P59095 (STAR6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
StAR-related lipid transfer protein 6

Alternative name(s):
START domain-containing protein 6
Short name=StARD6

Gene names

Name:

STARD6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols By similarity.
Sequence similarities	Contains 1 START domain.

Ontologies

Keywords
Biological process	Lipid transport Transport
Coding sequence diversity	Polymorphism
Ligand	Lipid-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lipid transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	lipid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	StAR-related lipid transfer protein 6		PRO_0000220672
Regions
	Domain	1 – 208	208	START
Natural variations
	Natural variant	159	1	E → K. Corresponds to variant rs2917782 [ dbSNP | Ensembl ].		VAR_024651

Sequences

	Sequence		Length	Mass (Da)
	P59095 [UniParc]. Last modified November 15, 2002. Version 1. Checksum: 5AC49FFF5C953234	FASTA	220	25,022
	10 20 30 40 50 60 MDFKAIAQQT AQEVLGYNRD TSGWKVVKTS KKITVSSKAS RKFHGNLYRV EGIIPESPAK 70 80 90 100 110 120 LSDFLYQTGD RITWDKSLQV YNMVHRIDSD TFICHTITQS FAVGSISPRD FIDLVYIKRY 130 140 150 160 170 180 EGNMNIISSK SVDFPEYPPS SNYIRGYNHP CGFVCSPMEE NPAYSKLVMF VQTEMRGKLS 190 200 210 220 PSIIEKTMPS NLVNFILNAK DGIKAHRTPS RRGFHHNSHS

References

[1]

"The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6." Soccio R.E., Adams R.M., Romanowski M.J., Sehayek E., Burley S.K., Breslow J.L. Proc. Natl. Acad. Sci. U.S.A. 99:6943-6948(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF480305 mRNA. Translation: AAL89655.1.
IPI	IPI00171432.
RefSeq	NP_631910.1. NM_139171.1.
UniGene	Hs.438779.
3D structure databases
ProteinModelPortal	P59095.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000310814.
Polymorphism databases
DMDM	25091297.
Proteomic databases
PaxDb	P59095.
PRIDE	P59095.
Protocols and materials databases
DNASU	147323.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000307844; ENSP00000310814; ENSG00000174448. ENST00000581310; ENSP00000462349; ENSG00000174448.
GeneID	147323.
KEGG	hsa:147323.
UCSC	uc010xdt.2. human.
Organism-specific databases
CTD	147323.
GeneCards	GC18M051850.
HGNC	HGNC:18066. STARD6.
HPA	HPA042583.
MIM	607051. gene.
neXtProt	NX_P59095.
PharmGKB	PA38287.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG255993.
HOGENOM	HOG000137345.
HOVERGEN	HBG055194.
InParanoid	P59095.
OMA	QTEMRGK.
OrthoDB	EOG45HRZJ.
PhylomeDB	P59095.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism. REACT_15493. Steroid hormones.
Gene expression databases
Bgee	P59095.
CleanEx	HS_STARD6.
Genevestigator	P59095.
GermOnline	ENSG00000174448. Homo sapiens.
Family and domain databases
Gene3D	3.30.530.20. 1 hit.
InterPro	IPR023393. START-like_dom. IPR002913. START_lipid-bd_dom. [Graphical view]
Pfam	PF01852. START. 1 hit. [Graphical view]
SMART	SM00234. START. 1 hit. [Graphical view]
PROSITE	PS50848. START. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	147323.
NextBio	85583.
SOURCE	Search...

Entry information

Entry name

STAR6_HUMAN

Accession

Primary (citable) accession number: P59095

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	November 15, 2002
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.