Reviewed, UniProtKB/Swiss-Prot P59090 (CU090_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C21orf90

Gene names

Name:

C21orf90

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	65 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Tissue specificity

Widely expressed. Not expressed in liver and muscle. Ref.1

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P59090-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P59090-2)

The sequence of this isoform differs from the canonical sequence as follows:
     15-37: FSGFLSNIRGPLAGEDGMGDTQL → GARLCSQDPLEARPLPPTSSFVR
     38-65: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 65	65	Uncharacterized protein C21orf90		PRO_0000079540
Natural variations
	Alternative sequence	15 – 37	23	FSGFL…GDTQL → GARLCSQDPLEARPLPPTSS FVR in isoform 2.		VSP_003838
	Alternative sequence	38 – 65	28	Missing in isoform 2.		VSP_003839

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 15, 2002. Version 1. Checksum: 2B103050E43F93A0	FASTA	65	7,097
	10 20 30 40 50 60 MGNPRLPRLL CALKFSGFLS NIRGPLAGED GMGDTQLARV RDSALKTPWR PAPCPPPAHS LDDWK
	Isoform 2. Checksum: EC0A2401494BFF2A	FASTA	37	4,062
	10 20 30 MGNPRLPRLL CALKGARLCS QDPLEARPLP PTSSFVR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nineteen additional unpredicted transcripts from human chromosome 21." Reymond A., Camargo A.A., Deutsch S., Stevenson B.J., Parmigiani R.B., Ucla C., Bettoni F., Rossier C., Lyle R., Guipponi M., de Souza S., Iseli C., Jongeneel C.V., Bucher P., Simpson A.J.G., Antonarakis S.E. Genomics 79:824-832(2002) [PubMed: 12036297] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Cerebellum.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF426269 mRNA. Translation: AAM53525.1. AF426270 mRNA. Translation: AAM53526.1. BC101650 mRNA. Translation: AAI01651.1. BC101654 mRNA. Translation: AAI01655.1.
IPI	IPI00171428. IPI00219882.
UniGene	Hs.592163
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P59090.
Genome annotation databases
Ensembl	ENST00000330490; ENSP00000333592; ENSG00000182912; Homo sapiens. [Genome view]
Organism-specific databases
GeneCards	GC21P044761.
HGNC	HGNC:16428. C21orf90.
PharmGKB	PA25878.
GenAtlas	Search...
Phylogenomic databases
InParanoid	P59090.
OMA	EDGMGDT.
Gene expression databases
ArrayExpress	P59090.
Bgee	P59090.
CleanEx	HS_C21orf90.
Genevestigator	P59090.
GermOnline	ENSG00000182912. Homo sapiens.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

CU090_HUMAN

Accession

Primary (citable) accession number: P59090
Secondary accession number(s): Q3MIX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	November 15, 2002
Last modified:	December 15, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.