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P59206

- LYTB_STRR6

UniProt

P59206 - LYTB_STRR6

Protein

Putative endo-beta-N-acetylglucosaminidase

Gene

lytB

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (10 Jan 2003)
      Previous versions | rss
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    Functioni

    Plays an important role in cell wall degradation and cell separation.

    Catalytic activityi

    Endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -(Man(GlcNAc)2)Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact.

    GO - Molecular functioni

    1. amidase activity Source: InterPro
    2. mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule metabolic process Source: InterPro
    2. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Cell wall biogenesis/degradation

    Enzyme and pathway databases

    BioCyciSPNE171101:GJC8-878-MONOMER.

    Protein family/group databases

    CAZyiGH73. Glycoside Hydrolase Family 73.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative endo-beta-N-acetylglucosaminidase (EC:3.2.1.96)
    Alternative name(s):
    Murein hydrolase
    Gene namesi
    Name:lytB
    Ordered Locus Names:spr0867
    OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
    Taxonomic identifieri171101 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000586: Chromosome

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23231 PublicationAdd
    BLAST
    Chaini24 – 702679Putative endo-beta-N-acetylglucosaminidasePRO_0000012117Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi171101.spr0867.

    Structurei

    3D structure databases

    ProteinModelPortaliP59206.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati42 – 6322Cell wall-binding 1Add
    BLAST
    Repeati65 – 8420Cell wall-binding 2Add
    BLAST
    Repeati86 – 10520Cell wall-binding 3Add
    BLAST
    Repeati124 – 14522Cell wall-binding 4Add
    BLAST
    Repeati147 – 16620Cell wall-binding 5Add
    BLAST
    Repeati185 – 20622Cell wall-binding 6Add
    BLAST
    Repeati208 – 22720Cell wall-binding 7Add
    BLAST
    Repeati229 – 24820Cell wall-binding 8Add
    BLAST
    Repeati250 – 27122Cell wall-binding 9Add
    BLAST
    Repeati273 – 29220Cell wall-binding 10Add
    BLAST
    Repeati294 – 31522Cell wall-binding 11Add
    BLAST
    Repeati317 – 33620Cell wall-binding 12Add
    BLAST
    Repeati338 – 35922Cell wall-binding 13Add
    BLAST
    Repeati361 – 38020Cell wall-binding 14Add
    BLAST
    Repeati382 – 40322Cell wall-binding 15Add
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 73 family.Curated
    Contains 15 cell wall-binding repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG5263.
    HOGENOMiHOG000284998.
    KOiK01227.
    OrthoDBiEOG6BKJGD.

    Family and domain databases

    InterProiIPR018337. Cell_wall/Cho-bd_repeat.
    IPR013338. Lysozyme_subfam2_dom.
    IPR002901. MGlyc_endo_b_GlcNAc_like_dom.
    [Graphical view]
    PfamiPF01473. CW_binding_1. 12 hits.
    PF01832. Glucosaminidase. 1 hit.
    [Graphical view]
    SMARTiSM00047. LYZ2. 1 hit.
    [Graphical view]
    PROSITEiPS51170. CW. 15 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P59206-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKVRFIFLA LLFFLASPEG AMASDGTWQG KQYLKEDGSQ AANEWVFDTH    50
    YQSWFYIKAD ANYAENEWLK QGDDYFYLKS GGYMAKSEWV EDKGAFYYLD 100
    QDGKMKRNAW VGTSYVGATG AKVIEDWVYD SQYDAWFYIK ADGQHAEKEW 150
    LQIKGKDYYF KSGGYLLTSQ WINQAYVNAS GAKVQQGWLF DKQYQSWFYI 200
    KENGNYADKE WIFENGHYYY LKSGGYMAAN EWIWDKESWF YLKFDGKIAE 250
    KEWVYDSHSQ AWYYFKSGGY MAANEWIWDK ESWFYLKFDG KMAEKEWVYD 300
    SHSQAWYYFK SGGYMTANEW IWDKESWFYL KSDGKIAEKE WVYDSHSQAW 350
    YYFKSGGYMT ANEWIWDKES WFYLKSDGKM AEKEWVYDSH SQAWYYFKSG 400
    GYMAKNETVD GYQLGSDGKW LGGKATNKNA AYYQVVPVTA NVYDSDGEKL 450
    SYISQGSVVW LDKDRKSDDK RLAITISGLS GYMKTEDLQA LDASKDFIPY 500
    YESDGHRFYH YVAQNASIPV ASHLSDMEVG KKYYSADGLH FDGFKLENPF 550
    LFKDLTEATN YSAEELDKVF SLLNINNSLL ENKGATFKEA EEHYHINALY 600
    LLAHSALESN WGRSKIAKDK NNFFGITAYD TTPYLSAKTF DDVDKGILGA 650
    TKWIKENYID RGRTFLGNKA SGMNVEYASD PYWGEKIASV MMKINEKLGG 700
    KD 702
    Length:702
    Mass (Da):81,900
    Last modified:January 10, 2003 - v1
    Checksum:i84B6536E75301FE5
    GO

    Sequence cautioni

    The sequence AAK99671.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ010312 Genomic DNA. Translation: CAA09078.2.
    AE007317 Genomic DNA. Translation: AAK99671.1. Different initiation.
    PIRiC97980.
    RefSeqiNP_358461.1. NC_003098.1.

    Genome annotation databases

    EnsemblBacteriaiAAK99671; AAK99671; spr0867.
    GeneIDi934406.
    KEGGispr:spr0867.
    PATRICi19701673. VBIStrPne107296_0955.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ010312 Genomic DNA. Translation: CAA09078.2 .
    AE007317 Genomic DNA. Translation: AAK99671.1 . Different initiation.
    PIRi C97980.
    RefSeqi NP_358461.1. NC_003098.1.

    3D structure databases

    ProteinModelPortali P59206.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 171101.spr0867.

    Protein family/group databases

    CAZyi GH73. Glycoside Hydrolase Family 73.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK99671 ; AAK99671 ; spr0867 .
    GeneIDi 934406.
    KEGGi spr:spr0867.
    PATRICi 19701673. VBIStrPne107296_0955.

    Phylogenomic databases

    eggNOGi COG5263.
    HOGENOMi HOG000284998.
    KOi K01227.
    OrthoDBi EOG6BKJGD.

    Enzyme and pathway databases

    BioCyci SPNE171101:GJC8-878-MONOMER.

    Family and domain databases

    InterProi IPR018337. Cell_wall/Cho-bd_repeat.
    IPR013338. Lysozyme_subfam2_dom.
    IPR002901. MGlyc_endo_b_GlcNAc_like_dom.
    [Graphical view ]
    Pfami PF01473. CW_binding_1. 12 hits.
    PF01832. Glucosaminidase. 1 hit.
    [Graphical view ]
    SMARTi SM00047. LYZ2. 1 hit.
    [Graphical view ]
    PROSITEi PS51170. CW. 15 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "LytB, a novel pneumococcal murein hydrolase essential for cell separation."
      Garcia P., Gonzalez M.P., Garcia E., Lopez R., Garcia J.L.
      Mol. Microbiol. 31:1275-1281(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 24-30.
    2. Garcia J.
      Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-255 / R6.

    Entry informationi

    Entry nameiLYTB_STRR6
    AccessioniPrimary (citable) accession number: P59206
    Secondary accession number(s): Q9Z4P7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: January 10, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3