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Protein

Cysteine/serine-rich nuclear protein 3

Gene

Csrnp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. Plays a role in apoptosis.2 Publications

GO - Molecular functioni

  • DNA binding transcription factor activity Source: UniProtKB
  • sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processApoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine/serine-rich nuclear protein 3
Short name:
CSRNP-3
Alternative name(s):
Protein FAM130A2
TGF-beta-induced apoptosis protein 2
Short name:
TAIP-2
Gene namesi
Name:Csrnp3
Synonyms:Fam130a2, Mbu1, Taip2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1925021 Csrnp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice display no obvious defects in development, hematopoiesis or T-cell function. Deletion of Axud1, Csnrp2 and Csnrp3 together causes partial neonatal lethality, suggesting that they have redundant functions.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147891 – 597Cysteine/serine-rich nuclear protein 3Add BLAST597

Proteomic databases

MaxQBiP59055
PaxDbiP59055
PRIDEiP59055

PTM databases

PhosphoSitePlusiP59055

Expressioni

Tissue specificityi

Detected only in the brain of E15, E18, newborn and P6 mice (at protein level).2 Publications

Developmental stagei

Expressed during embryonic development and also detected a week after birth. Expression decreases by 14 days after birth and is not detected in the adult (at protein level).

Gene expression databases

BgeeiENSMUSG00000044647
ExpressionAtlasiP59055 baseline and differential
GenevisibleiP59055 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055719

Structurei

3D structure databases

SMRiP59055
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi27 – 64Ser-richAdd BLAST38
Compositional biasi224 – 262Cys-richAdd BLAST39
Compositional biasi330 – 395Glu-richAdd BLAST66

Sequence similaritiesi

Belongs to the AXUD1 family.Curated

Phylogenomic databases

eggNOGiKOG3813 Eukaryota
ENOG410XREB LUCA
GeneTreeiENSGT00390000015510
HOGENOMiHOG000039987
HOVERGENiHBG067792
InParanoidiP59055
KOiK17494
OMAiECIKSPV
OrthoDBiEOG091G04PA
PhylomeDBiP59055
TreeFamiTF323969

Family and domain databases

InterProiView protein in InterPro
IPR031972 CSRNP_N
IPR023260 Cys/Ser-rich_nuc_prot
PANTHERiPTHR13580 PTHR13580, 1 hit
PfamiView protein in Pfam
PF16019 CSRNP_N, 1 hit
PRINTSiPR02031 CYSSERRICHNP

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P59055-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSQGTCDNA AAMSGILKRK FEDVDASSPC SSARESDDEV SSSESADSGD
60 70 80 90 100
SVNPSTSNHF TPSSILKREK RLRTKNVHFS CVTVYYFTRR QGFTSVPSQG
110 120 130 140 150
GSTLGMSSRH NSVRQYTLGE FAREQERLHR EMLREHLREE KLNSLKLKMT
160 170 180 190 200
KNGTVESEEA STLTVDDISD DDIDLDNTEV DEYFFLQPLP TKKRRALLRA
210 220 230 240 250
SGVKKIDVDE KHELRAIRLS REDCGCDCRV FCDPETCTCS LAGIKCQVDR
260 270 280 290 300
MSFPCGCTKE GCSNTAGRIE FNPIRVRTHF LHTIMKLELE KNREQQTPTL
310 320 330 340 350
NGCHGEISAH GPSMGPVAHS VEYSIADNFE IETEPQAAVL HLQEELDCQG
360 370 380 390 400
DEEEEEEDGS SFCSGATDSS TQSLAPSESD EEEEEEEEEE EEEEEDDDDD
410 420 430 440 450
KGDGFVEGLG AHTEVVPLPS VLCYSDGTAV HESHTKNASF YASSSTLYYQ
460 470 480 490 500
IDSHIPGTPS QLSDNYSERD TVKNGALSLV PYAMTPERFV DYARQAEEAY
510 520 530 540 550
GASHYPAANP SVIVCCPTSE NDSGVPCNPL YPEHRSNLPQ VEFHSYLKGP
560 570 580 590
AQEGFVSTLN GDSHISEHPA ENPLSLAEKS RLHEECIQSP VVETVPV
Length:597
Mass (Da):66,121
Last modified:June 10, 2008 - v2
Checksum:i20AEA5E37793E522
GO
Isoform 2 (identifier: P59055-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Show »
Length:585
Mass (Da):64,915
Checksum:iE662DFBD6B3FE75E
GO

Sequence cautioni

The sequence ABN14256 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC30257 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti246C → R in BAC16315 (PubMed:18291095).Curated1
Sequence conflicti304H → R in BAC16315 (PubMed:18291095).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0342601 – 12Missing in isoform 2. 2 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF210820 mRNA Translation: ABN14256.1 Different initiation.
AB091688 mRNA Translation: BAC16315.1
AK039150 mRNA Translation: BAC30257.1 Different initiation.
AK082649 mRNA Translation: BAC38559.1
AK158873 mRNA Translation: BAE34706.1
AL929230, AL935061 Genomic DNA Translation: CAM20334.1
AL929230, AL935061 Genomic DNA Translation: CAM20335.1
AL935061, AL929230 Genomic DNA Translation: CAM16899.1
AL935061, AL929230 Genomic DNA Translation: CAM16900.1
CCDSiCCDS16074.2 [P59055-1]
CCDS71060.1 [P59055-2]
RefSeqiNP_001277594.1, NM_001290665.1 [P59055-2]
NP_700458.3, NM_153409.5 [P59055-1]
NP_848749.2, NM_178634.2 [P59055-1]
XP_006500465.1, XM_006500402.2 [P59055-2]
XP_006500466.1, XM_006500403.3 [P59055-2]
UniGeneiMm.102025

Genome annotation databases

EnsembliENSMUST00000053910; ENSMUSP00000055719; ENSMUSG00000044647 [P59055-1]
ENSMUST00000112394; ENSMUSP00000108013; ENSMUSG00000044647 [P59055-2]
ENSMUST00000122912; ENSMUSP00000117533; ENSMUSG00000044647 [P59055-1]
ENSMUST00000145598; ENSMUSP00000135605; ENSMUSG00000044647 [P59055-2]
ENSMUST00000176109; ENSMUSP00000135019; ENSMUSG00000044647 [P59055-2]
GeneIDi77771
KEGGimmu:77771
UCSCiuc008jwq.2 mouse [P59055-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCSRN3_MOUSE
AccessioniPrimary (citable) accession number: P59055
Secondary accession number(s): A3F6Q4, Q8BUT9, Q8BYL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: June 10, 2008
Last modified: March 28, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health