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P59111 (KCNH8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily H member 8
Alternative name(s):
Ether-a-go-go-like potassium channel 3
Short name=ELK channel 3
Short name=ELK3
Voltage-gated potassium channel subunit Kv12.1
Gene names
Name:Kcnh8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1102 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current By similarity. Channel properties may be modulated by cAMP and subunit assembly By similarity.

Subunit structure

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

Subcellular location

Membrane; Multi-pass membrane protein.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.1/KCNH8 sub-subfamily. [View classification]

Contains 1 cyclic nucleotide-binding domain.

Contains 1 PAC (PAS-associated C-terminal) domain.

Contains 1 PAS (PER-ARNT-SIM) domain.

Caution

There seems to be a problem in the assembly of the Mouse genome in the region covered by contigs AC125051 and AC131674.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11021102Potassium voltage-gated channel subfamily H member 8
PRO_0000054019

Regions

Topological domain1 – 225225Cytoplasmic Potential
Transmembrane226 – 24621Helical; Name=Segment S1; Potential
Topological domain247 – 2559Extracellular Potential
Transmembrane256 – 27621Helical; Name=Segment S2; Potential
Topological domain277 – 29822Cytoplasmic Potential
Transmembrane299 – 31921Helical; Name=Segment S3; Potential
Topological domain320 – 3278Extracellular Potential
Transmembrane328 – 34821Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain349 – 3579Cytoplasmic Potential
Transmembrane358 – 37821Helical; Name=Segment S5; Potential
Topological domain379 – 41941Extracellular Potential
Intramembrane420 – 44021Pore-forming; Name=Segment H5; Potential
Topological domain441 – 4488Extracellular Potential
Transmembrane449 – 46921Helical; Name=Segment S6; Potential
Topological domain470 – 1102633Cytoplasmic Potential
Domain18 – 9073PAS
Domain93 – 14553PAC
Nucleotide binding551 – 668118cNMP
Motif434 – 4396Selectivity filter By similarity
Compositional bias711 – 72212Poly-Glu

Amino acid modifications

Glycosylation3201N-linked (GlcNAc...) Potential
Glycosylation4091N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict3761V → I in BAC33401. Ref.2
Sequence conflict5431N → D in BAC33401. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P59111 [UniParc].

Last modified January 9, 2007. Version 2.
Checksum: B2E6FE590A15E03F

FASTA1,102123,277
        10         20         30         40         50         60 
MPVMKGLLAP QNTFLDTIAT RFDGTHSNFI LANAQVAKGF PIVYCSDGFC ELAGFARTEV 

        70         80         90        100        110        120 
MQKSCSCKFL FGVETNEQLM LQIEKSLEEK VEFKGEIMFY KKNGAPFWCL LDIVPIKNEK 

       130        140        150        160        170        180 
GDVVLFLASF KDITDTKVKI TSEDKKEDRT KGRSRAGSHF DSARRRSRAV LYHISGHLQR 

       190        200        210        220        230        240 
REKNKLKINN NVFVDKPAFP EYKASDAKKS KFILLHFSTF KAGWDWLILL ATFYVAVTVP 

       250        260        270        280        290        300 
YNVCFIGNED LSTTRSTTVS DIAVEILFII DIILNFRTTY VSKSGQVIFE ARSICIHYVT 

       310        320        330        340        350        360 
TWFIIDLIAA LPFDLLYAFN VTVVSLVHLL KTVRLLRLLR LLQKLDRYSQ HSTIVLTLLM 

       370        380        390        400        410        420 
SMFALLAHWM ACIWYVIGKM EREDNSLLKW EVGWLHELGK RLESPYYGNN TLGGPSIRSA 

       430        440        450        460        470        480 
YIAALYFTLS SLTSVGFGNV SANTDAEKIF SICTMLIGAL MHALVFGNVT AIIQRMYSRW 

       490        500        510        520        530        540 
SLYHTRTKDL KDFIRVHHLP QQLKQRMLEY FQTTWSVNNG IDSNELLKDF PDELRSDITM 

       550        560        570        580        590        600 
HLNKEILQLS LFECASRGCL RSLSLHIKTS FCAPGEYLLR QGDALQAIYF VCSGSMEVLK 

       610        620        630        640        650        660 
DSMVLAILGK GDLIGANLSI KDQVIKTNAD VKALTYCDLQ CIILKGLFEV LGLYPEYAHK 

       670        680        690        700        710        720 
FVEDIQHDLT YNLREGHESD VISRLSNKST VSQAEPKGNG SINKRLPSIV EDEEEEEVEE 

       730        740        750        760        770        780 
EETTSLSPIY TRGSSVSHSK KTGSNKTYLG LSLKQLASGT VPFHSPIRVS SANSPKTKQE 

       790        800        810        820        830        840 
ADPPNHGRKK EKNLKVQLSS LGSAGTPELS PRIVDGIEDG NSNEETQTFD FGSEQIRPEP 

       850        860        870        880        890        900 
RISPPLAESE IGAAFLFIKA EETKQQINKL NSEVTTLTQE VSQLGRDMRS IMQLLENILS 

       910        920        930        940        950        960 
PQQPSQFCSL HPTPMCPSRE SLQTRVSWSA HQPCLHLQAG GAHLYHGNVA SGIWSVDPSL 

       970        980        990       1000       1010       1020 
VGSSPQRTEA HEQNPADSEL HHSPNLDYSP SHCQVIQEGH LQFLRCISPH SDTTLTPLQS 

      1030       1040       1050       1060       1070       1080 
ISATLSSSVC SSSETSLHLV LPSRSEEGSI THGPVSSFSL ENLPGSWDRE QMMSASSERL 

      1090       1100 
ENFPVEVVTS TADVKDSKAI NV 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-1102.
Strain: C57BL/6J.
Tissue: Head.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 227-1102.
Strain: C57BL/6.
Tissue: Retina.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC122055 Genomic DNA. No translation available.
AC122540 Genomic DNA. No translation available.
AC125051 Genomic DNA. No translation available.
AC131674 Genomic DNA. No translation available.
AK048629 mRNA. Translation: BAC33401.1.
BC029690 mRNA. Translation: AAH29690.1.
RefSeqNP_001026981.2. NM_001031811.2.
UniGeneMm.399068.
Mm.490760.

3D structure databases

ProteinModelPortalP59111.
SMRP59111. Positions 11-136, 421-472, 481-675.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000049206.

PTM databases

PhosphoSiteP59111.

Proteomic databases

PRIDEP59111.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID211468.
KEGGmmu:211468.
UCSCuc029tiu.1. mouse.

Organism-specific databases

CTD131096.
MGIMGI:2445160. Kcnh8.

Phylogenomic databases

eggNOGCOG2202.
HOGENOMHOG000230794.
HOVERGENHBG052232.
InParanoidP59111.
KOK04911.
PhylomeDBP59111.

Gene expression databases

GenevestigatorP59111.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSPR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsTIGR00229. sensory_box. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio373240.
PROP59111.
SOURCESearch...

Entry information

Entry nameKCNH8_MOUSE
AccessionPrimary (citable) accession number: P59111
Secondary accession number(s): Q8BX82
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot