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P59190

- RAB15_HUMAN

UniProt

P59190 - RAB15_HUMAN

Protein

Ras-related protein Rab-15

Gene

RAB15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (10 Jan 2003)
      Previous versions | rss
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    Functioni

    May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 228GTPBy similarity
    Nucleotide bindingi63 – 675GTPBy similarity
    Nucleotide bindingi121 – 1244GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. protein binding Source: UniProt

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-15
    Gene namesi
    Name:RAB15
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20150. RAB15.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProt
    2. endosome membrane Source: UniProt
    3. extracellular vesicular exosome Source: UniProt
    4. perinuclear region of cytoplasm Source: UniProt
    5. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134901572.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Ras-related protein Rab-15PRO_0000121188Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi210 – 2101S-geranylgeranyl cysteineBy similarity
    Modified residuei212 – 2121Cysteine methyl esterBy similarity
    Lipidationi212 – 2121S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    MaxQBiP59190.
    PaxDbiP59190.
    PRIDEiP59190.

    PTM databases

    PhosphoSiteiP59190.

    Expressioni

    Gene expression databases

    ArrayExpressiP59190.
    BgeeiP59190.
    CleanExiHS_RAB15.
    GenevestigatoriP59190.

    Organism-specific databases

    HPAiHPA041177.

    Interactioni

    Subunit structurei

    The GTP bound form of RAB15 interacts with REP15.1 Publication

    Protein-protein interaction databases

    BioGridi132005. 4 interactions.
    IntActiP59190. 1 interaction.
    STRINGi9606.ENSP00000267512.

    Structurei

    3D structure databases

    ProteinModelPortaliP59190.
    SMRiP59190. Positions 7-197.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    KOiK07908.
    OMAiFTIMESS.
    OrthoDBiEOG7V4B0R.
    PhylomeDBiP59190.
    TreeFamiTF314097.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P59190-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAKQYDVLFR LLLIGDSGVG KTCLLCRFTD NEFHSSHIST IGVDFKMKTI    50
    EVDGIKVRIQ IWDTAGQERY QTITKQYYRR AQGIFLVYDI SSERSYQHIM 100
    KWVSDVDEYA PEGVQKILIG NKADEEQKRQ VGREQGQQLA KEYGMDFYET 150
    SACTNLNIKE SFTRLTELVL QAHRKELEGL RMRASNELAL AELEEEEGKP 200
    EGPANSSKTC WC 212
    Length:212
    Mass (Da):24,391
    Last modified:January 10, 2003 - v1
    Checksum:iD16A0C71797ED782
    GO
    Isoform 2 (identifier: P59190-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         109-212: YAPEGVQKIL...PANSSKTCWC → VGDATSLPGC...TSTLKSHSRV

    Show »
    Length:208
    Mass (Da):23,518
    Checksum:i58D700ECA3174682
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei109 – 212104YAPEG…KTCWC → VGDATSLPGCGEGASPGKAR RGPDGKANASRKLCLPQPWM KTSGTHQKASRRSLLGIRLM RSRNGRWEESKGSSWRRSMA WTSMKQVPAPTSTLKSHSRV in isoform 2. 3 PublicationsVSP_010420Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB678452 mRNA. Translation: BAL14289.1.
    AL139022 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW80893.1.
    BC040679 mRNA. Translation: AAH40679.2.
    BX248046 mRNA. Translation: CAD62353.1.
    CCDSiCCDS9768.1. [P59190-2]
    RefSeqiNP_941959.1. NM_198686.2. [P59190-2]
    XP_005267654.1. XM_005267597.2. [P59190-1]
    UniGeneiHs.512492.

    Genome annotation databases

    EnsembliENST00000267512; ENSP00000267512; ENSG00000139998. [P59190-2]
    ENST00000533601; ENSP00000434103; ENSG00000139998. [P59190-1]
    GeneIDi376267.
    KEGGihsa:376267.
    UCSCiuc001xhz.2. human.
    uc021rut.1. human. [P59190-1]

    Polymorphism databases

    DMDMi27734452.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB678452 mRNA. Translation: BAL14289.1 .
    AL139022 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW80893.1 .
    BC040679 mRNA. Translation: AAH40679.2 .
    BX248046 mRNA. Translation: CAD62353.1 .
    CCDSi CCDS9768.1. [P59190-2 ]
    RefSeqi NP_941959.1. NM_198686.2. [P59190-2 ]
    XP_005267654.1. XM_005267597.2. [P59190-1 ]
    UniGenei Hs.512492.

    3D structure databases

    ProteinModelPortali P59190.
    SMRi P59190. Positions 7-197.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 132005. 4 interactions.
    IntActi P59190. 1 interaction.
    STRINGi 9606.ENSP00000267512.

    PTM databases

    PhosphoSitei P59190.

    Polymorphism databases

    DMDMi 27734452.

    Proteomic databases

    MaxQBi P59190.
    PaxDbi P59190.
    PRIDEi P59190.

    Protocols and materials databases

    DNASUi 376267.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000267512 ; ENSP00000267512 ; ENSG00000139998 . [P59190-2 ]
    ENST00000533601 ; ENSP00000434103 ; ENSG00000139998 . [P59190-1 ]
    GeneIDi 376267.
    KEGGi hsa:376267.
    UCSCi uc001xhz.2. human.
    uc021rut.1. human. [P59190-1 ]

    Organism-specific databases

    CTDi 376267.
    GeneCardsi GC14M065412.
    HGNCi HGNC:20150. RAB15.
    HPAi HPA041177.
    neXtProti NX_P59190.
    PharmGKBi PA134901572.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    KOi K07908.
    OMAi FTIMESS.
    OrthoDBi EOG7V4B0R.
    PhylomeDBi P59190.
    TreeFami TF314097.

    Miscellaneous databases

    GeneWikii RAB15.
    GenomeRNAii 376267.
    NextBioi 100634.
    PROi P59190.

    Gene expression databases

    ArrayExpressi P59190.
    Bgeei P59190.
    CleanExi HS_RAB15.
    Genevestigatori P59190.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Aberrant Rab15 expression."
      Pham T., Hartoma T., Nishimura N.
      Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    5. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 42-212 (ISOFORM 2).
      Tissue: Placenta.
    6. "Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment."
      Strick D.J., Elferink L.A.
      Mol. Biol. Cell 16:5699-5709(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH REP15.

    Entry informationi

    Entry nameiRAB15_HUMAN
    AccessioniPrimary (citable) accession number: P59190
    Secondary accession number(s): G5EMR7, Q86TX7, Q8IW89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: January 10, 2003
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3