P59103 (DAOA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-amino acid oxidase activator

Alternative name(s):
Protein G72

Gene names

Name:	DAOA
Synonyms:	G72

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	153 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Seems to activate D-amino acid oxidase.
Subunit structure	Associates with D-amino acid oxidase (DAAO).
Subcellular location	Golgi apparatus.
Tissue specificity	Expressed in amygdala, caudate nucleus, spinal cord and testis.

Ontologies

Keywords
Cellular component	Golgi apparatus
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P59103-1)

Also known as: LG72;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 2 (identifier: P59103-2)

Also known as: SG72;

The sequence of this isoform differs from the canonical sequence as follows:
     16-16: S → V
     17-153: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 153	153	D-amino acid oxidase activator		PRO_0000079781
Natural variations
	Alternative sequence	16	1	S → V in isoform 2.		VSP_004053
	Alternative sequence	17 – 153	137	Missing in isoform 2.		VSP_004054
	Natural variant	30	1	R → K. Ref.1 Corresponds to variant rs2391191 [ dbSNP | Ensembl ].		VAR_014313
	Natural variant	62	1	K → E. Corresponds to variant rs9558562 [ dbSNP | Ensembl ].		VAR_050943

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (LG72) [UniParc]. Last modified December 20, 2005. Version 2. Checksum: 597E2DE432A48EAE	FASTA	153	18,108
	10 20 30 40 50 60 MLEKLMGADS LQLFRSRYTL GKIYFIGFQR SILLSKSENS LNSIAKETEE GRETVTRKEG 70 80 90 100 110 120 WKRRHEDGYL EMAQRHLQRS LCPWVSYLPQ PYAELEEVSS HVGKVFMARN YEFLAYEASK 130 140 150 DRRQPLERMW TCNYNQQKDQ SCNHKEITST KAE
	Isoform 2 (SG72) [UniParc]. Checksum: B7B6CDA012257A99	FASTA	16	1,851
	10 MLEKLMGADS LQLFRV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia." Chumakov I., Blumenfeld M., Guerassimenko O., Cavarec L., Palicio M., Abderrahim H., Bougueleret L., Barry C., Tanaka H., La Rosa P., Puech A., Tahri N., Cohen-Akenine A., Delabrosse S., Lissarrague S., Picard F.-P., Maurice K., Essioux L. , Millasseau P., Grel P., Debailleul V., Simon A.-M., Caterina D., Dufaure I., Malekzadeh K., Belova M., Luan J.-J., Bouillot M., Sambucy J.-L., Primas G., Saumier M., Boubkiri N., Martin-Saumier S., Nasroune M., Peixoto H., Delaye A., Pinchot V., Bastucci M., Guillou S., Chevillon M., Sainz-Fuertes R., Meguenni S., Aurich-Costa J., Cherif D., Gimalac A., Van Duijn C., Gauvreau D., Ouellette G., Fortier I., Raelson J., Sherbatich T., Riazanskay N., Rogaev E., Raeymaekers P., Aerssens J., Konings F., Luyten W., Macciardi F., Sham P.C., Straub R.E., Weinberger D.R., Cohen N., Cohen D. Proc. Natl. Acad. Sci. U.S.A. 99:13675-13680(2002) [PubMed: 12364586] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, VARIANT LYS-30, INTERACTION WITH DAAO.
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:R8.1-R8.16(2004) [PubMed: 14759258] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014294 Genomic DNA. Translation: AAN16027.1. AE014294 Genomic DNA. Translation: AAN16028.1. AY138546 mRNA. Translation: AAN08432.1. AY138547 mRNA. Translation: AAN08433.1. AL359751 Genomic DNA. Translation: CAH70815.1. BC121091 mRNA. Translation: AAI21092.1.
IPI	IPI00171483. IPI00218119.
RefSeq	NP_001155284.1. NM_001161812.1. NP_001155286.1. NM_001161814.1. NP_758958.3. NM_172370.3.
UniGene	Hs.381382.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P59103.
Polymorphism databases
DMDM	84028201.
Proteomic databases
PRIDE	P59103.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000375936; ENSP00000365103; ENSG00000182346.
GeneID	267012.
KEGG	hsa:267012.
NMPDR	fig|9606.3.peg.9060.
UCSC	uc001vqb.1. human.
Organism-specific databases
CTD	267012.
GeneCards	GC13P106118.
HGNC	HGNC:21191. DAOA.
MIM	607408. gene.
neXtProt	NX_P59103.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21869.
InParanoid	P59103.
OrthoDB	EOG4P5KBD.
Gene expression databases
ArrayExpress	P59103.
CleanEx	HS_DAOA.
Genevestigator	P59103.
GermOnline	ENSG00000182346. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	93398.
SOURCE	Search...

Entry information

Entry name

DAOA_HUMAN

Accession

Primary (citable) accession number: P59103
Secondary accession number(s): Q0VAE6, Q5VX59

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	December 20, 2005
Last modified:	January 25, 2012
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.