Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P59024 (FKB14_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-prolyl cis-trans isomerase FKBP14

Short name=PPIase FKBP14
EC=5.2.1.8
Alternative name(s):
FK506-binding protein 14
Short name=FKBP-14
Rotamase
Gene names
Name:Fkbp14
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Contains 2 EF-hand domains.

Contains 1 PPIase FKBP-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 211192Peptidyl-prolyl cis-trans isomerase FKBP14
PRO_0000025522

Regions

Domain45 – 13591PPIase FKBP-type
Domain135 – 17036EF-hand 1
Domain179 – 21133EF-hand 2
Calcium binding148 – 159121 Potential
Calcium binding192 – 203122 Potential
Motif208 – 2114Prevents secretion from ER Potential

Amino acid modifications

Glycosylation1761N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P59024 [UniParc].

Last modified September 19, 2002. Version 1.
Checksum: AB81F686794A8CDD

FASTA21124,252
        10         20         30         40         50         60 
MRFFLWNAIL ALWVTVLSGA LIPEPEVKIE VLQKPFICHR KTKGGDLMLV HYEGYLEKDG 

        70         80         90        100        110        120 
SLFHSTHKHN NGQPVWFTLG ILEVLKGWDQ GLKGMCVGEK RKLTVPPALG YGKEGKGKIP 

       130        140        150        160        170        180 
PESTLIFNID LLEIRNGPRS HESFQEMDLN DDWRLSKHEV KVYLQKEFEK HGAVVNESHH 

       190        200        210 
DALVEDIFDK EDEDKDGFIS AREFTYVHDE L 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC029109 mRNA. Translation: AAH29109.1.
RefSeqNP_705801.1. NM_153573.1.
UniGeneMm.274693.

3D structure databases

ProteinModelPortalP59024.
SMRP59024. Positions 19-138, 143-206.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid231206. 1 interaction.

PTM databases

PhosphoSiteP59024.

Proteomic databases

PRIDEP59024.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000046520; ENSMUSP00000046070; ENSMUSG00000038074.
GeneID231997.
KEGGmmu:231997.
UCSCuc009bzy.1. mouse.

Organism-specific databases

CTD55033.
MGIMGI:2387639. Fkbp14.

Phylogenomic databases

eggNOGCOG0545.
HOGENOMHOG000154887.
HOVERGENHBG051623.
InParanoidP59024.
KOK09577.
OMAMMLVHYE.
OrthoDBEOG7T1R9S.
PhylomeDBP59024.
TreeFamTF105296.

Gene expression databases

ArrayExpressP59024.
BgeeP59024.
CleanExMM_FKBP14.
GenevestigatorP59024.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF13499. EF-hand_7. 1 hit.
PF00254. FKBP_C. 1 hit.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio380904.
PROP59024.
SOURCESearch...

Entry information

Entry nameFKB14_MOUSE
AccessionPrimary (citable) accession number: P59024
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot