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Protein

Ras-related protein Rab-15

Gene

RAB15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228GTPBy similarity
Nucleotide bindingi63 – 675GTPBy similarity
Nucleotide bindingi121 – 1244GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: GO_Central
  2. GTPase activity Source: GO_Central
  3. GTP binding Source: GO_Central

GO - Biological processi

  1. GTP catabolic process Source: GO_Central
  2. intracellular protein transport Source: GO_Central
  3. positive regulation of regulated secretory pathway Source: UniProtKB
  4. protein localization to plasma membrane Source: GO_Central
  5. protein secretion Source: GO_Central
  6. Rab protein signal transduction Source: GO_Central
  7. regulation of exocytosis Source: GO_Central
  8. vesicle docking involved in exocytosis Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-15
Gene namesi
Name:RAB15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20150. RAB15.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endosome membrane Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProtKB
  4. perinuclear region of cytoplasm Source: UniProtKB
  5. plasma membrane Source: UniProtKB-SubCell
  6. primary cilium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134901572.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Ras-related protein Rab-15PRO_0000121188Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi210 – 2101S-geranylgeranyl cysteineBy similarity
Modified residuei212 – 2121Cysteine methyl esterBy similarity
Lipidationi212 – 2121S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP59190.
PaxDbiP59190.
PRIDEiP59190.

PTM databases

PhosphoSiteiP59190.

Expressioni

Gene expression databases

BgeeiP59190.
CleanExiHS_RAB15.
ExpressionAtlasiP59190. baseline and differential.
GenevestigatoriP59190.

Organism-specific databases

HPAiHPA041177.

Interactioni

Subunit structurei

The GTP bound form of RAB15 interacts with REP15.1 Publication

Protein-protein interaction databases

BioGridi132005. 4 interactions.
IntActiP59190. 1 interaction.
STRINGi9606.ENSP00000267512.

Structurei

3D structure databases

ProteinModelPortaliP59190.
SMRiP59190. Positions 7-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00740000115017.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP59190.
KOiK07908.
OMAiREYGMDF.
OrthoDBiEOG7V4B0R.
PhylomeDBiP59190.
TreeFamiTF314097.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P59190-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKQYDVLFR LLLIGDSGVG KTCLLCRFTD NEFHSSHIST IGVDFKMKTI
60 70 80 90 100
EVDGIKVRIQ IWDTAGQERY QTITKQYYRR AQGIFLVYDI SSERSYQHIM
110 120 130 140 150
KWVSDVDEYA PEGVQKILIG NKADEEQKRQ VGREQGQQLA KEYGMDFYET
160 170 180 190 200
SACTNLNIKE SFTRLTELVL QAHRKELEGL RMRASNELAL AELEEEEGKP
210
EGPANSSKTC WC
Length:212
Mass (Da):24,391
Last modified:January 10, 2003 - v1
Checksum:iD16A0C71797ED782
GO
Isoform 2 (identifier: P59190-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-212: YAPEGVQKIL...PANSSKTCWC → VGDATSLPGC...TSTLKSHSRV

Show »
Length:208
Mass (Da):23,518
Checksum:i58D700ECA3174682
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei109 – 212104YAPEG…KTCWC → VGDATSLPGCGEGASPGKAR RGPDGKANASRKLCLPQPWM KTSGTHQKASRRSLLGIRLM RSRNGRWEESKGSSWRRSMA WTSMKQVPAPTSTLKSHSRV in isoform 2. 3 PublicationsVSP_010420Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB678452 mRNA. Translation: BAL14289.1.
AL139022 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW80893.1.
BC040679 mRNA. Translation: AAH40679.2.
BX248046 mRNA. Translation: CAD62353.1.
CCDSiCCDS9768.1. [P59190-2]
RefSeqiNP_941959.1. NM_198686.2. [P59190-2]
XP_005267654.1. XM_005267597.2. [P59190-1]
UniGeneiHs.512492.

Genome annotation databases

EnsembliENST00000267512; ENSP00000267512; ENSG00000139998. [P59190-2]
ENST00000533601; ENSP00000434103; ENSG00000139998. [P59190-1]
GeneIDi376267.
KEGGihsa:376267.
UCSCiuc001xhz.2. human.
uc021rut.1. human. [P59190-1]

Polymorphism databases

DMDMi27734452.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB678452 mRNA. Translation: BAL14289.1.
AL139022 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW80893.1.
BC040679 mRNA. Translation: AAH40679.2.
BX248046 mRNA. Translation: CAD62353.1.
CCDSiCCDS9768.1. [P59190-2]
RefSeqiNP_941959.1. NM_198686.2. [P59190-2]
XP_005267654.1. XM_005267597.2. [P59190-1]
UniGeneiHs.512492.

3D structure databases

ProteinModelPortaliP59190.
SMRiP59190. Positions 7-197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132005. 4 interactions.
IntActiP59190. 1 interaction.
STRINGi9606.ENSP00000267512.

PTM databases

PhosphoSiteiP59190.

Polymorphism databases

DMDMi27734452.

Proteomic databases

MaxQBiP59190.
PaxDbiP59190.
PRIDEiP59190.

Protocols and materials databases

DNASUi376267.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267512; ENSP00000267512; ENSG00000139998. [P59190-2]
ENST00000533601; ENSP00000434103; ENSG00000139998. [P59190-1]
GeneIDi376267.
KEGGihsa:376267.
UCSCiuc001xhz.2. human.
uc021rut.1. human. [P59190-1]

Organism-specific databases

CTDi376267.
GeneCardsiGC14M065412.
HGNCiHGNC:20150. RAB15.
HPAiHPA041177.
neXtProtiNX_P59190.
PharmGKBiPA134901572.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00740000115017.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP59190.
KOiK07908.
OMAiREYGMDF.
OrthoDBiEOG7V4B0R.
PhylomeDBiP59190.
TreeFamiTF314097.

Miscellaneous databases

GeneWikiiRAB15.
GenomeRNAii376267.
NextBioi100634.
PROiP59190.

Gene expression databases

BgeeiP59190.
CleanExiHS_RAB15.
ExpressionAtlasiP59190. baseline and differential.
GenevestigatoriP59190.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Aberrant Rab15 expression."
    Pham T., Hartoma T., Nishimura N.
    Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 42-212 (ISOFORM 2).
    Tissue: Placenta.
  6. "Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment."
    Strick D.J., Elferink L.A.
    Mol. Biol. Cell 16:5699-5709(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH REP15.

Entry informationi

Entry nameiRAB15_HUMAN
AccessioniPrimary (citable) accession number: P59190
Secondary accession number(s): G5EMR7, Q86TX7, Q8IW89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: February 4, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.