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Protein

Lethal(3)malignant brain tumor-like protein 2

Gene

L3mbtl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri81 – 11636FCS-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-4551638. SUMOylation of chromatin organization proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Lethal(3)malignant brain tumor-like protein 2
Short name:
L(3)mbt-like protein 2
Gene namesi
Name:L3mbtl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2443584. L3mbtl2.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 703703Lethal(3)malignant brain tumor-like protein 2PRO_0000084449Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphoserineBy similarity
Modified residuei338 – 3381PhosphoserineBy similarity
Cross-linki673 – 673Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei681 – 6811PhosphoserineBy similarity
Modified residuei685 – 6851PhosphoserineBy similarity
Modified residuei687 – 6871PhosphoserineBy similarity
Cross-linki698 – 698Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP59178.
PaxDbiP59178.
PRIDEiP59178.

PTM databases

iPTMnetiP59178.
PhosphoSiteiP59178.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiP59178.
CleanExiMM_L3MBTL2.
ExpressionAtlasiP59178. baseline and differential.
GenevisibleiP59178. MM.

Interactioni

Subunit structurei

Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229554. 51 interactions.
IntActiP59178. 14 interactions.
STRINGi10090.ENSMUSP00000023029.

Structurei

3D structure databases

ProteinModelPortaliP59178.
SMRiP59178. Positions 82-124, 143-609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati179 – 283105MBT 1Add
BLAST
Repeati291 – 391101MBT 2Add
BLAST
Repeati397 – 500104MBT 3Add
BLAST
Repeati508 – 60497MBT 4Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 215Poly-Glu
Compositional biasi620 – 6245Poly-Lys

Sequence similaritiesi

Contains 1 FCS-type zinc finger.PROSITE-ProRule annotation
Contains 4 MBT repeats.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri81 – 11636FCS-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410KCPG. Eukaryota.
ENOG410ZYE4. LUCA.
GeneTreeiENSGT00760000119024.
HOVERGENiHBG057974.
InParanoidiP59178.
OrthoDBiEOG7M98G1.
TreeFamiTF316498.

Family and domain databases

InterProiIPR004092. Mbt.
IPR012313. Znf_FCS.
[Graphical view]
PfamiPF02820. MBT. 4 hits.
[Graphical view]
SMARTiSM00561. MBT. 4 hits.
[Graphical view]
PROSITEiPS51079. MBT. 4 hits.
PS51024. ZF_FCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59178-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKPRGTEEA PSSEPMEEEE EDDLDLFGGY DSFRSYNSSA GSESSSYLEE
60 70 80 90 100
SSEAENEDRE AGELPTSPLH LFSSANNRSL DGSGSEPAVC EMCGIVGTRE
110 120 130 140 150
AFFSKTKRFC SVSCSRSYSS NSKKASILAR LQGKPPTKKA KVLHKAAWSA
160 170 180 190 200
KIGAFLHAQG TGQLADGTPT GQDALVLGFD WGKFLKDHSY KAAPVSCFKH
210 220 230 240 250
VPLYDQWEDV MKGMKVEVLN SDAVLPSRVY WIATVIQAAG YRVLLRYEGF
260 270 280 290 300
ENDASHDFWC NLGTVDVHPI GWCAINSKIL VPPRTIHAKF TDWKSYLMKR
310 320 330 340 350
LVGSRTLPAD FHIKMVESMK YPFRQGMRLE VVDKTQVSRT RMAVVDTVIG
360 370 380 390 400
GRLRLLYEDG DSDDDFWCHM WSPLIHPVGW SRRVGHGIKM SDRRCDMSHH
410 420 430 440 450
PTFRKIYCDA VPYLFKKVRA VYTEGGWFEE GMKLEAIDPL NLGSICVATI
460 470 480 490 500
CKVLLDGYLM ICVDGGPSTD GSDWFCYHAS SHAIFPATFC QKNDIELTPP
510 520 530 540 550
KGYETQPFAW ETYLEKTKSK AAPARLFNMD CPNHGFKVGM KLEAVDLMEP
560 570 580 590 600
RLICVATVKR VVHRLLSIHF DGWDNEYDQW VDCESPDIYP VGWCELTGYQ
610 620 630 640 650
LQPPVSAEPN TPQKGKDTTK KKKKQFGKKR KRIPSAKTRP LRQGSKKPLL
660 670 680 690 700
EDNLEALGVS EPVPDDIIAV CVKEEHQDIS SLDRSPSPQL PLPIESIKQE

