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Protein

Antihypertensive protein BDS-2

Gene
N/A
Organism
Anemonia sulcata (Mediterranean snakelocks sea anemone) (Anemonia viridis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Blocks specifically the Kv3.4/KCNC4 potassium channel. Reduces blood pressure.1 Publication

GO - Molecular functioni

  1. ion channel inhibitor activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Antihypertensive protein BDS-2
Alternative name(s):
Blood depressing substance II
Short name:
BDS-II
OrganismiAnemonia sulcata (Mediterranean snakelocks sea anemone) (Anemonia viridis)
Taxonomic identifieri6108 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaNynantheaeActiniidaeAnemonia

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. nematocyst Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nematocyst, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4343Antihypertensive protein BDS-2PRO_0000221542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi4 ↔ 39By similarity
Disulfide bondi6 ↔ 32By similarity
Disulfide bondi22 ↔ 40By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP59084.
SMRiP59084. Positions 1-43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.20.20.10. 1 hit.
InterProiIPR012414. BDS_K_chnl_tox.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamiPF07936. Defensin_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
AAPCFCPGKP DRGDLWILRG TCPGGYGYTS NCYKWPNICC YPH
Length:43
Mass (Da):4,782
Last modified:November 8, 2002 - v1
Checksum:i7EEAABBE8A1FDE08
GO

Cross-referencesi

3D structure databases

ProteinModelPortaliP59084.
SMRiP59084. Positions 1-43.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.20.20.10. 1 hit.
InterProiIPR012414. BDS_K_chnl_tox.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamiPF07936. Defensin_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Polypeptides, process for their preparation, and their use as hypotensive active compounds."
    Doppelfeld I.-S., Henschen-Edman A., Graf E., Zwick J., Beress L., Etschenberg E.
    Patent number DE3324689, 17-JAN-1985
    Cited for: PROTEIN SEQUENCE.
  2. "Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4."
    Diochot S., Schweitz H., Beress L., Lazdunski M.
    J. Biol. Chem. 273:6744-6749(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION.

Entry informationi

Entry nameiBDS2_ANESU
AccessioniPrimary (citable) accession number: P59084
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: January 7, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.