P59084 (BDS2_ANESU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Antihypertensive protein BDS-2 Alternative name(s): Blood depressing substance II Short name=BDS-II
Organism	Anemonia sulcata (Mediterranean snakelocks sea anemone) (Anemonia viridis)
Taxonomic identifier	6108 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Cnidaria › Anthozoa › Hexacorallia › Actiniaria › Nynantheae › Actiniidae › Anemonia

Protein attributes

Sequence length	43 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Blocks specifically the Kv3.4/KCNC4 potassium channel. Reduces blood pressure. Ref.2
Subcellular location	Secreted. Nematocyst.
Sequence similarities	Belongs to the sea anemone type 3 (BDS) potassium channel toxin family.

Ontologies

Keywords
Cellular component	Nematocyst Secreted
Molecular function	Ion channel impairing toxin Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell nematocyst Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 43	43	Antihypertensive protein BDS-2		PRO_0000221542
Amino acid modifications
	Disulfide bond	4 ↔ 39		By similarity
	Disulfide bond	6 ↔ 32		By similarity
	Disulfide bond	22 ↔ 40		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P59084 [UniParc]. Last modified November 8, 2002. Version 1. Checksum: 7EEAABBE8A1FDE08	FASTA	43	4,782
	10 20 30 40 AAPCFCPGKP DRGDLWILRG TCPGGYGYTS NCYKWPNICC YPH

References

[1]	"Polypeptides, process for their preparation, and their use as hypotensive active compounds." Doppelfeld I.-S., Henschen-Edman A., Graf E., Zwick J., Beress L., Etschenberg E. Patent number DE3324689, 17-JAN-1985 Cited for: PROTEIN SEQUENCE.
[2]	"Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4." Diochot S., Schweitz H., Beress L., Lazdunski M. J. Biol. Chem. 273:6744-6749(1998) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, FUNCTION.

Cross-references

3D structure databases
ProteinModelPortal	P59084.
SMR	P59084. Positions 1-43.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.20.20.10. 1 hit.
InterPro	IPR012414. BDS_K_chnl_tox. IPR023355. Myo_neuro_toxin. [Graphical view]
Pfam	PF07936. Defensin_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BDS2_ANESU

Accession

Primary (citable) accession number: P59084

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	November 8, 2002
Last modified:	April 3, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program