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Protein

DeltaKappa-actitoxin-Avd4b

Gene
N/A
Organism
Anemonia sulcata (Mediterranean snakelocks sea anemone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a gating modifier on both Kv and Nav ion channels. Voltage-dependently inhibits voltage-gated potassium channels Kv3 (Kv3.1/KCNC1, Kv3.2/KCNC2 and Kv3.4/KCNC4) (PubMed:9506974, PubMed:16177043). Slows inactivation of the voltage-gated sodium channel Nav1.7/SCN9A (By similarity). Inhibits all Kv3.1, Kv3.2 and Kv3.4 by about 50% when tested at a voltage of +40 mV (PubMed:16177043). May act by binding residues in voltage-sensing domains S3b and S4 of Kv3 (PubMed:16177043). Tests have been done on human Nav1.7/SCN9A and rat SCG neurons that mostly carry Nav1.7 channels (EC(50)=300 nM) (By similarity). This toxin also reduces blood pressure (Ref. 1).By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
DeltaKappa-actitoxin-Avd4b1 Publication
Short name:
DeltaKappa-AITX-Avd4b1 Publication
Alternative name(s):
Antihypertensive protein BDS-2
Blood depressing substance II1 Publication
Short name:
BDS-II1 Publication
OrganismiAnemonia sulcata (Mediterranean snakelocks sea anemone)
Taxonomic identifieri6108 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaNynantheaeActiniidaeAnemonia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nematocyst, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002215421 – 43DeltaKappa-actitoxin-Avd4b2 PublicationsAdd BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi4 ↔ 39By similarity
Disulfide bondi6 ↔ 32By similarity
Disulfide bondi22 ↔ 40By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP59084.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.20.20.10. 1 hit.
InterProiIPR012414. BDS_K_chnl_tox.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamiPF07936. Defensin_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
AAPCFCPGKP DRGDLWILRG TCPGGYGYTS NCYKWPNICC YPH
Length:43
Mass (Da):4,782
Last modified:November 8, 2002 - v1
Checksum:i7EEAABBE8A1FDE08
GO

Cross-referencesi

3D structure databases

ProteinModelPortaliP59084.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.20.20.10. 1 hit.
InterProiIPR012414. BDS_K_chnl_tox.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamiPF07936. Defensin_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBDS2_ANESU
AccessioniPrimary (citable) accession number: P59084
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: October 5, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Caution

Opinions are divided on whether Anemonia viridis (Forsskal, 1775) and Anemonia sulcata (Pennant, 1777) are separate species.Curated

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.