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P59084

- BDS2_ANESU

UniProt

P59084 - BDS2_ANESU

Protein

Antihypertensive protein BDS-2

Gene
N/A
Organism
Anemonia sulcata (Mediterranean snakelocks sea anemone) (Anemonia viridis)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Blocks specifically the Kv3.4/KCNC4 potassium channel. Reduces blood pressure.1 Publication

    GO - Molecular functioni

    1. ion channel inhibitor activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Antihypertensive protein BDS-2
    Alternative name(s):
    Blood depressing substance II
    Short name:
    BDS-II
    OrganismiAnemonia sulcata (Mediterranean snakelocks sea anemone) (Anemonia viridis)
    Taxonomic identifieri6108 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaNynantheaeActiniidaeAnemonia

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. nematocyst Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nematocyst, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4343Antihypertensive protein BDS-2PRO_0000221542Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi4 ↔ 39By similarity
    Disulfide bondi6 ↔ 32By similarity
    Disulfide bondi22 ↔ 40By similarity

    Keywords - PTMi

    Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliP59084.
    SMRiP59084. Positions 1-43.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di2.20.20.10. 1 hit.
    InterProiIPR012414. BDS_K_chnl_tox.
    IPR023355. Myo_neuro_toxin.
    [Graphical view]
    PfamiPF07936. Defensin_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59084-1 [UniParc]FASTAAdd to Basket

    « Hide

    AAPCFCPGKP DRGDLWILRG TCPGGYGYTS NCYKWPNICC YPH          43
    Length:43
    Mass (Da):4,782
    Last modified:November 8, 2002 - v1
    Checksum:i7EEAABBE8A1FDE08
    GO

    Cross-referencesi

    3D structure databases

    ProteinModelPortali P59084.
    SMRi P59084. Positions 1-43.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.20.20.10. 1 hit.
    InterProi IPR012414. BDS_K_chnl_tox.
    IPR023355. Myo_neuro_toxin.
    [Graphical view ]
    Pfami PF07936. Defensin_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Polypeptides, process for their preparation, and their use as hypotensive active compounds."
      Doppelfeld I.-S., Henschen-Edman A., Graf E., Zwick J., Beress L., Etschenberg E.
      Patent number DE3324689, 17-JAN-1985
      Cited for: PROTEIN SEQUENCE.
    2. "Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4."
      Diochot S., Schweitz H., Beress L., Lazdunski M.
      J. Biol. Chem. 273:6744-6749(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION.

    Entry informationi

    Entry nameiBDS2_ANESU
    AccessioniPrimary (citable) accession number: P59084
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: November 8, 2002
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3