Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P59017

- B2L13_MOUSE

UniProt

P59017 - B2L13_MOUSE

Protein

Bcl-2-like protein 13

Gene

Bcl2l13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May promote the activation of caspase-3 and apoptosis.

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. regulation of apoptotic process Source: InterPro

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bcl-2-like protein 13
    Short name:
    Bcl2-L-13
    Alternative name(s):
    Bcl-rambo
    Protein Mil1
    Gene namesi
    Name:Bcl2l13
    Synonyms:Mil1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2136959. Bcl2l13.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. mitochondrial membrane Source: UniProtKB-SubCell
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Bcl-2-like protein 13PRO_0000143074Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei35 – 351PhosphoserineBy similarity
    Modified residuei343 – 3431Phosphoserine1 Publication
    Modified residuei387 – 3871PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP59017.
    PaxDbiP59017.
    PRIDEiP59017.

    PTM databases

    PhosphoSiteiP59017.

    Expressioni

    Gene expression databases

    BgeeiP59017.
    CleanExiMM_BCL2L13.
    GenevestigatoriP59017.

    Interactioni

    Subunit structurei

    Monomer.Curated

    Protein-protein interaction databases

    IntActiP59017. 1 interaction.
    MINTiMINT-4088925.

    Structurei

    3D structure databases

    ProteinModelPortaliP59017.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei409 – 42921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati243 – 25311AAdd
    BLAST
    Repeati258 – 26811A; approximateAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi14 – 3017BH4Add
    BLAST
    Motifi97 – 11317BH3Add
    BLAST
    Motifi144 – 15411BH1Add
    BLAST
    Motifi190 – 20314BH2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi204 – 2096Poly-Glu
    Compositional biasi308 – 37972Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Bcl-2 family.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44929.
    GeneTreeiENSGT00390000015552.
    HOGENOMiHOG000059276.
    HOVERGENiHBG050648.
    InParanoidiQ543S1.
    KOiK15485.
    OMAiSQPVTYQ.
    OrthoDBiEOG77M8PW.
    TreeFamiTF330744.

    Family and domain databases

    InterProiIPR002475. Bcl2-like.
    IPR026298. Blc2_fam.
    [Graphical view]
    PfamiPF00452. Bcl-2. 1 hit.
    [Graphical view]
    PROSITEiPS50062. BCL2_FAMILY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P59017-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSTTASLG FHYETKYVVL SYLGLLSQEK QQGPSPPGVQ LDVAPQSLNP    50
    EVLLKLKSEI EEELKTLDKE VSEAFTSTGF DCHTSPVFSP ANPESSIEDC 100
    LAHLGERVSQ DLKEPLQKAL QTILSQPVTY EAYRECTVET AVHASGWNKL 150
    LVPLVLLQHL LLELTRRGQE PLRMLLQFGV MYLEEHAAEF IIQQGGWGSV 200
    FSLEPEEEEY PGIIAEDSND IYILPSDNSG QVSPPESPTV TTSWQSESLP 250
    VSLSASQSWH TESLPVSLGP ESWQQIAMDP EEVKSLDSSG AGEKSENNSS 300
    NSDIVHVEKE EVPEEAFPGA AAPLLTQVPT VEAPEMMRAE KTSPTPSVFV 350
    ELGEEELEAV TARPEAVERA EGAAQLSEER AGSRKKSHTG EAAAVRGAKS 400
    GLPAEGKAVL LFGGAAAVAI LAVAVGVALA LRRK 434
    Length:434
    Mass (Da):46,719
    Last modified:July 27, 2011 - v2
    Checksum:iE84790F7CBCE9B67
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81S → P in AAH27307. (PubMed:15489334)Curated
    Sequence conflicti66 – 661T → A in AAH27307. (PubMed:15489334)Curated
    Sequence conflicti326 – 3261T → A in AAH27307. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK047223 mRNA. Translation: BAC32999.1.
    AK132774 mRNA. Translation: BAE21351.1.
    AK168833 mRNA. Translation: BAE40657.1.
    CH466523 Genomic DNA. Translation: EDK99647.1.
    BC027307 mRNA. Translation: AAH27307.1.
    BC029016 mRNA. Translation: AAH29016.1.
    CCDSiCCDS20485.1.
    RefSeqiNP_705736.1. NM_153516.2.
    UniGeneiMm.27990.

    Genome annotation databases

    EnsembliENSMUST00000009256; ENSMUSP00000009256; ENSMUSG00000009112.
    GeneIDi94044.
    KEGGimmu:94044.
    UCSCiuc009dnt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK047223 mRNA. Translation: BAC32999.1 .
    AK132774 mRNA. Translation: BAE21351.1 .
    AK168833 mRNA. Translation: BAE40657.1 .
    CH466523 Genomic DNA. Translation: EDK99647.1 .
    BC027307 mRNA. Translation: AAH27307.1 .
    BC029016 mRNA. Translation: AAH29016.1 .
    CCDSi CCDS20485.1.
    RefSeqi NP_705736.1. NM_153516.2.
    UniGenei Mm.27990.

    3D structure databases

    ProteinModelPortali P59017.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P59017. 1 interaction.
    MINTi MINT-4088925.

    PTM databases

    PhosphoSitei P59017.

    Proteomic databases

    MaxQBi P59017.
    PaxDbi P59017.
    PRIDEi P59017.

    Protocols and materials databases

    DNASUi 94044.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000009256 ; ENSMUSP00000009256 ; ENSMUSG00000009112 .
    GeneIDi 94044.
    KEGGi mmu:94044.
    UCSCi uc009dnt.1. mouse.

    Organism-specific databases

    CTDi 23786.
    MGIi MGI:2136959. Bcl2l13.

    Phylogenomic databases

    eggNOGi NOG44929.
    GeneTreei ENSGT00390000015552.
    HOGENOMi HOG000059276.
    HOVERGENi HBG050648.
    InParanoidi Q543S1.
    KOi K15485.
    OMAi SQPVTYQ.
    OrthoDBi EOG77M8PW.
    TreeFami TF330744.

    Miscellaneous databases

    NextBioi 351999.
    PROi P59017.
    SOURCEi Search...

    Gene expression databases

    Bgeei P59017.
    CleanExi MM_BCL2L13.
    Genevestigatori P59017.

    Family and domain databases

    InterProi IPR002475. Bcl2-like.
    IPR026298. Blc2_fam.
    [Graphical view ]
    Pfami PF00452. Bcl-2. 1 hit.
    [Graphical view ]
    PROSITEi PS50062. BCL2_FAMILY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum, Liver and Testis.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Eye and Mammary tumor.
    4. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiB2L13_MOUSE
    AccessioniPrimary (citable) accession number: P59017
    Secondary accession number(s): Q543S1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3