Reviewed, UniProtKB/Swiss-Prot P59099 (ARGA_BUCAP)

Names and origin

Protein names

Recommended name:
    Amino-acid acetyltransferase
    EC=2.3.1.1
Alternative name(s):
    N-acetylglutamate synthase
      Short name=AGS
      Short name=NAGS

Gene names

Name:	argA
Ordered Locus Names:	BUsg_441

Organism

Buchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP]

Taxonomic identifier

98794 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	442 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. HAMAP MF_01105
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4. HAMAP MF_01105
Subunit structure	Homohexamer Probable.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the acetyltransferase family. ArgA subfamily. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	amino-acid N-acetyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 442	442	Amino-acid acetyltransferase HAMAP MF_01105		PRO_0000186789
Regions
	Domain	295 – 442	148	N-acetyltransferase

Sequences

	Sequence		Length	Mass (Da)
	P59099-1 [UniParc]. Last modified November 15, 2002. Version 1. Checksum: 15074C28D9107753	FASTA	442	49,585
	10 20 30 40 50 60 MRERTTELVQ GFRHSVPYIN AHRGKKFVIM LSGEAIKYGN FSGIINDIGL LHSLGIRLIV 70 80 90 100 110 120 VYGSCPQINA NLKEKNIKIT YHKYIRVTDL LSLEQVKQAA GRLQLDITAR LSMSLSNTPL 130 140 150 160 170 180 QGANINVVSG NFIIAQPLGV DDGIDYCHSG RIRRIDKKAI NCQLENGAIV LIGPVAVSVT 190 200 210 220 230 240 GESFNLTSEE IATQVSIKLK AEKMIGFCSK QGVIDSQGKT ISELLPNNIQ NEIKKLEGKG 250 260 270 280 290 300 DYISSTIRFL RGSIKACKSG VNRSHLISYH KNGALLQELF SRDGIGTQMV MESAEKIRQA 310 320 330 340 350 360 NINDIGGILE LIRPLEKKGI LVRRSREQLE MEVDKFTIIE RDNLTIACAA LYPFFKEKIG 370 380 390 400 410 420 EMACVAVHPD YRNSSRGDLL LQTMKLNAKK LNLKKIFVLT TQSIHWFQER GFILVDVEIL 430 440 PESKKKMYNY QRCSKILMID LF

References

[1]

"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013218 Genomic DNA. Translation: AAM67984.1.
RefSeq	NP_660773.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1005723.
GenomeReviews	Gene locus BUsg_441 in contig AE013218_GR.
KEGG	bas:BUsg441.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P59099.
OMA	P59099. DLIRPLE.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG441-MON.
Family and domain databases
HAMAP	MF_01105. [Tree]
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR001048. Asp/Glu/Uridylate_kinase. IPR000182. GCN5-rel_AcTrfase. IPR010167. NH2A_AcTrfase_ArgA. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit. G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. PF00583. Acetyltransf_1. 1 hit. [Graphical view]
PIRSF	PIRSF000423. ArgA. 1 hit.
TIGRFAMs	TIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGA_BUCAP

Accession

Primary (citable) accession number: P59099

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	November 15, 2002
Last modified:	June 16, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)