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Protein

Putative uncharacterized protein TSPEAR-AS2

Gene

TSPEAR-AS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Names & Taxonomyi

Protein namesi
Recommended name:
Putative uncharacterized protein TSPEAR-AS2Imported
Alternative name(s):
TSPEAR antisense RNA 2Imported
TSPEAR antisense gene protein 2Curated
Gene namesi
Name:TSPEAR-AS2Imported
Synonyms:C21orf90Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:16428. TSPEAR-AS2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6565Putative uncharacterized protein TSPEAR-AS2PRO_0000079540Add
BLAST

Proteomic databases

PRIDEiP59090.

Expressioni

Tissue specificityi

Widely expressed. Not expressed in liver and muscle.1 Publication

Gene expression databases

BgeeiP59090.
CleanExiHS_C21orf90.
GenevestigatoriP59090.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333592.

Structurei

3D structure databases

ProteinModelPortaliP59090.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG279263.
HOGENOMiHOG000112066.
InParanoidiP59090.
OMAiCALKFSG.
OrthoDBiEOG72C53M.
PhylomeDBiP59090.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P59090-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNPRLPRLL CALKFSGFLS NIRGPLAGED GMGDTQLARV RDSALKTPWR
60
PAPCPPPAHS LDDWK
Length:65
Mass (Da):7,097
Last modified:November 15, 2002 - v1
Checksum:i2B103050E43F93A0
GO
Isoform 2 (identifier: P59090-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-37: FSGFLSNIRGPLAGEDGMGDTQL → GARLCSQDPLEARPLPPTSSFVR
     38-65: Missing.

Show »
Length:37
Mass (Da):4,062
Checksum:iEC0A2401494BFF2A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei15 – 3723FSGFL…GDTQL → GARLCSQDPLEARPLPPTSS FVR in isoform 2. 1 PublicationVSP_003838Add
BLAST
Alternative sequencei38 – 6528Missing in isoform 2. 1 PublicationVSP_003839Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426269 mRNA. Translation: AAM53525.1.
AF426270 mRNA. Translation: AAM53526.1.
AP001066 Genomic DNA. No translation available.
BC101650 mRNA. No translation available.
BC101654 mRNA. No translation available.
UniGeneiHs.592163.

Genome annotation databases

EnsembliENST00000330490; ENSP00000333592; ENSG00000182912.
ENST00000354333; ENSP00000346295; ENSG00000182912.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426269 mRNA. Translation: AAM53525.1.
AF426270 mRNA. Translation: AAM53526.1.
AP001066 Genomic DNA. No translation available.
BC101650 mRNA. No translation available.
BC101654 mRNA. No translation available.
UniGeneiHs.592163.

3D structure databases

ProteinModelPortaliP59090.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333592.

Proteomic databases

PRIDEiP59090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330490; ENSP00000333592; ENSG00000182912.
ENST00000354333; ENSP00000346295; ENSG00000182912.

Organism-specific databases

GeneCardsiGC21P045937.
HGNCiHGNC:16428. TSPEAR-AS2.
neXtProtiNX_P59090.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG279263.
HOGENOMiHOG000112066.
InParanoidiP59090.
OMAiCALKFSG.
OrthoDBiEOG72C53M.
PhylomeDBiP59090.

Gene expression databases

BgeeiP59090.
CleanExiHS_C21orf90.
GenevestigatoriP59090.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cerebellum.

Entry informationi

Entry nameiTSAS2_HUMAN
AccessioniPrimary (citable) accession number: P59090
Secondary accession number(s): Q3MIX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: January 7, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Product of a dubious gene prediction. Encoded in intron of TSPEAR.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.