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P59090 (CU090_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative uncharacterized protein C21orf90
Gene names
Name:C21orf90
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length65 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Tissue specificity

Widely expressed. Not expressed in liver and muscle. Ref.1

Caution

Product of a dubious gene prediction. Encoded in intron of TSPEAR.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P59090-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P59090-2)

The sequence of this isoform differs from the canonical sequence as follows:
     15-37: FSGFLSNIRGPLAGEDGMGDTQL → GARLCSQDPLEARPLPPTSSFVR
     38-65: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6565Putative uncharacterized protein C21orf90
PRO_0000079540

Natural variations

Alternative sequence15 – 3723FSGFL…GDTQL → GARLCSQDPLEARPLPPTSS FVR in isoform 2.
VSP_003838
Alternative sequence38 – 6528Missing in isoform 2.
VSP_003839

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 15, 2002. Version 1.
Checksum: 2B103050E43F93A0

FASTA657,097
        10         20         30         40         50         60 
MGNPRLPRLL CALKFSGFLS NIRGPLAGED GMGDTQLARV RDSALKTPWR PAPCPPPAHS 


LDDWK 

« Hide

Isoform 2 [UniParc].

Checksum: EC0A2401494BFF2A
Show »

FASTA374,062

References

« Hide 'large scale' references
[1]"Nineteen additional unpredicted transcripts from human chromosome 21."
Reymond A., Camargo A.A., Deutsch S., Stevenson B.J., Parmigiani R.B., Ucla C., Bettoni F., Rossier C., Lyle R., Guipponi M., de Souza S., Iseli C., Jongeneel C.V., Bucher P., Simpson A.J.G., Antonarakis S.E.
Genomics 79:824-832(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
[2]"The DNA sequence of human chromosome 21."
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. expand/collapse author list , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Cerebellum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF426269 mRNA. Translation: AAM53525.1.
AF426270 mRNA. Translation: AAM53526.1.
AP001066 Genomic DNA. No translation available.
BC101650 mRNA. No translation available.
BC101654 mRNA. No translation available.
UniGeneHs.592163.

3D structure databases

ProteinModelPortalP59090.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000333592.

Proteomic databases

PRIDEP59090.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000330490; ENSP00000333592; ENSG00000182912. [P59090-1]
ENST00000354333; ENSP00000346295; ENSG00000182912. [P59090-2]
ENST00000609217; ENSP00000476950; ENSG00000272929. [P59090-2]
ENST00000609395; ENSP00000477384; ENSG00000272929. [P59090-1]

Organism-specific databases

GeneCardsGC21P045937.
HGNCHGNC:16428. C21orf90.
neXtProtNX_P59090.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG279263.
HOGENOMHOG000112066.
InParanoidP59090.
OMAMENPRLP.
OrthoDBEOG72C53M.
PhylomeDBP59090.

Gene expression databases

BgeeP59090.
CleanExHS_C21orf90.
GenevestigatorP59090.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameCU090_HUMAN
AccessionPrimary (citable) accession number: P59090
Secondary accession number(s): Q3MIX8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM