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P59056

- SYFA_BUCAP

UniProt

P59056 - SYFA_BUCAP

Protein

Phenylalanine--tRNA ligase alpha subunit

Gene

pheS

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (25 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).

    Cofactori

    Binds 2 magnesium ions per tetramer.Curated

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. phenylalanine-tRNA ligase activity Source: UniProtKB-HAMAP
    4. tRNA binding Source: InterPro

    GO - Biological processi

    1. phenylalanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBAPH198804:GHMG-131-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phenylalanine--tRNA ligase alpha subunit (EC:6.1.1.20)
    Alternative name(s):
    Phenylalanyl-tRNA synthetase alpha subunit
    Short name:
    PheRS
    Gene namesi
    Name:pheS
    Ordered Locus Names:BUsg_121
    OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
    Taxonomic identifieri198804 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000000416: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 329329Phenylalanine--tRNA ligase alpha subunitPRO_0000126677Add
    BLAST

    Proteomic databases

    PRIDEiP59056.

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta subunits.By similarity

    Protein-protein interaction databases

    STRINGi198804.BUsg121.

    Structurei

    3D structure databases

    ProteinModelPortaliP59056.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0016.
    KOiK01889.
    OMAiQIRTMEH.
    OrthoDBiEOG6WX4QN.

    Family and domain databases

    HAMAPiMF_00281. Phe_tRNA_synth_alpha1.
    InterProiIPR006195. aa-tRNA-synth_II.
    IPR004529. Phe-tRNA-synth_IIc_asu.
    IPR004188. Phe-tRNA_ligase_II_N.
    IPR022911. Phe_tRNA_ligase_alpha1_bac.
    IPR002319. Phenylalanyl-tRNA_Synthase.
    IPR010978. tRNA-bd_arm.
    [Graphical view]
    PfamiPF02912. Phe_tRNA-synt_N. 1 hit.
    PF01409. tRNA-synt_2d. 1 hit.
    [Graphical view]
    SUPFAMiSSF46589. SSF46589. 1 hit.
    TIGRFAMsiTIGR00468. pheS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59056-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLILQKLFDS VKIEIKNSHT IDKLDHIRIK YLGKKGIFSN LIKDLKNFSL    50
    EERKKYFIIF NEIKKKTINQ INKKKIELNK IILDKQIEKE KIDVSLPGRR 100
    IKNGVIHPIN HTITYIKNFF SKLGFESISG FEIEDEYHNF DALNIPKDHP 150
    ARNIHDTFWF DENRLLRTQT SSMQIRIMKK EKPPIRLIFP GKVYRNDYDS 200
    THTPMFHQVE GLIVEKNINF SNLKWIIYNF LRNFFHKDIA IRFRPSYFPF 250
    TTPSAEVDVV TNNGKLLEVL GCGMVHPSVL KNVNIDSNFY SACAFGIGIE 300
    RITMLRYGIS DLRSFFENDI RFIKQFKHI 329
    Length:329
    Mass (Da):38,862
    Last modified:October 25, 2002 - v1
    Checksum:iBD51678030D4E6D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67689.1.
    RefSeqiNP_660478.1. NC_004061.1.
    WP_011053656.1. NC_004061.1.

    Genome annotation databases

    EnsemblBacteriaiAAM67689; AAM67689; BUsg_121.
    GeneIDi1005938.
    KEGGibas:BUsg121.
    PATRICi21247023. VBIBucAph100086_0125.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE013218 Genomic DNA. Translation: AAM67689.1 .
    RefSeqi NP_660478.1. NC_004061.1.
    WP_011053656.1. NC_004061.1.

    3D structure databases

    ProteinModelPortali P59056.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198804.BUsg121.

    Proteomic databases

    PRIDEi P59056.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM67689 ; AAM67689 ; BUsg_121 .
    GeneIDi 1005938.
    KEGGi bas:BUsg121.
    PATRICi 21247023. VBIBucAph100086_0125.

    Phylogenomic databases

    eggNOGi COG0016.
    KOi K01889.
    OMAi QIRTMEH.
    OrthoDBi EOG6WX4QN.

    Enzyme and pathway databases

    BioCyci BAPH198804:GHMG-131-MONOMER.

    Family and domain databases

    HAMAPi MF_00281. Phe_tRNA_synth_alpha1.
    InterProi IPR006195. aa-tRNA-synth_II.
    IPR004529. Phe-tRNA-synth_IIc_asu.
    IPR004188. Phe-tRNA_ligase_II_N.
    IPR022911. Phe_tRNA_ligase_alpha1_bac.
    IPR002319. Phenylalanyl-tRNA_Synthase.
    IPR010978. tRNA-bd_arm.
    [Graphical view ]
    Pfami PF02912. Phe_tRNA-synt_N. 1 hit.
    PF01409. tRNA-synt_2d. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46589. SSF46589. 1 hit.
    TIGRFAMsi TIGR00468. pheS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Sg.

    Entry informationi

    Entry nameiSYFA_BUCAP
    AccessioniPrimary (citable) accession number: P59056
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: October 25, 2002
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Lacks the conserved glutamate residue that binds magnesium.Curated

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Buchnera aphidicola (subsp. Schizaphis graminum)
      Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3