Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cysteine/serine-rich nuclear protein 1

Gene

Csrnp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. May have a tumor-suppressor function. May play a role in apoptosis.1 Publication

GO - Molecular functioni

  • DNA binding transcription factor activity Source: UniProtKB
  • sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • face morphogenesis Source: MGI
  • platelet-derived growth factor receptor signaling pathway Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • post-embryonic development Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • roof of mouth development Source: MGI
  • skeletal system morphogenesis Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processApoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine/serine-rich nuclear protein 1
Short name:
CSRNP-1
Alternative name(s):
Axin-1 up-regulated gene 1 protein
TGF-beta-induced apoptosis protein 3
Short name:
TAIP-3
Gene namesi
Name:Csrnp1
Synonyms:Axud1, Taip3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2387989 Csrnp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice display no obvious defects in development, hematopoiesis or T-cell function. Deletion of Csrnp1, Csrnp2 and Csrnp3 together causes partial neonatal lethality, suggesting that they have redundant functions.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147871 – 583Cysteine/serine-rich nuclear protein 1Add BLAST583

Proteomic databases

PaxDbiP59054
PRIDEiP59054

PTM databases

iPTMnetiP59054
PhosphoSitePlusiP59054

Expressioni

Tissue specificityi

Widely expressed with highest levels in thymus and lung. Low levels detected in naive T-cells.1 Publication

Inductioni

By interleukin-2.1 Publication

Gene expression databases

BgeeiENSMUSG00000032515
CleanExiMM_AXUD1
ExpressionAtlasiP59054 baseline and differential
GenevisibleiP59054 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035101

Structurei

3D structure databases

ProteinModelPortaliP59054
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 40Ser-richAdd BLAST24
Compositional biasi237 – 275Cys-richAdd BLAST39

Sequence similaritiesi

Belongs to the AXUD1 family.Curated

Phylogenomic databases

eggNOGiKOG3813 Eukaryota
ENOG410XREB LUCA
GeneTreeiENSGT00390000015510
HOGENOMiHOG000039987
InParanoidiP59054
KOiK17494
OMAiPRHSACR
OrthoDBiEOG091G04PA
PhylomeDBiP59054
TreeFamiTF323969

Family and domain databases

InterProiView protein in InterPro
IPR031972 CSRNP_N
IPR023260 Cys/Ser-rich_nuc_prot
PANTHERiPTHR13580 PTHR13580, 1 hit
PfamiView protein in Pfam
PF16019 CSRNP_N, 1 hit
PRINTSiPR02031 CYSSERRICHNP

Sequencei

Sequence statusi: Complete.

P59054-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGLLKRKFD QLEEDDSSSS SSSSFSSRLS LSSFPASSAS PAWNSDEEGP
60 70 80 90 100
GGQAPQSDQD SCGLQSFTPP SILKRAPRER PGHVAFNGIT VYYFPRCQGF
110 120 130 140 150
TSVPSRGGCT LGMASRHSTC RLFSLAEFTQ EQVRARREKL RRRLKEEKLE
160 170 180 190 200
MLRWKFSVAG VPESGAGVPL TADAIDDASV EEDLAVAVAN GRLEEANFLQ
210 220 230 240 250
PHPPRQRRAL LRASGVRRID REEKRELQVL RQSREDCGCH CDGVCDPETC
260 270 280 290 300
SCSLAGIKCQ MDHTSFPCGC CREGCENPNG RVEFNQTRVQ THFIHTLTRL
310 320 330 340 350
QMEQGAESLG DLESPVEDTP VEQAALSPFP PSKPPVSSEL GDSSCSSDMT
360 370 380 390 400
DSSTTLSSGS SEPPNHPAHP SLPGPSFRSG VDEDSLEQIL NFSDSDLGIE
410 420 430 440 450
EEEEEGGGVG NLDNLSCFHL ADIFGTGDPG SLASWTHSQS GSSLASGILD
460 470 480 490 500
ENANLDASCF LNSGLGGLRE GSLPGSSGSP EGDAVQSSSW DLSLSSCDSF
510 520 530 540 550
ELLQALPDYS LGPHYTSRRV SGSPDSLETF HPLPSFSPPR DASTCFLESL
560 570 580
VGLSEPVTEV LAPLLESQFE DAALAPLLEP VPV
Length:583
Mass (Da):62,525
Last modified:October 25, 2002 - v1
Checksum:i9061F7A80404FF27
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60D → S in BAE24284 (PubMed:16141072).Curated1
Sequence conflicti81P → A in BAE24284 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB091687 mRNA Translation: BAC16314.1
AK029893 mRNA Translation: BAC26661.1
AK140213 mRNA Translation: BAE24284.1
BC029720 mRNA Translation: AAH29720.1
BC050066 mRNA Translation: AAH50066.1
CCDSiCCDS23620.1
RefSeqiNP_695019.1, NM_153287.3
XP_006512100.1, XM_006512037.3
XP_006512101.1, XM_006512038.2
XP_006512103.1, XM_006512040.3
XP_006512104.1, XM_006512041.3
XP_011241256.1, XM_011242954.2
UniGeneiMm.491094

Genome annotation databases

EnsembliENSMUST00000035101; ENSMUSP00000035101; ENSMUSG00000032515
ENSMUST00000214058; ENSMUSP00000150628; ENSMUSG00000032515
ENSMUST00000215916; ENSMUSP00000149214; ENSMUSG00000032515
GeneIDi215418
KEGGimmu:215418
UCSCiuc009sbu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCSRN1_MOUSE
AccessioniPrimary (citable) accession number: P59054
Secondary accession number(s): Q3USP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health