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P59025

- RTP1_HUMAN

UniProt

P59025 - RTP1_HUMAN

Protein

Receptor-transporting protein 1

Gene

RTP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.By similarity

    GO - Molecular functioni

    1. olfactory receptor binding Source: HGNC

    GO - Biological processi

    1. protein insertion into membrane Source: HGNC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-transporting protein 1
    Gene namesi
    Name:RTP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:28580. RTP1.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type III membrane protein By similarity
    Note: Effective cell surface expression depends upon interaction with olfactory receptors.By similarity

    GO - Cellular componenti

    1. cell surface Source: HGNC
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485604.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263Receptor-transporting protein 1PRO_0000181988Add
    BLAST

    Proteomic databases

    PaxDbiP59025.
    PRIDEiP59025.

    PTM databases

    PhosphoSiteiP59025.

    Expressioni

    Gene expression databases

    BgeeiP59025.
    CleanExiHS_RTP1.
    GenevestigatoriP59025.

    Interactioni

    Subunit structurei

    Interacts with olfactory receptors.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000311712.

    Structurei

    3D structure databases

    ProteinModelPortaliP59025.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 238238CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 2634ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM7 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG29570.
    HOGENOMiHOG000060180.
    HOVERGENiHBG079158.
    InParanoidiP59025.
    OMAiDLIIDPN.
    OrthoDBiEOG7N8ZW9.
    PhylomeDBiP59025.
    TreeFamiTF333246.

    Family and domain databases

    InterProiIPR026096. R-trans_p/CXXC11.
    IPR026692. RTP1.
    IPR027377. Znf-3CxxC.
    [Graphical view]
    PANTHERiPTHR14402. PTHR14402. 1 hit.
    PTHR14402:SF1. PTHR14402:SF1. 1 hit.
    PfamiPF13695. zf-3CxxC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59025-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIFRPWRLR CPALHLPSLS VFSLRWKLPS LTTDETMCKS VTTDEWKKVF    50
    YEKMEEAKPA DSWDLIIDPN LKHNVLSPGW KQYLELHASG RFHCSWCWHT 100
    WQSPYVVILF HMFLDRAQRA GSVRMRVFKQ LCYECGTARL DESSMLEENI 150
    EGLVDNLITS LREQCYGERG GQYRIHVASR QDNRRHRGEF CEACQEGIVH 200
    WKPSEKLLEE EATTYTFSRA PSPTKSQDQT GSGWNFCSIP WCLFWATVLL 250
    LIIYLQFSFR SSV 263
    Length:263
    Mass (Da):30,913
    Last modified:March 15, 2005 - v2
    Checksum:i80B2F845DDC81F2B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti124 – 1241R → S in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036122
    Natural varianti212 – 2121A → G.
    Corresponds to variant rs35053281 [ dbSNP | Ensembl ].
    VAR_053729
    Natural varianti229 – 2291Q → E.
    Corresponds to variant rs6764714 [ dbSNP | Ensembl ].
    VAR_053730

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC034744 mRNA. Translation: AAH34744.4.
    BC065202 mRNA. Translation: AAH65202.2.
    AY562235 mRNA. Translation: AAT70680.1.
    CCDSiCCDS3287.2.
    RefSeqiNP_714919.2. NM_153708.2.
    UniGeneiHs.518480.

    Genome annotation databases

    EnsembliENST00000312295; ENSP00000311712; ENSG00000175077.
    GeneIDi132112.
    KEGGihsa:132112.
    UCSCiuc003frg.3. human.

    Polymorphism databases

    DMDMi61252249.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC034744 mRNA. Translation: AAH34744.4 .
    BC065202 mRNA. Translation: AAH65202.2 .
    AY562235 mRNA. Translation: AAT70680.1 .
    CCDSi CCDS3287.2.
    RefSeqi NP_714919.2. NM_153708.2.
    UniGenei Hs.518480.

    3D structure databases

    ProteinModelPortali P59025.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000311712.

    PTM databases

    PhosphoSitei P59025.

    Polymorphism databases

    DMDMi 61252249.

    Proteomic databases

    PaxDbi P59025.
    PRIDEi P59025.

    Protocols and materials databases

    DNASUi 132112.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312295 ; ENSP00000311712 ; ENSG00000175077 .
    GeneIDi 132112.
    KEGGi hsa:132112.
    UCSCi uc003frg.3. human.

    Organism-specific databases

    CTDi 132112.
    GeneCardsi GC03P186915.
    H-InvDB HIX0024412.
    HGNCi HGNC:28580. RTP1.
    MIMi 609137. gene.
    neXtProti NX_P59025.
    PharmGKBi PA143485604.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG29570.
    HOGENOMi HOG000060180.
    HOVERGENi HBG079158.
    InParanoidi P59025.
    OMAi DLIIDPN.
    OrthoDBi EOG7N8ZW9.
    PhylomeDBi P59025.
    TreeFami TF333246.

    Miscellaneous databases

    GenomeRNAii 132112.
    NextBioi 83014.
    PROi P59025.
    SOURCEi Search...

    Gene expression databases

    Bgeei P59025.
    CleanExi HS_RTP1.
    Genevestigatori P59025.

    Family and domain databases

    InterProi IPR026096. R-trans_p/CXXC11.
    IPR026692. RTP1.
    IPR027377. Znf-3CxxC.
    [Graphical view ]
    PANTHERi PTHR14402. PTHR14402. 1 hit.
    PTHR14402:SF1. PTHR14402:SF1. 1 hit.
    Pfami PF13695. zf-3CxxC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "RTP family members induce functional expression of mammalian odorant receptors."
      Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.
      Cell 119:679-691(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 37-263.
    3. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-124.

    Entry informationi

    Entry nameiRTP1_HUMAN
    AccessioniPrimary (citable) accession number: P59025
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3