHNERI.
OrthoDBiEOG09360XKI.
PhylomeDBiP59259.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SMARTiSM00417. H4. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00047. HISTONE_H4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: P59259-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL
60 70 80 90 100
IYEETRGVLK IFLENVIRDA VTYTEHARRK TVTAMDVVYA LKRQGRTLYG

FGG
Length:103
Mass (Da):11,409
Last modified:January 23, 2007 - v2
Checksum:iA9FD57725A2A7598
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17132 Genomic DNA. Translation: AAA32810.1.
M17133 Genomic DNA. Translation: AAA32811.1.
AC007583 Genomic DNA. Translation: AAF75089.1.
AC007583 Genomic DNA. Translation: AAF75072.1.
AC005727 Genomic DNA. Translation: AAC79580.1.
AC007184 Genomic DNA. Translation: AAM15445.1.
AL162459 Genomic DNA. Translation: CAB82817.1.
AL133298 Genomic DNA. Translation: CAB62023.1.
AL132960 Genomic DNA. Translation: CAB88335.1.
AB006705 Genomic DNA. Translation: BAB09507.1.
AB015475 Genomic DNA. Translation: BAB08365.1.
CP002684 Genomic DNA. Translation: AEE28158.1.
CP002684 Genomic DNA. Translation: AEE28187.1.
CP002684 Genomic DNA. Translation: AEE28188.1.
CP002685 Genomic DNA. Translation: AEC08165.1.
CP002686 Genomic DNA. Translation: AEE78091.1.
CP002686 Genomic DNA. Translation: AEE78146.1.
CP002686 Genomic DNA. Translation: AEE79133.1.
CP002688 Genomic DNA. Translation: AED97220.1.
CP002688 Genomic DNA. Translation: AED97260.1.
AF325058 mRNA. Translation: AAG40410.1.
AF334729 mRNA. Translation: AAG50107.1.
AY057609 mRNA. Translation: AAL14404.1.
AY062717 mRNA. Translation: AAL32795.1.
AY063857 mRNA. Translation: AAL36213.1.
AY093353 mRNA. Translation: AAM13352.1.
AY099675 mRNA. Translation: AAM20526.1.
AY124836 mRNA. Translation: AAM70545.1.
AY128855 mRNA. Translation: AAM91255.1.
AY142651 mRNA. Translation: AAN13189.1.
AY085175 mRNA. Translation: AAM61726.1.
AY085495 mRNA. Translation: AAM62721.1.
AY085965 mRNA. Translation: AAM63175.1.
AY086789 mRNA. Translation: AAM63839.1.
AY086185 mRNA. Translation: AAM64264.1.
AY087061 mRNA. Translation: AAM64622.1.
AY087188 mRNA. Translation: AAM64744.1.
PIRiE84688.
S06904.
RefSeqiNP_180441.1. NM_128434.3. [P59259-1]
NP_190179.1. NM_114462.4. [P59259-1]
NP_190941.1. NM_115233.2. [P59259-1]
NP_563793.1. NM_100639.2. [P59259-1]
NP_563797.1. NM_100656.5. [P59259-1]
NP_568911.1. NM_125361.2. [P59259-1]
NP_568918.1. NM_125390.3. [P59259-1]
NP_850660.1. NM_180329.2. [P59259-1]
NP_850939.1. NM_180608.2. [P59259-1]
UniGeneiAt.25388.
At.27255.
At.27457.
At.43267.
At.48166.
At.49195.
At.66138.
At.68113.
At.71937.
At.71990.
At.72015.
At.75642.
At.75657.

