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Protein

Cysteine/serine-rich nuclear protein 3

Gene

Csrnp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. Plays a role in apoptosis.2 Publications

GO - Molecular functioni

  • sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Source: NTNU_SB
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine/serine-rich nuclear protein 3
Short name:
CSRNP-3
Alternative name(s):
Protein FAM130A2
TGF-beta-induced apoptosis protein 2
Short name:
TAIP-2
Gene namesi
Name:Csrnp3
Synonyms:Fam130a2, Mbu1, Taip2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1925021. Csrnp3.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice display no obvious defects in development, hematopoiesis or T-cell function. Deletion of Axud1, Csnrp2 and Csnrp3 together causes partial neonatal lethality, suggesting that they have redundant functions.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 597597Cysteine/serine-rich nuclear protein 3PRO_0000114789Add
BLAST

Proteomic databases

MaxQBiP59055.
PaxDbiP59055.
PRIDEiP59055.

PTM databases

PhosphoSiteiP59055.

Expressioni

Tissue specificityi

Detected only in the brain of E15, E18, newborn and P6 mice (at protein level).2 Publications

Developmental stagei

Expressed during embryonic development and also detected a week after birth. Expression decreases by 14 days after birth and is not detected in the adult (at protein level).

Gene expression databases

BgeeiENSMUSG00000044647.
ExpressionAtlasiP59055. baseline and differential.
GenevisibleiP59055. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055719.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 6438Ser-richAdd
BLAST
Compositional biasi224 – 26239Cys-richAdd
BLAST
Compositional biasi330 – 39566Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the AXUD1 family.Curated

Phylogenomic databases

eggNOGiKOG3813. Eukaryota.
ENOG410XREB. LUCA.
GeneTreeiENSGT00390000015510.
HOGENOMiHOG000039987.
HOVERGENiHBG067792.
InParanoidiP59055.
KOiK17494.
OMAiECIKSPV.
OrthoDBiEOG091G04PA.
PhylomeDBiP59055.
TreeFamiTF323969.

Family and domain databases

InterProiIPR031972. CSRNP_N.
IPR023260. Cys/Ser-rich_nuc_prot.
[Graphical view]
PANTHERiPTHR13580. PTHR13580. 1 hit.
PfamiPF16019. CSRNP_N. 1 hit.
[Graphical view]
PRINTSiPR02031. CYSSERRICHNP.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P59055-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSQGTCDNA AAMSGILKRK FEDVDASSPC SSARESDDEV SSSESADSGD
60 70 80 90 100
SVNPSTSNHF TPSSILKREK RLRTKNVHFS CVTVYYFTRR QGFTSVPSQG
110 120 130 140 150
GSTLGMSSRH NSVRQYTLGE FAREQERLHR EMLREHLREE KLNSLKLKMT
160 170 180 190 200
KNGTVESEEA STLTVDDISD DDIDLDNTEV DEYFFLQPLP TKKRRALLRA
210 220 230 240 250
SGVKKIDVDE KHELRAIRLS REDCGCDCRV FCDPETCTCS LAGIKCQVDR
260 270 280 290 300
MSFPCGCTKE GCSNTAGRIE FNPIRVRTHF LHTIMKLELE KNREQQTPTL
310 320 330 340 350
NGCHGEISAH GPSMGPVAHS VEYSIADNFE IETEPQAAVL HLQEELDCQG
360 370 380 390 400
DEEEEEEDGS SFCSGATDSS TQSLAPSESD EEEEEEEEEE EEEEEDDDDD
410 420 430 440 450
KGDGFVEGLG AHTEVVPLPS VLCYSDGTAV HESHTKNASF YASSSTLYYQ
460 470 480 490 500
IDSHIPGTPS QLSDNYSERD TVKNGALSLV PYAMTPERFV DYARQAEEAY
510 520 530 540 550
GASHYPAANP SVIVCCPTSE NDSGVPCNPL YPEHRSNLPQ VEFHSYLKGP
560 570 580 590
AQEGFVSTLN GDSHISEHPA ENPLSLAEKS RLHEECIQSP VVETVPV
Length:597
Mass (Da):66,121
Last modified:June 10, 2008 - v2
Checksum:i20AEA5E37793E522
GO
Isoform 2 (identifier: P59055-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Show »
Length:585
Mass (Da):64,915
Checksum:iE662DFBD6B3FE75E
GO

