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Protein

Calmodulin-7

Gene

CAM7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases. Activates MPK8 in vitro.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi57 – 682PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi94 – 1053PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi130 – 1414PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • detection of calcium ion Source: TAIR
  • regulation of photomorphogenesis Source: TAIR
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-7
Short name:
CaM-7
Gene namesi
Name:CAM7
Ordered Locus Names:At3g43810
ORF Names:T28A8_100
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G43810.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001982831 – 149Calmodulin-7Add BLAST149

Proteomic databases

PaxDbiP59220.
PRIDEiP59220.

PTM databases

iPTMnetiP59220.

Expressioni

Gene expression databases

ExpressionAtlasiP59220. baseline and differential.
GenevisibleiP59220. AT.

Interactioni

Subunit structurei

Interacts with MPK8.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
At1g54610Q9ZVM92EBI-1236031,EBI-1235713
At5g20810Q2V3592EBI-1236031,EBI-1235819
BI-1Q9LD452EBI-1236031,EBI-1644586
CIPK24Q9LDI32EBI-1236031,EBI-537551
CPK3Q424792EBI-1236031,EBI-1235782
CPK30Q9SSF82EBI-1236031,EBI-1235738
HSP90-2P557372EBI-1236031,EBI-1235834
psbAP837552EBI-1236031,EBI-1236013

Protein-protein interaction databases

BioGridi8812. 7 interactors.
IntActiP59220. 121 interactors.
STRINGi3702.AT3G43810.1.

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 20Combined sources14
Beta strandi25 – 28Combined sources4
Helixi30 – 39Combined sources10
Helixi46 – 56Combined sources11
Beta strandi61 – 64Combined sources4
Helixi66 – 74Combined sources9
Helixi82 – 93Combined sources12
Helixi103 – 112Combined sources10
Helixi119 – 129Combined sources11
Beta strandi131 – 137Combined sources7
Helixi139 – 146Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AQRX-ray1.95A/B1-149[»]
5A2HX-ray2.27A1-149[»]
ProteinModelPortaliP59220.
SMRiP59220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 116EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 149EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the calmodulin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
HOGENOMiHOG000233018.
InParanoidiP59220.
KOiK02183.
OMAiHRISGKA.
OrthoDBiEOG09360QIJ.
PhylomeDBiP59220.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQLTDDQI SEFKEAFSLF DKDGDGCITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL NLMARKMKDT DSEEELKEAF RVFDKDQNGF
110 120 130 140
ISAAELRHVM TNLGEKLTDE EVDEMIREAD VDGDGQINYE EFVKVMMAK
Length:149
Mass (Da):16,848
Last modified:January 23, 2007 - v2
Checksum:iEB2B188A90AD508D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178073 mRNA. Translation: AAD53313.1.
AL162691 Genomic DNA. Translation: CAB83153.1.
CP002686 Genomic DNA. Translation: AEE77831.1.
AY088477 mRNA. Translation: AAM66013.1.
PIRiT47417.
RefSeqiNP_189967.1. NM_114249.4.
UniGeneiAt.23208.

Genome annotation databases

EnsemblPlantsiAT3G43810.1; AT3G43810.1; AT3G43810.
GeneIDi823492.
GrameneiAT3G43810.1; AT3G43810.1; AT3G43810.
KEGGiath:AT3G43810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178073 mRNA. Translation: AAD53313.1.
AL162691 Genomic DNA. Translation: CAB83153.1.
CP002686 Genomic DNA. Translation: AEE77831.1.
AY088477 mRNA. Translation: AAM66013.1.
PIRiT47417.
RefSeqiNP_189967.1. NM_114249.4.
UniGeneiAt.23208.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AQRX-ray1.95A/B1-149[»]
5A2HX-ray2.27A1-149[»]
ProteinModelPortaliP59220.
SMRiP59220.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi8812. 7 interactors.
IntActiP59220. 121 interactors.
STRINGi3702.AT3G43810.1.

PTM databases

iPTMnetiP59220.

Proteomic databases

PaxDbiP59220.
PRIDEiP59220.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G43810.1; AT3G43810.1; AT3G43810.
GeneIDi823492.
GrameneiAT3G43810.1; AT3G43810.1; AT3G43810.
KEGGiath:AT3G43810.

Organism-specific databases

TAIRiAT3G43810.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
HOGENOMiHOG000233018.
InParanoidiP59220.
KOiK02183.
OMAiHRISGKA.
OrthoDBiEOG09360QIJ.
PhylomeDBiP59220.

Miscellaneous databases

PROiP59220.

Gene expression databases

ExpressionAtlasiP59220. baseline and differential.
GenevisibleiP59220. AT.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALM7_ARATH
AccessioniPrimary (citable) accession number: P59220
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein has four functional calcium-binding sites.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.