Genome annotation databases

EnsemblPlantsiAT1G07660.1; AT1G07660.1; AT1G07660. [P59259-1]
AT1G07820.1; AT1G07820.1; AT1G07820. [P59259-1]
AT1G07820.2; AT1G07820.2; AT1G07820. [P59259-1]
AT2G28740.1; AT2G28740.1; AT2G28740. [P59259-1]
AT3G45930.1; AT3G45930.1; AT3G45930. [P59259-1]
AT3G46320.1; AT3G46320.1; AT3G46320. [P59259-1]
AT3G53730.1; AT3G53730.1; AT3G53730. [P59259-1]
AT5G59690.1; AT5G59690.1; AT5G59690. [P59259-1]
AT5G59970.1; AT5G59970.1; AT5G59970. [P59259-1]
GeneIDi817423.
823736.
823777.
824540.
836090.
836119.
837279.
837297.
KEGGiath:AT1G07660.
ath:AT1G07820.
ath:AT2G28740.
ath:AT3G45930.
ath:AT3G46320.
ath:AT3G53730.
ath:AT5G59690.
ath:AT5G59970.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17132 Genomic DNA. Translation: AAA32810.1.
M17133 Genomic DNA. Translation: AAA32811.1.
AC007583 Genomic DNA. Translation: AAF75089.1.
AC007583 Genomic DNA. Translation: AAF75072.1.
AC005727 Genomic DNA. Translation: AAC79580.1.
AC007184 Genomic DNA. Translation: AAM15445.1.
AL162459 Genomic DNA. Translation: CAB82817.1.
AL133298 Genomic DNA. Translation: CAB62023.1.
AL132960 Genomic DNA. Translation: CAB88335.1.
AB006705 Genomic DNA. Translation: BAB09507.1.
AB015475 Genomic DNA. Translation: BAB08365.1.
CP002684 Genomic DNA. Translation: AEE28158.1.
CP002684 Genomic DNA. Translation: AEE28187.1.
CP002684 Genomic DNA. Translation: AEE28188.1.
CP002685 Genomic DNA. Translation: AEC08165.1.
CP002686 Genomic DNA. Translation: AEE78091.1.
CP002686 Genomic DNA. Translation: AEE78146.1.
CP002686 Genomic DNA. Translation: AEE79133.1.
CP002688 Genomic DNA. Translation: AED97220.1.
CP002688 Genomic DNA. Translation: AED97260.1.
AF325058 mRNA. Translation: AAG40410.1.
AF334729 mRNA. Translation: AAG50107.1.
AY057609 mRNA. Translation: AAL14404.1.
AY062717 mRNA. Translation: AAL32795.1.
AY063857 mRNA. Translation: AAL36213.1.
AY093353 mRNA. Translation: AAM13352.1.
AY099675 mRNA. Translation: AAM20526.1.
AY124836 mRNA. Translation: AAM70545.1.
AY128855 mRNA. Translation: AAM91255.1.
AY142651 mRNA. Translation: AAN13189.1.
AY085175 mRNA. Translation: AAM61726.1.
AY085495 mRNA. Translation: AAM62721.1.
AY085965 mRNA. Translation: AAM63175.1.
AY086789 mRNA. Translation: AAM63839.1.
AY086185 mRNA. Translation: AAM64264.1.
AY087061 mRNA. Translation: AAM64622.1.
AY087188 mRNA. Translation: AAM64744.1.
PIRiE84688.
S06904.
RefSeqiNP_180441.1. NM_128434.3. [P59259-1]
NP_190179.1. NM_114462.4. [P59259-1]
NP_190941.1. NM_115233.2. [P59259-1]
NP_563793.1. NM_100639.2. [P59259-1]
NP_563797.1. NM_100656.5. [P59259-1]
NP_568911.1. NM_125361.2. [P59259-1]
NP_568918.1. NM_125390.3. [P59259-1]
NP_850660.1. NM_180329.2. [P59259-1]
NP_850939.1. NM_180608.2. [P59259-1]
UniGeneiAt.25388.
At.27255.
At.27457.
At.43267.
At.48166.
At.49195.
At.66138.
At.68113.
At.71937.
At.71990.
At.72015.
At.75642.
At.75657.

3D structure databases

ProteinModelPortaliP59259.
SMRiP59259. Positions 2-103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi21363. 1 interaction.
22520. 4 interactions.
2773. 12 interactions.
9097. 1 interaction.
9857. 1 interaction.
IntActiP59259. 9 interactions.
STRINGi3702.AT5G59970.1.

Proteomic databases

PaxDbiP59259.
PRIDEiP59259.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G07660.1; AT1G07660.1; AT1G07660. [P59259-1]
AT1G07820.1; AT1G07820.1; AT1G07820. [P59259-1]
AT1G07820.2; AT1G07820.2; AT1G07820. [P59259-1]
AT2G28740.1; AT2G28740.1; AT2G28740. [P59259-1]
AT3G45930.1; AT3G45930.1; AT3G45930. [P59259-1]
AT3G46320.1; AT3G46320.1; AT3G46320. [P59259-1]
AT3G53730.1; AT3G53730.1; AT3G53730. [P59259-1]
AT5G59690.1; AT5G59690.1; AT5G59690. [P59259-1]
AT5G59970.1; AT5G59970.1; AT5G59970. [P59259-1]
GeneIDi817423.
823736.
823777.
824540.
836090.
836119.
837279.
837297.
KEGGiath:AT1G07660.
ath:AT1G07820.
ath:AT2G28740.
ath:AT3G45930.
ath:AT3G46320.
ath:AT3G53730.
ath:AT5G59690.
ath:AT5G59970.

Organism-specific databases

TAIRiAT1G07660.
AT1G07820.
AT2G28740.
AT3G45930.
AT3G46320.
AT3G53730.
AT5G59690.
AT5G59970.

Phylogenomic databases

eggNOGiKOG3467. Eukaryota.
COG2036. LUCA.
HOGENOMiHOG000234654.
KOiK11254.
OMAiSTHNERI.
OrthoDBiEOG09360XKI.
PhylomeDBiP59259.

Miscellaneous databases

PROiP59259.

Gene expression databases

ExpressionAtlasiP59259. baseline and differential.
GenevisibleiP59259. AT.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR001951. Histone_H4.
IPR019809. Histone_H4_CS.
[Graphical view]
PRINTSiPR00623. HISTONEH4.
SMARTiSM00417. H4. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00047. HISTONE_H4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH4_ARATH
AccessioniPrimary (citable) accession number: P59259
Secondary accession number(s): P02308
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.