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P59095

- STAR6_HUMAN

UniProt

P59095 - STAR6_HUMAN

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Protein

StAR-related lipid transfer protein 6

Gene

STARD6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).By similarity

GO - Molecular functioni

  1. lipid binding Source: UniProtKB-KW

GO - Biological processi

  1. lipid transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiREACT_11038. Pregnenolone biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
StAR-related lipid transfer protein 6
Alternative name(s):
START domain-containing protein 6
Short name:
StARD6
Gene namesi
Name:STARD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:18066. STARD6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38287.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220StAR-related lipid transfer protein 6PRO_0000220672Add
BLAST

Proteomic databases

PaxDbiP59095.
PRIDEiP59095.

Expressioni

Gene expression databases

BgeeiP59095.
CleanExiHS_STARD6.
ExpressionAtlasiP59095. baseline.
GenevestigatoriP59095.

Organism-specific databases

HPAiHPA042583.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310814.

Structurei

Secondary structure

1
220
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1816Combined sources
Beta strandi26 – 294Combined sources
Beta strandi31 – 377Combined sources
Beta strandi41 – 455Combined sources
Beta strandi48 – 569Combined sources
Helixi58 – 647Combined sources
Beta strandi65 – 706Combined sources
Turni71 – 733Combined sources
Beta strandi76 – 838Combined sources
Beta strandi88 – 9811Combined sources
Beta strandi109 – 12012Combined sources
Turni121 – 1233Combined sources
Beta strandi124 – 1318Combined sources
Beta strandi141 – 1455Combined sources
Beta strandi148 – 15811Combined sources
Beta strandi161 – 17313Combined sources
Helixi181 – 20727Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MOUNMR-A1-220[»]
ProteinModelPortaliP59095.
SMRiP59095. Positions 1-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 208208STARTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 START domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG255993.
GeneTreeiENSGT00530000063294.
HOGENOMiHOG000137345.
HOVERGENiHBG055194.
InParanoidiP59095.
OMAiQTEMRGK.
PhylomeDBiP59095.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF01852. START. 1 hit.
[Graphical view]
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59095-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFKAIAQQT AQEVLGYNRD TSGWKVVKTS KKITVSSKAS RKFHGNLYRV
60 70 80 90 100
EGIIPESPAK LSDFLYQTGD RITWDKSLQV YNMVHRIDSD TFICHTITQS
110 120 130 140 150
FAVGSISPRD FIDLVYIKRY EGNMNIISSK SVDFPEYPPS SNYIRGYNHP
160 170 180 190 200
CGFVCSPMEE NPAYSKLVMF VQTEMRGKLS PSIIEKTMPS NLVNFILNAK
210 220
DGIKAHRTPS RRGFHHNSHS
Length:220
Mass (Da):25,022
Last modified:November 15, 2002 - v1
Checksum:i5AC49FFF5C953234
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti159 – 1591E → K.
Corresponds to variant rs2917782 [ dbSNP | Ensembl ].
VAR_024651

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF480305 mRNA. Translation: AAL89655.1.
CCDSiCCDS11955.1.
RefSeqiNP_631910.1. NM_139171.1.
UniGeneiHs.438779.

Genome annotation databases

EnsembliENST00000307844; ENSP00000310814; ENSG00000174448.
ENST00000581310; ENSP00000462349; ENSG00000174448.
GeneIDi147323.
KEGGihsa:147323.
UCSCiuc010xdt.2. human.

Polymorphism databases

DMDMi25091297.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF480305 mRNA. Translation: AAL89655.1 .
CCDSi CCDS11955.1.
RefSeqi NP_631910.1. NM_139171.1.
UniGenei Hs.438779.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2MOU NMR - A 1-220 [» ]
ProteinModelPortali P59095.
SMRi P59095. Positions 1-220.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000310814.

Polymorphism databases

DMDMi 25091297.

Proteomic databases

PaxDbi P59095.
PRIDEi P59095.

Protocols and materials databases

DNASUi 147323.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307844 ; ENSP00000310814 ; ENSG00000174448 .
ENST00000581310 ; ENSP00000462349 ; ENSG00000174448 .
GeneIDi 147323.
KEGGi hsa:147323.
UCSCi uc010xdt.2. human.

Organism-specific databases

CTDi 147323.
GeneCardsi GC18M051850.
HGNCi HGNC:18066. STARD6.
HPAi HPA042583.
MIMi 607051. gene.
neXtProti NX_P59095.
PharmGKBi PA38287.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG255993.
GeneTreei ENSGT00530000063294.
HOGENOMi HOG000137345.
HOVERGENi HBG055194.
InParanoidi P59095.
OMAi QTEMRGK.
PhylomeDBi P59095.

Enzyme and pathway databases

Reactomei REACT_11038. Pregnenolone biosynthesis.

Miscellaneous databases

GenomeRNAii 147323.
NextBioi 85583.
PROi P59095.
SOURCEi Search...

Gene expression databases

Bgeei P59095.
CleanExi HS_STARD6.
ExpressionAtlasi P59095. baseline.
Genevestigatori P59095.

Family and domain databases

Gene3Di 3.30.530.20. 1 hit.
InterProi IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view ]
Pfami PF01852. START. 1 hit.
[Graphical view ]
SMARTi SM00234. START. 1 hit.
[Graphical view ]
PROSITEi PS50848. START. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6."
    Soccio R.E., Adams R.M., Romanowski M.J., Sehayek E., Burley S.K., Breslow J.L.
    Proc. Natl. Acad. Sci. U.S.A. 99:6943-6948(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSTAR6_HUMAN
AccessioniPrimary (citable) accession number: P59095
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3