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P59053 (KCNG3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily G member 3
Alternative name(s):
Voltage-gated potassium channel subunit Kv10.1
Voltage-gated potassium channel subunit Kv6.3
Gene names
Name:Kcng3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potassium channel subunit. Modulates channel activity By similarity.

Subunit structure

Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cytoplasm By similarity. Note: Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1 By similarity.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.3/KCNG3 sub-subfamily. [View classification]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P59053-1)

Also known as: Kv10.1b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P59053-2)

Also known as: Kv10.1a;

The sequence of this isoform differs from the canonical sequence as follows:
     209-219: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Potassium voltage-gated channel subfamily G member 3
PRO_0000054078

Regions

Topological domain1 – 164164Cytoplasmic Potential
Transmembrane165 – 18521Helical; Name=Segment S1; Potential
Transmembrane219 – 23921Helical; Name=Segment S2; Potential
Topological domain240 – 25213Cytoplasmic Potential
Transmembrane253 – 27321Helical; Name=Segment S3; Potential
Transmembrane284 – 30421Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain305 – 31915Cytoplasmic Potential
Transmembrane320 – 34021Helical; Name=Segment S5; Potential
Intramembrane358 – 37821Pore-forming; Name=Segment H5; Potential
Transmembrane385 – 41026Helical; Name=Segment S6; Potential
Topological domain411 – 43323Cytoplasmic Potential
Motif370 – 3756Selectivity filter By similarity

Natural variations

Alternative sequence209 – 21911Missing in isoform 2.
VSP_001027

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Kv10.1b) [UniParc].

Last modified October 25, 2002. Version 1.
Checksum: E9A7C010F4B0CA6C

FASTA43349,247
        10         20         30         40         50         60 
MTFGRGGAAS VVLNVGGARY SLSRELLKDF PLRRVSRLHG CRSERDVLEV CDDYDRERNE 

        70         80         90        100        110        120 
YFFDRHSEAF GFILLYVRGH GKLRFAPRMC ELSFYNEMIY WGLEGAHLEY CCQRRLDDRM 

       130        140        150        160        170        180 
SDTHTFHAAD ELGREQPRPA GPEAAPSRRW LERMRRTFEE PTSSLAAQIL ASVSVVFVIV 

       190        200        210        220        230        240 
SMVVLCASTL PDWRAAVADN RSLDDRSRYS ASPGREPSGI IEAICIGWFT AECIVRFIVS 

       250        260        270        280        290        300 
KNKCEFVKRP LNIIDLLAIT PYYISVLMTV FTGENSQLQR AGVTLRVLRM MRIFWVIKLA 

       310        320        330        340        350        360 
RHFIGLQTLG LTLKRCYREM AMLLVFICVA MAIFSALSQL LEHGLDLETS NKDFASIPAA 

       370        380        390        400        410        420 
CWWVIISMTT VGYGDMYPIT VPGRILGGVC VVSGIVLLAL PITFIYHSFV QCYHELKFRS 

       430 
ARYSRSLSAE FLN 

« Hide

Isoform 2 (Kv10.1a) [UniParc].

Checksum: B76D12B546E3A5C0
Show »

FASTA42248,158

References

[1]"Kv10.1a and Kv10.1b: two novel alternatively spliced potassium channel subunits."
Vega-Saenz de Miera E.C., Rudy B.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF454551 mRNA. Translation: AAM93552.1.
AF454552 mRNA. Translation: AAM93553.1.
RefSeqNP_705732.1. NM_153512.1.
XP_006524263.1. XM_006524200.1.
UniGeneMm.223506.

3D structure databases

ProteinModelPortalP59053.
SMRP59053. Positions 11-414.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000054910.

PTM databases

PhosphoSiteP59053.

Proteomic databases

PRIDEP59053.

Protocols and materials databases

DNASU225030.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000051482; ENSMUSP00000054910; ENSMUSG00000045053. [P59053-1]
GeneID225030.
KEGGmmu:225030.
UCSCuc008dsd.1. mouse. [P59053-1]
uc008dse.1. mouse. [P59053-2]

Organism-specific databases

CTD170850.
MGIMGI:2663923. Kcng3.

Phylogenomic databases

eggNOGCOG1226.
GeneTreeENSGT00730000110784.
HOGENOMHOG000231014.
HOVERGENHBG100172.
InParanoidP59053.
KOK04902.
OMAHMCELSF.
OrthoDBEOG7VB2F7.
PhylomeDBP59053.
TreeFamTF313103.

Gene expression databases

BgeeP59053.
GenevestigatorP59053.

Family and domain databases

Gene3D1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

NextBio377516.
PROP59053.
SOURCESearch...

Entry information

Entry nameKCNG3_MOUSE
AccessionPrimary (citable) accession number: P59053
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot