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P59206 (LYTB_STRR6) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative endo-beta-N-acetylglucosaminidase

EC=3.2.1.96
Alternative name(s):
Murein hydrolase
Gene names
Name:lytB
Ordered Locus Names:spr0867
OrganismStreptococcus pneumoniae (strain ATCC BAA-255 / R6) [Reference proteome] [HAMAP]
Taxonomic identifier171101 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length702 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in cell wall degradation and cell separation.

Catalytic activity

Endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -(Man(GlcNAc)2)Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 73 family.

Contains 15 cell wall-binding repeats.

Sequence caution

The sequence AAK99671.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.1
Chain24 – 702679Putative endo-beta-N-acetylglucosaminidase
PRO_0000012117

Regions

Repeat42 – 6322Cell wall-binding 1
Repeat65 – 8420Cell wall-binding 2
Repeat86 – 10520Cell wall-binding 3
Repeat124 – 14522Cell wall-binding 4
Repeat147 – 16620Cell wall-binding 5
Repeat185 – 20622Cell wall-binding 6
Repeat208 – 22720Cell wall-binding 7
Repeat229 – 24820Cell wall-binding 8
Repeat250 – 27122Cell wall-binding 9
Repeat273 – 29220Cell wall-binding 10
Repeat294 – 31522Cell wall-binding 11
Repeat317 – 33620Cell wall-binding 12
Repeat338 – 35922Cell wall-binding 13
Repeat361 – 38020Cell wall-binding 14
Repeat382 – 40322Cell wall-binding 15

Sequences

Sequence LengthMass (Da)Tools
P59206 [UniParc].

Last modified January 10, 2003. Version 1.
Checksum: 84B6536E75301FE5

FASTA70281,900
        10         20         30         40         50         60 
MKKVRFIFLA LLFFLASPEG AMASDGTWQG KQYLKEDGSQ AANEWVFDTH YQSWFYIKAD 

        70         80         90        100        110        120 
ANYAENEWLK QGDDYFYLKS GGYMAKSEWV EDKGAFYYLD QDGKMKRNAW VGTSYVGATG 

       130        140        150        160        170        180 
AKVIEDWVYD SQYDAWFYIK ADGQHAEKEW LQIKGKDYYF KSGGYLLTSQ WINQAYVNAS 

       190        200        210        220        230        240 
GAKVQQGWLF DKQYQSWFYI KENGNYADKE WIFENGHYYY LKSGGYMAAN EWIWDKESWF 

       250        260        270        280        290        300 
YLKFDGKIAE KEWVYDSHSQ AWYYFKSGGY MAANEWIWDK ESWFYLKFDG KMAEKEWVYD 

       310        320        330        340        350        360 
SHSQAWYYFK SGGYMTANEW IWDKESWFYL KSDGKIAEKE WVYDSHSQAW YYFKSGGYMT 

       370        380        390        400        410        420 
ANEWIWDKES WFYLKSDGKM AEKEWVYDSH SQAWYYFKSG GYMAKNETVD GYQLGSDGKW 

       430        440        450        460        470        480 
LGGKATNKNA AYYQVVPVTA NVYDSDGEKL SYISQGSVVW LDKDRKSDDK RLAITISGLS 

       490        500        510        520        530        540 
GYMKTEDLQA LDASKDFIPY YESDGHRFYH YVAQNASIPV ASHLSDMEVG KKYYSADGLH 

       550        560        570        580        590        600 
FDGFKLENPF LFKDLTEATN YSAEELDKVF SLLNINNSLL ENKGATFKEA EEHYHINALY 

       610        620        630        640        650        660 
LLAHSALESN WGRSKIAKDK NNFFGITAYD TTPYLSAKTF DDVDKGILGA TKWIKENYID 

       670        680        690        700 
RGRTFLGNKA SGMNVEYASD PYWGEKIASV MMKINEKLGG KD 

« Hide

References

« Hide 'large scale' references
[1]"LytB, a novel pneumococcal murein hydrolase essential for cell separation."
Garcia P., Gonzalez M.P., Garcia E., Lopez R., Garcia J.L.
Mol. Microbiol. 31:1275-1281(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 24-30.
[2]Garcia J.
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Genome of the bacterium Streptococcus pneumoniae strain R6."
Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S., DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C., Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J., Lee L.N. expand/collapse author list , Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M., McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B., Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y., Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R., Rosteck P.R. Jr., Skatrud P.L., Glass J.I.
J. Bacteriol. 183:5709-5717(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-255 / R6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ010312 Genomic DNA. Translation: CAA09078.2.
AE007317 Genomic DNA. Translation: AAK99671.1. Different initiation.
PIRC97980.
RefSeqNP_358461.1. NC_003098.1.

3D structure databases

ProteinModelPortalP59206.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING171101.spr0867.

Protein family/group databases

CAZyGH73. Glycoside Hydrolase Family 73.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK99671; AAK99671; spr0867.
GeneID934406.
KEGGspr:spr0867.
PATRIC19701673. VBIStrPne107296_0955.

Phylogenomic databases

eggNOGCOG5263.
HOGENOMHOG000284998.
KOK01227.
OrthoDBEOG6BKJGD.

Enzyme and pathway databases

BioCycSPNE171101:GJC8-878-MONOMER.

Family and domain databases

InterProIPR018337. Cell_wall/Cho-bd_repeat.
IPR013338. Lysozyme_dom_subfam2.
IPR002901. Mano_Glyc_endo_b_GlcNAc.
[Graphical view]
PfamPF01473. CW_binding_1. 12 hits.
PF01832. Glucosaminidase. 1 hit.
[Graphical view]
SMARTSM00047. LYZ2. 1 hit.
[Graphical view]
PROSITEPS51170. CW. 15 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLYTB_STRR6
AccessionPrimary (citable) accession number: P59206
Secondary accession number(s): Q9Z4P7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries