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P59056

- SYFA_BUCAP

UniProt

P59056 - SYFA_BUCAP

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Protein
Phenylalanine--tRNA ligase alpha subunit
Gene
pheS, BUsg_121
Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotation

Cofactori

Binds 2 magnesium ions per tetramer Reviewed prediction.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. phenylalanine-tRNA ligase activity Source: UniProtKB-HAMAP
  4. tRNA binding Source: InterPro

GO - Biological processi

  1. phenylalanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH198804:GHMG-131-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase alpha subunit (EC:6.1.1.20)
Alternative name(s):
Phenylalanyl-tRNA synthetase alpha subunit
Short name:
PheRS
Gene namesi
Name:pheS
Ordered Locus Names:BUsg_121
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000000416: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Phenylalanine--tRNA ligase alpha subunitUniRule annotation
PRO_0000126677Add
BLAST

Proteomic databases

PRIDEiP59056.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits By similarity.

Protein-protein interaction databases

STRINGi198804.BUsg121.

Structurei

3D structure databases

ProteinModelPortaliP59056.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0016.
KOiK01889.
OMAiQIRTMEH.
OrthoDBiEOG6WX4QN.

Family and domain databases

HAMAPiMF_00281. Phe_tRNA_synth_alpha1.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004529. Phe-tRNA-synth_IIc_asu.
IPR004188. Phe-tRNA_ligase_II_N.
IPR022911. Phe_tRNA_ligase_alpha1_bac.
IPR002319. Phenylalanyl-tRNA_Synthase.
IPR010978. tRNA-bd_arm.
[Graphical view]
PfamiPF02912. Phe_tRNA-synt_N. 1 hit.
PF01409. tRNA-synt_2d. 1 hit.
[Graphical view]
SUPFAMiSSF46589. SSF46589. 1 hit.
TIGRFAMsiTIGR00468. pheS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59056-1 [UniParc]FASTAAdd to Basket

« Hide

MLILQKLFDS VKIEIKNSHT IDKLDHIRIK YLGKKGIFSN LIKDLKNFSL    50
EERKKYFIIF NEIKKKTINQ INKKKIELNK IILDKQIEKE KIDVSLPGRR 100
IKNGVIHPIN HTITYIKNFF SKLGFESISG FEIEDEYHNF DALNIPKDHP 150
ARNIHDTFWF DENRLLRTQT SSMQIRIMKK EKPPIRLIFP GKVYRNDYDS 200
THTPMFHQVE GLIVEKNINF SNLKWIIYNF LRNFFHKDIA IRFRPSYFPF 250
TTPSAEVDVV TNNGKLLEVL GCGMVHPSVL KNVNIDSNFY SACAFGIGIE 300
RITMLRYGIS DLRSFFENDI RFIKQFKHI 329
Length:329
Mass (Da):38,862
Last modified:October 25, 2002 - v1
Checksum:iBD51678030D4E6D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67689.1.
RefSeqiNP_660478.1. NC_004061.1.
WP_011053656.1. NC_004061.1.

Genome annotation databases

EnsemblBacteriaiAAM67689; AAM67689; BUsg_121.
GeneIDi1005938.
KEGGibas:BUsg121.
PATRICi21247023. VBIBucAph100086_0125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE013218 Genomic DNA. Translation: AAM67689.1 .
RefSeqi NP_660478.1. NC_004061.1.
WP_011053656.1. NC_004061.1.

3D structure databases

ProteinModelPortali P59056.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198804.BUsg121.

Proteomic databases

PRIDEi P59056.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM67689 ; AAM67689 ; BUsg_121 .
GeneIDi 1005938.
KEGGi bas:BUsg121.
PATRICi 21247023. VBIBucAph100086_0125.

Phylogenomic databases

eggNOGi COG0016.
KOi K01889.
OMAi QIRTMEH.
OrthoDBi EOG6WX4QN.

Enzyme and pathway databases

BioCyci BAPH198804:GHMG-131-MONOMER.

Family and domain databases

HAMAPi MF_00281. Phe_tRNA_synth_alpha1.
InterProi IPR006195. aa-tRNA-synth_II.
IPR004529. Phe-tRNA-synth_IIc_asu.
IPR004188. Phe-tRNA_ligase_II_N.
IPR022911. Phe_tRNA_ligase_alpha1_bac.
IPR002319. Phenylalanyl-tRNA_Synthase.
IPR010978. tRNA-bd_arm.
[Graphical view ]
Pfami PF02912. Phe_tRNA-synt_N. 1 hit.
PF01409. tRNA-synt_2d. 1 hit.
[Graphical view ]
SUPFAMi SSF46589. SSF46589. 1 hit.
TIGRFAMsi TIGR00468. pheS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Sg.

Entry informationi

Entry nameiSYFA_BUCAP
AccessioniPrimary (citable) accession number: P59056
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Lacks the conserved glutamate residue that binds magnesium.

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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