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Protein

Copine-2

Gene

Cpne2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties (PubMed:21087455, PubMed:26175110).2 Publications

GO - Biological processi

  • cellular response to calcium ion Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Copine-2Curated
Alternative name(s):
Copine IIBy similarityImported
Gene namesi
Name:Cpne2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2387578 Cpne2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi37D → N: Does not inhibit calcium-dependent translocation to the cell membrane; when associated with N-39; N-97 and N-99. 1 Publication1
Mutagenesisi39D → N: Does not inhibit calcium-dependent translocation to the cell membrane; when associated with N-37; N-97 and N-99. 1 Publication1
Mutagenesisi97D → N: Does not inhibit calcium-dependent translocation to the cell membrane; when associated with N-37; N-39 and N-99. 1 Publication1
Mutagenesisi99D → N: Does not inhibit calcium-dependent translocation to the cell membrane; when associated with N-37; N-39 and N-97. 1 Publication1
Mutagenesisi170D → N: Leads to a reduction in the amount of calcium-dependent translocation to the cell membrane. Leads to the constitutive (calcium-independent) attachment to the cell membrane; when associated with N-176; N-232 and N-234. 1 Publication1
Mutagenesisi176D → N: Does not inhibit calcium-dependent translocation to the cell membrane. Leads to the constitutive (calcium-independent) attachment to the cell membrane; when associated with N-170; N-232 and N-234. 1 Publication1
Mutagenesisi232D → N: Leads to a reduction in the amount of calcium-dependent translocation to the cell membrane. Leads to the constitutive (calcium-independent) attachment to the cell membrane; when associated with N-170; N-176 and N-234. 1 Publication1
Mutagenesisi234D → N: Leads to a reduction in the amount of calcium-dependent translocation to the cell membrane. Leads to the constitutive (calcium-independent) attachment to the cell membrane; when associated with N-170; N-176 and N-232. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448371 – 548Copine-2Add BLAST548

Proteomic databases

EPDiP59108
MaxQBiP59108
PaxDbiP59108
PeptideAtlasiP59108
PRIDEiP59108

PTM databases

iPTMnetiP59108
PhosphoSitePlusiP59108

Expressioni

Gene expression databases

BgeeiENSMUSG00000034361
CleanExiMM_CPNE2
ExpressionAtlasiP59108 baseline and differential
GenevisibleiP59108 MM

Interactioni

Protein-protein interaction databases

BioGridi231541, 1 interactor
IntActiP59108, 2 interactors
MINTiP59108
STRINGi10090.ENSMUSP00000045755

Structurei

3D structure databases

ProteinModelPortaliP59108
SMRiP59108
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 115C2 1PROSITE-ProRule annotationAdd BLAST106
Domaini141 – 246C2 2PROSITE-ProRule annotationAdd BLAST106
Domaini305 – 507VWFAPROSITE-ProRule annotationAdd BLAST203

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni247 – 304Linker region1 PublicationAdd BLAST58

Domaini

The C2 domain 2, but not the C2 domain 1, is necessary for calcium-mediated membrane association (PubMed:21087455, PubMed:26175110). The linker region is necessary for calcium-dependent cell membrane association (PubMed:21087455).2 Publications

Sequence similaritiesi

Belongs to the copine family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1327 Eukaryota
ENOG410XPC8 LUCA
GeneTreeiENSGT00760000119085
HOGENOMiHOG000220898
HOVERGENiHBG066841
InParanoidiP59108
OMAiQDKSSMQ
OrthoDBiEOG091G05IT
PhylomeDBiP59108
TreeFamiTF316419

Family and domain databases

CDDicd04047 C2B_Copine, 1 hit
Gene3Di2.60.40.150, 2 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037768 C2B_Copine
IPR010734 Copine
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF07002 Copine, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits

Sequencei

Sequence statusi: Complete.

P59108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYIPDGGAP TAGAIPLGSQ CCVCKVELSV SGQNLLDRDV TSKSDPFCVL
60 70 80 90 100
FIEDNGRWME FDRTETAVNN LNPAFSKKFV LDYHFEEVQK LKFALFDQDK
110 120 130 140 150
SSAQLDEHDF LGQFSCSLGT IVSSKKITRP LLLMNDKPAG KGVITIAAQE
160 170 180 190 200
LSDNRVITLS LAGRKLDKKD LFGKSDPFLE FYKPGDDGKW MLVHRTEVIK
210 220 230 240 250
YTLDPVWKPF TVPLVSLCDG DLEKPIQVMC YDYDSNGGHD FIGEFQTSVL
260 270 280 290 300
QMSEARDGVP LEIECINPKK QRKKKSYKNS GIIILRSCKI HRNYSFLDYI
310 320 330 340 350
LGGCQLMFTV GIDFTASNGN PLDPSSLHYI NPMGTNEYLS AIWAVGQIIQ
360 370 380 390 400
DYDSDKMFPA LGFGAQLPPD WKVSHEFAIN FNPTNPFCSG VDGIAQAYSA
410 420 430 440 450
CLPHIRFYGP TNFSPIVNHV ARFAAQATQQ QTATQYFILL IITDGVISDM
460 470 480 490 500
EETRHAVVQA SKLPMSIIIV GVGNADFAAM EFLDGDNRRL RSHTGEEAAR
510 520 530 540
DIVQFVPFRE FRNAAKETLA KAVLAELPQQ VVQYFKHKNL PPTNSEPA
Length:548
Mass (Da):61,036
Last modified:November 28, 2002 - v1
Checksum:i796F26124D2A0E13
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti435Missing in AAH22128 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC022128 mRNA Translation: AAH22128.2
BC031801 mRNA Translation: AAH31801.1
CCDSiCCDS22543.1
RefSeqiNP_705727.1, NM_153507.2
UniGeneiMm.291815

Genome annotation databases

EnsembliENSMUST00000048653; ENSMUSP00000045755; ENSMUSG00000034361
GeneIDi234577
KEGGimmu:234577
UCSCiuc009mwm.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCPNE2_MOUSE
AccessioniPrimary (citable) accession number: P59108
Secondary accession number(s): Q8K1D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 28, 2002
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health