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P59235

- NUP43_MOUSE

UniProt

P59235 - NUP43_MOUSE

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Protein

Nucleoporin Nup43

Gene

Nup43

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation (By similarity).By similarity

GO - Biological processi

  1. chromosome segregation Source: UniProtKB-KW
  2. mitotic nuclear division Source: UniProtKB-KW
  3. mRNA transport Source: UniProtKB-KW
  4. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Mitosis, mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiREACT_196650. Nuclear Pore Complex (NPC) Disassembly.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_207679. Separation of Sister Chromatids.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin Nup43
Alternative name(s):
Nup107-160 subcomplex subunit Nup43
Gene namesi
Name:Nup43
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1917162. Nup43.

Subcellular locationi

Chromosomecentromerekinetochore By similarity. Nucleusnuclear pore complex By similarity

GO - Cellular componenti

  1. kinetochore Source: UniProtKB-KW
  2. nuclear pore outer ring Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Nucleoporin Nup43PRO_0000051112Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP59235.
PaxDbiP59235.
PRIDEiP59235.

PTM databases

PhosphoSiteiP59235.

Expressioni

Gene expression databases

BgeeiP59235.
CleanExiMM_NUP43.
ExpressionAtlasiP59235. baseline and differential.
GenevestigatoriP59235.

Interactioni

Subunit structurei

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13 (By similarity).By similarity

Protein-protein interaction databases

IntActiP59235. 1 interaction.
MINTiMINT-4104279.

Structurei

3D structure databases

ProteinModelPortaliP59235.
SMRiP59235. Positions 4-380.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati8 – 5750WD 1Add
BLAST
Repeati72 – 11039WD 2Add
BLAST
Repeati119 – 16648WD 3Add
BLAST
Repeati170 – 20839WD 4Add
BLAST
Repeati215 – 25541WD 5Add
BLAST
Repeati259 – 29941WD 6Add
BLAST

Sequence similaritiesi

Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG270547.
GeneTreeiENSGT00390000004803.
HOGENOMiHOG000007964.
HOVERGENiHBG052696.
InParanoidiP59235.
KOiK14305.
OMAiQWTAAHY.
OrthoDBiEOG7Z3F4F.
TreeFamiTF321692.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59235-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEIYAKFVS QKISKTRWRP VPSGSLQTTE TFATGSWDNE ENCVSLWSIG
60 70 80 90 100
DFGNLDSDGG FEGDHQLLCD IRHHGDVMDL QFFDQERIVA ASSTGCVTVF
110 120 130 140 150
LHHPNNQTLS VNQQWPAAHY HTGPSSPSYS SAPCTGIVCD NPEIVTVGED
160 170 180 190 200
GRINLFRVDH KEAVRTIDNA DSSTLHAVTF LRTPEIVTVN SIGQLKIWDF
210 220 230 240 250
RQQGSEPCQI LSLTGDRVPL HCVDRHPDQQ HVVATGGQDG MLSIWDVRQG
260 270 280 290 300
TMPVSLLKAH EAEMWEVHFH PSNPDHLFTC SEDGSLWHWD ASTDAPEKSS
310 320 330 340 350
LFHQGGRSST FLSHSLSNQA GVHQSLVSSW LSTDPAKDRI EITSLLPSRT
360 370 380
LSVNSLDVLG PCLVCGTDAE AIYVTRQLFS
Length:380
Mass (Da):41,990
Last modified:July 27, 2011 - v2
Checksum:iABDE8D4C78AA8BCD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031H → Y in BAC41049. (PubMed:16141072)Curated
Sequence conflicti294 – 2941D → N in BAC41049. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK090019 mRNA. Translation: BAC41049.1.
AC156391 Genomic DNA. No translation available.
CCDSiCCDS48493.1.
RefSeqiNP_663752.2. NM_145706.2.
UniGeneiMm.299887.

Genome annotation databases

EnsembliENSMUST00000040135; ENSMUSP00000046732; ENSMUSG00000040034.
GeneIDi69912.
KEGGimmu:69912.
UCSCiuc007eic.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK090019 mRNA. Translation: BAC41049.1 .
AC156391 Genomic DNA. No translation available.
CCDSi CCDS48493.1.
RefSeqi NP_663752.2. NM_145706.2.
UniGenei Mm.299887.

3D structure databases

ProteinModelPortali P59235.
SMRi P59235. Positions 4-380.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P59235. 1 interaction.
MINTi MINT-4104279.

PTM databases

PhosphoSitei P59235.

Proteomic databases

MaxQBi P59235.
PaxDbi P59235.
PRIDEi P59235.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040135 ; ENSMUSP00000046732 ; ENSMUSG00000040034 .
GeneIDi 69912.
KEGGi mmu:69912.
UCSCi uc007eic.2. mouse.

Organism-specific databases

CTDi 348995.
MGIi MGI:1917162. Nup43.

Phylogenomic databases

eggNOGi NOG270547.
GeneTreei ENSGT00390000004803.
HOGENOMi HOG000007964.
HOVERGENi HBG052696.
InParanoidi P59235.
KOi K14305.
OMAi QWTAAHY.
OrthoDBi EOG7Z3F4F.
TreeFami TF321692.

Enzyme and pathway databases

Reactomei REACT_196650. Nuclear Pore Complex (NPC) Disassembly.
REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_207679. Separation of Sister Chromatids.

Miscellaneous databases

NextBioi 330593.
PROi P59235.
SOURCEi Search...

Gene expression databases

Bgeei P59235.
CleanExi MM_NUP43.
ExpressionAtlasi P59235. baseline and differential.
Genevestigatori P59235.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 2 hits.
[Graphical view ]
SMARTi SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiNUP43_MOUSE
AccessioniPrimary (citable) accession number: P59235
Secondary accession number(s): E9QPN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3