Reviewed, UniProtKB/Swiss-Prot P59115 (PHL1_LEPIN)

Names and origin

Protein names

Recommended name:
    Sphingomyelinase C 1
    EC=3.1.4.12
Alternative name(s):
    Sphingomyelin phosphodiesterase 1
      Short name=SMase 1

Gene names

Name:	sph1
Ordered Locus Names:	LA_1027

Organism

Leptospira interrogans [Complete proteome] [HAMAP]

Taxonomic identifier

173 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Leptospiraceae › Leptospira

Protein attributes

Sequence length	597 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Sphingomyelin + H2O = N-acylsphingosine + choline phosphate.
Subcellular location	Secreted By similarity.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sphingomyelin phosphodiesterase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 37	37	Potential
	Chain	38 – 597	560	Sphingomyelinase C 1		PRO_0000022050

Sequences

	Sequence		Length	Mass (Da)
	P59115-1 [UniParc]. Last modified December 6, 2002. Version 1. Checksum: 2601745BC37DCEE9	FASTA	597	68,192
	10 20 30 40 50 60 MITKRNIPPC KKNWKYKKKS ISLTLITICY MFLFLTSCKP GKKNSINLLL LLLNTLDNKN 70 80 90 100 110 120 VNEKIEDSTN TDPSSNVNEE DENSINANAN DNAPSDSDSS NPRSPDKNPV NPTSPNSSSA 130 140 150 160 170 180 DIGIKILSHS IFMAPTNLSS WGDLGQEERA QRIASSSYIK NQDIIVFEGL SHNNAEKILL 190 200 210 220 230 240 EKIRSEYPYQ TNVVGRTKKG WNATLGAYTT SPMANGGVII VSKWPIEEKV QYIFNNSNCG 250 260 270 280 290 300 QDQYYNKGFA YVKINKDGKK FHVIGTQLQA REPDCFNSGE TIRKLQLNDI KSFIDSKDIP 310 320 330 340 350 360 KDETVLITGD LNIIKGSNEY FDMISKLNVN EPRYVGVPFT LDTKTNALAA YYYEKEKPIY 370 380 390 400 410 420 LDYILVSKLH AQPPVWQNLA YDPISNTTWK RSDGYTSYEF SDRYPVYGFI YADSSTPTKS 430 440 450 460 470 480 GHKRKYDQVS FQSTFNRKFI QADHNKKDGW LKADTRIKTD FTKFNLLQEN VSESNPSCMN 490 500 510 520 530 540 SGSVRIESSY YLNYYWNWFI GAASGDYGYY TKFNNGSDSL GIKNLDNGCL KDGSRVAFYD 550 560 570 580 590 WDTIGGGYYY LTVWDKGSWK EHLFLWVQSF LSSREIFYLH LDSNPPKDWS KDLIYHH

References

[1]

"Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing." Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X., Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X., Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H. , Yin H.-F., Zhang Y., Zhu G.-F., Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y., Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P. Nature 422:888-893(2003) [PubMed: 12712204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 56601 / Serogroup Icterohaemorrhagiae / Serovar lai.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE010300 Genomic DNA. Translation: AAN48226.1.
RefSeq	NP_711208.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1150370.
GenomeReviews	Gene locus LA_1027 in contig AE010300_GR.
KEGG	lil:LA1027.
NMPDR	fig|189518.1.peg.1027.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P59115.
OMA	NANDNAP.
Enzyme and pathway databases
BioCyc	LINT189518:LA1027-MON.
BRENDA	3.1.4.12. 258108.
Family and domain databases
InterPro	IPR005135. Endo/exonuclease/phosphatase. IPR017766. Sphingomyelinase/phospholipase. [Graphical view]
Pfam	PF03372. Exo_endo_phos. 1 hit. [Graphical view]
TIGRFAMs	TIGR03395. sphingomy. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PHL1_LEPIN

Accession

Primary (citable) accession number: P59115

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2002
Last sequence update:	December 6, 2002
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)