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Protein

Lachrymatory-factor synthase

Gene

LFS

Organism
Allium cepa (Onion)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Produces lacrymatory factor (propanthial S-oxide) from 1-propenylsulphenic acid, an unstable compound resulting from the degradation of trans-1-propenyl-L-cysteine sulphoxide (PRENCSO) by alliinase.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13498.

Names & Taxonomyi

Protein namesi
Recommended name:
Lachrymatory-factor synthase
Gene namesi
Name:LFS
OrganismiAllium cepa (Onion)
Taxonomic identifieri4679 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaAsparagalesAmaryllidaceaeAllioideaeAllieaeAllium

Subcellular locationi

Vacuole Curated

GO - Cellular componenti

  1. vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

Pathology & Biotechi

Biotechnological usei

It may be possible to develop a non-lachrymal onion that still retains its characteristic flavor and high nutritional value by down-regulating the activity of this enzyme.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 12121 PublicationPRO_0000021591Add
BLAST
Chaini13 – 169157Lachrymatory-factor synthasePRO_0000021592Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP59082.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR019587. Polyketide_cyclase/dehydratase.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF10604. Polyketide_cyc2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59082-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELNPGAPAV VADSANGARK WSGKVHALLP NTKPEQAWTL LKDFINLHKV
60 70 80 90 100
MPSLSVCELV EGEANVVGCV RYVKGIMHPI EEEFWAKEKL VALDNKNMSY
110 120 130 140 150
SYIFTECFTG YEDYTATMQI VEGPEHKGSR FDWSFQCKYI EGMTESAFTE
160
ILQHWATEIG QKIEEVCSA
Length:169
Mass (Da):19,057
Last modified:November 8, 2002 - v1
Checksum:iD1D2DBD00A244EF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089203 mRNA. Translation: BAC21275.1.

Cross-referencesi

Web resourcesi

Protein Spotlight

No LFS, no cry - Issue 28 of November 2002

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089203 mRNA. Translation: BAC21275.1.

3D structure databases

ProteinModelPortaliP59082.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13498.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR019587. Polyketide_cyclase/dehydratase.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF10604. Polyketide_cyc2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 13-22.

Entry informationi

Entry nameiLFS_ALLCE
AccessioniPrimary (citable) accession number: P59082
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: January 7, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.