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P59190 (RAB15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-15
Gene names
Name:RAB15
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal By similarity.

Subunit structure

The GTP bound form of RAB15 interacts with REP15. Ref.6

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P59190-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P59190-2)

The sequence of this isoform differs from the canonical sequence as follows:
     109-212: YAPEGVQKIL...PANSSKTCWC → VGDATSLPGC...TSTLKSHSRV

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Ras-related protein Rab-15
PRO_0000121188

Regions

Nucleotide binding15 – 228GTP By similarity
Nucleotide binding63 – 675GTP By similarity
Nucleotide binding121 – 1244GTP By similarity

Amino acid modifications

Modified residue2121Cysteine methyl ester By similarity
Lipidation2101S-geranylgeranyl cysteine By similarity
Lipidation2121S-geranylgeranyl cysteine By similarity

Natural variations

Alternative sequence109 – 212104YAPEG…KTCWC → VGDATSLPGCGEGASPGKAR RGPDGKANASRKLCLPQPWM KTSGTHQKASRRSLLGIRLM RSRNGRWEESKGSSWRRSMA WTSMKQVPAPTSTLKSHSRV in isoform 2.
VSP_010420

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 10, 2003. Version 1.
Checksum: D16A0C71797ED782

FASTA21224,391
        10         20         30         40         50         60 
MAKQYDVLFR LLLIGDSGVG KTCLLCRFTD NEFHSSHIST IGVDFKMKTI EVDGIKVRIQ 

        70         80         90        100        110        120 
IWDTAGQERY QTITKQYYRR AQGIFLVYDI SSERSYQHIM KWVSDVDEYA PEGVQKILIG 

       130        140        150        160        170        180 
NKADEEQKRQ VGREQGQQLA KEYGMDFYET SACTNLNIKE SFTRLTELVL QAHRKELEGL 

       190        200        210 
RMRASNELAL AELEEEEGKP EGPANSSKTC WC 

« Hide

Isoform 2 [UniParc].

Checksum: 58D700ECA3174682
Show »

FASTA20823,518

References

« Hide 'large scale' references
[1]"Aberrant Rab15 expression."
Pham T., Hartoma T., Nishimura N.
Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[5]"Full-length cDNA libraries and normalization."
Li W.B., Gruber C., Jessee J., Polayes D.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 42-212 (ISOFORM 2).
Tissue: Placenta.
[6]"Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment."
Strick D.J., Elferink L.A.
Mol. Biol. Cell 16:5699-5709(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH REP15.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB678452 mRNA. Translation: BAL14289.1.
AL139022 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW80893.1.
BC040679 mRNA. Translation: AAH40679.2.
BX248046 mRNA. Translation: CAD62353.1.
CCDSCCDS9768.1. [P59190-2]
RefSeqNP_941959.1. NM_198686.2. [P59190-2]
XP_005267654.1. XM_005267597.2. [P59190-1]
UniGeneHs.512492.

3D structure databases

ProteinModelPortalP59190.
SMRP59190. Positions 7-197.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid132005. 4 interactions.
IntActP59190. 1 interaction.
STRING9606.ENSP00000267512.

PTM databases

PhosphoSiteP59190.

Polymorphism databases

DMDM27734452.

Proteomic databases

MaxQBP59190.
PaxDbP59190.
PRIDEP59190.

Protocols and materials databases

DNASU376267.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000267512; ENSP00000267512; ENSG00000139998. [P59190-2]
ENST00000533601; ENSP00000434103; ENSG00000139998. [P59190-1]
GeneID376267.
KEGGhsa:376267.
UCSCuc021rut.1. human. [P59190-1]

Organism-specific databases

CTD376267.
GeneCardsGC14M065412.
HGNCHGNC:20150. RAB15.
HPAHPA041177.
neXtProtNX_P59190.
PharmGKBPA134901572.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233968.
HOVERGENHBG009351.
KOK07908.
OMAFTIMESS.
OrthoDBEOG7V4B0R.
PhylomeDBP59190.
TreeFamTF314097.

Gene expression databases

ArrayExpressP59190.
BgeeP59190.
CleanExHS_RAB15.
GenevestigatorP59190.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiRAB15.
GenomeRNAi376267.
NextBio100634.
PROP59190.

Entry information

Entry nameRAB15_HUMAN
AccessionPrimary (citable) accession number: P59190
Secondary accession number(s): G5EMR7, Q86TX7, Q8IW89
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM