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Protein

DNA polymerase I

Gene

polA

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity.By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA damage, DNA repair, DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-38-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase I (EC:2.7.7.7)
Short name:
POL I
Gene namesi
Name:polA
Ordered Locus Names:SP_0032
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 877877DNA polymerase IPRO_0000101253Add
BLAST

Interactioni

Subunit structurei

Single-chain monomer with multiple functions.By similarity

Protein-protein interaction databases

STRINGi170187.SpneT_02001792.

Structurei

3D structure databases

ProteinModelPortaliP59199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated
Contains 1 3'-5' exonuclease domain.Curated
Contains 1 5'-3' exonuclease domain.Curated

Phylogenomic databases

eggNOGiENOG4105C2M. Bacteria.
COG0258. LUCA.
COG0749. LUCA.
HOGENOMiHOG000020998.
KOiK02335.
OMAiCFDTETT.
OrthoDBiEOG6SJJH7.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.40.50.1010. 1 hit.
InterProiIPR002562. 3'-5'_exonuclease_dom.
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSiPR00868. DNAPOLI.
SMARTiSM00474. 35EXOc. 1 hit.
SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsiTIGR00593. pola. 1 hit.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59199-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKKKLLLID GSSVAFRAFF ALYQQLDRFK NVAGLHTNAI YGFQLMLSHL
60 70 80 90 100
LERVEPSHIL VAFDAGKTTF RTEMYADYKG GRAKTPDEFR EQFPFIRELL
110 120 130 140 150
DHMGIRHYDL AQYEADDIIG TLDKLAEQDG FDITIVSGDK DLIQLTDEHT
160 170 180 190 200
VVEISKKGVA EFEAFTPDYL MEEMGLTPAQ FIDLKALMGD KSDNIPGVTK
210 220 230 240 250
VGEKTGIKLL LEHGSLEGIY ENIDGMKTSK MKENLINDKE QAFLSKTLAT
260 270 280 290 300
IDTKAPIAIG LEDLVYSGPD VENLGKFYDE MGFKQLKQAL NVSSADVSES
310 320 330 340 350
LDFTIVDQIS QDMLSEESIF HFELFGENYH TDNLVGFVWS CGDKLYATDK
360 370 380 390 400
LELLQDPIFK DFLEKTSLRV YDFKKVKVLL QRFGVDLQAP AFDIRLAKYL
410 420 430 440 450
LSTVEDNEIA TIASLYGQTY LVDDETFYGK GVKKAIPERE KFLEHLACKL
460 470 480 490 500
AVLVETEPIL LEKLSENGQL ELLYDMEQPL AFVLAKMEIA GIMVKKETLL
510 520 530 540 550
EMQAENELVI EKLTQEIYEL AGEEFNVNSP KQLGVLLFEK LGLPLEYTKK
560 570 580 590 600
TKTGYSTAVD VLERLAPIAP IVKKILDYRQ IAKIQSTYVI GLQDWILADG
610 620 630 640 650
KIHTRYVQDL TQTGRLSSVD PNLQNIPARL EQGRLIRKAF VPEWEDSVLL
660 670 680 690 700
SSDYSQIELR VLAHISKDEH LIKAFQEGAD IHTSTAMRVF GIERPDDVTA
710 720 730 740 750
NDRRNAKAVN FGVVYGISDF GLSNNLGISR KEAKAYIDTY FERFPGIKNY
760 770 780 790 800
MDEVVREARD KGYVETLFKR RRELPDINSR NFNIRGFAER TAINSPIQGS
810 820 830 840 850
AADILKIAMI QLDKALVAGG YQTKMLLQVH DEIVLEVPKS ELVEMKKLVK
860 870
QTMEEAIQLS VPLIADENEG ATWYEAK
Length:877
Mass (Da):99,253
Last modified:January 10, 2003 - v1
Checksum:i2621865B94586913
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK74222.1.
PIRiE95003.
RefSeqiWP_001808750.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK74222; AAK74222; SP_0032.
KEGGispn:SP_0032.
PATRICi19704385. VBIStrPne105772_0037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK74222.1.
PIRiE95003.
RefSeqiWP_001808750.1. NZ_AKVY01000001.1.

3D structure databases

ProteinModelPortaliP59199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi170187.SpneT_02001792.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK74222; AAK74222; SP_0032.
KEGGispn:SP_0032.
PATRICi19704385. VBIStrPne105772_0037.

Phylogenomic databases

eggNOGiENOG4105C2M. Bacteria.
COG0258. LUCA.
COG0749. LUCA.
HOGENOMiHOG000020998.
KOiK02335.
OMAiCFDTETT.
OrthoDBiEOG6SJJH7.

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-38-MONOMER.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.40.50.1010. 1 hit.
InterProiIPR002562. 3'-5'_exonuclease_dom.
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSiPR00868. DNAPOLI.
SMARTiSM00474. 35EXOc. 1 hit.
SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsiTIGR00593. pola. 1 hit.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.

Entry informationi

Entry nameiDPO1_STRPN
AccessioniPrimary (citable) accession number: P59199
Secondary accession number(s): P13252
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: November 11, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.