P59050 (LDH1_BIFLO) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 71.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: L-lactate dehydrogenase 1 Short name=L-LDH 1 EC=1.1.1.27 | ||||
| Gene names |
| ||||
| Organism | Bifidobacterium longum (strain NCC 2705) | ||||
| Taxonomic identifier | 206672 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium |
Protein attributes
| Sequence length | 316 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | (S)-lactate + NAD+ = pyruvate + NADH. HAMAP MF_00488 |
| Pathway | Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. HAMAP MF_00488 |
| Subunit structure | Homotetramer By similarity. HAMAP MF_00488 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00488. |
| Sequence similarities | Belongs to the LDH/MDH superfamily. LDH family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycolysis |
| Cellular component | Cytoplasm |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | glycolysis Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | L-lactate dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 316 | 316 | L-lactate dehydrogenase 1 HAMAP MF_00488 | PRO_0000168330 | |||||
Regions | |||||||||
| Nucleotide binding | 15 – 43 | 29 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 179 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 92 | 1 | Substrate By similarity | ||||||
| Binding site | 124 | 1 | NAD or substrate By similarity | ||||||
| Binding site | 155 | 1 | Substrate By similarity | ||||||
| Binding site | 234 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract." Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F. Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed: 12381787] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCC 2705. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE014295 Genomic DNA. Translation: AAN24529.1. |
| RefSeq | NP_695893.1. NC_004307.2. |
3D structure databases | |
| ProteinModelPortal | P59050. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1023257. |
| GenomeReviews | Gene locus BL0710 in contig AE014295_GR. |
| KEGG | blo:BL0710. |
| NMPDR | fig|206672.1.peg.660. |
| PATRIC | 21117861. VBIBifLon107831_0409. |
Phylogenomic databases | |
| HOGENOM | HBG566126. |
| OMA | NEYSMEK. |
| PhylomeDB | P59050. |
| ProtClustDB | CLSK2304224. |
Enzyme and pathway databases | |
| BioCyc | BLON206672:BL0710-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00488. Lactate_dehydrog. [Tree] |
| InterPro | IPR001557. L-lactate/malate_DH. IPR011304. L-lactate_DH. IPR018177. L-lactate_DH_AS. IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.90.110.10. lact_mal_DH. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| KO | K00016. |
| PANTHER | PTHR11540:SF3. PTHR11540:SF3. 1 hit. |
| Pfam | PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000102. Lac_mal_DH. 1 hit. |
| PRINTS | PR00086. LLDHDRGNASE. |
| SUPFAM | SSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit. |
| TIGRFAMs | TIGR01771. L-LDH-NAD. 1 hit. |
| PROSITE | PS00064. L_LDH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LDH1_BIFLO | ||||||||
| Accession | Primary (citable) accession number: P59050 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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