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P59190

- RAB15_HUMAN

UniProt

P59190 - RAB15_HUMAN

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Protein

Ras-related protein Rab-15

Gene
RAB15
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228GTP By similarity
Nucleotide bindingi63 – 675GTP By similarity
Nucleotide bindingi121 – 1244GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. protein binding Source: UniProt

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-15
Gene namesi
Name:RAB15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20150. RAB15.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProt
  2. endosome membrane Source: UniProt
  3. extracellular vesicular exosome Source: UniProt
  4. perinuclear region of cytoplasm Source: UniProt
  5. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134901572.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Ras-related protein Rab-15PRO_0000121188Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi210 – 2101S-geranylgeranyl cysteine By similarity
Modified residuei212 – 2121Cysteine methyl ester By similarity
Lipidationi212 – 2121S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP59190.
PaxDbiP59190.
PRIDEiP59190.

PTM databases

PhosphoSiteiP59190.

Expressioni

Gene expression databases

ArrayExpressiP59190.
BgeeiP59190.
CleanExiHS_RAB15.
GenevestigatoriP59190.

Organism-specific databases

HPAiHPA041177.

Interactioni

Subunit structurei

The GTP bound form of RAB15 interacts with REP15.1 Publication

Protein-protein interaction databases

BioGridi132005. 4 interactions.
IntActiP59190. 1 interaction.
STRINGi9606.ENSP00000267512.

Structurei

3D structure databases

ProteinModelPortaliP59190.
SMRiP59190. Positions 7-197.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
KOiK07908.
OMAiFTIMESS.
OrthoDBiEOG7V4B0R.
PhylomeDBiP59190.
TreeFamiTF314097.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P59190-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAKQYDVLFR LLLIGDSGVG KTCLLCRFTD NEFHSSHIST IGVDFKMKTI    50
EVDGIKVRIQ IWDTAGQERY QTITKQYYRR AQGIFLVYDI SSERSYQHIM 100
KWVSDVDEYA PEGVQKILIG NKADEEQKRQ VGREQGQQLA KEYGMDFYET 150
SACTNLNIKE SFTRLTELVL QAHRKELEGL RMRASNELAL AELEEEEGKP 200
EGPANSSKTC WC 212
Length:212
Mass (Da):24,391
Last modified:January 10, 2003 - v1
Checksum:iD16A0C71797ED782
GO
Isoform 2 (identifier: P59190-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-212: YAPEGVQKIL...PANSSKTCWC → VGDATSLPGC...TSTLKSHSRV

Show »
Length:208
Mass (Da):23,518
Checksum:i58D700ECA3174682
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei109 – 212104YAPEG…KTCWC → VGDATSLPGCGEGASPGKAR RGPDGKANASRKLCLPQPWM KTSGTHQKASRRSLLGIRLM RSRNGRWEESKGSSWRRSMA WTSMKQVPAPTSTLKSHSRV in isoform 2. VSP_010420Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB678452 mRNA. Translation: BAL14289.1.
AL139022 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW80893.1.
BC040679 mRNA. Translation: AAH40679.2.
BX248046 mRNA. Translation: CAD62353.1.
CCDSiCCDS9768.1. [P59190-2]
RefSeqiNP_941959.1. NM_198686.2. [P59190-2]
XP_005267654.1. XM_005267597.2. [P59190-1]
UniGeneiHs.512492.

Genome annotation databases

EnsembliENST00000267512; ENSP00000267512; ENSG00000139998. [P59190-2]
ENST00000533601; ENSP00000434103; ENSG00000139998. [P59190-1]
GeneIDi376267.
KEGGihsa:376267.
UCSCiuc001xhz.2. human.
uc021rut.1. human. [P59190-1]

Polymorphism databases

DMDMi27734452.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB678452 mRNA. Translation: BAL14289.1 .
AL139022 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW80893.1 .
BC040679 mRNA. Translation: AAH40679.2 .
BX248046 mRNA. Translation: CAD62353.1 .
CCDSi CCDS9768.1. [P59190-2 ]
RefSeqi NP_941959.1. NM_198686.2. [P59190-2 ]
XP_005267654.1. XM_005267597.2. [P59190-1 ]
UniGenei Hs.512492.

3D structure databases

ProteinModelPortali P59190.
SMRi P59190. Positions 7-197.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 132005. 4 interactions.
IntActi P59190. 1 interaction.
STRINGi 9606.ENSP00000267512.

PTM databases

PhosphoSitei P59190.

Polymorphism databases

DMDMi 27734452.

Proteomic databases

MaxQBi P59190.
PaxDbi P59190.
PRIDEi P59190.

Protocols and materials databases

DNASUi 376267.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000267512 ; ENSP00000267512 ; ENSG00000139998 . [P59190-2 ]
ENST00000533601 ; ENSP00000434103 ; ENSG00000139998 . [P59190-1 ]
GeneIDi 376267.
KEGGi hsa:376267.
UCSCi uc001xhz.2. human.
uc021rut.1. human. [P59190-1 ]

Organism-specific databases

CTDi 376267.
GeneCardsi GC14M065412.
HGNCi HGNC:20150. RAB15.
HPAi HPA041177.
neXtProti NX_P59190.
PharmGKBi PA134901572.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
KOi K07908.
OMAi FTIMESS.
OrthoDBi EOG7V4B0R.
PhylomeDBi P59190.
TreeFami TF314097.

Miscellaneous databases

GeneWikii RAB15.
GenomeRNAii 376267.
NextBioi 100634.
PROi P59190.

Gene expression databases

ArrayExpressi P59190.
Bgeei P59190.
CleanExi HS_RAB15.
Genevestigatori P59190.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Aberrant Rab15 expression."
    Pham T., Hartoma T., Nishimura N.
    Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 42-212 (ISOFORM 2).
    Tissue: Placenta.
  6. "Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment."
    Strick D.J., Elferink L.A.
    Mol. Biol. Cell 16:5699-5709(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH REP15.

Entry informationi

Entry nameiRAB15_HUMAN
AccessioniPrimary (citable) accession number: P59190
Secondary accession number(s): G5EMR7, Q86TX7, Q8IW89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: September 3, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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