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Protein

Receptor-transporting protein 1

Gene

RTP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.By similarity

GO - Molecular functioni

  • olfactory receptor binding Source: HGNC

GO - Biological processi

  • protein insertion into membrane Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-transporting protein 1
Alternative name(s):
3CxxC-type zinc finger protein 1
Gene namesi
Name:RTP1
Synonyms:Z3CXXC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28580. RTP1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 238238CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST
Topological domaini260 – 2634ExtracellularSequence Analysis

GO - Cellular componenti

  • cell surface Source: HGNC
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485604.

Polymorphism and mutation databases

BioMutaiRTP1.
DMDMi61252249.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Receptor-transporting protein 1PRO_0000181988Add
BLAST

Proteomic databases

PaxDbiP59025.
PRIDEiP59025.

PTM databases

PhosphoSiteiP59025.

Expressioni

Gene expression databases

BgeeiP59025.
CleanExiHS_RTP1.
GenevisibleiP59025. HS.

Interactioni

Subunit structurei

Interacts with olfactory receptors.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000311712.

Structurei

3D structure databases

ProteinModelPortaliP59025.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM7 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG29570.
GeneTreeiENSGT00530000063222.
HOGENOMiHOG000060180.
HOVERGENiHBG079158.
InParanoidiP59025.
OMAiGSGCNFC.
OrthoDBiEOG7N8ZW9.
PhylomeDBiP59025.
TreeFamiTF333246.

Family and domain databases

InterProiIPR026096. R-trans_p/CXXC11.
IPR026692. RTP1.
IPR027377. Znf-3CxxC.
[Graphical view]
PANTHERiPTHR14402. PTHR14402. 1 hit.
PTHR14402:SF1. PTHR14402:SF1. 1 hit.
PfamiPF13695. zf-3CxxC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59025-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIFRPWRLR CPALHLPSLS VFSLRWKLPS LTTDETMCKS VTTDEWKKVF
60 70 80 90 100
YEKMEEAKPA DSWDLIIDPN LKHNVLSPGW KQYLELHASG RFHCSWCWHT
110 120 130 140 150
WQSPYVVILF HMFLDRAQRA GSVRMRVFKQ LCYECGTARL DESSMLEENI
160 170 180 190 200
EGLVDNLITS LREQCYGERG GQYRIHVASR QDNRRHRGEF CEACQEGIVH
210 220 230 240 250
WKPSEKLLEE EATTYTFSRA PSPTKSQDQT GSGWNFCSIP WCLFWATVLL
260
LIIYLQFSFR SSV
Length:263
Mass (Da):30,913
Last modified:March 15, 2005 - v2
Checksum:i80B2F845DDC81F2B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241R → S in a breast cancer sample; somatic mutation. 1 Publication
VAR_036122
Natural varianti212 – 2121A → G.
Corresponds to variant rs35053281 [ dbSNP | Ensembl ].
VAR_053729
Natural varianti229 – 2291Q → E.
Corresponds to variant rs6764714 [ dbSNP | Ensembl ].
VAR_053730

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034744 mRNA. Translation: AAH34744.4.
BC065202 mRNA. Translation: AAH65202.2.
AY562235 mRNA. Translation: AAT70680.1.
CCDSiCCDS3287.2.
RefSeqiNP_714919.2. NM_153708.2.
UniGeneiHs.518480.

Genome annotation databases

EnsembliENST00000312295; ENSP00000311712; ENSG00000175077.
GeneIDi132112.
KEGGihsa:132112.
UCSCiuc003frg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034744 mRNA. Translation: AAH34744.4.
BC065202 mRNA. Translation: AAH65202.2.
AY562235 mRNA. Translation: AAT70680.1.
CCDSiCCDS3287.2.
RefSeqiNP_714919.2. NM_153708.2.
UniGeneiHs.518480.

3D structure databases

ProteinModelPortaliP59025.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000311712.

PTM databases

PhosphoSiteiP59025.

Polymorphism and mutation databases

BioMutaiRTP1.
DMDMi61252249.

Proteomic databases

PaxDbiP59025.
PRIDEiP59025.

Protocols and materials databases

DNASUi132112.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312295; ENSP00000311712; ENSG00000175077.
GeneIDi132112.
KEGGihsa:132112.
UCSCiuc003frg.3. human.

Organism-specific databases

CTDi132112.
GeneCardsiGC03P186915.
H-InvDBHIX0024412.
HGNCiHGNC:28580. RTP1.
MIMi609137. gene.
neXtProtiNX_P59025.
PharmGKBiPA143485604.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG29570.
GeneTreeiENSGT00530000063222.
HOGENOMiHOG000060180.
HOVERGENiHBG079158.
InParanoidiP59025.
OMAiGSGCNFC.
OrthoDBiEOG7N8ZW9.
PhylomeDBiP59025.
TreeFamiTF333246.

Miscellaneous databases

GenomeRNAii132112.
NextBioi83014.
PROiP59025.
SOURCEiSearch...

Gene expression databases

BgeeiP59025.
CleanExiHS_RTP1.
GenevisibleiP59025. HS.

Family and domain databases

InterProiIPR026096. R-trans_p/CXXC11.
IPR026692. RTP1.
IPR027377. Znf-3CxxC.
[Graphical view]
PANTHERiPTHR14402. PTHR14402. 1 hit.
PTHR14402:SF1. PTHR14402:SF1. 1 hit.
PfamiPF13695. zf-3CxxC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "RTP family members induce functional expression of mammalian odorant receptors."
    Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.
    Cell 119:679-691(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 37-263.
  3. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-124.

Entry informationi

Entry nameiRTP1_HUMAN
AccessioniPrimary (citable) accession number: P59025
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 15, 2005
Last modified: July 22, 2015
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.