P59098 (ARGB_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	BUsg_046

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subunit structure	Homodimer By similarity. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	Acetylglutamate kinase HAMAP MF_00082_B		PRO_0000112599
Regions
	Nucleotide binding	181 – 186	6	ATP By similarity
	Nucleotide binding	209 – 211	3	ATP By similarity
	Region	44 – 45	2	Substrate binding By similarity
Sites
	Binding site	66	1	Substrate By similarity
	Binding site	158	1	Substrate By similarity
	Site	8	1	Transition state stabilizer By similarity
	Site	217	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	P59098 [UniParc]. Last modified November 15, 2002. Version 1. Checksum: 166EA6D39AF8441D	FASTA	258	27,821
	10 20 30 40 50 60 MMSPLVIKLG GVLLESDNAM MRLFKALLDY QKSNKRHILI IHGGGRLIDD LMNKLSLPIE 70 80 90 100 110 120 KKNGLRITQS EHINVITGAL AGTANKILLS WALKYKINAV GLCLADGKSV NVEKLDQDLG 130 140 150 160 170 180 HVGKAKPGSP LFLTKLCEQG ILPIISSIGI TDDGLLMNVN ADLAATALAT TLKANLILLS 190 200 210 220 230 240 DISSILDGKG QRISEINYLQ AKKLISQGII TNGMIVKVNA ALEAARVLQR SIDIASWQNT 250 DQLKLLFNGI NIGTRVLV

References

[1]	"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE013218 Genomic DNA. Translation: AAM67617.1.
RefSeq	NP_660406.1. NC_004061.1.
3D structure databases
ProteinModelPortal	P59098.
SMR	P59098. Positions 1-257.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000000538; EBBUCP00000000538; EBBUCG00000000538.
GeneID	1005862.
GenomeReviews	Gene locus BUsg_046 in contig AE013218_GR.
KEGG	bas:BUsg046.
PATRIC	21246857. VBIBucAph100086_0046.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000008092.
HOGENOM	HBG497643.
OMA	GGCLVDD.
ProtClustDB	PRK00942.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG046-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_BUCAP

Accession

Primary (citable) accession number: P59098

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	November 15, 2002
Last modified:	January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program