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Protein

Calmodulin-7

Gene

CAM7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases. Activates MPK8 in vitro.1 Publication

Miscellaneous

This protein has four functional calcium-binding sites.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi57 – 682PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi94 – 1053PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi130 – 1414PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • detection of calcium ion Source: TAIR
  • regulation of photomorphogenesis Source: TAIR

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-ATH-114608 Platelet degranulation
R-ATH-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-ATH-4086398 Ca2+ pathway
R-ATH-418359 Reduction of cytosolic Ca++ levels
R-ATH-425561 Sodium/Calcium exchangers
R-ATH-442729 CREB phosphorylation through the activation of CaMKII
R-ATH-445355 Smooth Muscle Contraction
R-ATH-5578775 Ion homeostasis
R-ATH-5627123 RHO GTPases activate PAKs
R-ATH-8876725 Protein methylation
R-ATH-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-7
Short name:
CaM-7
Gene namesi
Name:CAM7
Ordered Locus Names:At3g43810
ORF Names:T28A8_100
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G43810
TAIRilocus:2101049 AT3G43810

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001982831 – 149Calmodulin-7Add BLAST149

Proteomic databases

PaxDbiP59220
PRIDEiP59220

PTM databases

iPTMnetiP59220

Expressioni

Gene expression databases

ExpressionAtlasiP59220 baseline and differential
GenevisibleiP59220 AT

Interactioni

Subunit structurei

Interacts with MPK8.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi88127 interactors.
IntActiP59220 121 interactors.
STRINGi3702.AT3G43810.1

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 20Combined sources14
Beta strandi25 – 28Combined sources4
Helixi30 – 39Combined sources10
Helixi46 – 56Combined sources11
Beta strandi61 – 64Combined sources4
Helixi66 – 74Combined sources9
Helixi82 – 93Combined sources12
Helixi103 – 112Combined sources10
Helixi119 – 129Combined sources11
Beta strandi131 – 137Combined sources7
Helixi139 – 146Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AQRX-ray1.95A/B1-149[»]
5A2HX-ray2.27A1-149[»]
ProteinModelPortaliP59220
SMRiP59220
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 116EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 149EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the calmodulin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
HOGENOMiHOG000233018
InParanoidiP59220
KOiK02183
OMAiESELTDM
OrthoDBiEOG09360QIJ
PhylomeDBiP59220

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

P59220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQLTDDQI SEFKEAFSLF DKDGDGCITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL NLMARKMKDT DSEEELKEAF RVFDKDQNGF
110 120 130 140
ISAAELRHVM TNLGEKLTDE EVDEMIREAD VDGDGQINYE EFVKVMMAK
Length:149
Mass (Da):16,848
Last modified:January 23, 2007 - v2
Checksum:iEB2B188A90AD508D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178073 mRNA Translation: AAD53313.1
AL162691 Genomic DNA Translation: CAB83153.1
CP002686 Genomic DNA Translation: AEE77831.1
AY088477 mRNA Translation: AAM66013.1
PIRiT47417
RefSeqiNP_189967.1, NM_114249.4
UniGeneiAt.23208

Genome annotation databases

EnsemblPlantsiAT3G43810.1; AT3G43810.1; AT3G43810
GeneIDi823492
GrameneiAT3G43810.1; AT3G43810.1; AT3G43810
KEGGiath:AT3G43810

Similar proteinsi

Entry informationi

Entry nameiCALM7_ARATH
AccessioniPrimary (citable) accession number: P59220
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome