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P59053

- KCNG3_MOUSE

UniProt

P59053 - KCNG3_MOUSE

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Protein

Potassium voltage-gated channel subfamily G member 3

Gene

Kcng3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Potassium channel subunit. Modulates channel activity (By similarity).By similarity

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome
  2. voltage-gated potassium channel activity Source: MGI

GO - Biological processi

  1. potassium ion transport Source: MGI
  2. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily G member 3
Alternative name(s):
Voltage-gated potassium channel subunit Kv10.1
Voltage-gated potassium channel subunit Kv6.3
Gene namesi
Name:Kcng3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:2663923. Kcng3.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Cytoplasm By similarity
Note: Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1 (By similarity).By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Potassium voltage-gated channel subfamily G member 3PRO_0000054078Add
BLAST

Proteomic databases

PRIDEiP59053.

PTM databases

PhosphoSiteiP59053.

Expressioni

Gene expression databases

BgeeiP59053.
GenevestigatoriP59053.

Interactioni

Subunit structurei

Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054910.

Structurei

3D structure databases

ProteinModelPortaliP59053.
SMRiP59053. Positions 11-414.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 164164CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini240 – 25213CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini305 – 31915CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini411 – 43323CytoplasmicSequence AnalysisAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei358 – 37821Pore-forming; Name=Segment H5Sequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei165 – 18521Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei219 – 23921Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei253 – 27321Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei284 – 30421Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei320 – 34021Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei385 – 41026Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi370 – 3756Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiP59053.
KOiK04902.
OMAiHMCELSF.
OrthoDBiEOG7VB2F7.
PhylomeDBiP59053.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P59053-1) [UniParc]FASTAAdd to Basket

Also known as: Kv10.1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTFGRGGAAS VVLNVGGARY SLSRELLKDF PLRRVSRLHG CRSERDVLEV
60 70 80 90 100
CDDYDRERNE YFFDRHSEAF GFILLYVRGH GKLRFAPRMC ELSFYNEMIY
110 120 130 140 150
WGLEGAHLEY CCQRRLDDRM SDTHTFHAAD ELGREQPRPA GPEAAPSRRW
160 170 180 190 200
LERMRRTFEE PTSSLAAQIL ASVSVVFVIV SMVVLCASTL PDWRAAVADN
210 220 230 240 250
RSLDDRSRYS ASPGREPSGI IEAICIGWFT AECIVRFIVS KNKCEFVKRP
260 270 280 290 300
LNIIDLLAIT PYYISVLMTV FTGENSQLQR AGVTLRVLRM MRIFWVIKLA
310 320 330 340 350
RHFIGLQTLG LTLKRCYREM AMLLVFICVA MAIFSALSQL LEHGLDLETS
360 370 380 390 400
NKDFASIPAA CWWVIISMTT VGYGDMYPIT VPGRILGGVC VVSGIVLLAL
410 420 430
PITFIYHSFV QCYHELKFRS ARYSRSLSAE FLN
Length:433
Mass (Da):49,247
Last modified:October 25, 2002 - v1
Checksum:iE9A7C010F4B0CA6C
GO
Isoform 2 (identifier: P59053-2) [UniParc]FASTAAdd to Basket

Also known as: Kv10.1a

The sequence of this isoform differs from the canonical sequence as follows:
     209-219: Missing.

Show »
Length:422
Mass (Da):48,158
Checksum:iB76D12B546E3A5C0
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei209 – 21911Missing in isoform 2. 1 PublicationVSP_001027Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF454551 mRNA. Translation: AAM93552.1.
AF454552 mRNA. Translation: AAM93553.1.
CCDSiCCDS28996.1. [P59053-1]
RefSeqiNP_705732.1. NM_153512.1. [P59053-1]
XP_006524263.1. XM_006524200.1. [P59053-2]
UniGeneiMm.223506.

Genome annotation databases

EnsembliENSMUST00000051482; ENSMUSP00000054910; ENSMUSG00000045053. [P59053-1]
GeneIDi225030.
KEGGimmu:225030.
UCSCiuc008dsd.1. mouse. [P59053-1]
uc008dse.1. mouse. [P59053-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF454551 mRNA. Translation: AAM93552.1 .
AF454552 mRNA. Translation: AAM93553.1 .
CCDSi CCDS28996.1. [P59053-1 ]
RefSeqi NP_705732.1. NM_153512.1. [P59053-1 ]
XP_006524263.1. XM_006524200.1. [P59053-2 ]
UniGenei Mm.223506.

3D structure databases

ProteinModelPortali P59053.
SMRi P59053. Positions 11-414.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000054910.

PTM databases

PhosphoSitei P59053.

Proteomic databases

PRIDEi P59053.

Protocols and materials databases

DNASUi 225030.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000051482 ; ENSMUSP00000054910 ; ENSMUSG00000045053 . [P59053-1 ]
GeneIDi 225030.
KEGGi mmu:225030.
UCSCi uc008dsd.1. mouse. [P59053-1 ]
uc008dse.1. mouse. [P59053-2 ]

Organism-specific databases

CTDi 170850.
MGIi MGI:2663923. Kcng3.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00760000118981.
HOGENOMi HOG000231014.
HOVERGENi HBG100172.
InParanoidi P59053.
KOi K04902.
OMAi HMCELSF.
OrthoDBi EOG7VB2F7.
PhylomeDBi P59053.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 377516.
PROi P59053.
SOURCEi Search...

Gene expression databases

Bgeei P59053.
Genevestigatori P59053.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Kv10.1a and Kv10.1b: two novel alternatively spliced potassium channel subunits."
    Vega-Saenz de Miera E.C., Rudy B.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).

Entry informationi

Entry nameiKCNG3_MOUSE
AccessioniPrimary (citable) accession number: P59053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3