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P59111

- KCNH8_MOUSE

UniProt

P59111 - KCNH8_MOUSE

Protein

Potassium voltage-gated channel subfamily H member 8

Gene

Kcnh8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current By similarity. Channel properties may be modulated by cAMP and subunit assembly By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi551 – 668118cNMPAdd
    BLAST

    GO - Molecular functioni

    1. phosphorelay sensor kinase activity Source: InterPro
    2. voltage-gated potassium channel activity Source: RefGenome

    GO - Biological processi

    1. potassium ion transmembrane transport Source: RefGenome
    2. regulation of membrane potential Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily H member 8
    Alternative name(s):
    Ether-a-go-go-like potassium channel 3
    Short name:
    ELK channel 3
    Short name:
    ELK3
    Voltage-gated potassium channel subunit Kv12.1
    Gene namesi
    Name:Kcnh8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2445160. Kcnh8.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11021102Potassium voltage-gated channel subfamily H member 8PRO_0000054019Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi409 – 4091N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP59111.

    PTM databases

    PhosphoSiteiP59111.

    Expressioni

    Gene expression databases

    GenevestigatoriP59111.

    Interactioni

    Subunit structurei

    The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000049206.

    Structurei

    3D structure databases

    ProteinModelPortaliP59111.
    SMRiP59111. Positions 11-136, 420-474, 481-675.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 225225CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini247 – 2559ExtracellularSequence Analysis
    Topological domaini277 – 29822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini320 – 3278ExtracellularSequence Analysis
    Topological domaini349 – 3579CytoplasmicSequence Analysis
    Topological domaini379 – 41941ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini441 – 4488ExtracellularSequence Analysis
    Topological domaini470 – 1102633CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei420 – 44021Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei226 – 24621Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei256 – 27621Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei299 – 31921Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei328 – 34821Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei358 – 37821Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei449 – 46921Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 9073PASAdd
    BLAST
    Domaini93 – 14553PACPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi434 – 4396Selectivity filterBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi711 – 72212Poly-GluAdd
    BLAST

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 PAC (PAS-associated C-terminal) domain.PROSITE-ProRule annotation
    Contains 1 PAS (PER-ARNT-SIM) domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2202.
    HOGENOMiHOG000230794.
    HOVERGENiHBG052232.
    InParanoidiP59111.
    KOiK04911.
    PhylomeDBiP59111.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR003950. K_chnl_volt-dep_ELK.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view]
    PRINTSiPR01463. EAGCHANLFMLY.
    PR01465. ELKCHANNEL.
    SMARTiSM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsiTIGR00229. sensory_box. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59111-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVMKGLLAP QNTFLDTIAT RFDGTHSNFI LANAQVAKGF PIVYCSDGFC     50
    ELAGFARTEV MQKSCSCKFL FGVETNEQLM LQIEKSLEEK VEFKGEIMFY 100
    KKNGAPFWCL LDIVPIKNEK GDVVLFLASF KDITDTKVKI TSEDKKEDRT 150
    KGRSRAGSHF DSARRRSRAV LYHISGHLQR REKNKLKINN NVFVDKPAFP 200
    EYKASDAKKS KFILLHFSTF KAGWDWLILL ATFYVAVTVP YNVCFIGNED 250
    LSTTRSTTVS DIAVEILFII DIILNFRTTY VSKSGQVIFE ARSICIHYVT 300
    TWFIIDLIAA LPFDLLYAFN VTVVSLVHLL KTVRLLRLLR LLQKLDRYSQ 350
    HSTIVLTLLM SMFALLAHWM ACIWYVIGKM EREDNSLLKW EVGWLHELGK 400
    RLESPYYGNN TLGGPSIRSA YIAALYFTLS SLTSVGFGNV SANTDAEKIF 450
    SICTMLIGAL MHALVFGNVT AIIQRMYSRW SLYHTRTKDL KDFIRVHHLP 500
    QQLKQRMLEY FQTTWSVNNG IDSNELLKDF PDELRSDITM HLNKEILQLS 550
    LFECASRGCL RSLSLHIKTS FCAPGEYLLR QGDALQAIYF VCSGSMEVLK 600
    DSMVLAILGK GDLIGANLSI KDQVIKTNAD VKALTYCDLQ CIILKGLFEV 650
    LGLYPEYAHK FVEDIQHDLT YNLREGHESD VISRLSNKST VSQAEPKGNG 700
    SINKRLPSIV EDEEEEEVEE EETTSLSPIY TRGSSVSHSK KTGSNKTYLG 750
    LSLKQLASGT VPFHSPIRVS SANSPKTKQE ADPPNHGRKK EKNLKVQLSS 800
    LGSAGTPELS PRIVDGIEDG NSNEETQTFD FGSEQIRPEP RISPPLAESE 850
    IGAAFLFIKA EETKQQINKL NSEVTTLTQE VSQLGRDMRS IMQLLENILS 900
    PQQPSQFCSL HPTPMCPSRE SLQTRVSWSA HQPCLHLQAG GAHLYHGNVA 950
    SGIWSVDPSL VGSSPQRTEA HEQNPADSEL HHSPNLDYSP SHCQVIQEGH 1000
    LQFLRCISPH SDTTLTPLQS ISATLSSSVC SSSETSLHLV LPSRSEEGSI 1050
    THGPVSSFSL ENLPGSWDRE QMMSASSERL ENFPVEVVTS TADVKDSKAI 1100
    NV 1102
    Length:1,102
    Mass (Da):123,277
    Last modified:January 9, 2007 - v2
    Checksum:iB2E6FE590A15E03F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti376 – 3761V → I in BAC33401. (PubMed:16141072)Curated
    Sequence conflicti543 – 5431N → D in BAC33401. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC122055 Genomic DNA. No translation available.
    AC122540 Genomic DNA. No translation available.
    AC125051 Genomic DNA. No translation available.
    AC131674 Genomic DNA. No translation available.
    AK048629 mRNA. Translation: BAC33401.1.
    BC029690 mRNA. Translation: AAH29690.1.
    CCDSiCCDS57101.1.
    RefSeqiNP_001026981.2. NM_001031811.2.
    UniGeneiMm.399068.
    Mm.490760.

