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P59052

- CU088_HUMAN

UniProt

P59052 - CU088_HUMAN

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Protein

Putative uncharacterized protein C21orf88

Gene
C21orf88
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Protein uncertaini

Names & Taxonomyi

Protein namesi
Recommended name:
Putative uncharacterized protein C21orf88
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 21

Organism-specific databases

HGNCiHGNC:16424. C21orf88.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145Putative uncharacterized protein C21orf88PRO_0000079538Add
BLAST

Proteomic databases

PaxDbiP59052.
PRIDEiP59052.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ArrayExpressiP59052.
BgeeiP59052.
CleanExiHS_C21orf88.
GenevestigatoriP59052.

Organism-specific databases

HPAiHPA021156.

Structurei

3D structure databases

ProteinModelPortaliP59052.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG86931.
HOGENOMiHOG000112064.
InParanoidiP59052.
OMAiCWLLCFV.
OrthoDBiEOG7PVWR1.
PhylomeDBiP59052.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P59052-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRRLRHREVR GPVLGHTATG GPQNGTSGCT TAPQQRPPPG TQGMLEQYLN    50
RGGQKSHGLC WLLCFVSQGQ NQDVISAELW CRIHVQAHWG CWQNSAVWGC 100
RNEVLVSLLA VGQGLPSASG GRLPSLVHGP SHPDSQHPRE VPLAL 145
Length:145
Mass (Da):15,706
Last modified:November 25, 2008 - v2
Checksum:iC03DC22DB80E0C51
GO
Isoform 2 (identifier: P59052-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-64: GGQKSHGLCWLLC → NIQWHKRDQLGDN
     65-145: Missing.

Note: No experimental confirmation available.

Show »
Length:64
Mass (Da):7,173
Checksum:iF5896ECA90C0EFDA
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei52 – 6413GGQKS…CWLLC → NIQWHKRDQLGDN in isoform 2. VSP_003836Add
BLAST
Alternative sequencei65 – 14581Missing in isoform 2. VSP_003837Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811C → W in AAM53522. 1 Publication
Sequence conflicti81 – 811C → W in BC119737. 1 Publication
Sequence conflicti81 – 811C → W in BC119738. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF426266 mRNA. Translation: AAM53522.1.
AF426267 mRNA. Translation: AAM53523.1.
AF064860 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09636.1.
BC119737 mRNA. No translation available.
BC119738 mRNA. No translation available.
UniGeneiHs.375120.

Genome annotation databases

EnsembliENST00000380604; ENSP00000369978; ENSG00000184809. [P59052-2]
ENST00000380612; ENSP00000369986; ENSG00000184809. [P59052-1]
UCSCiuc010gok.4. human. [P59052-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF426266 mRNA. Translation: AAM53522.1 .
AF426267 mRNA. Translation: AAM53523.1 .
AF064860 Genomic DNA. No translation available.
CH471079 Genomic DNA. Translation: EAX09636.1 .
BC119737 mRNA. No translation available.
BC119738 mRNA. No translation available.
UniGenei Hs.375120.

3D structure databases

ProteinModelPortali P59052.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P59052.
PRIDEi P59052.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380604 ; ENSP00000369978 ; ENSG00000184809 . [P59052-2 ]
ENST00000380612 ; ENSP00000369986 ; ENSG00000184809 . [P59052-1 ]
UCSCi uc010gok.4. human. [P59052-1 ]

Organism-specific databases

GeneCardsi GC21M040969.
HGNCi HGNC:16424. C21orf88.
HPAi HPA021156.
neXtProti NX_P59052.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG86931.
HOGENOMi HOG000112064.
InParanoidi P59052.
OMAi CWLLCFV.
OrthoDBi EOG7PVWR1.
PhylomeDBi P59052.

Gene expression databases

ArrayExpressi P59052.
Bgeei P59052.
CleanExi HS_C21orf88.
Genevestigatori P59052.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiCU088_HUMAN
AccessioniPrimary (citable) accession number: P59052
Secondary accession number(s): Q0VDC1, Q547X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM

External Data

Dasty 3

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