P59052 (CU088_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative uncharacterized protein C21orf88

Gene names

Name:

C21orf88

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Tissue specificity	Ubiquitous.
Caution	Product of a dubious CDS prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P59052-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P59052-2)

The sequence of this isoform differs from the canonical sequence as follows:
     52-64: GGQKSHGLCWLLC → NIQWHKRDQLGDN
     65-145: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 145	145	Putative uncharacterized protein C21orf88		PRO_0000079538
Natural variations
	Alternative sequence	52 – 64	13	GGQKS…CWLLC → NIQWHKRDQLGDN in isoform 2.		VSP_003836
	Alternative sequence	65 – 145	81	Missing in isoform 2.		VSP_003837
Experimental info
	Sequence conflict	81	1	C → W in AAM53522. Ref.1
	Sequence conflict	81	1	C → W in BC119737. Ref.4
	Sequence conflict	81	1	C → W in BC119738. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: C03DC22DB80E0C51	FASTA	145	15,706
	10 20 30 40 50 60 MRRLRHREVR GPVLGHTATG GPQNGTSGCT TAPQQRPPPG TQGMLEQYLN RGGQKSHGLC 70 80 90 100 110 120 WLLCFVSQGQ NQDVISAELW CRIHVQAHWG CWQNSAVWGC RNEVLVSLLA VGQGLPSASG 130 140 GRLPSLVHGP SHPDSQHPRE VPLAL
	Isoform 2 [UniParc]. Checksum: F5896ECA90C0EFDA	FASTA	64	7,173
	10 20 30 40 50 60 MRRLRHREVR GPVLGHTATG GPQNGTSGCT TAPQQRPPPG TQGMLEQYLN RNIQWHKRDQ LGDN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nineteen additional unpredicted transcripts from human chromosome 21." Reymond A., Camargo A.A., Deutsch S., Stevenson B.J., Parmigiani R.B., Ucla C., Bettoni F., Rossier C., Lyle R., Guipponi M., de Souza S., Iseli C., Jongeneel C.V., Bucher P., Simpson A.J.G., Antonarakis S.E. Genomics 79:824-832(2002) [PubMed: 12036297] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed: 10830953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF426266 mRNA. Translation: AAM53522.1. AF426267 mRNA. Translation: AAM53523.1. AF064860 Genomic DNA. No translation available. CH471079 Genomic DNA. Translation: EAX09636.1. BC119737 mRNA. No translation available. BC119738 mRNA. No translation available.
IPI	IPI00168289. IPI00218783.
UniGene	Hs.375120.
3D structure databases
ProteinModelPortal	P59052.
ModBase	Search...
Proteomic databases
PRIDE	P59052.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000380612; ENSP00000369986; ENSG00000184809.
Organism-specific databases
GeneCards	GC21M040969.
HGNC	HGNC:16424. C21orf88.
HPA	HPA021156.
neXtProt	NX_P59052.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21716.
GeneTree	ENSGT00390000018450.
InParanoid	P59052.
OMA	CWLLCFV.
OrthoDB	EOG4STS5V.
Gene expression databases
ArrayExpress	P59052.
Bgee	P59052.
CleanEx	HS_C21orf88.
Genevestigator	P59052.
GermOnline	ENSG00000184809. Homo sapiens.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

CU088_HUMAN

Accession

Primary (citable) accession number: P59052
Secondary accession number(s): Q0VDC1, Q547X5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	November 25, 2008
Last modified:	January 25, 2012
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.