Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P59025 (RTP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Receptor-transporting protein 1
Gene names
Name:RTP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs By similarity.

Subunit structure

Interacts with olfactory receptors By similarity.

Subcellular location

Cell membrane; Single-pass type III membrane protein By similarity. Note: Effective cell surface expression depends upon interaction with olfactory receptors By similarity.

Sequence similarities

Belongs to the TMEM7 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein insertion into membrane

Inferred from direct assay Ref.2. Source: HGNC

   Cellular_componentcell surface

Inferred from direct assay Ref.2. Source: HGNC

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionolfactory receptor binding

Inferred from mutant phenotype Ref.2. Source: HGNC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 263263Receptor-transporting protein 1
PRO_0000181988

Regions

Topological domain1 – 238238Cytoplasmic Potential
Transmembrane239 – 25921Helical; Potential
Topological domain260 – 2634Extracellular Potential

Natural variations

Natural variant1241R → S in a breast cancer sample; somatic mutation. Ref.3
VAR_036122
Natural variant2121A → G.
Corresponds to variant rs35053281 [ dbSNP | Ensembl ].
VAR_053729
Natural variant2291Q → E.
Corresponds to variant rs6764714 [ dbSNP | Ensembl ].
VAR_053730

Sequences

Sequence LengthMass (Da)Tools
P59025 [UniParc].

Last modified March 15, 2005. Version 2.
Checksum: 80B2F845DDC81F2B

FASTA26330,913
        10         20         30         40         50         60 
MRIFRPWRLR CPALHLPSLS VFSLRWKLPS LTTDETMCKS VTTDEWKKVF YEKMEEAKPA 

        70         80         90        100        110        120 
DSWDLIIDPN LKHNVLSPGW KQYLELHASG RFHCSWCWHT WQSPYVVILF HMFLDRAQRA 

       130        140        150        160        170        180 
GSVRMRVFKQ LCYECGTARL DESSMLEENI EGLVDNLITS LREQCYGERG GQYRIHVASR 

       190        200        210        220        230        240 
QDNRRHRGEF CEACQEGIVH WKPSEKLLEE EATTYTFSRA PSPTKSQDQT GSGWNFCSIP 

       250        260 
WCLFWATVLL LIIYLQFSFR SSV 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"RTP family members induce functional expression of mammalian odorant receptors."
Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.
Cell 119:679-691(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 37-263.
[3]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-124.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC034744 mRNA. Translation: AAH34744.4.
BC065202 mRNA. Translation: AAH65202.2.
AY562235 mRNA. Translation: AAT70680.1.
RefSeqNP_714919.2. NM_153708.2.
UniGeneHs.518480.

3D structure databases

ProteinModelPortalP59025.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000311712.

PTM databases

PhosphoSiteP59025.

Polymorphism databases

DMDM61252249.

Proteomic databases

PaxDbP59025.
PRIDEP59025.

Protocols and materials databases

DNASU132112.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000312295; ENSP00000311712; ENSG00000175077.
GeneID132112.
KEGGhsa:132112.
UCSCuc003frg.3. human.

Organism-specific databases

CTD132112.
GeneCardsGC03P186915.
H-InvDBHIX0024412.
HGNCHGNC:28580. RTP1.
MIM609137. gene.
neXtProtNX_P59025.
PharmGKBPA143485604.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG29570.
HOGENOMHOG000060180.
HOVERGENHBG079158.
InParanoidP59025.
OMADLIIDPN.
OrthoDBEOG7N8ZW9.
PhylomeDBP59025.
TreeFamTF333246.

Gene expression databases

BgeeP59025.
CleanExHS_RTP1.
GenevestigatorP59025.

Family and domain databases

InterProIPR026096. R-trans_p/CXXC11.
IPR026692. RTP1/RTP2.
IPR027377. Znf-3CxxC.
[Graphical view]
PANTHERPTHR14402. PTHR14402. 1 hit.
PTHR14402:SF1. PTHR14402:SF1. 1 hit.
PfamPF13695. zf-3CxxC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi132112.
NextBio83014.
PROP59025.
SOURCESearch...

Entry information

Entry nameRTP1_HUMAN
AccessionPrimary (citable) accession number: P59025
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 15, 2005
Last modified: April 16, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM