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P59090

- CU090_HUMAN

UniProt

P59090 - CU090_HUMAN

Protein

Putative uncharacterized protein C21orf90

Gene

C21orf90

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative uncharacterized protein C21orf90
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:16428. C21orf90.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6565Putative uncharacterized protein C21orf90PRO_0000079540Add
    BLAST

    Proteomic databases

    PRIDEiP59090.

    Expressioni

    Tissue specificityi

    Widely expressed. Not expressed in liver and muscle.1 Publication

    Gene expression databases

    BgeeiP59090.
    CleanExiHS_C21orf90.
    GenevestigatoriP59090.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000333592.

    Structurei

    3D structure databases

    ProteinModelPortaliP59090.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG279263.
    HOGENOMiHOG000112066.
    InParanoidiP59090.
    OMAiMENPRLP.
    OrthoDBiEOG72C53M.
    PhylomeDBiP59090.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P59090-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGNPRLPRLL CALKFSGFLS NIRGPLAGED GMGDTQLARV RDSALKTPWR   50
    PAPCPPPAHS LDDWK 65
    Length:65
    Mass (Da):7,097
    Last modified:November 15, 2002 - v1
    Checksum:i2B103050E43F93A0
    GO
    Isoform 2 (identifier: P59090-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         15-37: FSGFLSNIRGPLAGEDGMGDTQL → GARLCSQDPLEARPLPPTSSFVR
         38-65: Missing.

    Show »
    Length:37
    Mass (Da):4,062
    Checksum:iEC0A2401494BFF2A
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei15 – 3723FSGFL…GDTQL → GARLCSQDPLEARPLPPTSS FVR in isoform 2. 1 PublicationVSP_003838Add
    BLAST
    Alternative sequencei38 – 6528Missing in isoform 2. 1 PublicationVSP_003839Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF426269 mRNA. Translation: AAM53525.1.
    AF426270 mRNA. Translation: AAM53526.1.
    AP001066 Genomic DNA. No translation available.
    BC101650 mRNA. No translation available.
    BC101654 mRNA. No translation available.
    UniGeneiHs.592163.

    Genome annotation databases

    EnsembliENST00000330490; ENSP00000333592; ENSG00000182912. [P59090-1]
    ENST00000354333; ENSP00000346295; ENSG00000182912. [P59090-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF426269 mRNA. Translation: AAM53525.1 .
    AF426270 mRNA. Translation: AAM53526.1 .
    AP001066 Genomic DNA. No translation available.
    BC101650 mRNA. No translation available.
    BC101654 mRNA. No translation available.
    UniGenei Hs.592163.

    3D structure databases

    ProteinModelPortali P59090.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000333592.

    Proteomic databases

    PRIDEi P59090.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000330490 ; ENSP00000333592 ; ENSG00000182912 . [P59090-1 ]
    ENST00000354333 ; ENSP00000346295 ; ENSG00000182912 . [P59090-2 ]

    Organism-specific databases

    GeneCardsi GC21P045937.
    HGNCi HGNC:16428. C21orf90.
    neXtProti NX_P59090.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279263.
    HOGENOMi HOG000112066.
    InParanoidi P59090.
    OMAi MENPRLP.
    OrthoDBi EOG72C53M.
    PhylomeDBi P59090.

    Gene expression databases

    Bgeei P59090.
    CleanExi HS_C21orf90.
    Genevestigatori P59090.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    2. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cerebellum.

    Entry informationi

    Entry nameiCU090_HUMAN
    AccessioniPrimary (citable) accession number: P59090
    Secondary accession number(s): Q3MIX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: November 15, 2002
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Product of a dubious gene prediction. Encoded in intron of TSPEAR.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM

    External Data

    Dasty 3