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P59206

- LYTB_STRR6

UniProt

P59206 - LYTB_STRR6

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Protein

Putative endo-beta-N-acetylglucosaminidase

Gene

lytB

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Plays an important role in cell wall degradation and cell separation.

Catalytic activityi

Endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -(Man(GlcNAc)2)Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact.

GO - Molecular functioni

  1. amidase activity Source: InterPro
  2. mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-878-MONOMER.

Protein family/group databases

CAZyiGH73. Glycoside Hydrolase Family 73.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative endo-beta-N-acetylglucosaminidase (EC:3.2.1.96)
Alternative name(s):
Murein hydrolase
Gene namesi
Name:lytB
Ordered Locus Names:spr0867
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000586: Chromosome

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 702679Putative endo-beta-N-acetylglucosaminidasePRO_0000012117Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi171101.spr0867.

Structurei

3D structure databases

ProteinModelPortaliP59206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati42 – 6322Cell wall-binding 1Add
BLAST
Repeati65 – 8420Cell wall-binding 2Add
BLAST
Repeati86 – 10520Cell wall-binding 3Add
BLAST
Repeati124 – 14522Cell wall-binding 4Add
BLAST
Repeati147 – 16620Cell wall-binding 5Add
BLAST
Repeati185 – 20622Cell wall-binding 6Add
BLAST
Repeati208 – 22720Cell wall-binding 7Add
BLAST
Repeati229 – 24820Cell wall-binding 8Add
BLAST
Repeati250 – 27122Cell wall-binding 9Add
BLAST
Repeati273 – 29220Cell wall-binding 10Add
BLAST
Repeati294 – 31522Cell wall-binding 11Add
BLAST
Repeati317 – 33620Cell wall-binding 12Add
BLAST
Repeati338 – 35922Cell wall-binding 13Add
BLAST
Repeati361 – 38020Cell wall-binding 14Add
BLAST
Repeati382 – 40322Cell wall-binding 15Add
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 73 family.Curated
Contains 15 cell wall-binding repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG5263.
HOGENOMiHOG000284998.
KOiK01227.
OrthoDBiEOG6BKJGD.

Family and domain databases

InterProiIPR018337. Cell_wall/Cho-bd_repeat.
IPR013338. Lysozyme_subfam2_dom.
IPR002901. MGlyc_endo_b_GlcNAc_like_dom.
[Graphical view]
PfamiPF01473. CW_binding_1. 12 hits.
PF01832. Glucosaminidase. 1 hit.
[Graphical view]
SMARTiSM00047. LYZ2. 1 hit.
[Graphical view]
PROSITEiPS51170. CW. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59206 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKVRFIFLA LLFFLASPEG AMASDGTWQG KQYLKEDGSQ AANEWVFDTH
60 70 80 90 100
YQSWFYIKAD ANYAENEWLK QGDDYFYLKS GGYMAKSEWV EDKGAFYYLD
110 120 130 140 150
QDGKMKRNAW VGTSYVGATG AKVIEDWVYD SQYDAWFYIK ADGQHAEKEW
160 170 180 190 200
LQIKGKDYYF KSGGYLLTSQ WINQAYVNAS GAKVQQGWLF DKQYQSWFYI
210 220 230 240 250
KENGNYADKE WIFENGHYYY LKSGGYMAAN EWIWDKESWF YLKFDGKIAE
260 270 280 290 300
KEWVYDSHSQ AWYYFKSGGY MAANEWIWDK ESWFYLKFDG KMAEKEWVYD
310 320 330 340 350
SHSQAWYYFK SGGYMTANEW IWDKESWFYL KSDGKIAEKE WVYDSHSQAW
360 370 380 390 400
YYFKSGGYMT ANEWIWDKES WFYLKSDGKM AEKEWVYDSH SQAWYYFKSG
410 420 430 440 450
GYMAKNETVD GYQLGSDGKW LGGKATNKNA AYYQVVPVTA NVYDSDGEKL
460 470 480 490 500
SYISQGSVVW LDKDRKSDDK RLAITISGLS GYMKTEDLQA LDASKDFIPY
510 520 530 540 550
YESDGHRFYH YVAQNASIPV ASHLSDMEVG KKYYSADGLH FDGFKLENPF
560 570 580 590 600
LFKDLTEATN YSAEELDKVF SLLNINNSLL ENKGATFKEA EEHYHINALY
610 620 630 640 650
LLAHSALESN WGRSKIAKDK NNFFGITAYD TTPYLSAKTF DDVDKGILGA
660 670 680 690 700
TKWIKENYID RGRTFLGNKA SGMNVEYASD PYWGEKIASV MMKINEKLGG

KD
Length:702
Mass (Da):81,900
Last modified:January 10, 2003 - v1
Checksum:i84B6536E75301FE5
GO

Sequence cautioni

The sequence AAK99671.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ010312 Genomic DNA. Translation: CAA09078.2.
AE007317 Genomic DNA. Translation: AAK99671.1. Different initiation.
PIRiC97980.
RefSeqiNP_358461.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaiAAK99671; AAK99671; spr0867.
GeneIDi934406.
KEGGispr:spr0867.
PATRICi19701673. VBIStrPne107296_0955.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ010312 Genomic DNA. Translation: CAA09078.2 .
AE007317 Genomic DNA. Translation: AAK99671.1 . Different initiation.
PIRi C97980.
RefSeqi NP_358461.1. NC_003098.1.

3D structure databases

ProteinModelPortali P59206.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 171101.spr0867.

Protein family/group databases

CAZyi GH73. Glycoside Hydrolase Family 73.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK99671 ; AAK99671 ; spr0867 .
GeneIDi 934406.
KEGGi spr:spr0867.
PATRICi 19701673. VBIStrPne107296_0955.

Phylogenomic databases

eggNOGi COG5263.
HOGENOMi HOG000284998.
KOi K01227.
OrthoDBi EOG6BKJGD.

Enzyme and pathway databases

BioCyci SPNE171101:GJC8-878-MONOMER.

Family and domain databases

InterProi IPR018337. Cell_wall/Cho-bd_repeat.
IPR013338. Lysozyme_subfam2_dom.
IPR002901. MGlyc_endo_b_GlcNAc_like_dom.
[Graphical view ]
Pfami PF01473. CW_binding_1. 12 hits.
PF01832. Glucosaminidase. 1 hit.
[Graphical view ]
SMARTi SM00047. LYZ2. 1 hit.
[Graphical view ]
PROSITEi PS51170. CW. 15 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "LytB, a novel pneumococcal murein hydrolase essential for cell separation."
    Garcia P., Gonzalez M.P., Garcia E., Lopez R., Garcia J.L.
    Mol. Microbiol. 31:1275-1281(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 24-30.
  2. Garcia J.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-255 / R6.

Entry informationi

Entry nameiLYTB_STRR6
AccessioniPrimary (citable) accession number: P59206
Secondary accession number(s): Q9Z4P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3