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P59017 (B2L13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bcl-2-like protein 13
Short name=Bcl2-L-13
Alternative name(s):
Bcl-rambo
Protein Mil1
Gene names
Name:Bcl2l13
Synonyms:Mil1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May promote the activation of caspase-3 and apoptosis.

Subunit structure

Monomer Probable.

Subcellular location

Mitochondrion membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the Bcl-2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 434434Bcl-2-like protein 13
PRO_0000143074

Regions

Transmembrane409 – 42921Helical; Potential
Repeat243 – 25311A
Repeat258 – 26811A; approximate
Motif14 – 3017BH4
Motif97 – 11317BH3
Motif144 – 15411BH1
Motif190 – 20314BH2
Compositional bias204 – 2096Poly-Glu
Compositional bias308 – 37972Glu-rich

Amino acid modifications

Modified residue351Phosphoserine By similarity
Modified residue3431Phosphoserine Ref.5
Modified residue3871Phosphoserine Ref.4

Experimental info

Sequence conflict81S → P in AAH27307. Ref.3
Sequence conflict661T → A in AAH27307. Ref.3
Sequence conflict3261T → A in AAH27307. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P59017 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: E84790F7CBCE9B67

FASTA43446,719
        10         20         30         40         50         60 
MASSTTASLG FHYETKYVVL SYLGLLSQEK QQGPSPPGVQ LDVAPQSLNP EVLLKLKSEI 

        70         80         90        100        110        120 
EEELKTLDKE VSEAFTSTGF DCHTSPVFSP ANPESSIEDC LAHLGERVSQ DLKEPLQKAL 

       130        140        150        160        170        180 
QTILSQPVTY EAYRECTVET AVHASGWNKL LVPLVLLQHL LLELTRRGQE PLRMLLQFGV 

       190        200        210        220        230        240 
MYLEEHAAEF IIQQGGWGSV FSLEPEEEEY PGIIAEDSND IYILPSDNSG QVSPPESPTV 

       250        260        270        280        290        300 
TTSWQSESLP VSLSASQSWH TESLPVSLGP ESWQQIAMDP EEVKSLDSSG AGEKSENNSS 

       310        320        330        340        350        360 
NSDIVHVEKE EVPEEAFPGA AAPLLTQVPT VEAPEMMRAE KTSPTPSVFV ELGEEELEAV 

       370        380        390        400        410        420 
TARPEAVERA EGAAQLSEER AGSRKKSHTG EAAAVRGAKS GLPAEGKAVL LFGGAAAVAI 

       430 
LAVAVGVALA LRRK

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum, Liver and Testis.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Eye and Mammary tumor.
[4]"Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS."
Lee J., Xu Y., Chen Y., Sprung R., Kim S.C., Xie S., Zhao Y.
Mol. Cell. Proteomics 6:669-676(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-387, MASS SPECTROMETRY.
Tissue: Liver.
[5]"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343, MASS SPECTROMETRY.
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK047223 mRNA. Translation: BAC32999.1.
AK132774 mRNA. Translation: BAE21351.1.
AK168833 mRNA. Translation: BAE40657.1.
CH466523 Genomic DNA. Translation: EDK99647.1.
BC027307 mRNA. Translation: AAH27307.1.
BC029016 mRNA. Translation: AAH29016.1.
IPIIPI00321499.
RefSeqNP_705736.1. NM_153516.2.
UniGeneMm.27990.

3D structure databases

ProteinModelPortalP59017.
ModBaseSearch...

PTM databases

PhosphoSiteP59017.

Proteomic databases

PaxDbP59017.
PRIDEP59017.

Protocols and materials databases

DNASU94044.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000009256; ENSMUSP00000009256; ENSMUSG00000009112.
GeneID94044.
KEGGmmu:94044.

Organism-specific databases

CTD23786.
MGIMGI:2136959. Bcl2l13.

Phylogenomic databases

eggNOGNOG44929.
GeneTreeENSGT00390000015552.
HOGENOMHOG000059276.
HOVERGENHBG050648.
InParanoidQ543S1.
KOK15485.
OMAQPVTYQA.
OrthoDBEOG40VVPX.

Gene expression databases

BgeeP59017.
CleanExMM_BCL2L13.
GenevestigatorP59017.
GermOnlineENSMUSG00000009112. Mus musculus.

Family and domain databases

InterProIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
[Graphical view]
PfamPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. False negative.
PS01258. BH2. False negative.
PS01259. BH3. False negative.
PS01260. BH4_1. False negative.
PS50063. BH4_2. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio351999.
SOURCESearch...

Entry information

Entry nameB2L13_MOUSE
AccessionPrimary (citable) accession number: P59017
Secondary accession number(s): Q543S1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 27, 2011
Last modified: April 3, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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