Sequence cautioni

The sequence ABN14256 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC30257 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti246 – 2461C → R in BAC16315 (PubMed:18291095).Curated
Sequence conflicti304 – 3041H → R in BAC16315 (PubMed:18291095).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1212Missing in isoform 2. 2 PublicationsVSP_034260Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF210820 mRNA. Translation: ABN14256.1. Different initiation.
AB091688 mRNA. Translation: BAC16315.1.
AK039150 mRNA. Translation: BAC30257.1. Different initiation.
AK082649 mRNA. Translation: BAC38559.1.
AK158873 mRNA. Translation: BAE34706.1.
AL929230, AL935061 Genomic DNA. Translation: CAM20334.1.
AL929230, AL935061 Genomic DNA. Translation: CAM20335.1.
AL935061, AL929230 Genomic DNA. Translation: CAM16899.1.
AL935061, AL929230 Genomic DNA. Translation: CAM16900.1.
CCDSiCCDS16074.2. [P59055-1]
CCDS71060.1. [P59055-2]
RefSeqiNP_001277594.1. NM_001290665.1. [P59055-2]
NP_700458.3. NM_153409.5. [P59055-1]
NP_848749.2. NM_178634.2. [P59055-1]
XP_006500465.1. XM_006500402.1. [P59055-2]
XP_006500466.1. XM_006500403.2. [P59055-2]
UniGeneiMm.102025.

Genome annotation databases

EnsembliENSMUST00000053910; ENSMUSP00000055719; ENSMUSG00000044647. [P59055-1]
ENSMUST00000112394; ENSMUSP00000108013; ENSMUSG00000044647. [P59055-2]
ENSMUST00000122912; ENSMUSP00000117533; ENSMUSG00000044647. [P59055-1]
ENSMUST00000145598; ENSMUSP00000135605; ENSMUSG00000044647. [P59055-2]
ENSMUST00000176109; ENSMUSP00000135019; ENSMUSG00000044647. [P59055-2]
GeneIDi77771.
KEGGimmu:77771.
UCSCiuc008jwq.2. mouse. [P59055-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF210820 mRNA. Translation: ABN14256.1. Different initiation.
AB091688 mRNA. Translation: BAC16315.1.
AK039150 mRNA. Translation: BAC30257.1. Different initiation.
AK082649 mRNA. Translation: BAC38559.1.
AK158873 mRNA. Translation: BAE34706.1.
AL929230, AL935061 Genomic DNA. Translation: CAM20334.1.
AL929230, AL935061 Genomic DNA. Translation: CAM20335.1.
AL935061, AL929230 Genomic DNA. Translation: CAM16899.1.
AL935061, AL929230 Genomic DNA. Translation: CAM16900.1.
CCDSiCCDS16074.2. [P59055-1]
CCDS71060.1. [P59055-2]
RefSeqiNP_001277594.1. NM_001290665.1. [P59055-2]
NP_700458.3. NM_153409.5. [P59055-1]
NP_848749.2. NM_178634.2. [P59055-1]
XP_006500465.1. XM_006500402.1. [P59055-2]
XP_006500466.1. XM_006500403.2. [P59055-2]
UniGeneiMm.102025.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055719.

PTM databases

PhosphoSiteiP59055.

Proteomic databases

MaxQBiP59055.
PaxDbiP59055.
PRIDEiP59055.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053910; ENSMUSP00000055719; ENSMUSG00000044647. [P59055-1]
ENSMUST00000112394; ENSMUSP00000108013; ENSMUSG00000044647. [P59055-2]
ENSMUST00000122912; ENSMUSP00000117533; ENSMUSG00000044647. [P59055-1]
ENSMUST00000145598; ENSMUSP00000135605; ENSMUSG00000044647. [P59055-2]
ENSMUST00000176109; ENSMUSP00000135019; ENSMUSG00000044647. [P59055-2]
GeneIDi77771.
KEGGimmu:77771.
UCSCiuc008jwq.2. mouse. [P59055-1]

Organism-specific databases

CTDi80034.
MGIiMGI:1925021. Csrnp3.

Phylogenomic databases

eggNOGiKOG3813. Eukaryota.
ENOG410XREB. LUCA.
GeneTreeiENSGT00390000015510.
HOGENOMiHOG000039987.
HOVERGENiHBG067792.
InParanoidiP59055.
KOiK17494.
OMAiECIKSPV.
OrthoDBiEOG091G04PA.
PhylomeDBiP59055.
TreeFamiTF323969.

Miscellaneous databases

ChiTaRSiCsrnp3. mouse.
PROiP59055.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044647.
ExpressionAtlasiP59055. baseline and differential.
GenevisibleiP59055. MM.

Family and domain databases

InterProiIPR031972. CSRNP_N.
IPR023260. Cys/Ser-rich_nuc_prot.
[Graphical view]
PANTHERiPTHR13580. PTHR13580. 1 hit.
PfamiPF16019. CSRNP_N. 1 hit.
[Graphical view]
PRINTSiPR02031. CYSSERRICHNP.
ProtoNetiSearch...

Entry informationi

Entry nameiCSRN3_MOUSE
AccessioniPrimary (citable) accession number: P59055
Secondary accession number(s): A3F6Q4, Q8BUT9, Q8BYL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: June 10, 2008
Last modified: September 7, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.