RNN
Length:703
Mass (Da):78,971
Last modified:July 27, 2011 - v2
Checksum:i2E9B5DF5BFCEAFF9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti682 – 6821L → P in AAH23933 (PubMed:15489334).Curated
Sequence conflicti682 – 6821L → P in AAH30864 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237000 mRNA. Translation: AAP44771.1.
AK029115 mRNA. Translation: BAC26305.1.
AK036510 mRNA. Translation: BAC29456.1.
CH466550 Genomic DNA. Translation: EDL04569.1.
BC023933 mRNA. Translation: AAH23933.1.
BC030864 mRNA. Translation: AAH30864.1.
CCDSiCCDS27669.1.
RefSeqiNP_666105.2. NM_145993.5.
UniGeneiMm.280768.
Mm.486476.
Mm.491152.

Genome annotation databases

EnsembliENSMUST00000023029; ENSMUSP00000023029; ENSMUSG00000022394.
GeneIDi214669.
KEGGimmu:214669.
UCSCiuc007wwu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237000 mRNA. Translation: AAP44771.1.
AK029115 mRNA. Translation: BAC26305.1.
AK036510 mRNA. Translation: BAC29456.1.
CH466550 Genomic DNA. Translation: EDL04569.1.
BC023933 mRNA. Translation: AAH23933.1.
BC030864 mRNA. Translation: AAH30864.1.
CCDSiCCDS27669.1.
RefSeqiNP_666105.2. NM_145993.5.
UniGeneiMm.280768.
Mm.486476.
Mm.491152.

3D structure databases

ProteinModelPortaliP59178.
SMRiP59178. Positions 82-124, 143-609.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229554. 51 interactions.
IntActiP59178. 14 interactions.
STRINGi10090.ENSMUSP00000023029.

PTM databases

iPTMnetiP59178.
PhosphoSiteiP59178.

Proteomic databases

MaxQBiP59178.
PaxDbiP59178.
PRIDEiP59178.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023029; ENSMUSP00000023029; ENSMUSG00000022394.
GeneIDi214669.
KEGGimmu:214669.
UCSCiuc007wwu.2. mouse.

Organism-specific databases

CTDi83746.
MGIiMGI:2443584. L3mbtl2.

Phylogenomic databases

eggNOGiENOG410KCPG. Eukaryota.
ENOG410ZYE4. LUCA.
GeneTreeiENSGT00760000119024.
HOVERGENiHBG057974.
InParanoidiP59178.
OrthoDBiEOG7M98G1.
TreeFamiTF316498.

Enzyme and pathway databases

ReactomeiR-MMU-4551638. SUMOylation of chromatin organization proteins.

Miscellaneous databases

ChiTaRSiL3mbtl2. mouse.
PROiP59178.
SOURCEiSearch...

Gene expression databases

BgeeiP59178.
CleanExiMM_L3MBTL2.
ExpressionAtlasiP59178. baseline and differential.
GenevisibleiP59178. MM.

Family and domain databases

InterProiIPR004092. Mbt.
IPR012313. Znf_FCS.
[Graphical view]
PfamiPF02820. MBT. 4 hits.
[Graphical view]
SMARTiSM00561. MBT. 4 hits.
[Graphical view]
PROSITEiPS51079. MBT. 4 hits.
PS51024. ZF_FCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Proliferation-linked expression of the novel murine gene m4mbt encoding a nuclear zinc finger protein with four mbt domains."
    Markus J., Feikova S., Sramko M., Wolff L., Bies J.
    Gene 319:117-126(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, PHOSPHORYLATION, TISSUE SPECIFICITY.
    Strain: Swiss Webster.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone and Skin.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver and Mammary gland.

Entry informationi

Entry nameiLMBL2_MOUSE
AccessioniPrimary (citable) accession number: P59178
Secondary accession number(s): Q8BHD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.