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P59115 (PHL1_LEPIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sphingomyelinase C 1
EC=3.1.4.12
Alternative name(s):
Sphingomyelin phosphodiesterase 1
Short name=SMase 1
Gene names
Name:sph1
Ordered Locus Names:LA_1027
OrganismLeptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Taxonomic identifier189518 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Leptospiraceae › Leptospira

Protein attributes

Sequence length597 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Sphingomyelin + H2O = N-acylsphingosine + choline phosphate.

Subcellular location

Secreted By similarity.

Sequence caution

The sequence AAN48226.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionsphingomyelin phosphodiesterase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3737 Potential
Chain38 – 597560Sphingomyelinase C 1
PRO_0000022050

Sequences

Sequence LengthMass (Da)Tools
P59115 [UniParc].

Last modified December 6, 2002. Version 1.
Checksum: 2601745BC37DCEE9

FASTA59768,192
        10         20         30         40         50         60 
MITKRNIPPC KKNWKYKKKS ISLTLITICY MFLFLTSCKP GKKNSINLLL LLLNTLDNKN 

        70         80         90        100        110        120 
VNEKIEDSTN TDPSSNVNEE DENSINANAN DNAPSDSDSS NPRSPDKNPV NPTSPNSSSA 

       130        140        150        160        170        180 
DIGIKILSHS IFMAPTNLSS WGDLGQEERA QRIASSSYIK NQDIIVFEGL SHNNAEKILL 

       190        200        210        220        230        240 
EKIRSEYPYQ TNVVGRTKKG WNATLGAYTT SPMANGGVII VSKWPIEEKV QYIFNNSNCG 

       250        260        270        280        290        300 
QDQYYNKGFA YVKINKDGKK FHVIGTQLQA REPDCFNSGE TIRKLQLNDI KSFIDSKDIP 

       310        320        330        340        350        360 
KDETVLITGD LNIIKGSNEY FDMISKLNVN EPRYVGVPFT LDTKTNALAA YYYEKEKPIY 

       370        380        390        400        410        420 
LDYILVSKLH AQPPVWQNLA YDPISNTTWK RSDGYTSYEF SDRYPVYGFI YADSSTPTKS 

       430        440        450        460        470        480 
GHKRKYDQVS FQSTFNRKFI QADHNKKDGW LKADTRIKTD FTKFNLLQEN VSESNPSCMN 

       490        500        510        520        530        540 
SGSVRIESSY YLNYYWNWFI GAASGDYGYY TKFNNGSDSL GIKNLDNGCL KDGSRVAFYD 

       550        560        570        580        590 
WDTIGGGYYY LTVWDKGSWK EHLFLWVQSF LSSREIFYLH LDSNPPKDWS KDLIYHH

« Hide

References

[1]"Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing."
Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X., Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X., Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H. expand/collapse author list , Yin H.-F., Zhang Y., Zhu G.-F., Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y., Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P.
Nature 422:888-893(2003) [PubMed: 12712204] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 56601.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE010300 Genomic DNA. Translation: AAN48226.2. Different initiation.
RefSeqNP_711208.2. NC_004342.2.

3D structure databases

ProteinModelPortalP59115.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1150370.
GenomeReviewsGene locus LA_1027 in contig AE010300_GR.
KEGGlil:LA_1027.
NMPDRfig|189518.1.peg.1027.
PATRIC22382895. VBILepInt91350_1024.

Phylogenomic databases

HOGENOMHBG110590.
OMALITICYM.
ProtClustDBCLSK638897.

Enzyme and pathway databases

BioCycLINT189518:LA1027-MONOMER.

Family and domain databases

InterProIPR005135. Endo/exonuclease/phosphatase.
IPR017766. Sphingomyelinase/PLipase_C.
[Graphical view]
KOK01117.
PfamPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SUPFAMSSF56219. Exo_endo_phos. 1 hit.
TIGRFAMsTIGR03395. Sphingomy. 1 hit.
ProtoNetSearch...

Entry information

Entry namePHL1_LEPIN
AccessionPrimary (citable) accession number: P59115
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 6, 2002
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
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