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Protein

Putative endo-beta-N-acetylglucosaminidase

Gene

lytB

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in cell wall degradation and cell separation.By similarity

Catalytic activityi

Endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -(Man(GlcNAc)2)Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation

Protein family/group databases

CAZyiGH73. Glycoside Hydrolase Family 73.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative endo-beta-N-acetylglucosaminidase (EC:3.2.1.96)
Alternative name(s):
Murein hydrolase
Gene namesi
Name:lytB
Ordered Locus Names:SP_0965
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000001211624 – 658Putative endo-beta-N-acetylglucosaminidaseAdd BLAST635

Interactioni

Protein-protein interaction databases

STRINGi170187.SP_0965.

Structurei

Secondary structure

1658
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi387 – 391Combined sources5
Beta strandi393 – 399Combined sources7
Beta strandi405 – 410Combined sources6
Beta strandi414 – 417Combined sources4
Beta strandi425 – 432Combined sources8
Beta strandi435 – 440Combined sources6
Helixi441 – 443Combined sources3
Beta strandi444 – 446Combined sources3
Turni449 – 451Combined sources3
Beta strandi456 – 459Combined sources4
Beta strandi461 – 469Combined sources9
Beta strandi472 – 478Combined sources7
Beta strandi492 – 496Combined sources5
Turni505 – 508Combined sources4
Helixi519 – 528Combined sources10
Turni535 – 538Combined sources4
Helixi540 – 550Combined sources11
Helixi554 – 565Combined sources12
Turni566 – 569Combined sources4
Helixi571 – 576Combined sources6
Helixi598 – 613Combined sources16
Helixi615 – 617Combined sources3
Beta strandi625 – 628Combined sources4
Helixi630 – 633Combined sources4
Helixi639 – 653Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q2WX-ray1.65A375-658[»]
ProteinModelPortaliP59205.
SMRiP59205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati42 – 63Cell wall-binding 1Add BLAST22
Repeati65 – 84Cell wall-binding 2Add BLAST20
Repeati86 – 105Cell wall-binding 3Add BLAST20
Repeati124 – 145Cell wall-binding 4Add BLAST22
Repeati147 – 166Cell wall-binding 5Add BLAST20
Repeati185 – 206Cell wall-binding 6Add BLAST22
Repeati208 – 227Cell wall-binding 7Add BLAST20
Repeati229 – 248Cell wall-binding 8Add BLAST20
Repeati250 – 271Cell wall-binding 9Add BLAST22
Repeati273 – 292Cell wall-binding 10Add BLAST20
Repeati294 – 315Cell wall-binding 11Add BLAST22
Repeati317 – 336Cell wall-binding 12Add BLAST20
Repeati338 – 359Cell wall-binding 13Add BLAST22

Sequence similaritiesi

Belongs to the glycosyl hydrolase 73 family.Curated
Contains 13 cell wall-binding repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG4105IEH. Bacteria.
COG4193. LUCA.
HOGENOMiHOG000284998.
KOiK01227.
OMAiYYFKSGG.

Family and domain databases

InterProiIPR018337. Cell_wall/Cho-bd_repeat.
IPR002901. MGlyc_endo_b_GlcNAc-like_dom.
[Graphical view]
PfamiPF01473. CW_binding_1. 10 hits.
PF01832. Glucosaminidase. 1 hit.
[Graphical view]
SMARTiSM00047. LYZ2. 1 hit.
[Graphical view]
PROSITEiPS51170. CW. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVRFIFLA LLFFLASPEG AMASDGTWQG KQYLKEDGSQ AANEWVFDTH
60 70 80 90 100
YQSWFYIKAD ANYAENEWLK QGDDYFYLKS GGYMAKSEWV EDKGAFYYLD
110 120 130 140 150
QDGKMKRNAW VGTSYVGATG AKVIEDWVYD SQYDAWFYIK ADGQHAEKEW
160 170 180 190 200
LQIKGKDYYF KSGGYLLTSQ WINQAYVNAS GAKVQQGWLF DKQYQSWFYI
210 220 230 240 250
KENGNYADKE WIFENGHYYY LKSGGYMAAN EWIWDKESWF YLKFDGKMAE
260 270 280 290 300
KEWVYDSHSQ AWYYFKSGGY MTANEWIWDK ESWFYLKSDG KIAEKEWVYD
310 320 330 340 350
SHSQAWYYFK SGGYMTANEW IWDKESWFYL KSDGKIAEKE WVYDSHSQAW
360 370 380 390 400
YYFKSGGYMA KNETVDGYQL GSDGKWLGGK TTNENAAYYQ VVPVTANVYD
410 420 430 440 450
SDGEKLSYIS QGSVVWLDKD RKSDDKRLAI TISGLSGYMK TEDLQALDAS
460 470 480 490 500
KDFIPYYESD GHRFYHYVAQ NASIPVASHL SDMEVGKKYY SADGLHFDGF
510 520 530 540 550
KLENPFLFKD LTEATNYSAE ELDKVFSLLN INNSLLENKG ATFKEAEEHY
560 570 580 590 600
HINALYLLAH SALESNWGRS KIAKDKNNFF GITAYDTTPY LSAKTFDDVD
610 620 630 640 650
KGILGATKWI KENYIDRGRT FLGNKASGMN VEYASDPYWG EKIASVMMKI

NEKLGGKD
Length:658
Mass (Da):76,469
Last modified:January 10, 2003 - v1
Checksum:iB625515006C9CB36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK75086.1.
PIRiE95111.
RefSeqiWP_000757741.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK75086; AAK75086; SP_0965.
KEGGispn:SP_0965.
PATRICi19706335. VBIStrPne105772_1012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK75086.1.
PIRiE95111.
RefSeqiWP_000757741.1. NZ_AKVY01000001.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q2WX-ray1.65A375-658[»]
ProteinModelPortaliP59205.
SMRiP59205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi170187.SP_0965.

Protein family/group databases

CAZyiGH73. Glycoside Hydrolase Family 73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK75086; AAK75086; SP_0965.
KEGGispn:SP_0965.
PATRICi19706335. VBIStrPne105772_1012.

Phylogenomic databases

eggNOGiENOG4105IEH. Bacteria.
COG4193. LUCA.
HOGENOMiHOG000284998.
KOiK01227.
OMAiYYFKSGG.

Family and domain databases

InterProiIPR018337. Cell_wall/Cho-bd_repeat.
IPR002901. MGlyc_endo_b_GlcNAc-like_dom.
[Graphical view]
PfamiPF01473. CW_binding_1. 10 hits.
PF01832. Glucosaminidase. 1 hit.
[Graphical view]
SMARTiSM00047. LYZ2. 1 hit.
[Graphical view]
PROSITEiPS51170. CW. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYTB_STRPN
AccessioniPrimary (citable) accession number: P59205
Secondary accession number(s): Q9Z4P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.