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Protein

Ras-related protein Rab-15

Gene

RAB15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi121 – 124GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • positive regulation of regulated secretory pathway Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139998-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-15
Gene namesi
Name:RAB15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20150. RAB15.

Subcellular locationi

GO - Cellular componenti

  • cilium Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • endosome membrane Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi376267.
OpenTargetsiENSG00000139998.
PharmGKBiPA134901572.

Polymorphism and mutation databases

BioMutaiRAB15.
DMDMi27734452.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211881 – 212Ras-related protein Rab-15Add BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi210S-geranylgeranyl cysteineBy similarity1
Modified residuei212Cysteine methyl esterBy similarity1
Lipidationi212S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP59190.
MaxQBiP59190.
PeptideAtlasiP59190.
PRIDEiP59190.

PTM databases

iPTMnetiP59190.
PhosphoSitePlusiP59190.
SwissPalmiP59190.

Expressioni

Gene expression databases

BgeeiENSG00000139998.
CleanExiHS_RAB15.
ExpressionAtlasiP59190. baseline and differential.
GenevisibleiP59190. HS.

Organism-specific databases

HPAiHPA041177.

Interactioni

Subunit structurei

The GTP bound form of RAB15 interacts with REP15.1 Publication

Protein-protein interaction databases

BioGridi132005. 5 interactors.
IntActiP59190. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliP59190.
SMRiP59190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

GeneTreeiENSGT00860000133675.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP59190.
KOiK07908.
OMAiITETFTR.
OrthoDBiEOG091G0J9F.
PhylomeDBiP59190.
TreeFamiTF314097.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P59190-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKQYDVLFR LLLIGDSGVG KTCLLCRFTD NEFHSSHIST IGVDFKMKTI
60 70 80 90 100
EVDGIKVRIQ IWDTAGQERY QTITKQYYRR AQGIFLVYDI SSERSYQHIM
110 120 130 140 150
KWVSDVDEYA PEGVQKILIG NKADEEQKRQ VGREQGQQLA KEYGMDFYET
160 170 180 190 200
SACTNLNIKE SFTRLTELVL QAHRKELEGL RMRASNELAL AELEEEEGKP
210
EGPANSSKTC WC
Length:212
Mass (Da):24,391
Last modified:January 10, 2003 - v1
Checksum:iD16A0C71797ED782
GO
Isoform 2 (identifier: P59190-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-212: YAPEGVQKIL...PANSSKTCWC → VGDATSLPGC...TSTLKSHSRV

Show »
Length:208
Mass (Da):23,518
Checksum:i58D700ECA3174682
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010420109 – 212YAPEG…KTCWC → VGDATSLPGCGEGASPGKAR RGPDGKANASRKLCLPQPWM KTSGTHQKASRRSLLGIRLM RSRNGRWEESKGSSWRRSMA WTSMKQVPAPTSTLKSHSRV in isoform 2. 3 PublicationsAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB678452 mRNA. Translation: BAL14289.1.
AL139022 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW80893.1.
BC040679 mRNA. Translation: AAH40679.2.
BX248046 mRNA. Translation: CAD62353.1.
CCDSiCCDS76691.1. [P59190-1]
CCDS9768.1. [P59190-2]
RefSeqiNP_001295083.1. NM_001308154.1. [P59190-1]
NP_941959.1. NM_198686.2. [P59190-2]
UniGeneiHs.512492.

Genome annotation databases

EnsembliENST00000267512; ENSP00000267512; ENSG00000139998. [P59190-2]
ENST00000533601; ENSP00000434103; ENSG00000139998. [P59190-1]
GeneIDi376267.
KEGGihsa:376267.
UCSCiuc001xhz.2. human. [P59190-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB678452 mRNA. Translation: BAL14289.1.
AL139022 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW80893.1.
BC040679 mRNA. Translation: AAH40679.2.
BX248046 mRNA. Translation: CAD62353.1.
CCDSiCCDS76691.1. [P59190-1]
CCDS9768.1. [P59190-2]
RefSeqiNP_001295083.1. NM_001308154.1. [P59190-1]
NP_941959.1. NM_198686.2. [P59190-2]
UniGeneiHs.512492.

3D structure databases

ProteinModelPortaliP59190.
SMRiP59190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132005. 5 interactors.
IntActiP59190. 1 interactor.

PTM databases

iPTMnetiP59190.
PhosphoSitePlusiP59190.
SwissPalmiP59190.

Polymorphism and mutation databases

BioMutaiRAB15.
DMDMi27734452.

Proteomic databases

EPDiP59190.
MaxQBiP59190.
PeptideAtlasiP59190.
PRIDEiP59190.

Protocols and materials databases

DNASUi376267.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267512; ENSP00000267512; ENSG00000139998. [P59190-2]
ENST00000533601; ENSP00000434103; ENSG00000139998. [P59190-1]
GeneIDi376267.
KEGGihsa:376267.
UCSCiuc001xhz.2. human. [P59190-1]

Organism-specific databases

CTDi376267.
DisGeNETi376267.
GeneCardsiRAB15.
HGNCiHGNC:20150. RAB15.
HPAiHPA041177.
neXtProtiNX_P59190.
OpenTargetsiENSG00000139998.
PharmGKBiPA134901572.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00860000133675.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP59190.
KOiK07908.
OMAiITETFTR.
OrthoDBiEOG091G0J9F.
PhylomeDBiP59190.
TreeFamiTF314097.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139998-MONOMER.

Miscellaneous databases

GeneWikiiRAB15.
GenomeRNAii376267.
PROiP59190.

Gene expression databases

BgeeiENSG00000139998.
CleanExiHS_RAB15.
ExpressionAtlasiP59190. baseline and differential.
GenevisibleiP59190. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB15_HUMAN
AccessioniPrimary (citable) accession number: P59190
Secondary accession number(s): G5EMR7, Q86TX7, Q8IW89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.