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Protein

Cysteine/serine-rich nuclear protein 1

Gene

Csrnp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. May have a tumor-suppressor function. May play a role in apoptosis.1 Publication

GO - Molecular functioni

  • sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Source: NTNU_SB
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • face morphogenesis Source: MGI
  • palate development Source: MGI
  • platelet-derived growth factor receptor signaling pathway Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • post-embryonic development Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • skeletal system morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine/serine-rich nuclear protein 1
Short name:
CSRNP-1
Alternative name(s):
Axin-1 up-regulated gene 1 protein
TGF-beta-induced apoptosis protein 3
Short name:
TAIP-3
Gene namesi
Name:Csrnp1
Synonyms:Axud1, Taip3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2387989. Csrnp1.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice display no obvious defects in development, hematopoiesis or T-cell function. Deletion of Csrnp1, Csrnp2 and Csrnp3 together causes partial neonatal lethality, suggesting that they have redundant functions.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147871 – 583Cysteine/serine-rich nuclear protein 1Add BLAST583

Proteomic databases

PaxDbiP59054.
PRIDEiP59054.

PTM databases

iPTMnetiP59054.
PhosphoSitePlusiP59054.

Expressioni

Tissue specificityi

Widely expressed with highest levels in thymus and lung. Low levels detected in naive T-cells.1 Publication

Inductioni

By interleukin-2.1 Publication

Gene expression databases

BgeeiENSMUSG00000032515.
CleanExiMM_AXUD1.
GenevisibleiP59054. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035101.

Structurei

3D structure databases

ProteinModelPortaliP59054.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 40Ser-richAdd BLAST24
Compositional biasi237 – 275Cys-richAdd BLAST39

Sequence similaritiesi

Belongs to the AXUD1 family.Curated

Phylogenomic databases

eggNOGiKOG3813. Eukaryota.
ENOG410XREB. LUCA.
GeneTreeiENSGT00390000015510.
HOGENOMiHOG000039987.
InParanoidiP59054.
KOiK17494.
OMAiPRHSACR.
OrthoDBiEOG091G04PA.
PhylomeDBiP59054.
TreeFamiTF323969.

Family and domain databases

InterProiIPR031972. CSRNP_N.
IPR023260. Cys/Ser-rich_nuc_prot.
[Graphical view]
PANTHERiPTHR13580. PTHR13580. 1 hit.
PfamiPF16019. CSRNP_N. 1 hit.
[Graphical view]
PRINTSiPR02031. CYSSERRICHNP.

Sequencei

Sequence statusi: Complete.

P59054-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGLLKRKFD QLEEDDSSSS SSSSFSSRLS LSSFPASSAS PAWNSDEEGP
60 70 80 90 100
GGQAPQSDQD SCGLQSFTPP SILKRAPRER PGHVAFNGIT VYYFPRCQGF
110 120 130 140 150
TSVPSRGGCT LGMASRHSTC RLFSLAEFTQ EQVRARREKL RRRLKEEKLE
160 170 180 190 200
MLRWKFSVAG VPESGAGVPL TADAIDDASV EEDLAVAVAN GRLEEANFLQ
210 220 230 240 250
PHPPRQRRAL LRASGVRRID REEKRELQVL RQSREDCGCH CDGVCDPETC
260 270 280 290 300
SCSLAGIKCQ MDHTSFPCGC CREGCENPNG RVEFNQTRVQ THFIHTLTRL
310 320 330 340 350
QMEQGAESLG DLESPVEDTP VEQAALSPFP PSKPPVSSEL GDSSCSSDMT
360 370 380 390 400
DSSTTLSSGS SEPPNHPAHP SLPGPSFRSG VDEDSLEQIL NFSDSDLGIE
410 420 430 440 450
EEEEEGGGVG NLDNLSCFHL ADIFGTGDPG SLASWTHSQS GSSLASGILD
460 470 480 490 500
ENANLDASCF LNSGLGGLRE GSLPGSSGSP EGDAVQSSSW DLSLSSCDSF
510 520 530 540 550
ELLQALPDYS LGPHYTSRRV SGSPDSLETF HPLPSFSPPR DASTCFLESL
560 570 580
VGLSEPVTEV LAPLLESQFE DAALAPLLEP VPV
Length:583
Mass (Da):62,525
Last modified:October 25, 2002 - v1
Checksum:i9061F7A80404FF27
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60D → S in BAE24284 (PubMed:16141072).Curated1
Sequence conflicti81P → A in BAE24284 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB091687 mRNA. Translation: BAC16314.1.
AK029893 mRNA. Translation: BAC26661.1.
AK140213 mRNA. Translation: BAE24284.1.
BC029720 mRNA. Translation: AAH29720.1.
BC050066 mRNA. Translation: AAH50066.1.
CCDSiCCDS23620.1.
RefSeqiNP_695019.1. NM_153287.3.
XP_006512100.1. XM_006512037.3.
XP_006512101.1. XM_006512038.2.
XP_006512103.1. XM_006512040.3.
XP_006512104.1. XM_006512041.3.
XP_011241256.1. XM_011242954.2.
UniGeneiMm.491094.

Genome annotation databases

EnsembliENSMUST00000035101; ENSMUSP00000035101; ENSMUSG00000032515.
GeneIDi215418.
KEGGimmu:215418.
UCSCiuc009sbu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB091687 mRNA. Translation: BAC16314.1.
AK029893 mRNA. Translation: BAC26661.1.
AK140213 mRNA. Translation: BAE24284.1.
BC029720 mRNA. Translation: AAH29720.1.
BC050066 mRNA. Translation: AAH50066.1.
CCDSiCCDS23620.1.
RefSeqiNP_695019.1. NM_153287.3.
XP_006512100.1. XM_006512037.3.
XP_006512101.1. XM_006512038.2.
XP_006512103.1. XM_006512040.3.
XP_006512104.1. XM_006512041.3.
XP_011241256.1. XM_011242954.2.
UniGeneiMm.491094.

3D structure databases

ProteinModelPortaliP59054.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035101.

PTM databases

iPTMnetiP59054.
PhosphoSitePlusiP59054.

Proteomic databases

PaxDbiP59054.
PRIDEiP59054.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035101; ENSMUSP00000035101; ENSMUSG00000032515.
GeneIDi215418.
KEGGimmu:215418.
UCSCiuc009sbu.1. mouse.

Organism-specific databases

CTDi64651.
MGIiMGI:2387989. Csrnp1.

Phylogenomic databases

eggNOGiKOG3813. Eukaryota.
ENOG410XREB. LUCA.
GeneTreeiENSGT00390000015510.
HOGENOMiHOG000039987.
InParanoidiP59054.
KOiK17494.
OMAiPRHSACR.
OrthoDBiEOG091G04PA.
PhylomeDBiP59054.
TreeFamiTF323969.

Miscellaneous databases

ChiTaRSiCsrnp1. mouse.
PROiP59054.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032515.
CleanExiMM_AXUD1.
GenevisibleiP59054. MM.

Family and domain databases

InterProiIPR031972. CSRNP_N.
IPR023260. Cys/Ser-rich_nuc_prot.
[Graphical view]
PANTHERiPTHR13580. PTHR13580. 1 hit.
PfamiPF16019. CSRNP_N. 1 hit.
[Graphical view]
PRINTSiPR02031. CYSSERRICHNP.
ProtoNetiSearch...

Entry informationi

Entry nameiCSRN1_MOUSE
AccessioniPrimary (citable) accession number: P59054
Secondary accession number(s): Q3USP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.