Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P59024

- FKB14_MOUSE

UniProt

P59024 - FKB14_MOUSE

Protein

Peptidyl-prolyl cis-trans isomerase FKBP14

Gene

Fkbp14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (19 Sep 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    PPIases accelerate the folding of proteins during protein synthesis.

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi148 – 159121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi192 – 203122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. FK506 binding Source: RefGenome
    3. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

    GO - Biological processi

    1. chaperone-mediated protein folding Source: RefGenome
    2. protein peptidyl-prolyl isomerization Source: RefGenome

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_106572. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP14 (EC:5.2.1.8)
    Short name:
    PPIase FKBP14
    Alternative name(s):
    FK506-binding protein 14
    Short name:
    FKBP-14
    Rotamase
    Gene namesi
    Name:Fkbp14
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2387639. Fkbp14.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    2. endoplasmic reticulum membrane Source: RefGenome

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919By similarityAdd
    BLAST
    Chaini20 – 211192Peptidyl-prolyl cis-trans isomerase FKBP14PRO_0000025522Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP59024.

    PTM databases

    PhosphoSiteiP59024.

    Expressioni

    Gene expression databases

    ArrayExpressiP59024.
    BgeeiP59024.
    CleanExiMM_FKBP14.
    GenevestigatoriP59024.

    Interactioni

    Protein-protein interaction databases

    BioGridi231206. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP59024.
    SMRiP59024. Positions 19-209.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini45 – 13591PPIase FKBP-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini135 – 17036EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini179 – 21133EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi208 – 2114Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0545.
    HOGENOMiHOG000154887.
    HOVERGENiHBG051623.
    InParanoidiP59024.
    KOiK09577.
    OMAiMMLVHYE.
    OrthoDBiEOG7T1R9S.
    PhylomeDBiP59024.
    TreeFamiTF105296.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF13499. EF-hand_7. 1 hit.
    PF00254. FKBP_C. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P59024-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRFFLWNAIL ALWVTVLSGA LIPEPEVKIE VLQKPFICHR KTKGGDLMLV    50
    HYEGYLEKDG SLFHSTHKHN NGQPVWFTLG ILEVLKGWDQ GLKGMCVGEK 100
    RKLTVPPALG YGKEGKGKIP PESTLIFNID LLEIRNGPRS HESFQEMDLN 150
    DDWRLSKHEV KVYLQKEFEK HGAVVNESHH DALVEDIFDK EDEDKDGFIS 200
    AREFTYVHDE L 211
    Length:211
    Mass (Da):24,252
    Last modified:September 19, 2002 - v1
    Checksum:iAB81F686794A8CDD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC029109 mRNA. Translation: AAH29109.1.
    CCDSiCCDS20157.1.
    RefSeqiNP_705801.1. NM_153573.1.
    UniGeneiMm.274693.

    Genome annotation databases

    EnsembliENSMUST00000046520; ENSMUSP00000046070; ENSMUSG00000038074.
    GeneIDi231997.
    KEGGimmu:231997.
    UCSCiuc009bzy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC029109 mRNA. Translation: AAH29109.1 .
    CCDSi CCDS20157.1.
    RefSeqi NP_705801.1. NM_153573.1.
    UniGenei Mm.274693.

    3D structure databases

    ProteinModelPortali P59024.
    SMRi P59024. Positions 19-209.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 231206. 1 interaction.

    PTM databases

    PhosphoSitei P59024.

    Proteomic databases

    PRIDEi P59024.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000046520 ; ENSMUSP00000046070 ; ENSMUSG00000038074 .
    GeneIDi 231997.
    KEGGi mmu:231997.
    UCSCi uc009bzy.1. mouse.

    Organism-specific databases

    CTDi 55033.
    MGIi MGI:2387639. Fkbp14.

    Phylogenomic databases

    eggNOGi COG0545.
    HOGENOMi HOG000154887.
    HOVERGENi HBG051623.
    InParanoidi P59024.
    KOi K09577.
    OMAi MMLVHYE.
    OrthoDBi EOG7T1R9S.
    PhylomeDBi P59024.
    TreeFami TF105296.

    Enzyme and pathway databases

    Reactomei REACT_106572. XBP1(S) activates chaperone genes.

    Miscellaneous databases

    NextBioi 380904.
    PROi P59024.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P59024.
    Bgeei P59024.
    CleanExi MM_FKBP14.
    Genevestigatori P59024.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF13499. EF-hand_7. 1 hit.
    PF00254. FKBP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiFKB14_MOUSE
    AccessioniPrimary (citable) accession number: P59024
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: September 19, 2002
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3