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Protein

Peptidyl-prolyl cis-trans isomerase FKBP14

Gene

Fkbp14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi148 – 1591PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi192 – 2032PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP14 (EC:5.2.1.8)
Short name:
PPIase FKBP14
Alternative name(s):
FK506-binding protein 14
Short name:
FKBP-14
Rotamase
Gene namesi
Name:Fkbp14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2387639. Fkbp14.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000002552220 – 211Peptidyl-prolyl cis-trans isomerase FKBP14Add BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi176N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP59024.
PeptideAtlasiP59024.
PRIDEiP59024.

PTM databases

PhosphoSitePlusiP59024.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038074.
CleanExiMM_FKBP14.
ExpressionAtlasiP59024. baseline and differential.
GenevisibleiP59024. MM.

Interactioni

Protein-protein interaction databases

BioGridi231206. 1 interactor.
STRINGi10090.ENSMUSP00000046070.

Structurei

3D structure databases

ProteinModelPortaliP59024.
SMRiP59024.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 135PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST91
Domaini135 – 170EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini179 – 211EF-hand 2PROSITE-ProRule annotationAdd BLAST33

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi208 – 211Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiP59024.
KOiK09577.
OMAiNDTQHDA.
OrthoDBiEOG091G02W1.
PhylomeDBiP59024.
TreeFamiTF105296.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF00254. FKBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P59024-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFFLWNAIL ALWVTVLSGA LIPEPEVKIE VLQKPFICHR KTKGGDLMLV
60 70 80 90 100
HYEGYLEKDG SLFHSTHKHN NGQPVWFTLG ILEVLKGWDQ GLKGMCVGEK
110 120 130 140 150
RKLTVPPALG YGKEGKGKIP PESTLIFNID LLEIRNGPRS HESFQEMDLN
160 170 180 190 200
DDWRLSKHEV KVYLQKEFEK HGAVVNESHH DALVEDIFDK EDEDKDGFIS
210
AREFTYVHDE L
Length:211
Mass (Da):24,252
Last modified:September 19, 2002 - v1
Checksum:iAB81F686794A8CDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029109 mRNA. Translation: AAH29109.1.
CCDSiCCDS20157.1.
RefSeqiNP_705801.1. NM_153573.1.
UniGeneiMm.274693.

Genome annotation databases

EnsembliENSMUST00000046520; ENSMUSP00000046070; ENSMUSG00000038074.
GeneIDi231997.
KEGGimmu:231997.
UCSCiuc009bzy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029109 mRNA. Translation: AAH29109.1.
CCDSiCCDS20157.1.
RefSeqiNP_705801.1. NM_153573.1.
UniGeneiMm.274693.

3D structure databases

ProteinModelPortaliP59024.
SMRiP59024.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231206. 1 interactor.
STRINGi10090.ENSMUSP00000046070.

PTM databases

PhosphoSitePlusiP59024.

Proteomic databases

PaxDbiP59024.
PeptideAtlasiP59024.
PRIDEiP59024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046520; ENSMUSP00000046070; ENSMUSG00000038074.
GeneIDi231997.
KEGGimmu:231997.
UCSCiuc009bzy.1. mouse.

Organism-specific databases

CTDi55033.
MGIiMGI:2387639. Fkbp14.

Phylogenomic databases

eggNOGiKOG0549. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00530000062784.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiP59024.
KOiK09577.
OMAiNDTQHDA.
OrthoDBiEOG091G02W1.
PhylomeDBiP59024.
TreeFamiTF105296.

Miscellaneous databases

PROiP59024.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038074.
CleanExiMM_FKBP14.
ExpressionAtlasiP59024. baseline and differential.
GenevisibleiP59024. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF00254. FKBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKB14_MOUSE
AccessioniPrimary (citable) accession number: P59024
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.