Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

StAR-related lipid transfer protein 6

Gene

STARD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-196108. Pregnenolone biosynthesis.

Chemistry databases

SwissLipidsiSLP:000000717.

Names & Taxonomyi

Protein namesi
Recommended name:
StAR-related lipid transfer protein 6
Alternative name(s):
START domain-containing protein 6
Short name:
StARD6
Gene namesi
Name:STARD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:18066. STARD6.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174448.
PharmGKBiPA38287.

Polymorphism and mutation databases

BioMutaiSTARD6.
DMDMi25091297.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002206721 – 220StAR-related lipid transfer protein 6Add BLAST220

Proteomic databases

PaxDbiP59095.
PRIDEiP59095.

PTM databases

iPTMnetiP59095.
PhosphoSitePlusiP59095.

Expressioni

Gene expression databases

BgeeiENSG00000174448.
CleanExiHS_STARD6.
ExpressionAtlasiP59095. baseline and differential.
GenevisibleiP59095. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310814.

Structurei

Secondary structure

1220
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 18Combined sources16
Beta strandi26 – 29Combined sources4
Beta strandi31 – 37Combined sources7
Beta strandi41 – 45Combined sources5
Beta strandi48 – 56Combined sources9
Helixi58 – 64Combined sources7
Beta strandi65 – 70Combined sources6
Turni71 – 73Combined sources3
Beta strandi76 – 83Combined sources8
Beta strandi88 – 98Combined sources11
Beta strandi109 – 120Combined sources12
Turni121 – 123Combined sources3
Beta strandi124 – 131Combined sources8
Beta strandi141 – 145Combined sources5
Beta strandi148 – 158Combined sources11
Beta strandi161 – 173Combined sources13
Helixi181 – 207Combined sources27

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MOUNMR-A1-220[»]
ProteinModelPortaliP59095.
SMRiP59095.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 208STARTPROSITE-ProRule annotationAdd BLAST208

Phylogenomic databases

eggNOGiKOG3845. Eukaryota.
ENOG41100B5. LUCA.
GeneTreeiENSGT00530000063294.
HOGENOMiHOG000137345.
HOVERGENiHBG055194.
InParanoidiP59095.
OMAiGYNHACG.
OrthoDBiEOG091G0INO.
PhylomeDBiP59095.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiView protein in InterPro
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
PfamiView protein in Pfam
PF01852. START. 1 hit.
SMARTiView protein in SMART
SM00234. START. 1 hit.
PROSITEiView protein in PROSITE
PS50848. START. 1 hit.

Sequencei

Sequence statusi: Complete.

P59095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFKAIAQQT AQEVLGYNRD TSGWKVVKTS KKITVSSKAS RKFHGNLYRV
60 70 80 90 100
EGIIPESPAK LSDFLYQTGD RITWDKSLQV YNMVHRIDSD TFICHTITQS
110 120 130 140 150
FAVGSISPRD FIDLVYIKRY EGNMNIISSK SVDFPEYPPS SNYIRGYNHP
160 170 180 190 200
CGFVCSPMEE NPAYSKLVMF VQTEMRGKLS PSIIEKTMPS NLVNFILNAK
210 220
DGIKAHRTPS RRGFHHNSHS
Length:220
Mass (Da):25,022
Last modified:November 15, 2002 - v1
Checksum:i5AC49FFF5C953234
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024651159E → K. Corresponds to variant dbSNP:rs2917782Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF480305 mRNA. Translation: AAL89655.1.
CCDSiCCDS11955.1.
RefSeqiNP_631910.1. NM_139171.1.
XP_011524123.1. XM_011525821.1.
UniGeneiHs.438779.

Genome annotation databases

EnsembliENST00000307844; ENSP00000310814; ENSG00000174448.
ENST00000581310; ENSP00000462349; ENSG00000174448.
GeneIDi147323.
KEGGihsa:147323.
UCSCiuc010xdt.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSTAR6_HUMAN
AccessioniPrimary (citable) accession number: P59095
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: March 15, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references