P59090 (CU090_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative uncharacterized protein C21orf90

Gene names

Name:

C21orf90

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	65 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Tissue specificity	Widely expressed. Not expressed in liver and muscle. Ref.1
Caution	Product of a dubious gene prediction. Encoded in intron of TSPEAR.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P59090-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P59090-2)

The sequence of this isoform differs from the canonical sequence as follows:
     15-37: FSGFLSNIRGPLAGEDGMGDTQL → GARLCSQDPLEARPLPPTSSFVR
     38-65: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 65	65	Putative uncharacterized protein C21orf90		PRO_0000079540
Natural variations
	Alternative sequence	15 – 37	23	FSGFL…GDTQL → GARLCSQDPLEARPLPPTSS FVR in isoform 2.		VSP_003838
	Alternative sequence	38 – 65	28	Missing in isoform 2.		VSP_003839

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 15, 2002. Version 1. Checksum: 2B103050E43F93A0	FASTA	65	7,097
	10 20 30 40 50 60 MGNPRLPRLL CALKFSGFLS NIRGPLAGED GMGDTQLARV RDSALKTPWR PAPCPPPAHS LDDWK
	Isoform 2 [UniParc]. Checksum: EC0A2401494BFF2A	FASTA	37	4,062
	10 20 30 MGNPRLPRLL CALKGARLCS QDPLEARPLP PTSSFVR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nineteen additional unpredicted transcripts from human chromosome 21." Reymond A., Camargo A.A., Deutsch S., Stevenson B.J., Parmigiani R.B., Ucla C., Bettoni F., Rossier C., Lyle R., Guipponi M., de Souza S., Iseli C., Jongeneel C.V., Bucher P., Simpson A.J.G., Antonarakis S.E. Genomics 79:824-832(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
[2]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Cerebellum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF426269 mRNA. Translation: AAM53525.1. AF426270 mRNA. Translation: AAM53526.1. AP001066 Genomic DNA. No translation available. BC101650 mRNA. No translation available. BC101654 mRNA. No translation available.
IPI	IPI00171428. IPI00219882.
UniGene	Hs.592163.
3D structure databases
ProteinModelPortal	P59090.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000333592.
Proteomic databases
PRIDE	P59090.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000330490; ENSP00000333592; ENSG00000182912. ENST00000354333; ENSP00000346295; ENSG00000182912.
Organism-specific databases
GeneCards	GC21P045937.
HGNC	HGNC:16428. C21orf90.
neXtProt	NX_P59090.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG279263.
HOGENOM	HOG000112066.
InParanoid	P59090.
OMA	CALKFSG.
OrthoDB	EOG4VMFHN.
PhylomeDB	P59090.
Gene expression databases
Bgee	P59090.
CleanEx	HS_C21orf90.
Genevestigator	P59090.
GermOnline	ENSG00000182912. Homo sapiens.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

CU090_HUMAN

Accession

Primary (citable) accession number: P59090
Secondary accession number(s): Q3MIX8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	November 15, 2002
Last modified:	April 3, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.