    Genome annotation databases

    GeneIDi211468.
    KEGGimmu:211468.
    UCSCiuc029tiu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC122055 Genomic DNA. No translation available.
    AC122540 Genomic DNA. No translation available.
    AC125051 Genomic DNA. No translation available.
    AC131674 Genomic DNA. No translation available.
    AK048629 mRNA. Translation: BAC33401.1 .
    BC029690 mRNA. Translation: AAH29690.1 .
    CCDSi CCDS57101.1.
    RefSeqi NP_001026981.2. NM_001031811.2.
    UniGenei Mm.399068.
    Mm.490760.

    3D structure databases

    ProteinModelPortali P59111.
    SMRi P59111. Positions 11-136, 420-474, 481-675.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000049206.

    PTM databases

    PhosphoSitei P59111.

    Proteomic databases

    PRIDEi P59111.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 211468.
    KEGGi mmu:211468.
    UCSCi uc029tiu.1. mouse.

    Organism-specific databases

    CTDi 131096.
    MGIi MGI:2445160. Kcnh8.

    Phylogenomic databases

    eggNOGi COG2202.
    HOGENOMi HOG000230794.
    HOVERGENi HBG052232.
    InParanoidi P59111.
    KOi K04911.
    PhylomeDBi P59111.

    Miscellaneous databases

    NextBioi 373240.
    PROi P59111.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P59111.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR003950. K_chnl_volt-dep_ELK.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view ]
    PRINTSi PR01463. EAGCHANLFMLY.
    PR01465. ELKCHANNEL.
    SMARTi SM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsi TIGR00229. sensory_box. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-1102.
      Strain: C57BL/6J.
      Tissue: Head.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 227-1102.
      Strain: C57BL/6.
      Tissue: Retina.

    Entry informationi

    Entry nameiKCNH8_MOUSE
    AccessioniPrimary (citable) accession number: P59111
    Secondary accession number(s): Q8BX82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2002
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    There seems to be a problem in the assembly of the Mouse genome in the region covered by contigs AC125051 and AC131674.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3