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P59084 (BDS2_ANESU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Antihypertensive protein BDS-2
Alternative name(s):
Blood depressing substance II
Short name=BDS-II
OrganismAnemonia sulcata (Mediterranean snakelocks sea anemone) (Anemonia viridis)
Taxonomic identifier6108 [NCBI]
Taxonomic lineageEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaNynantheaeActiniidaeAnemonia

Protein attributes

Sequence length43 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Blocks specifically the Kv3.4/KCNC4 potassium channel. Reduces blood pressure. Ref.2

Subcellular location

Secreted. Nematocyst.

Sequence similarities

Belongs to the sea anemone type 3 (BDS) potassium channel toxin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4343Antihypertensive protein BDS-2
PRO_0000221542

Amino acid modifications

Disulfide bond4 ↔ 39 By similarity
Disulfide bond6 ↔ 32 By similarity
Disulfide bond22 ↔ 40 By similarity

Sequences

Sequence LengthMass (Da)Tools
P59084 [UniParc].

Last modified November 8, 2002. Version 1.
Checksum: 7EEAABBE8A1FDE08

FASTA434,782
        10         20         30         40 
AAPCFCPGKP DRGDLWILRG TCPGGYGYTS NCYKWPNICC YPH 

« Hide

References

[1]"Polypeptides, process for their preparation, and their use as hypotensive active compounds."
Doppelfeld I.-S., Henschen-Edman A., Graf E., Zwick J., Beress L., Etschenberg E.
Patent number DE3324689, 17-JAN-1985
Cited for: PROTEIN SEQUENCE.
[2]"Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4."
Diochot S., Schweitz H., Beress L., Lazdunski M.
J. Biol. Chem. 273:6744-6749(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION.

Cross-references

3D structure databases

ProteinModelPortalP59084.
SMRP59084. Positions 1-43.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.20.20.10. 1 hit.
InterProIPR012414. BDS_K_chnl_tox.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamPF07936. Defensin_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBDS2_ANESU
AccessionPrimary (citable) accession number: P59084
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: October 16, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families