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P59024

- FKB14_MOUSE

UniProt

P59024 - FKB14_MOUSE

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Protein

Peptidyl-prolyl cis-trans isomerase FKBP14

Gene

Fkbp14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi148 – 159121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi192 – 203122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. FK506 binding Source: RefGenome
  3. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

GO - Biological processi

  1. chaperone-mediated protein folding Source: RefGenome
  2. protein peptidyl-prolyl isomerization Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_106572. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP14 (EC:5.2.1.8)
Short name:
PPIase FKBP14
Alternative name(s):
FK506-binding protein 14
Short name:
FKBP-14
Rotamase
Gene namesi
Name:Fkbp14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2387639. Fkbp14.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 211192Peptidyl-prolyl cis-trans isomerase FKBP14PRO_0000025522Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP59024.
PRIDEiP59024.

PTM databases

PhosphoSiteiP59024.

Expressioni

Gene expression databases

BgeeiP59024.
CleanExiMM_FKBP14.
ExpressionAtlasiP59024. baseline and differential.
GenevestigatoriP59024.

Interactioni

Protein-protein interaction databases

BioGridi231206. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP59024.
SMRiP59024. Positions 19-209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 13591PPIase FKBP-typePROSITE-ProRule annotationAdd
BLAST
Domaini135 – 17036EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini179 – 21133EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi208 – 2114Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG0545.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiP59024.
KOiK09577.
OMAiMMLVHYE.
OrthoDBiEOG7T1R9S.
PhylomeDBiP59024.
TreeFamiTF105296.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF00254. FKBP_C. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59024-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRFFLWNAIL ALWVTVLSGA LIPEPEVKIE VLQKPFICHR KTKGGDLMLV
60 70 80 90 100
HYEGYLEKDG SLFHSTHKHN NGQPVWFTLG ILEVLKGWDQ GLKGMCVGEK
110 120 130 140 150
RKLTVPPALG YGKEGKGKIP PESTLIFNID LLEIRNGPRS HESFQEMDLN
160 170 180 190 200
DDWRLSKHEV KVYLQKEFEK HGAVVNESHH DALVEDIFDK EDEDKDGFIS
210
AREFTYVHDE L
Length:211
Mass (Da):24,252
Last modified:September 19, 2002 - v1
Checksum:iAB81F686794A8CDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029109 mRNA. Translation: AAH29109.1.
CCDSiCCDS20157.1.
RefSeqiNP_705801.1. NM_153573.1.
UniGeneiMm.274693.

Genome annotation databases

EnsembliENSMUST00000046520; ENSMUSP00000046070; ENSMUSG00000038074.
GeneIDi231997.
KEGGimmu:231997.
UCSCiuc009bzy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029109 mRNA. Translation: AAH29109.1 .
CCDSi CCDS20157.1.
RefSeqi NP_705801.1. NM_153573.1.
UniGenei Mm.274693.

3D structure databases

ProteinModelPortali P59024.
SMRi P59024. Positions 19-209.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 231206. 1 interaction.

PTM databases

PhosphoSitei P59024.

Proteomic databases

MaxQBi P59024.
PRIDEi P59024.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046520 ; ENSMUSP00000046070 ; ENSMUSG00000038074 .
GeneIDi 231997.
KEGGi mmu:231997.
UCSCi uc009bzy.1. mouse.

Organism-specific databases

CTDi 55033.
MGIi MGI:2387639. Fkbp14.

Phylogenomic databases

eggNOGi COG0545.
HOGENOMi HOG000154887.
HOVERGENi HBG051623.
InParanoidi P59024.
KOi K09577.
OMAi MMLVHYE.
OrthoDBi EOG7T1R9S.
PhylomeDBi P59024.
TreeFami TF105296.

Enzyme and pathway databases

Reactomei REACT_106572. XBP1(S) activates chaperone genes.

Miscellaneous databases

NextBioi 380904.
PROi P59024.
SOURCEi Search...

Gene expression databases

Bgeei P59024.
CleanExi MM_FKBP14.
ExpressionAtlasi P59024. baseline and differential.
Genevestigatori P59024.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF13499. EF-hand_7. 1 hit.
PF00254. FKBP_C. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiFKB14_MOUSE
AccessioniPrimary (citable) accession number: P59024
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3