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Protein

DNA polymerase I

Gene

polA

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication

Enzyme and pathway databases

BioCyciSPNE170187:G1FZB-37-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase I (EC:2.7.7.7)
Short name:
POL I
Gene namesi
Name:polA
Ordered Locus Names:SP_0032
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012531 – 877DNA polymerase IAdd BLAST877

Proteomic databases

PRIDEiP59199

Interactioni

Subunit structurei

Single-chain monomer with multiple functions.By similarity

Structurei

3D structure databases

ProteinModelPortaliP59199
SMRiP59199
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini177 – 2705'-3' exonucleaseSequence analysisAdd BLAST94
Domaini302 – 4653'-5' exonucleaseSequence analysisAdd BLAST164

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated

Phylogenomic databases

eggNOGiENOG4105C2M Bacteria
COG0258 LUCA
COG0749 LUCA
HOGENOMiHOG000020998
KOiK02335
OMAiETGRVHT

Family and domain databases

CDDicd09898 H3TH_53EXO, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR002562 3'-5'_exonuclease_dom
IPR020046 5-3_exonucl_a-hlix_arch_N
IPR036279 5-3_exonuclease_C_sf
IPR002421 5-3_exonuclease_N
IPR019760 DNA-dir_DNA_pol_A_CS
IPR001098 DNA-dir_DNA_pol_A_palm_dom
IPR020045 DNA_polI_H3TH
IPR018320 DNA_polymerase_1
IPR002298 DNA_polymerase_A
IPR008918 HhH2
IPR029060 PIN-like_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10133 PTHR10133, 1 hit
PfamiView protein in Pfam
PF01367 5_3_exonuc, 1 hit
PF02739 5_3_exonuc_N, 1 hit
PF00476 DNA_pol_A, 1 hit
PRINTSiPR00868 DNAPOLI
SMARTiView protein in SMART
SM00474 35EXOc, 1 hit
SM00475 53EXOc, 1 hit
SM00279 HhH2, 1 hit
SM00482 POLAc, 1 hit
SUPFAMiSSF47807 SSF47807, 1 hit
SSF53098 SSF53098, 1 hit
SSF88723 SSF88723, 1 hit
TIGRFAMsiTIGR00593 pola, 1 hit
PROSITEiView protein in PROSITE
PS00447 DNA_POLYMERASE_A, 1 hit

Sequencei

Sequence statusi: Complete.

P59199-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKKKLLLID GSSVAFRAFF ALYQQLDRFK NVAGLHTNAI YGFQLMLSHL
60 70 80 90 100
LERVEPSHIL VAFDAGKTTF RTEMYADYKG GRAKTPDEFR EQFPFIRELL
110 120 130 140 150
DHMGIRHYDL AQYEADDIIG TLDKLAEQDG FDITIVSGDK DLIQLTDEHT
160 170 180 190 200
VVEISKKGVA EFEAFTPDYL MEEMGLTPAQ FIDLKALMGD KSDNIPGVTK
210 220 230 240 250
VGEKTGIKLL LEHGSLEGIY ENIDGMKTSK MKENLINDKE QAFLSKTLAT
260 270 280 290 300
IDTKAPIAIG LEDLVYSGPD VENLGKFYDE MGFKQLKQAL NVSSADVSES
310 320 330 340 350
LDFTIVDQIS QDMLSEESIF HFELFGENYH TDNLVGFVWS CGDKLYATDK
360 370 380 390 400
LELLQDPIFK DFLEKTSLRV YDFKKVKVLL QRFGVDLQAP AFDIRLAKYL
410 420 430 440 450
LSTVEDNEIA TIASLYGQTY LVDDETFYGK GVKKAIPERE KFLEHLACKL
460 470 480 490 500
AVLVETEPIL LEKLSENGQL ELLYDMEQPL AFVLAKMEIA GIMVKKETLL
510 520 530 540 550
EMQAENELVI EKLTQEIYEL AGEEFNVNSP KQLGVLLFEK LGLPLEYTKK
560 570 580 590 600
TKTGYSTAVD VLERLAPIAP IVKKILDYRQ IAKIQSTYVI GLQDWILADG
610 620 630 640 650
KIHTRYVQDL TQTGRLSSVD PNLQNIPARL EQGRLIRKAF VPEWEDSVLL
660 670 680 690 700
SSDYSQIELR VLAHISKDEH LIKAFQEGAD IHTSTAMRVF GIERPDDVTA
710 720 730 740 750
NDRRNAKAVN FGVVYGISDF GLSNNLGISR KEAKAYIDTY FERFPGIKNY
760 770 780 790 800
MDEVVREARD KGYVETLFKR RRELPDINSR NFNIRGFAER TAINSPIQGS
810 820 830 840 850
AADILKIAMI QLDKALVAGG YQTKMLLQVH DEIVLEVPKS ELVEMKKLVK
860 870
QTMEEAIQLS VPLIADENEG ATWYEAK
Length:877
Mass (Da):99,253
Last modified:January 10, 2003 - v1
Checksum:i2621865B94586913
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA Translation: AAK74222.1
PIRiE95003
RefSeqiWP_001808750.1, NZ_AKVY01000001.1

Genome annotation databases

EnsemblBacteriaiAAK74222; AAK74222; SP_0032
KEGGispn:SP_0032

Similar proteinsi

Entry informationi

Entry nameiDPO1_STRPN
AccessioniPrimary (citable) accession number: P59199
Secondary accession number(s): P13252
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health