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P59235 (NUP43_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleoporin Nup43
Alternative name(s):
Nup107-160 subcomplex subunit Nup43
Gene names
Name:Nup43
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation By similarity.

Subunit structure

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13 By similarity.

Subcellular location

Chromosomecentromerekinetochore By similarity. Nucleusnuclear pore complex By similarity.

Sequence similarities

Contains 6 WD repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Nucleoporin Nup43
PRO_0000051112

Regions

Repeat8 – 5750WD 1
Repeat72 – 11039WD 2
Repeat119 – 16648WD 3
Repeat170 – 20839WD 4
Repeat215 – 25541WD 5
Repeat259 – 29941WD 6

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Experimental info

Sequence conflict1031H → Y in BAC41049. Ref.1
Sequence conflict2941D → N in BAC41049. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P59235 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: ABDE8D4C78AA8BCD

FASTA38041,990
        10         20         30         40         50         60 
MEEIYAKFVS QKISKTRWRP VPSGSLQTTE TFATGSWDNE ENCVSLWSIG DFGNLDSDGG 

        70         80         90        100        110        120 
FEGDHQLLCD IRHHGDVMDL QFFDQERIVA ASSTGCVTVF LHHPNNQTLS VNQQWPAAHY 

       130        140        150        160        170        180 
HTGPSSPSYS SAPCTGIVCD NPEIVTVGED GRINLFRVDH KEAVRTIDNA DSSTLHAVTF 

       190        200        210        220        230        240 
LRTPEIVTVN SIGQLKIWDF RQQGSEPCQI LSLTGDRVPL HCVDRHPDQQ HVVATGGQDG 

       250        260        270        280        290        300 
MLSIWDVRQG TMPVSLLKAH EAEMWEVHFH PSNPDHLFTC SEDGSLWHWD ASTDAPEKSS 

       310        320        330        340        350        360 
LFHQGGRSST FLSHSLSNQA GVHQSLVSSW LSTDPAKDRI EITSLLPSRT LSVNSLDVLG 

       370        380 
PCLVCGTDAE AIYVTRQLFS 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK090019 mRNA. Translation: BAC41049.1.
AC156391 Genomic DNA. No translation available.
RefSeqNP_663752.2. NM_145706.2.
UniGeneMm.299887.

3D structure databases

ProteinModelPortalP59235.
SMRP59235. Positions 4-380.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP59235. 1 interaction.
MINTMINT-4104279.

PTM databases

PhosphoSiteP59235.

Proteomic databases

PaxDbP59235.
PRIDEP59235.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040135; ENSMUSP00000046732; ENSMUSG00000040034.
GeneID69912.
KEGGmmu:69912.
UCSCuc007eic.2. mouse.

Organism-specific databases

CTD348995.
MGIMGI:1917162. Nup43.

Phylogenomic databases

eggNOGNOG270547.
GeneTreeENSGT00390000004803.
HOGENOMHOG000007964.
HOVERGENHBG052696.
InParanoidP59235.
KOK14305.
OMAQWTAAHY.
OrthoDBEOG7Z3F4F.
TreeFamTF321692.

Gene expression databases

ArrayExpressP59235.
BgeeP59235.
CleanExMM_NUP43.
GenevestigatorP59235.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 2 hits.
[Graphical view]
SMARTSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
PROSITEPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio330593.
PROP59235.
SOURCESearch...

Entry information

Entry nameNUP43_MOUSE
AccessionPrimary (citable) accession number: P59235
Secondary accession number(s): E9QPN3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: July 27, 2011
Last modified: February 19, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot