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P59025

- RTP1_HUMAN

UniProt

P59025 - RTP1_HUMAN

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Protein

Receptor-transporting protein 1

Gene
RTP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs By similarity.

GO - Molecular functioni

  1. olfactory receptor binding Source: HGNC

GO - Biological processi

  1. protein insertion into membrane Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-transporting protein 1
Gene namesi
Name:RTP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:28580. RTP1.

Subcellular locationi

Cell membrane; Single-pass type III membrane protein By similarity
Note: Effective cell surface expression depends upon interaction with olfactory receptors By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 238238Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei239 – 25921Helical; Reviewed predictionAdd
BLAST
Topological domaini260 – 2634Extracellular Reviewed prediction

GO - Cellular componenti

  1. cell surface Source: HGNC
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485604.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Receptor-transporting protein 1PRO_0000181988Add
BLAST

Proteomic databases

PaxDbiP59025.
PRIDEiP59025.

PTM databases

PhosphoSiteiP59025.

Expressioni

Gene expression databases

BgeeiP59025.
CleanExiHS_RTP1.
GenevestigatoriP59025.

Interactioni

Subunit structurei

Interacts with olfactory receptors By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000311712.

Structurei

3D structure databases

ProteinModelPortaliP59025.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM7 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG29570.
HOGENOMiHOG000060180.
HOVERGENiHBG079158.
InParanoidiP59025.
OMAiDLIIDPN.
OrthoDBiEOG7N8ZW9.
PhylomeDBiP59025.
TreeFamiTF333246.

Family and domain databases

InterProiIPR026096. R-trans_p/CXXC11.
IPR026692. RTP1.
IPR027377. Znf-3CxxC.
[Graphical view]
PANTHERiPTHR14402. PTHR14402. 1 hit.
PTHR14402:SF1. PTHR14402:SF1. 1 hit.
PfamiPF13695. zf-3CxxC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59025-1 [UniParc]FASTAAdd to Basket

« Hide

MRIFRPWRLR CPALHLPSLS VFSLRWKLPS LTTDETMCKS VTTDEWKKVF    50
YEKMEEAKPA DSWDLIIDPN LKHNVLSPGW KQYLELHASG RFHCSWCWHT 100
WQSPYVVILF HMFLDRAQRA GSVRMRVFKQ LCYECGTARL DESSMLEENI 150
EGLVDNLITS LREQCYGERG GQYRIHVASR QDNRRHRGEF CEACQEGIVH 200
WKPSEKLLEE EATTYTFSRA PSPTKSQDQT GSGWNFCSIP WCLFWATVLL 250
LIIYLQFSFR SSV 263
Length:263
Mass (Da):30,913
Last modified:March 15, 2005 - v2
Checksum:i80B2F845DDC81F2B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241R → S in a breast cancer sample; somatic mutation. 1 Publication
VAR_036122
Natural varianti212 – 2121A → G.
Corresponds to variant rs35053281 [ dbSNP | Ensembl ].
VAR_053729
Natural varianti229 – 2291Q → E.
Corresponds to variant rs6764714 [ dbSNP | Ensembl ].
VAR_053730

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC034744 mRNA. Translation: AAH34744.4.
BC065202 mRNA. Translation: AAH65202.2.
AY562235 mRNA. Translation: AAT70680.1.
CCDSiCCDS3287.2.
RefSeqiNP_714919.2. NM_153708.2.
UniGeneiHs.518480.

Genome annotation databases

EnsembliENST00000312295; ENSP00000311712; ENSG00000175077.
GeneIDi132112.
KEGGihsa:132112.
UCSCiuc003frg.3. human.

Polymorphism databases

DMDMi61252249.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC034744 mRNA. Translation: AAH34744.4 .
BC065202 mRNA. Translation: AAH65202.2 .
AY562235 mRNA. Translation: AAT70680.1 .
CCDSi CCDS3287.2.
RefSeqi NP_714919.2. NM_153708.2.
UniGenei Hs.518480.

3D structure databases

ProteinModelPortali P59025.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000311712.

PTM databases

PhosphoSitei P59025.

Polymorphism databases

DMDMi 61252249.

Proteomic databases

PaxDbi P59025.
PRIDEi P59025.

Protocols and materials databases

DNASUi 132112.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000312295 ; ENSP00000311712 ; ENSG00000175077 .
GeneIDi 132112.
KEGGi hsa:132112.
UCSCi uc003frg.3. human.

Organism-specific databases

CTDi 132112.
GeneCardsi GC03P186915.
H-InvDB HIX0024412.
HGNCi HGNC:28580. RTP1.
MIMi 609137. gene.
neXtProti NX_P59025.
PharmGKBi PA143485604.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG29570.
HOGENOMi HOG000060180.
HOVERGENi HBG079158.
InParanoidi P59025.
OMAi DLIIDPN.
OrthoDBi EOG7N8ZW9.
PhylomeDBi P59025.
TreeFami TF333246.

Miscellaneous databases

GenomeRNAii 132112.
NextBioi 83014.
PROi P59025.
SOURCEi Search...

Gene expression databases

Bgeei P59025.
CleanExi HS_RTP1.
Genevestigatori P59025.

Family and domain databases

InterProi IPR026096. R-trans_p/CXXC11.
IPR026692. RTP1.
IPR027377. Znf-3CxxC.
[Graphical view ]
PANTHERi PTHR14402. PTHR14402. 1 hit.
PTHR14402:SF1. PTHR14402:SF1. 1 hit.
Pfami PF13695. zf-3CxxC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "RTP family members induce functional expression of mammalian odorant receptors."
    Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.
    Cell 119:679-691(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 37-263.
  3. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-124.

Entry informationi

Entry nameiRTP1_HUMAN
AccessioniPrimary (citable) accession number: P59025
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 15, 2005
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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