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P59205

- LYTB_STRPN

UniProt

P59205 - LYTB_STRPN

Protein

Putative endo-beta-N-acetylglucosaminidase

Gene

lytB

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (10 Jan 2003)
      Previous versions | rss
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    Functioni

    Plays an important role in cell wall degradation and cell separation.By similarity

    Catalytic activityi

    Endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -(Man(GlcNAc)2)Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact.

    GO - Molecular functioni

    1. amidase activity Source: InterPro
    2. mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell wall macromolecule metabolic process Source: InterPro
    2. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Cell wall biogenesis/degradation

    Enzyme and pathway databases

    BioCyciSPNE170187:GHGN-969-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative endo-beta-N-acetylglucosaminidase (EC:3.2.1.96)
    Alternative name(s):
    Murein hydrolase
    Gene namesi
    Name:lytB
    Ordered Locus Names:SP_0965
    OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
    Taxonomic identifieri170187 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000585: Chromosome

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 658635Putative endo-beta-N-acetylglucosaminidasePRO_0000012116Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi170187.SP_0965.

    Structurei

    3D structure databases

    ProteinModelPortaliP59205.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati42 – 6322Cell wall-binding 1Add
    BLAST
    Repeati65 – 8420Cell wall-binding 2Add
    BLAST
    Repeati86 – 10520Cell wall-binding 3Add
    BLAST
    Repeati124 – 14522Cell wall-binding 4Add
    BLAST
    Repeati147 – 16620Cell wall-binding 5Add
    BLAST
    Repeati185 – 20622Cell wall-binding 6Add
    BLAST
    Repeati208 – 22720Cell wall-binding 7Add
    BLAST
    Repeati229 – 24820Cell wall-binding 8Add
    BLAST
    Repeati250 – 27122Cell wall-binding 9Add
    BLAST
    Repeati273 – 29220Cell wall-binding 10Add
    BLAST
    Repeati294 – 31522Cell wall-binding 11Add
    BLAST
    Repeati317 – 33620Cell wall-binding 12Add
    BLAST
    Repeati338 – 35922Cell wall-binding 13Add
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 73 family.Curated
    Contains 13 cell wall-binding repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG5263.
    HOGENOMiHOG000284998.
    KOiK01227.
    OMAiYYFKSGG.
    OrthoDBiEOG6BKJGD.

    Family and domain databases

    InterProiIPR018337. Cell_wall/Cho-bd_repeat.
    IPR013338. Lysozyme_subfam2_dom.
    IPR002901. MGlyc_endo_b_GlcNAc_like_dom.
    [Graphical view]
    PfamiPF01473. CW_binding_1. 10 hits.
    PF01832. Glucosaminidase. 1 hit.
    [Graphical view]
    SMARTiSM00047. LYZ2. 1 hit.
    [Graphical view]
    PROSITEiPS51170. CW. 13 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P59205-1 [UniParc]FASTAAdd to Basket

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    MKKVRFIFLA LLFFLASPEG AMASDGTWQG KQYLKEDGSQ AANEWVFDTH    50
    YQSWFYIKAD ANYAENEWLK QGDDYFYLKS GGYMAKSEWV EDKGAFYYLD 100
    QDGKMKRNAW VGTSYVGATG AKVIEDWVYD SQYDAWFYIK ADGQHAEKEW 150
    LQIKGKDYYF KSGGYLLTSQ WINQAYVNAS GAKVQQGWLF DKQYQSWFYI 200
    KENGNYADKE WIFENGHYYY LKSGGYMAAN EWIWDKESWF YLKFDGKMAE 250
    KEWVYDSHSQ AWYYFKSGGY MTANEWIWDK ESWFYLKSDG KIAEKEWVYD 300
    SHSQAWYYFK SGGYMTANEW IWDKESWFYL KSDGKIAEKE WVYDSHSQAW 350
    YYFKSGGYMA KNETVDGYQL GSDGKWLGGK TTNENAAYYQ VVPVTANVYD 400
    SDGEKLSYIS QGSVVWLDKD RKSDDKRLAI TISGLSGYMK TEDLQALDAS 450
    KDFIPYYESD GHRFYHYVAQ NASIPVASHL SDMEVGKKYY SADGLHFDGF 500
    KLENPFLFKD LTEATNYSAE ELDKVFSLLN INNSLLENKG ATFKEAEEHY 550
    HINALYLLAH SALESNWGRS KIAKDKNNFF GITAYDTTPY LSAKTFDDVD 600
    KGILGATKWI KENYIDRGRT FLGNKASGMN VEYASDPYWG EKIASVMMKI 650
    NEKLGGKD 658
    Length:658
    Mass (Da):76,469
    Last modified:January 10, 2003 - v1
    Checksum:iB625515006C9CB36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005672 Genomic DNA. Translation: AAK75086.1.
    PIRiE95111.
    RefSeqiNP_345446.1. NC_003028.3.

    Genome annotation databases

    EnsemblBacteriaiAAK75086; AAK75086; SP_0965.
    GeneIDi931241.
    KEGGispn:SP_0965.
    PATRICi19706335. VBIStrPne105772_1012.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005672 Genomic DNA. Translation: AAK75086.1 .
    PIRi E95111.
    RefSeqi NP_345446.1. NC_003028.3.

    3D structure databases

    ProteinModelPortali P59205.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 170187.SP_0965.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK75086 ; AAK75086 ; SP_0965 .
    GeneIDi 931241.
    KEGGi spn:SP_0965.
    PATRICi 19706335. VBIStrPne105772_1012.

    Phylogenomic databases

    eggNOGi COG5263.
    HOGENOMi HOG000284998.
    KOi K01227.
    OMAi YYFKSGG.
    OrthoDBi EOG6BKJGD.

    Enzyme and pathway databases

    BioCyci SPNE170187:GHGN-969-MONOMER.

    Family and domain databases

    InterProi IPR018337. Cell_wall/Cho-bd_repeat.
    IPR013338. Lysozyme_subfam2_dom.
    IPR002901. MGlyc_endo_b_GlcNAc_like_dom.
    [Graphical view ]
    Pfami PF01473. CW_binding_1. 10 hits.
    PF01832. Glucosaminidase. 1 hit.
    [Graphical view ]
    SMARTi SM00047. LYZ2. 1 hit.
    [Graphical view ]
    PROSITEi PS51170. CW. 13 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-334 / TIGR4.

    Entry informationi

    Entry nameiLYTB_STRPN
    AccessioniPrimary (citable) accession number: P59205
    Secondary accession number(s): Q9Z4P7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: January 10, 2003
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3