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P59024

- FKB14_MOUSE

UniProt

P59024 - FKB14_MOUSE

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Protein
Peptidyl-prolyl cis-trans isomerase FKBP14
Gene
Fkbp14
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi148 – 159121 Reviewed prediction
Add
BLAST
Calcium bindingi192 – 203122 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. FK506 binding Source: RefGenome
  2. calcium ion binding Source: InterPro
  3. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

GO - Biological processi

  1. peptidyl-proline modification Source: RefGenome
  2. protein folding Source: UniProtKB-KW
  3. protein peptidyl-prolyl isomerization Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_106572. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP14 (EC:5.2.1.8)
Short name:
PPIase FKBP14
Alternative name(s):
FK506-binding protein 14
Short name:
FKBP-14
Rotamase
Gene namesi
Name:Fkbp14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2387639. Fkbp14.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  2. membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 By similarity
Add
BLAST
Chaini20 – 211192Peptidyl-prolyl cis-trans isomerase FKBP14
PRO_0000025522Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi176 – 1761N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP59024.

PTM databases

PhosphoSiteiP59024.

Expressioni

Gene expression databases

ArrayExpressiP59024.
BgeeiP59024.
CleanExiMM_FKBP14.
GenevestigatoriP59024.

Interactioni

Protein-protein interaction databases

BioGridi231206. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP59024.
SMRiP59024. Positions 19-209.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 13591PPIase FKBP-type
Add
BLAST
Domaini135 – 17036EF-hand 1
Add
BLAST
Domaini179 – 21133EF-hand 2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi208 – 2114Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Contains 2 EF-hand domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG0545.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiP59024.
KOiK09577.
OMAiMMLVHYE.
OrthoDBiEOG7T1R9S.
PhylomeDBiP59024.
TreeFamiTF105296.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF00254. FKBP_C. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59024-1 [UniParc]FASTAAdd to Basket

« Hide

MRFFLWNAIL ALWVTVLSGA LIPEPEVKIE VLQKPFICHR KTKGGDLMLV    50
HYEGYLEKDG SLFHSTHKHN NGQPVWFTLG ILEVLKGWDQ GLKGMCVGEK 100
RKLTVPPALG YGKEGKGKIP PESTLIFNID LLEIRNGPRS HESFQEMDLN 150
DDWRLSKHEV KVYLQKEFEK HGAVVNESHH DALVEDIFDK EDEDKDGFIS 200
AREFTYVHDE L 211
Length:211
Mass (Da):24,252
Last modified:September 19, 2002 - v1
Checksum:iAB81F686794A8CDD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC029109 mRNA. Translation: AAH29109.1.
CCDSiCCDS20157.1.
RefSeqiNP_705801.1. NM_153573.1.
UniGeneiMm.274693.

Genome annotation databases

EnsembliENSMUST00000046520; ENSMUSP00000046070; ENSMUSG00000038074.
GeneIDi231997.
KEGGimmu:231997.
UCSCiuc009bzy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC029109 mRNA. Translation: AAH29109.1 .
CCDSi CCDS20157.1.
RefSeqi NP_705801.1. NM_153573.1.
UniGenei Mm.274693.

3D structure databases

ProteinModelPortali P59024.
SMRi P59024. Positions 19-209.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 231206. 1 interaction.

PTM databases

PhosphoSitei P59024.

Proteomic databases

PRIDEi P59024.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046520 ; ENSMUSP00000046070 ; ENSMUSG00000038074 .
GeneIDi 231997.
KEGGi mmu:231997.
UCSCi uc009bzy.1. mouse.

Organism-specific databases

CTDi 55033.
MGIi MGI:2387639. Fkbp14.

Phylogenomic databases

eggNOGi COG0545.
HOGENOMi HOG000154887.
HOVERGENi HBG051623.
InParanoidi P59024.
KOi K09577.
OMAi MMLVHYE.
OrthoDBi EOG7T1R9S.
PhylomeDBi P59024.
TreeFami TF105296.

Enzyme and pathway databases

Reactomei REACT_106572. XBP1(S) activates chaperone genes.

Miscellaneous databases

NextBioi 380904.
PROi P59024.
SOURCEi Search...

Gene expression databases

ArrayExpressi P59024.
Bgeei P59024.
CleanExi MM_FKBP14.
Genevestigatori P59024.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF13499. EF-hand_7. 1 hit.
PF00254. FKBP_C. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiFKB14_MOUSE
AccessioniPrimary (citable) accession number: P59024
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi