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P59205 (LYTB_STRPN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative endo-beta-N-acetylglucosaminidase
EC=3.2.1.96
Alternative name(s):
Murein hydrolase
Gene names
Name:lytB
Ordered Locus Names:SP_0965
OrganismStreptococcus pneumoniae [Complete proteome] [HAMAP]
Taxonomic identifier1313 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length658 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays an important role in cell wall degradation and cell separation By similarity.

Catalytic activity

Endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -(Man(GlcNAc)2)Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 73 family.

Contains 13 cell wall-binding repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 658635Putative endo-beta-N-acetylglucosaminidase
PRO_0000012116

Regions

Repeat42 – 6322Cell wall-binding 1
Repeat65 – 8420Cell wall-binding 2
Repeat86 – 10520Cell wall-binding 3
Repeat124 – 14522Cell wall-binding 4
Repeat147 – 16620Cell wall-binding 5
Repeat185 – 20622Cell wall-binding 6
Repeat208 – 22720Cell wall-binding 7
Repeat229 – 24820Cell wall-binding 8
Repeat250 – 27122Cell wall-binding 9
Repeat273 – 29220Cell wall-binding 10
Repeat294 – 31522Cell wall-binding 11
Repeat317 – 33620Cell wall-binding 12
Repeat338 – 35922Cell wall-binding 13

Sequences

Sequence LengthMass (Da)Tools
P59205 [UniParc].

Last modified January 10, 2003. Version 1.
Checksum: B625515006C9CB36

FASTA65876,469
        10         20         30         40         50         60 
MKKVRFIFLA LLFFLASPEG AMASDGTWQG KQYLKEDGSQ AANEWVFDTH YQSWFYIKAD 

        70         80         90        100        110        120 
ANYAENEWLK QGDDYFYLKS GGYMAKSEWV EDKGAFYYLD QDGKMKRNAW VGTSYVGATG 

       130        140        150        160        170        180 
AKVIEDWVYD SQYDAWFYIK ADGQHAEKEW LQIKGKDYYF KSGGYLLTSQ WINQAYVNAS 

       190        200        210        220        230        240 
GAKVQQGWLF DKQYQSWFYI KENGNYADKE WIFENGHYYY LKSGGYMAAN EWIWDKESWF 

       250        260        270        280        290        300 
YLKFDGKMAE KEWVYDSHSQ AWYYFKSGGY MTANEWIWDK ESWFYLKSDG KIAEKEWVYD 

       310        320        330        340        350        360 
SHSQAWYYFK SGGYMTANEW IWDKESWFYL KSDGKIAEKE WVYDSHSQAW YYFKSGGYMA 

       370        380        390        400        410        420 
KNETVDGYQL GSDGKWLGGK TTNENAAYYQ VVPVTANVYD SDGEKLSYIS QGSVVWLDKD 

       430        440        450        460        470        480 
RKSDDKRLAI TISGLSGYMK TEDLQALDAS KDFIPYYESD GHRFYHYVAQ NASIPVASHL 

       490        500        510        520        530        540 
SDMEVGKKYY SADGLHFDGF KLENPFLFKD LTEATNYSAE ELDKVFSLLN INNSLLENKG 

       550        560        570        580        590        600 
ATFKEAEEHY HINALYLLAH SALESNWGRS KIAKDKNNFF GITAYDTTPY LSAKTFDDVD 

       610        620        630        640        650 
KGILGATKWI KENYIDRGRT FLGNKASGMN VEYASDPYWG EKIASVMMKI NEKLGGKD

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005672 Genomic DNA. Translation: AAK75086.1.
PIRE95111.
RefSeqNP_345446.1. NC_003028.3.

3D structure databases

ProteinModelPortalP59205.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTRT00000025359; EBSTRP00000024451; EBSTRG00000025359.
GeneID931241.
GenomeReviewsGene locus SP_0965 in contig AE005672_GR.
KEGGspn:SP_0965.
PATRIC19706335. VBIStrPne105772_1012.
TIGRSP_0965.

Phylogenomic databases

GeneTreeEBGT00050000026602.
HOGENOMHBG702253.
OMAYYFKSGG.
ProtClustDBCLSK559969.

Enzyme and pathway databases

BioCycSPNE170187-1:SP_0965-MONOMER.

Family and domain databases

InterProIPR018337. Cell_wall/Cho-bd_repeat.
IPR013338. Lysozyme_dom_subfam2.
IPR002901. Mano_Glyc_endo_b_GlcNAc.
[Graphical view]
KOK01227.
PfamPF01473. CW_binding_1. 10 hits.
PF01832. Glucosaminidase. 1 hit.
[Graphical view]
SMARTSM00047. LYZ2. 1 hit.
[Graphical view]
PROSITEPS51170. CW. 13 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLYTB_STRPN
AccessionPrimary (citable) accession number: P59205
Secondary accession number(s): Q9Z4P7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

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