Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphorylated CTD-interacting factor 1

Gene

Pcif1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphorylated CTD-interacting factor 1
Gene namesi
Name:Pcif1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2443858. Pcif1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 706706Phosphorylated CTD-interacting factor 1PRO_0000076088Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301PhosphoserineCombined sources
Modified residuei116 – 1161PhosphoserineBy similarity
Modified residuei152 – 1521PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP59114.
PaxDbiP59114.
PeptideAtlasiP59114.
PRIDEiP59114.

PTM databases

iPTMnetiP59114.
PhosphoSiteiP59114.

Expressioni

Gene expression databases

BgeeiP59114.
ExpressionAtlasiP59114. baseline and differential.
GenevisibleiP59114. MM.

Interactioni

Subunit structurei

Interacts with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit.By similarity

Protein-protein interaction databases

BioGridi230787. 1 interaction.
STRINGi10090.ENSMUSP00000039555.

Structurei

3D structure databases

ProteinModelPortaliP59114.
SMRiP59114. Positions 40-86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 7735WWPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi109 – 1135Nuclear localization signalSequence analysis
Motifi668 – 68619Nuclear localization signalSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi675 – 68612Poly-SerAdd
BLAST

Domaini

The WW domain is sufficient for direct and specific interaction with the phosphorylated CTD of RNAPII largest subunit.By similarity

Sequence similaritiesi

Contains 1 WW domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFAY. Eukaryota.
ENOG410XPH2. LUCA.
HOGENOMiHOG000048178.
HOVERGENiHBG053525.
InParanoidiP59114.
KOiK17584.
OMAiLKMWGTS.
OrthoDBiEOG7TJ3H6.
PhylomeDBiP59114.
TreeFamiTF350163.

Family and domain databases

InterProiIPR022035. PCIF1_WW.
IPR001202. WW_dom.
[Graphical view]
PfamiPF12237. PCIF1_WW. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANENHGSPR EGASLLSHSP GTSSQSQPCS PKPVRLVQDL PEELVHAGWE
60 70 80 90 100
KCWSRRESRP YYFNRFTNQS LWEMPVLGQH DVLSDPLGLN ATPLPQDSSL
110 120 130 140 150
VETPPVENKS RKRQLSEEQP SGNGVKKPKI EIPVTPTSQS VPSSPSIPGT
160 170 180 190 200
PTLKIWGSST EDKQAALLRP TEVYWDLDIQ TNAVIKHRGP SEVLPPHPDV
210 220 230 240 250
ELLRSQLILK LRQHYRELCQ QREGIEPPRE SFNRWMLERK VVDKGCDPLL
260 270 280 290 300
PSNCEPVVSP SMFREIMNDI PIRLSRIKFR EEAKRLLFKY AEAARRLIES
310 320 330 340 350
RSASPDSRKV VKWNVEDTFS WLRKEHSASK EDYMDRLEHL RRQCGPHVSA
360 370 380 390 400
AAKDSVEGIC SKIYHISLEY VKRIREKHLA VLKENNIPEE VEASELEPRL
410 420 430 440 450
VYCYPVRLAV SAPPMPSVEM HVENSVVCIR YKGEMVKVSR SYFSKLWLLY
460 470 480 490 500
RYSCVDDSAF ERFLPRVWCL LRRYQMMFGV GLYEGTGLQG SLPVHVFETL
510 520 530 540 550
HRLFGVSFEC FASPLNCYFR QYCSAFPDTD GYFGSRGPCL DFTPLSGSFE
560 570 580 590 600
ANPPFCEELM DAMVSHFEKL LESSAEPLSF IVFIPEWREP PTPALTRMEQ
610 620 630 640 650
SRFKRHQLVL PAFEHEYRSG SQHICKKEEM HYKAVHNTAV LFLQNGPGFA
660 670 680 690 700
KWGPTPERLQ ELTAAYKQSG RSHGSSSSSS SSSSSSEAKD RDSGREQGPS

REPHPT
Length:706
Mass (Da):80,504
Last modified:December 6, 2002 - v1
Checksum:i48646523758CF4FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031431 mRNA. Translation: AAH31431.1.
CCDSiCCDS17064.1.
RefSeqiNP_666241.1. NM_146129.3.
XP_011237796.1. XM_011239494.1.
XP_011237797.1. XM_011239495.1.
UniGeneiMm.241134.

Genome annotation databases

EnsembliENSMUST00000041643; ENSMUSP00000039555; ENSMUSG00000039849.
GeneIDi228866.
KEGGimmu:228866.
UCSCiuc008nwp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031431 mRNA. Translation: AAH31431.1.
CCDSiCCDS17064.1.
RefSeqiNP_666241.1. NM_146129.3.
XP_011237796.1. XM_011239494.1.
XP_011237797.1. XM_011239495.1.
UniGeneiMm.241134.

3D structure databases

ProteinModelPortaliP59114.
SMRiP59114. Positions 40-86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230787. 1 interaction.
STRINGi10090.ENSMUSP00000039555.

PTM databases

iPTMnetiP59114.
PhosphoSiteiP59114.

Proteomic databases

EPDiP59114.
PaxDbiP59114.
PeptideAtlasiP59114.
PRIDEiP59114.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041643; ENSMUSP00000039555; ENSMUSG00000039849.
GeneIDi228866.
KEGGimmu:228866.
UCSCiuc008nwp.1. mouse.

Organism-specific databases

CTDi63935.
MGIiMGI:2443858. Pcif1.

Phylogenomic databases

eggNOGiENOG410IFAY. Eukaryota.
ENOG410XPH2. LUCA.
HOGENOMiHOG000048178.
HOVERGENiHBG053525.
InParanoidiP59114.
KOiK17584.
OMAiLKMWGTS.
OrthoDBiEOG7TJ3H6.
PhylomeDBiP59114.
TreeFamiTF350163.

Miscellaneous databases

PROiP59114.
SOURCEiSearch...

Gene expression databases

BgeeiP59114.
ExpressionAtlasiP59114. baseline and differential.
GenevisibleiP59114. MM.

Family and domain databases

InterProiIPR022035. PCIF1_WW.
IPR001202. WW_dom.
[Graphical view]
PfamiPF12237. PCIF1_WW. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Lung, Spleen and Testis.

Entry informationi

Entry nameiPCIF1_MOUSE
AccessioniPrimary (citable) accession number: P59114
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 6, 2002
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.