Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P59205

- LYTB_STRPN

UniProt

P59205 - LYTB_STRPN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Putative endo-beta-N-acetylglucosaminidase

Gene

lytB

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Plays an important role in cell wall degradation and cell separation.By similarity

Catalytic activityi

Endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -(Man(GlcNAc)2)Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact.

GO - Molecular functioni

  1. amidase activity Source: InterPro
  2. mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-969-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative endo-beta-N-acetylglucosaminidase (EC:3.2.1.96)
Alternative name(s):
Murein hydrolase
Gene namesi
Name:lytB
Ordered Locus Names:SP_0965
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000585: Chromosome

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 658635Putative endo-beta-N-acetylglucosaminidasePRO_0000012116Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi170187.SP_0965.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4Q2WX-ray1.65A375-658[»]
ProteinModelPortaliP59205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati42 – 6322Cell wall-binding 1Add
BLAST
Repeati65 – 8420Cell wall-binding 2Add
BLAST
Repeati86 – 10520Cell wall-binding 3Add
BLAST
Repeati124 – 14522Cell wall-binding 4Add
BLAST
Repeati147 – 16620Cell wall-binding 5Add
BLAST
Repeati185 – 20622Cell wall-binding 6Add
BLAST
Repeati208 – 22720Cell wall-binding 7Add
BLAST
Repeati229 – 24820Cell wall-binding 8Add
BLAST
Repeati250 – 27122Cell wall-binding 9Add
BLAST
Repeati273 – 29220Cell wall-binding 10Add
BLAST
Repeati294 – 31522Cell wall-binding 11Add
BLAST
Repeati317 – 33620Cell wall-binding 12Add
BLAST
Repeati338 – 35922Cell wall-binding 13Add
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 73 family.Curated
Contains 13 cell wall-binding repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG5263.
HOGENOMiHOG000284998.
KOiK01227.
OMAiYYFKSGG.
OrthoDBiEOG6BKJGD.

Family and domain databases

InterProiIPR018337. Cell_wall/Cho-bd_repeat.
IPR013338. Lysozyme_subfam2_dom.
IPR002901. MGlyc_endo_b_GlcNAc_like_dom.
[Graphical view]
PfamiPF01473. CW_binding_1. 10 hits.
PF01832. Glucosaminidase. 1 hit.
[Graphical view]
SMARTiSM00047. LYZ2. 1 hit.
[Graphical view]
PROSITEiPS51170. CW. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59205-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKVRFIFLA LLFFLASPEG AMASDGTWQG KQYLKEDGSQ AANEWVFDTH
60 70 80 90 100
YQSWFYIKAD ANYAENEWLK QGDDYFYLKS GGYMAKSEWV EDKGAFYYLD
110 120 130 140 150
QDGKMKRNAW VGTSYVGATG AKVIEDWVYD SQYDAWFYIK ADGQHAEKEW
160 170 180 190 200
LQIKGKDYYF KSGGYLLTSQ WINQAYVNAS GAKVQQGWLF DKQYQSWFYI
210 220 230 240 250
KENGNYADKE WIFENGHYYY LKSGGYMAAN EWIWDKESWF YLKFDGKMAE
260 270 280 290 300
KEWVYDSHSQ AWYYFKSGGY MTANEWIWDK ESWFYLKSDG KIAEKEWVYD
310 320 330 340 350
SHSQAWYYFK SGGYMTANEW IWDKESWFYL KSDGKIAEKE WVYDSHSQAW
360 370 380 390 400
YYFKSGGYMA KNETVDGYQL GSDGKWLGGK TTNENAAYYQ VVPVTANVYD
410 420 430 440 450
SDGEKLSYIS QGSVVWLDKD RKSDDKRLAI TISGLSGYMK TEDLQALDAS
460 470 480 490 500
KDFIPYYESD GHRFYHYVAQ NASIPVASHL SDMEVGKKYY SADGLHFDGF
510 520 530 540 550
KLENPFLFKD LTEATNYSAE ELDKVFSLLN INNSLLENKG ATFKEAEEHY
560 570 580 590 600
HINALYLLAH SALESNWGRS KIAKDKNNFF GITAYDTTPY LSAKTFDDVD
610 620 630 640 650
KGILGATKWI KENYIDRGRT FLGNKASGMN VEYASDPYWG EKIASVMMKI

NEKLGGKD
Length:658
Mass (Da):76,469
Last modified:January 10, 2003 - v1
Checksum:iB625515006C9CB36
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK75086.1.
PIRiE95111.
RefSeqiNP_345446.1. NC_003028.3.
WP_000757741.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK75086; AAK75086; SP_0965.
GeneIDi931241.
KEGGispn:SP_0965.
PATRICi19706335. VBIStrPne105772_1012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK75086.1 .
PIRi E95111.
RefSeqi NP_345446.1. NC_003028.3.
WP_000757741.1. NZ_AKVY01000001.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4Q2W X-ray 1.65 A 375-658 [» ]
ProteinModelPortali P59205.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 170187.SP_0965.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK75086 ; AAK75086 ; SP_0965 .
GeneIDi 931241.
KEGGi spn:SP_0965.
PATRICi 19706335. VBIStrPne105772_1012.

Phylogenomic databases

eggNOGi COG5263.
HOGENOMi HOG000284998.
KOi K01227.
OMAi YYFKSGG.
OrthoDBi EOG6BKJGD.

Enzyme and pathway databases

BioCyci SPNE170187:GHGN-969-MONOMER.

Family and domain databases

InterProi IPR018337. Cell_wall/Cho-bd_repeat.
IPR013338. Lysozyme_subfam2_dom.
IPR002901. MGlyc_endo_b_GlcNAc_like_dom.
[Graphical view ]
Pfami PF01473. CW_binding_1. 10 hits.
PF01832. Glucosaminidase. 1 hit.
[Graphical view ]
SMARTi SM00047. LYZ2. 1 hit.
[Graphical view ]
PROSITEi PS51170. CW. 13 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.

Entry informationi

Entry nameiLYTB_STRPN
AccessioniPrimary (citable) accession number: P59205
Secondary accession number(s): Q9Z4P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3