Reviewed, UniProtKB/Swiss-Prot P59024 (FKB14_MOUSE)

Names and origin

Protein names

Recommended name:
    FK506-binding protein 14
    EC=5.2.1.8
Alternative name(s):
    Peptidyl-prolyl cis-trans isomerase
      Short name=PPIase
      Short name=Rotamase

Gene names

Name:

Fkbp14

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	PPIases accelerate the folding of proteins during protein synthesis.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subcellular location	Endoplasmic reticulum lumen Potential.
Sequence similarities	Contains 2 EF-hand domains. Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Repeat Signal
Ligand	Calcium
Molecular function	Isomerase Rotamase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	By similarity
	Chain	20 – 211	192	FK506-binding protein 14		PRO_0000025522
Regions
	Domain	45 – 135	91	PPIase FKBP-type
	Domain	135 – 170	36	EF-hand 1
	Domain	179 – 211	33	EF-hand 2
	Calcium binding	148 – 159	12	1 Potential
	Calcium binding	192 – 203	12	2 Potential
	Motif	208 – 211	4	Prevents secretion from ER Potential
Amino acid modifications
	Glycosylation	176	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P59024-1 [UniParc]. Last modified September 19, 2002. Version 1. Checksum: AB81F686794A8CDD	FASTA	211	24,252
	10 20 30 40 50 60 MRFFLWNAIL ALWVTVLSGA LIPEPEVKIE VLQKPFICHR KTKGGDLMLV HYEGYLEKDG 70 80 90 100 110 120 SLFHSTHKHN NGQPVWFTLG ILEVLKGWDQ GLKGMCVGEK RKLTVPPALG YGKEGKGKIP 130 140 150 160 170 180 PESTLIFNID LLEIRNGPRS HESFQEMDLN DDWRLSKHEV KVYLQKEFEK HGAVVNESHH 190 200 210 DALVEDIFDK EDEDKDGFIS AREFTYVHDE L

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC029109 mRNA. Translation: AAH29109.1.
IPI	IPI00165760.
RefSeq	NP_705801.1.
UniGene	Mm.274693
3D structure databases
HSSP	HSSP built from PDB template 1FKL based on UniProtKB P18203.
ModBase	Search...
Proteomic databases
PRIDE	P59024.
Genome annotation databases
Ensembl	ENSMUST00000046520; ENSMUSP00000046070; ENSMUSG00000038074; Mus musculus. [Genome view]
GeneID	231997.
KEGG	mmu:231997.
UCSC	uc009bzy.1. mouse.
Organism-specific databases
CTD	231997.
MGI	MGI:2387639. Fkbp14.
Phylogenomic databases
HOGENOM	P59024.
HOVERGEN	P59024.
OMA	NESHHDV.
Enzyme and pathway databases
BRENDA	5.2.1.8. 244.
Gene expression databases
ArrayExpress	P59024.
Bgee	P59024.
CleanEx	MM_FKBP14.
Genevestigator	P59024.
GermOnline	ENSMUSG00000038074. Mus musculus.
Family and domain databases
InterPro	IPR018247. EF_HAND_1_Ca_BS. IPR018249. EF_HAND_2. IPR002048. EF_hand_Ca_bd. IPR000886. ER_target_seq_motif. IPR001179. PPIase_FKBP. [Graphical view]
PANTHER	PTHR10516. PPIase_FKBP. 1 hit.
Pfam	PF00254. FKBP_C. 1 hit. [Graphical view]
SMART	SM00054. EFh. 2 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 2 hits. PS00014. ER_TARGET. 1 hit. PS50059. FKBP_PPIASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	380904.
SOURCE	Search...

Entry information

Entry name

FKB14_MOUSE

Accession

Primary (citable) accession number: P59024

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	September 19, 2002
Last modified:	November 3, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)