Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sentrin-specific protease 1

Gene

Senp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protease that catalyzes two essential functions in the SUMO pathway (PubMed:15923632, PubMed:29499132). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 (By similarity). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (By similarity). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (By similarity). Deconjugates SUMO2 from MTA1 (By similarity). Desumoylates CCAR2 which decreases its interaction with SIRT1 (By similarity). Deconjugates SUMO1 from GPS2 (PubMed:29499132).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei529By similarity1
Active sitei546By similarity1
Active sitei599NucleophileBy similarity1

GO - Molecular functioni

  • endopeptidase activity Source: GO_Central
  • SUMO-specific endopeptidase activity Source: MGI
  • SUMO-specific isopeptidase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Hydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

BRENDAi3.4.22.B70 3474
ReactomeiR-MMU-3065679 SUMO is proteolytically processed

Protein family/group databases

MEROPSiC48.002

Names & Taxonomyi

Protein namesi
Recommended name:
Sentrin-specific protease 1 (EC:3.4.22.-1 Publication)
Alternative name(s):
SUMO-1 protease 2
Short name:
SuPr-2
Sentrin/SUMO-specific protease SENP1
Gene namesi
Name:Senp1
Synonyms:Supr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2445054 Senp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Death between E13.5 and E14.5 due to abnormalities in fetal vessels.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017171 – 640Sentrin-specific protease 1Add BLAST640

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei57PhosphoserineBy similarity1
Modified residuei117PhosphoserineBy similarity1
Modified residuei157PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP59110
MaxQBiP59110
PaxDbiP59110
PRIDEiP59110

PTM databases

iPTMnetiP59110
PhosphoSitePlusiP59110

Expressioni

Developmental stagei

Expression starts at E9.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000033075
CleanExiMM_SENP1
ExpressionAtlasiP59110 baseline and differential
GenevisibleiP59110 MM

Interactioni

Subunit structurei

Interacts with MTA1. Interacts with CCAR2 (via N-terminus).By similarity

Protein-protein interaction databases

BioGridi230207, 5 interactors
IntActiP59110, 2 interactors
MINTiP59110
STRINGi10090.ENSMUSP00000046598

Structurei

3D structure databases

ProteinModelPortaliP59110
SMRiP59110
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 200Interaction with CCAR2By similarityAdd BLAST200
Regioni446 – 610ProteaseAdd BLAST165

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi171 – 177Nuclear localization signalBy similarity7
Motifi570 – 573Nuclear localization signalSequence analysis4
Motifi624 – 630Nuclear localization signalSequence analysis7
Motifi631 – 640Nuclear export signalBy similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 170Ser-richAdd BLAST129
Compositional biasi289 – 296His-rich8

Sequence similaritiesi

Belongs to the peptidase C48 family.Curated

Phylogenomic databases

eggNOGiKOG0778 Eukaryota
COG5160 LUCA
GeneTreeiENSGT00530000062941
HOGENOMiHOG000154286
HOVERGENiHBG057384
InParanoidiP59110
KOiK08592
PhylomeDBiP59110
TreeFamiTF316289

Family and domain databases

InterProiView protein in InterPro
IPR003653 Peptidase_C48_C
PfamiView protein in Pfam
PF02902 Peptidase_C48, 1 hit
PROSITEiView protein in PROSITE
PS50600 ULP_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

P59110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDTADGVKM DAGEVTLVNH GSTFRTHRPP QSGFPEEQLL LSDQQSLPFR
60 70 80 90 100
QGTLDGSFTC STRSPAYRPD YHSDNPSSDS FLGSGDVRTF GQSANGQWRN
110 120 130 140 150
STPASGSAPQ KPRNSRSLCL ETRKTSSGLS NTFVGKSNHH CHMSAYEKSF
160 170 180 190 200
PIKPAPSPSW SGSCRRSLLS PKKTQRRHFS TAEETVQEEE KEIYRQLLQM
210 220 230 240 250
VTGKQFCVAK PTTHFPLRLS RCLSSNKNSL KDSLLRNGNS CASHVIGSDT
260 270 280 290 300
SSSGSASILT AQEQLSHSAH SLSSGTPDVA FGSKDSDPHH HLAAPHQPNS
310 320 330 340 350
LPASNTQSEG SDSVILLKVK ESQTPASSPT FFQAELWIKE LTSVYDSRAR
360 370 380 390 400
ERLRRIEEQK ALALQLQNQR LQEQEHAVLD SVELHLRVPL EKEIPVTAAQ
410 420 430 440 450
ETRKKSHQLT DSEDEFPEIT EEMEKEIKNV FRNGNQDEVL SEAFRLTITR
460 470 480 490 500
KDIQTLNHLN WLNDEIINFY MNMLMERSKE KGFPSVHAFN TFFFTKLKTA
510 520 530 540 550
GYQAVKRWTK KVDVFSVDIL LVPIHLGVHW CLAVVDFRRK SITYYDSMGG
560 570 580 590 600
INNEACRILL QYLKQESVDK KRKEFDTNGW QLFSKKSQEI PQQMNGSDCG
610 620 630 640
MFACKYADCI TKDRPINFTQ QHMPYFRKRM VWEILHRKLL
Length:640
Mass (Da):72,511
Last modified:November 28, 2002 - v1
Checksum:i59B6BB70268A0477
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti432R → H in BAC40442 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028565 mRNA Translation: BAC26011.1
AK035581 mRNA Translation: BAC29112.1
AK088597 mRNA Translation: BAC40442.1
BC023129 mRNA Translation: AAH23129.1
CCDSiCCDS49717.1
RefSeqiNP_659100.1, NM_144851.5
UniGeneiMm.384023
Mm.487443

Genome annotation databases

EnsembliENSMUST00000044189; ENSMUSP00000046598; ENSMUSG00000033075
GeneIDi223870
KEGGimmu:223870
UCSCiuc007xls.3 mouse

Similar proteinsi

Entry informationi

Entry nameiSENP1_MOUSE
AccessioniPrimary (citable) accession number: P59110
Secondary accession number(s): Q8BTV5, Q8BZF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 28, 2002
Last modified: April 25, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health