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P59095

- STAR6_HUMAN

UniProt

P59095 - STAR6_HUMAN

Protein

StAR-related lipid transfer protein 6

Gene

STARD6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (15 Nov 2002)
      Previous versions | rss
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    Functioni

    May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols By similarity.By similarity

    GO - Molecular functioni

    1. lipid binding Source: UniProtKB-KW

    GO - Biological processi

    1. lipid transport Source: UniProtKB-KW

    Keywords - Biological processi

    Lipid transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Enzyme and pathway databases

    ReactomeiREACT_11038. Pregnenolone biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    StAR-related lipid transfer protein 6
    Alternative name(s):
    START domain-containing protein 6
    Short name:
    StARD6
    Gene namesi
    Name:STARD6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:18066. STARD6.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38287.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220StAR-related lipid transfer protein 6PRO_0000220672Add
    BLAST

    Proteomic databases

    PaxDbiP59095.
    PRIDEiP59095.

    Expressioni

    Gene expression databases

    ArrayExpressiP59095.
    BgeeiP59095.
    CleanExiHS_STARD6.
    GenevestigatoriP59095.

    Organism-specific databases

    HPAiHPA042583.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000310814.

    Structurei

    Secondary structure

    1
    220
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 1816
    Beta strandi26 – 294
    Beta strandi31 – 377
    Beta strandi41 – 455
    Beta strandi48 – 569
    Helixi58 – 647
    Beta strandi65 – 706
    Turni71 – 733
    Beta strandi76 – 838
    Beta strandi88 – 9811
    Beta strandi109 – 12012
    Turni121 – 1233
    Beta strandi124 – 1318
    Beta strandi141 – 1455
    Beta strandi148 – 15811
    Beta strandi161 – 17313
    Helixi181 – 20727

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2MOUNMR-A1-220[»]
    ProteinModelPortaliP59095.
    SMRiP59095. Positions 3-204.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 208208STARTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 START domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG255993.
    HOGENOMiHOG000137345.
    HOVERGENiHBG055194.
    InParanoidiP59095.
    OMAiQTEMRGK.
    PhylomeDBiP59095.

    Family and domain databases

    Gene3Di3.30.530.20. 1 hit.
    InterProiIPR023393. START-like_dom.
    IPR002913. START_lipid-bd_dom.
    [Graphical view]
    PfamiPF01852. START. 1 hit.
    [Graphical view]
    SMARTiSM00234. START. 1 hit.
    [Graphical view]
    PROSITEiPS50848. START. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59095-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDFKAIAQQT AQEVLGYNRD TSGWKVVKTS KKITVSSKAS RKFHGNLYRV    50
    EGIIPESPAK LSDFLYQTGD RITWDKSLQV YNMVHRIDSD TFICHTITQS 100
    FAVGSISPRD FIDLVYIKRY EGNMNIISSK SVDFPEYPPS SNYIRGYNHP 150
    CGFVCSPMEE NPAYSKLVMF VQTEMRGKLS PSIIEKTMPS NLVNFILNAK 200
    DGIKAHRTPS RRGFHHNSHS 220
    Length:220
    Mass (Da):25,022
    Last modified:November 15, 2002 - v1
    Checksum:i5AC49FFF5C953234
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti159 – 1591E → K.
    Corresponds to variant rs2917782 [ dbSNP | Ensembl ].
    VAR_024651

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF480305 mRNA. Translation: AAL89655.1.
    CCDSiCCDS11955.1.
    RefSeqiNP_631910.1. NM_139171.1.
    UniGeneiHs.438779.

    Genome annotation databases

    EnsembliENST00000307844; ENSP00000310814; ENSG00000174448.
    ENST00000581310; ENSP00000462349; ENSG00000174448.
    GeneIDi147323.
    KEGGihsa:147323.
    UCSCiuc010xdt.2. human.

    Polymorphism databases

    DMDMi25091297.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF480305 mRNA. Translation: AAL89655.1 .
    CCDSi CCDS11955.1.
    RefSeqi NP_631910.1. NM_139171.1.
    UniGenei Hs.438779.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2MOU NMR - A 1-220 [» ]
    ProteinModelPortali P59095.
    SMRi P59095. Positions 3-204.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000310814.

    Polymorphism databases

    DMDMi 25091297.

    Proteomic databases

    PaxDbi P59095.
    PRIDEi P59095.

    Protocols and materials databases

    DNASUi 147323.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307844 ; ENSP00000310814 ; ENSG00000174448 .
    ENST00000581310 ; ENSP00000462349 ; ENSG00000174448 .
    GeneIDi 147323.
    KEGGi hsa:147323.
    UCSCi uc010xdt.2. human.

    Organism-specific databases

    CTDi 147323.
    GeneCardsi GC18M051850.
    HGNCi HGNC:18066. STARD6.
    HPAi HPA042583.
    MIMi 607051. gene.
    neXtProti NX_P59095.
    PharmGKBi PA38287.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG255993.
    HOGENOMi HOG000137345.
    HOVERGENi HBG055194.
    InParanoidi P59095.
    OMAi QTEMRGK.
    PhylomeDBi P59095.

    Enzyme and pathway databases

    Reactomei REACT_11038. Pregnenolone biosynthesis.

    Miscellaneous databases

    GenomeRNAii 147323.
    NextBioi 85583.
    PROi P59095.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P59095.
    Bgeei P59095.
    CleanExi HS_STARD6.
    Genevestigatori P59095.

    Family and domain databases

    Gene3Di 3.30.530.20. 1 hit.
    InterProi IPR023393. START-like_dom.
    IPR002913. START_lipid-bd_dom.
    [Graphical view ]
    Pfami PF01852. START. 1 hit.
    [Graphical view ]
    SMARTi SM00234. START. 1 hit.
    [Graphical view ]
    PROSITEi PS50848. START. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6."
      Soccio R.E., Adams R.M., Romanowski M.J., Sehayek E., Burley S.K., Breslow J.L.
      Proc. Natl. Acad. Sci. U.S.A. 99:6943-6948(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiSTAR6_HUMAN
    AccessioniPrimary (citable) accession number: P59095
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: November 15, 2002
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3