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P59235

- NUP43_MOUSE

UniProt

P59235 - NUP43_MOUSE

Protein

Nucleoporin Nup43

Gene

Nup43

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation By similarity.By similarity

    GO - Biological processi

    1. chromosome segregation Source: UniProtKB-KW
    2. mitotic nuclear division Source: UniProtKB-KW
    3. mRNA transport Source: UniProtKB-KW
    4. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, Chromosome partition, Mitosis, mRNA transport, Protein transport, Translocation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_196650. Nuclear Pore Complex (NPC) Disassembly.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.
    REACT_207679. Separation of Sister Chromatids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoporin Nup43
    Alternative name(s):
    Nup107-160 subcomplex subunit Nup43
    Gene namesi
    Name:Nup43
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1917162. Nup43.

    Subcellular locationi

    Chromosomecentromerekinetochore By similarity. Nucleusnuclear pore complex By similarity

    GO - Cellular componenti

    1. condensed chromosome kinetochore Source: UniProtKB-SubCell
    2. nuclear pore outer ring Source: UniProtKB

    Keywords - Cellular componenti

    Centromere, Chromosome, Kinetochore, Nuclear pore complex, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 380380Nucleoporin Nup43PRO_0000051112Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP59235.
    PaxDbiP59235.
    PRIDEiP59235.

    PTM databases

    PhosphoSiteiP59235.

    Expressioni

    Gene expression databases

    ArrayExpressiP59235.
    BgeeiP59235.
    CleanExiMM_NUP43.
    GenevestigatoriP59235.

    Interactioni

    Subunit structurei

    Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13 By similarity.By similarity

    Protein-protein interaction databases

    IntActiP59235. 1 interaction.
    MINTiMINT-4104279.

    Structurei

    3D structure databases

    ProteinModelPortaliP59235.
    SMRiP59235. Positions 4-380.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati8 – 5750WD 1Add
    BLAST
    Repeati72 – 11039WD 2Add
    BLAST
    Repeati119 – 16648WD 3Add
    BLAST
    Repeati170 – 20839WD 4Add
    BLAST
    Repeati215 – 25541WD 5Add
    BLAST
    Repeati259 – 29941WD 6Add
    BLAST

    Sequence similaritiesi

    Contains 6 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG270547.
    GeneTreeiENSGT00390000004803.
    HOGENOMiHOG000007964.
    HOVERGENiHBG052696.
    InParanoidiP59235.
    KOiK14305.
    OMAiQWTAAHY.
    OrthoDBiEOG7Z3F4F.
    TreeFamiTF321692.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 2 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 5 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59235-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEIYAKFVS QKISKTRWRP VPSGSLQTTE TFATGSWDNE ENCVSLWSIG    50
    DFGNLDSDGG FEGDHQLLCD IRHHGDVMDL QFFDQERIVA ASSTGCVTVF 100
    LHHPNNQTLS VNQQWPAAHY HTGPSSPSYS SAPCTGIVCD NPEIVTVGED 150
    GRINLFRVDH KEAVRTIDNA DSSTLHAVTF LRTPEIVTVN SIGQLKIWDF 200
    RQQGSEPCQI LSLTGDRVPL HCVDRHPDQQ HVVATGGQDG MLSIWDVRQG 250
    TMPVSLLKAH EAEMWEVHFH PSNPDHLFTC SEDGSLWHWD ASTDAPEKSS 300
    LFHQGGRSST FLSHSLSNQA GVHQSLVSSW LSTDPAKDRI EITSLLPSRT 350
    LSVNSLDVLG PCLVCGTDAE AIYVTRQLFS 380
    Length:380
    Mass (Da):41,990
    Last modified:July 27, 2011 - v2
    Checksum:iABDE8D4C78AA8BCD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti103 – 1031H → Y in BAC41049. (PubMed:16141072)Curated
    Sequence conflicti294 – 2941D → N in BAC41049. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090019 mRNA. Translation: BAC41049.1.
    AC156391 Genomic DNA. No translation available.
    CCDSiCCDS48493.1.
    RefSeqiNP_663752.2. NM_145706.2.
    UniGeneiMm.299887.

    Genome annotation databases

    EnsembliENSMUST00000040135; ENSMUSP00000046732; ENSMUSG00000040034.
    GeneIDi69912.
    KEGGimmu:69912.
    UCSCiuc007eic.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090019 mRNA. Translation: BAC41049.1 .
    AC156391 Genomic DNA. No translation available.
    CCDSi CCDS48493.1.
    RefSeqi NP_663752.2. NM_145706.2.
    UniGenei Mm.299887.

    3D structure databases

    ProteinModelPortali P59235.
    SMRi P59235. Positions 4-380.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P59235. 1 interaction.
    MINTi MINT-4104279.

    PTM databases

    PhosphoSitei P59235.

    Proteomic databases

    MaxQBi P59235.
    PaxDbi P59235.
    PRIDEi P59235.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040135 ; ENSMUSP00000046732 ; ENSMUSG00000040034 .
    GeneIDi 69912.
    KEGGi mmu:69912.
    UCSCi uc007eic.2. mouse.

    Organism-specific databases

    CTDi 348995.
    MGIi MGI:1917162. Nup43.

    Phylogenomic databases

    eggNOGi NOG270547.
    GeneTreei ENSGT00390000004803.
    HOGENOMi HOG000007964.
    HOVERGENi HBG052696.
    InParanoidi P59235.
    KOi K14305.
    OMAi QWTAAHY.
    OrthoDBi EOG7Z3F4F.
    TreeFami TF321692.

    Enzyme and pathway databases

    Reactomei REACT_196650. Nuclear Pore Complex (NPC) Disassembly.
    REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_204192. Regulation of Glucokinase by Glucokinase Regulatory Protein.
    REACT_207679. Separation of Sister Chromatids.

    Miscellaneous databases

    NextBioi 330593.
    PROi P59235.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P59235.
    Bgeei P59235.
    CleanExi MM_NUP43.
    Genevestigatori P59235.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 2 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 5 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 2 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiNUP43_MOUSE
    AccessioniPrimary (citable) accession number: P59235
    Secondary accession number(s): E9QPN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 27, 2003
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3