Skip Header

Contribute Send feedback
Read comments (?) or add your own

P59116 (PHL2_LEPIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Sphingomyelinase C 2
EC=3.1.4.12
Alternative name(s):
Sphingomyelin phosphodiesterase 2
Short name=SMase 2
Gene names
Name:sph2
Ordered Locus Names:LA_1029
OrganismLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifier189518 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Leptospiraceae › Leptospira

Protein attributes

Sequence length623 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Sphingomyelin + H2O = N-acylsphingosine + choline phosphate.

Subcellular location

Secreted By similarity.

Sequence caution

The sequence AAN48228.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionsphingomyelin phosphodiesterase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 623598Sphingomyelinase C 2
PRO_0000022051

Sequences

Sequence LengthMass (Da)Tools
P59116 [UniParc].

Last modified December 6, 2002. Version 1.
Checksum: E94B065CC895767C

FASTA62371,030
        10         20         30         40         50         60 
MINKITKPKL LIGYYLLLFS LIRCLPEKES SYKDLFTSLL FLPNQTNSNQ VNSVSINNDP 

        70         80         90        100        110        120 
ANPNPVNPAS ANNNQVNAVP ENDDPANLNP VNPASANSNQ VNAAPENGSP ADPNPANLAS 

       130        140        150        160        170        180 
ANNNQVNAVP ANNYFTKEDS SNNIPKKVNS KNVEIKVLSH NVFMLPTNLP RWGNLGHDER 

       190        200        210        220        230        240 
AKRISKSDYV KNQDVIVFEE AFDTSARKIL LDNLREEYPY QTDVVGRTKK NWDASLGNFR 

       250        260        270        280        290        300 
SYSLVNGGVV ILSKWPIEEK IQYIFNDSGC GADWFANKGF VYVKINKEGK KFHVIGTHAQ 

       310        320        330        340        350        360 
SQDQNCSNLG IPNRANQFDD IRNFIYSKNI PKDETVLIVG DLNVIKESNE YYDMISRLNV 

       370        380        390        400        410        420 
NEPRYVGVPF TWDAKTNEIA AYYYENEEPV YLDYIFVSKS HAQPPVWQNL AYDPVSKQTW 

       430        440        450        460        470        480 
TVSGYTSDEF SDHYPIYGFV YADPSTPTKS GHKKKYDQVS FQSAANGKYI QADPNRKNGW 

       490        500        510        520        530        540 
LKADAVIETD FTKFNLLQEG NLNPSCIKNG LVRIESSRFL NYFWNWWLGG GSGNYGYYSK 

       550        560        570        580        590        600 
FNDASNQLEI INLSDECLEN GSKIVFKDYD TYSRNHYYLT VWDKGNWNEH LYLWKDSISQ 

       610        620 
REIFYLKLNS TPVRNWSADL IYR

« Hide

References

[1]"Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing."
Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X., Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X., Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H. expand/collapse author list , Yin H.-F., Zhang Y., Zhu G.-F., Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y., Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P.
Nature 422:888-893(2003) [PubMed: 12712204] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 56601.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE010300 Genomic DNA. Translation: AAN48228.2. Different initiation.
RefSeqNP_711210.2. NC_004342.2.

3D structure databases

ProteinModelPortalP59116.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1150372.
GenomeReviewsGene locus LA_1029 in contig AE010300_GR.
KEGGlil:LA_1029.
NMPDRfig|189518.1.peg.1029.
PATRIC22382901. VBILepInt91350_1027.

Phylogenomic databases

HOGENOMHBG110590.
OMANQVNAVP.
ProtClustDBCLSK638897.

Enzyme and pathway databases

BioCycLINT189518:LA1029-MONOMER.

Family and domain databases

InterProIPR005135. Endo/exonuclease/phosphatase.
IPR017766. Sphingomyelinase/PLipase_C.
[Graphical view]
KOK01117.
PfamPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SUPFAMSSF56219. Exo_endo_phos. 1 hit.
TIGRFAMsTIGR03395. Sphingomy. 1 hit.
ProtoNetSearch...

Entry information

Entry namePHL2_LEPIN
AccessionPrimary (citable) accession number: P59116
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 6, 2002
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info