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P59053

- KCNG3_MOUSE

UniProt

P59053 - KCNG3_MOUSE

Protein

Potassium voltage-gated channel subfamily G member 3

Gene

Kcng3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (25 Oct 2002)
      Previous versions | rss
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    Functioni

    Potassium channel subunit. Modulates channel activity By similarity.By similarity

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome
    2. voltage-gated potassium channel activity Source: MGI

    GO - Biological processi

    1. potassium ion transport Source: MGI
    2. protein homooligomerization Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199077. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily G member 3
    Alternative name(s):
    Voltage-gated potassium channel subunit Kv10.1
    Voltage-gated potassium channel subunit Kv6.3
    Gene namesi
    Name:Kcng3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:2663923. Kcng3.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Cytoplasm By similarity
    Note: Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1 By similarity.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Potassium voltage-gated channel subfamily G member 3PRO_0000054078Add
    BLAST

    Proteomic databases

    PRIDEiP59053.

    PTM databases

    PhosphoSiteiP59053.

    Expressioni

    Gene expression databases

    BgeeiP59053.
    GenevestigatoriP59053.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000054910.

    Structurei

    3D structure databases

    ProteinModelPortaliP59053.
    SMRiP59053. Positions 11-414.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 164164CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini240 – 25213CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini305 – 31915CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini411 – 43323CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei358 – 37821Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei165 – 18521Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei219 – 23921Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei253 – 27321Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei284 – 30421Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei320 – 34021Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei385 – 41026Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi370 – 3756Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    GeneTreeiENSGT00730000110784.
    HOGENOMiHOG000231014.
    HOVERGENiHBG100172.
    InParanoidiP59053.
    KOiK04902.
    OMAiHMCELSF.
    OrthoDBiEOG7VB2F7.
    PhylomeDBiP59053.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P59053-1) [UniParc]FASTAAdd to Basket

    Also known as: Kv10.1b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTFGRGGAAS VVLNVGGARY SLSRELLKDF PLRRVSRLHG CRSERDVLEV    50
    CDDYDRERNE YFFDRHSEAF GFILLYVRGH GKLRFAPRMC ELSFYNEMIY 100
    WGLEGAHLEY CCQRRLDDRM SDTHTFHAAD ELGREQPRPA GPEAAPSRRW 150
    LERMRRTFEE PTSSLAAQIL ASVSVVFVIV SMVVLCASTL PDWRAAVADN 200
    RSLDDRSRYS ASPGREPSGI IEAICIGWFT AECIVRFIVS KNKCEFVKRP 250
    LNIIDLLAIT PYYISVLMTV FTGENSQLQR AGVTLRVLRM MRIFWVIKLA 300
    RHFIGLQTLG LTLKRCYREM AMLLVFICVA MAIFSALSQL LEHGLDLETS 350
    NKDFASIPAA CWWVIISMTT VGYGDMYPIT VPGRILGGVC VVSGIVLLAL 400
    PITFIYHSFV QCYHELKFRS ARYSRSLSAE FLN 433
    Length:433
    Mass (Da):49,247
    Last modified:October 25, 2002 - v1
    Checksum:iE9A7C010F4B0CA6C
    GO
    Isoform 2 (identifier: P59053-2) [UniParc]FASTAAdd to Basket

    Also known as: Kv10.1a

    The sequence of this isoform differs from the canonical sequence as follows:
         209-219: Missing.

    Show »
    Length:422
    Mass (Da):48,158
    Checksum:iB76D12B546E3A5C0
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei209 – 21911Missing in isoform 2. 1 PublicationVSP_001027Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF454551 mRNA. Translation: AAM93552.1.
    AF454552 mRNA. Translation: AAM93553.1.
    CCDSiCCDS28996.1. [P59053-1]
    RefSeqiNP_705732.1. NM_153512.1. [P59053-1]
    XP_006524263.1. XM_006524200.1. [P59053-2]
    UniGeneiMm.223506.

    Genome annotation databases

    EnsembliENSMUST00000051482; ENSMUSP00000054910; ENSMUSG00000045053. [P59053-1]
    GeneIDi225030.
    KEGGimmu:225030.
    UCSCiuc008dsd.1. mouse. [P59053-1]
    uc008dse.1. mouse. [P59053-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF454551 mRNA. Translation: AAM93552.1 .
    AF454552 mRNA. Translation: AAM93553.1 .
    CCDSi CCDS28996.1. [P59053-1 ]
    RefSeqi NP_705732.1. NM_153512.1. [P59053-1 ]
    XP_006524263.1. XM_006524200.1. [P59053-2 ]
    UniGenei Mm.223506.

    3D structure databases

    ProteinModelPortali P59053.
    SMRi P59053. Positions 11-414.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000054910.

    PTM databases

    PhosphoSitei P59053.

    Proteomic databases

    PRIDEi P59053.

    Protocols and materials databases

    DNASUi 225030.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000051482 ; ENSMUSP00000054910 ; ENSMUSG00000045053 . [P59053-1 ]
    GeneIDi 225030.
    KEGGi mmu:225030.
    UCSCi uc008dsd.1. mouse. [P59053-1 ]
    uc008dse.1. mouse. [P59053-2 ]

    Organism-specific databases

    CTDi 170850.
    MGIi MGI:2663923. Kcng3.

    Phylogenomic databases

    eggNOGi COG1226.
    GeneTreei ENSGT00730000110784.
    HOGENOMi HOG000231014.
    HOVERGENi HBG100172.
    InParanoidi P59053.
    KOi K04902.
    OMAi HMCELSF.
    OrthoDBi EOG7VB2F7.
    PhylomeDBi P59053.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_199077. Voltage gated Potassium channels.

    Miscellaneous databases

    NextBioi 377516.
    PROi P59053.
    SOURCEi Search...

    Gene expression databases

    Bgeei P59053.
    Genevestigatori P59053.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Kv10.1a and Kv10.1b: two novel alternatively spliced potassium channel subunits."
      Vega-Saenz de Miera E.C., Rudy B.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).

    Entry informationi

    Entry nameiKCNG3_MOUSE
    AccessioniPrimary (citable) accession number: P59053
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: October 25, 2002
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3