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P59052

- CU088_HUMAN

UniProt

P59052 - CU088_HUMAN

Protein

Putative uncharacterized protein C21orf88

Gene

C21orf88

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative uncharacterized protein C21orf88
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 21

    Organism-specific databases

    HGNCiHGNC:16424. C21orf88.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 145145Putative uncharacterized protein C21orf88PRO_0000079538Add
    BLAST

    Proteomic databases

    PaxDbiP59052.
    PRIDEiP59052.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiP59052.
    BgeeiP59052.
    CleanExiHS_C21orf88.
    GenevestigatoriP59052.

    Organism-specific databases

    HPAiHPA021156.

    Structurei

    3D structure databases

    ProteinModelPortaliP59052.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG86931.
    HOGENOMiHOG000112064.
    InParanoidiP59052.
    OMAiCWLLCFV.
    OrthoDBiEOG7PVWR1.
    PhylomeDBiP59052.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P59052-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRRLRHREVR GPVLGHTATG GPQNGTSGCT TAPQQRPPPG TQGMLEQYLN    50
    RGGQKSHGLC WLLCFVSQGQ NQDVISAELW CRIHVQAHWG CWQNSAVWGC 100
    RNEVLVSLLA VGQGLPSASG GRLPSLVHGP SHPDSQHPRE VPLAL 145
    Length:145
    Mass (Da):15,706
    Last modified:November 25, 2008 - v2
    Checksum:iC03DC22DB80E0C51
    GO
    Isoform 2 (identifier: P59052-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         52-64: GGQKSHGLCWLLC → NIQWHKRDQLGDN
         65-145: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:64
    Mass (Da):7,173
    Checksum:iF5896ECA90C0EFDA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 811C → W in AAM53522. (PubMed:12036297)Curated
    Sequence conflicti81 – 811C → W in BC119737. (PubMed:15489334)Curated
    Sequence conflicti81 – 811C → W in BC119738. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei52 – 6413GGQKS…CWLLC → NIQWHKRDQLGDN in isoform 2. 1 PublicationVSP_003836Add
    BLAST
    Alternative sequencei65 – 14581Missing in isoform 2. 1 PublicationVSP_003837Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF426266 mRNA. Translation: AAM53522.1.
    AF426267 mRNA. Translation: AAM53523.1.
    AF064860 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09636.1.
    BC119737 mRNA. No translation available.
    BC119738 mRNA. No translation available.
    UniGeneiHs.375120.

    Genome annotation databases

    EnsembliENST00000380604; ENSP00000369978; ENSG00000184809. [P59052-2]
    ENST00000380612; ENSP00000369986; ENSG00000184809. [P59052-1]
    UCSCiuc010gok.4. human. [P59052-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF426266 mRNA. Translation: AAM53522.1 .
    AF426267 mRNA. Translation: AAM53523.1 .
    AF064860 Genomic DNA. No translation available.
    CH471079 Genomic DNA. Translation: EAX09636.1 .
    BC119737 mRNA. No translation available.
    BC119738 mRNA. No translation available.
    UniGenei Hs.375120.

    3D structure databases

    ProteinModelPortali P59052.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P59052.
    PRIDEi P59052.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380604 ; ENSP00000369978 ; ENSG00000184809 . [P59052-2 ]
    ENST00000380612 ; ENSP00000369986 ; ENSG00000184809 . [P59052-1 ]
    UCSCi uc010gok.4. human. [P59052-1 ]

    Organism-specific databases

    GeneCardsi GC21M040969.
    HGNCi HGNC:16424. C21orf88.
    HPAi HPA021156.
    neXtProti NX_P59052.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG86931.
    HOGENOMi HOG000112064.
    InParanoidi P59052.
    OMAi CWLLCFV.
    OrthoDBi EOG7PVWR1.
    PhylomeDBi P59052.

    Gene expression databases

    ArrayExpressi P59052.
    Bgeei P59052.
    CleanExi HS_C21orf88.
    Genevestigatori P59052.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. "The DNA sequence of human chromosome 21."
      Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
      , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
      Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

    Entry informationi

    Entry nameiCU088_HUMAN
    AccessioniPrimary (citable) accession number: P59052
    Secondary accession number(s): Q0VDC1, Q547X5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 72 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 21
      Human chromosome 21: entries, gene names and cross-references to MIM

    External Data

    Dasty 3