ID   RTP1_HUMAN              Reviewed;         263 AA.
AC   P59025;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 2.
DT   24-JAN-2024, entry version 154.
DE   RecName: Full=Receptor-transporting protein 1;
DE   AltName: Full=3CxxC-type zinc finger protein 1;
GN   Name=RTP1; Synonyms=Z3CXXC1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 37-263.
RX   PubMed=15550249; DOI=10.1016/j.cell.2004.11.021;
RA   Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.;
RT   "RTP family members induce functional expression of mammalian odorant
RT   receptors.";
RL   Cell 119:679-691(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=16720576; DOI=10.1074/jbc.m513637200;
RA   Behrens M., Bartelt J., Reichling C., Winnig M., Kuhn C., Meyerhof W.;
RT   "Members of RTP and REEP gene families influence functional bitter taste
RT   receptor expression.";
RL   J. Biol. Chem. 281:20650-20659(2006).
RN   [4]
RP   VARIANT [LARGE SCALE ANALYSIS] SER-124.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: Specifically promotes functional cell surface expression of
CC       olfactory receptors, but not of other GPCRs. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with olfactory receptors. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type III
CC       membrane protein {ECO:0000250}. Note=Effective cell surface expression
CC       depends upon interaction with olfactory receptors. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in testis. {ECO:0000269|PubMed:16720576}.
CC   -!- SIMILARITY: Belongs to the TMEM7 family. {ECO:0000305}.
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DR   EMBL; BC034744; AAH34744.4; -; mRNA.
DR   EMBL; BC065202; AAH65202.2; -; mRNA.
DR   EMBL; AY562235; AAT70680.1; -; mRNA.
DR   CCDS; CCDS3287.2; -.
DR   RefSeq; NP_714919.2; NM_153708.2.
DR   AlphaFoldDB; P59025; -.
DR   BioGRID; 126305; 1.
DR   STRING; 9606.ENSP00000311712; -.
DR   iPTMnet; P59025; -.
DR   PhosphoSitePlus; P59025; -.
DR   BioMuta; RTP1; -.
DR   DMDM; 61252249; -.
DR   MassIVE; P59025; -.
DR   PaxDb; 9606-ENSP00000311712; -.
DR   PeptideAtlas; P59025; -.
DR   ProteomicsDB; 57108; -.
DR   Antibodypedia; 46840; 100 antibodies from 19 providers.
DR   DNASU; 132112; -.
DR   Ensembl; ENST00000312295.5; ENSP00000311712.4; ENSG00000175077.6.
DR   Ensembl; ENST00000707985.1; ENSP00000517059.1; ENSG00000291554.1.
DR   GeneID; 132112; -.
DR   KEGG; hsa:132112; -.
DR   MANE-Select; ENST00000312295.5; ENSP00000311712.4; NM_153708.3; NP_714919.2.
DR   UCSC; uc003frg.3; human.
DR   AGR; HGNC:28580; -.
DR   CTD; 132112; -.
DR   DisGeNET; 132112; -.
DR   GeneCards; RTP1; -.
DR   HGNC; HGNC:28580; RTP1.
DR   HPA; ENSG00000175077; Tissue enhanced (brain).
DR   MIM; 609137; gene.
DR   neXtProt; NX_P59025; -.
DR   OpenTargets; ENSG00000175077; -.
DR   PharmGKB; PA143485604; -.
DR   VEuPathDB; HostDB:ENSG00000175077; -.
DR   eggNOG; ENOG502S1UZ; Eukaryota.
DR   GeneTree; ENSGT00940000161858; -.
DR   HOGENOM; CLU_092465_0_0_1; -.
DR   InParanoid; P59025; -.
DR   OMA; WDFIIDP; -.
DR   OrthoDB; 3020199at2759; -.
DR   PhylomeDB; P59025; -.
DR   TreeFam; TF333246; -.
DR   PathwayCommons; P59025; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; P59025; -.
DR   BioGRID-ORCS; 132112; 12 hits in 1138 CRISPR screens.
DR   GenomeRNAi; 132112; -.
DR   Pharos; P59025; Tbio.
DR   PRO; PR:P59025; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; P59025; Protein.
DR   Bgee; ENSG00000175077; Expressed in oocyte and 55 other cell types or tissues.
DR   GO; GO:0009986; C:cell surface; IDA:HGNC-UCL.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0031849; F:olfactory receptor binding; IMP:HGNC-UCL.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR   GO; GO:0051205; P:protein insertion into membrane; IDA:HGNC-UCL.
DR   GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR   InterPro; IPR026096; R-trans_p.
DR   InterPro; IPR027377; ZAR1/RTP1-5-like_Znf-3CxxC.
DR   PANTHER; PTHR14402; RECEPTOR TRANSPORTING PROTEIN; 1.
DR   PANTHER; PTHR14402:SF19; RECEPTOR-TRANSPORTING PROTEIN 1; 1.
DR   Pfam; PF13695; zf-3CxxC; 1.
DR   SMART; SM01328; zf-3CxxC; 1.
DR   Genevisible; P59025; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Metal-binding; Reference proteome; Transmembrane;
KW   Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..263
FT                   /note="Receptor-transporting protein 1"
FT                   /id="PRO_0000181988"
FT   TOPO_DOM        1..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..263
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         88..197
FT                   /note="3CxxC-type"
FT                   /evidence="ECO:0000255"
FT   VARIANT         124
FT                   /note="R -> S (in a breast cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_036122"
FT   VARIANT         212
FT                   /note="A -> G (in dbSNP:rs35053281)"
FT                   /id="VAR_053729"
FT   VARIANT         229
FT                   /note="Q -> E (in dbSNP:rs6764714)"
FT                   /id="VAR_053730"
SQ   SEQUENCE   263 AA;  30913 MW;  80B2F845DDC81F2B CRC64;
     MRIFRPWRLR CPALHLPSLS VFSLRWKLPS LTTDETMCKS VTTDEWKKVF YEKMEEAKPA
     DSWDLIIDPN LKHNVLSPGW KQYLELHASG RFHCSWCWHT WQSPYVVILF HMFLDRAQRA
     GSVRMRVFKQ LCYECGTARL DESSMLEENI EGLVDNLITS LREQCYGERG GQYRIHVASR
     QDNRRHRGEF CEACQEGIVH WKPSEKLLEE EATTYTFSRA PSPTKSQDQT GSGWNFCSIP
     WCLFWATVLL LIIYLQFSFR SSV
//