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P59095 (STAR6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
StAR-related lipid transfer protein 6
Alternative name(s):
START domain-containing protein 6
Short name=StARD6
Gene names
Name:STARD6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols By similarity.

Sequence similarities

Contains 1 START domain.

Ontologies

Keywords
   Biological processLipid transport
Transport
   Coding sequence diversityPolymorphism
   LigandLipid-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlipid transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220StAR-related lipid transfer protein 6
PRO_0000220672

Regions

Domain1 – 208208START

Natural variations

Natural variant1591E → K.
Corresponds to variant rs2917782 [ dbSNP | Ensembl ].
VAR_024651

Sequences

Sequence LengthMass (Da)Tools
P59095 [UniParc].

Last modified November 15, 2002. Version 1.
Checksum: 5AC49FFF5C953234

FASTA22025,022
        10         20         30         40         50         60 
MDFKAIAQQT AQEVLGYNRD TSGWKVVKTS KKITVSSKAS RKFHGNLYRV EGIIPESPAK 

        70         80         90        100        110        120 
LSDFLYQTGD RITWDKSLQV YNMVHRIDSD TFICHTITQS FAVGSISPRD FIDLVYIKRY 

       130        140        150        160        170        180 
EGNMNIISSK SVDFPEYPPS SNYIRGYNHP CGFVCSPMEE NPAYSKLVMF VQTEMRGKLS 

       190        200        210        220 
PSIIEKTMPS NLVNFILNAK DGIKAHRTPS RRGFHHNSHS 

« Hide

References

[1]"The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6."
Soccio R.E., Adams R.M., Romanowski M.J., Sehayek E., Burley S.K., Breslow J.L.
Proc. Natl. Acad. Sci. U.S.A. 99:6943-6948(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF480305 mRNA. Translation: AAL89655.1.
RefSeqNP_631910.1. NM_139171.1.
UniGeneHs.438779.

3D structure databases

ProteinModelPortalP59095.
SMRP59095. Positions 3-204.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000310814.

Polymorphism databases

DMDM25091297.

Proteomic databases

PaxDbP59095.
PRIDEP59095.

Protocols and materials databases

DNASU147323.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000307844; ENSP00000310814; ENSG00000174448.
ENST00000581310; ENSP00000462349; ENSG00000174448.
GeneID147323.
KEGGhsa:147323.
UCSCuc010xdt.2. human.

Organism-specific databases

CTD147323.
GeneCardsGC18M051850.
HGNCHGNC:18066. STARD6.
HPAHPA042583.
MIM607051. gene.
neXtProtNX_P59095.
PharmGKBPA38287.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG255993.
HOGENOMHOG000137345.
HOVERGENHBG055194.
InParanoidP59095.
OMAQTEMRGK.
PhylomeDBP59095.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_15493. Steroid hormones.

Gene expression databases

ArrayExpressP59095.
BgeeP59095.
CleanExHS_STARD6.
GenevestigatorP59095.

Family and domain databases

Gene3D3.30.530.20. 1 hit.
InterProIPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamPF01852. START. 1 hit.
[Graphical view]
SMARTSM00234. START. 1 hit.
[Graphical view]
PROSITEPS50848. START. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi147323.
NextBio85583.
PROP59095.
SOURCESearch...

Entry information

Entry nameSTAR6_HUMAN
AccessionPrimary (citable) accession number: P59095
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: January 22, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM