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Protein

Bcl-2-like protein 13

Gene

Bcl2l13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May promote the activation of caspase-3 and apoptosis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 13
Short name:
Bcl2-L-13
Alternative name(s):
Bcl-rambo
Protein Mil1
Gene namesi
Name:Bcl2l13
Synonyms:Mil1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2136959. Bcl2l13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • mitochondrial membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001430741 – 434Bcl-2-like protein 13Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35PhosphoserineBy similarity1
Modified residuei256PhosphoserineBy similarity1
Modified residuei258PhosphoserineBy similarity1
Modified residuei300PhosphoserineBy similarity1
Modified residuei343PhosphoserineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei377PhosphoserineBy similarity1
Modified residuei387PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP59017.
MaxQBiP59017.
PaxDbiP59017.
PeptideAtlasiP59017.
PRIDEiP59017.
TopDownProteomicsiP59017.

PTM databases

iPTMnetiP59017.
PhosphoSitePlusiP59017.
SwissPalmiP59017.

Expressioni

Gene expression databases

BgeeiENSMUSG00000009112.
CleanExiMM_BCL2L13.
ExpressionAtlasiP59017. baseline and differential.
GenevisibleiP59017. MM.

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

IntActiP59017. 1 interactor.
MINTiMINT-4088925.
STRINGi10090.ENSMUSP00000009256.

Structurei

3D structure databases

ProteinModelPortaliP59017.
SMRiP59017.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati243 – 253AAdd BLAST11
Repeati258 – 268A; approximateAdd BLAST11

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi14 – 30BH4Add BLAST17
Motifi97 – 113BH3Add BLAST17
Motifi144 – 154BH1Add BLAST11
Motifi190 – 203BH2Add BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi204 – 209Poly-Glu6
Compositional biasi308 – 379Glu-richAdd BLAST72

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK4J. Eukaryota.
ENOG410XT6A. LUCA.
GeneTreeiENSGT00390000015552.
HOGENOMiHOG000059276.
HOVERGENiHBG050648.
InParanoidiP59017.
KOiK15485.
OMAiTYLEDYA.
OrthoDBiEOG091G1AZK.
TreeFamiTF330744.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
[Graphical view]
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSTTASLG FHYETKYVVL SYLGLLSQEK QQGPSPPGVQ LDVAPQSLNP
60 70 80 90 100
EVLLKLKSEI EEELKTLDKE VSEAFTSTGF DCHTSPVFSP ANPESSIEDC
110 120 130 140 150
LAHLGERVSQ DLKEPLQKAL QTILSQPVTY EAYRECTVET AVHASGWNKL
160 170 180 190 200
LVPLVLLQHL LLELTRRGQE PLRMLLQFGV MYLEEHAAEF IIQQGGWGSV
210 220 230 240 250
FSLEPEEEEY PGIIAEDSND IYILPSDNSG QVSPPESPTV TTSWQSESLP
260 270 280 290 300
VSLSASQSWH TESLPVSLGP ESWQQIAMDP EEVKSLDSSG AGEKSENNSS
310 320 330 340 350
NSDIVHVEKE EVPEEAFPGA AAPLLTQVPT VEAPEMMRAE KTSPTPSVFV
360 370 380 390 400
ELGEEELEAV TARPEAVERA EGAAQLSEER AGSRKKSHTG EAAAVRGAKS
410 420 430
GLPAEGKAVL LFGGAAAVAI LAVAVGVALA LRRK
Length:434
Mass (Da):46,719
Last modified:July 27, 2011 - v2
Checksum:iE84790F7CBCE9B67
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8S → P in AAH27307 (PubMed:15489334).Curated1
Sequence conflicti66T → A in AAH27307 (PubMed:15489334).Curated1
Sequence conflicti326T → A in AAH27307 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047223 mRNA. Translation: BAC32999.1.
AK132774 mRNA. Translation: BAE21351.1.
AK168833 mRNA. Translation: BAE40657.1.
CH466523 Genomic DNA. Translation: EDK99647.1.
BC027307 mRNA. Translation: AAH27307.1.
BC029016 mRNA. Translation: AAH29016.1.
CCDSiCCDS20485.1.
RefSeqiNP_705736.1. NM_153516.2.
UniGeneiMm.27990.

Genome annotation databases

EnsembliENSMUST00000009256; ENSMUSP00000009256; ENSMUSG00000009112.
GeneIDi94044.
KEGGimmu:94044.
UCSCiuc009dnt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047223 mRNA. Translation: BAC32999.1.
AK132774 mRNA. Translation: BAE21351.1.
AK168833 mRNA. Translation: BAE40657.1.
CH466523 Genomic DNA. Translation: EDK99647.1.
BC027307 mRNA. Translation: AAH27307.1.
BC029016 mRNA. Translation: AAH29016.1.
CCDSiCCDS20485.1.
RefSeqiNP_705736.1. NM_153516.2.
UniGeneiMm.27990.

3D structure databases

ProteinModelPortaliP59017.
SMRiP59017.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP59017. 1 interactor.
MINTiMINT-4088925.
STRINGi10090.ENSMUSP00000009256.

PTM databases

iPTMnetiP59017.
PhosphoSitePlusiP59017.
SwissPalmiP59017.

Proteomic databases

EPDiP59017.
MaxQBiP59017.
PaxDbiP59017.
PeptideAtlasiP59017.
PRIDEiP59017.
TopDownProteomicsiP59017.

Protocols and materials databases

DNASUi94044.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009256; ENSMUSP00000009256; ENSMUSG00000009112.
GeneIDi94044.
KEGGimmu:94044.
UCSCiuc009dnt.1. mouse.

Organism-specific databases

CTDi23786.
MGIiMGI:2136959. Bcl2l13.

Phylogenomic databases

eggNOGiENOG410IK4J. Eukaryota.
ENOG410XT6A. LUCA.
GeneTreeiENSGT00390000015552.
HOGENOMiHOG000059276.
HOVERGENiHBG050648.
InParanoidiP59017.
KOiK15485.
OMAiTYLEDYA.
OrthoDBiEOG091G1AZK.
TreeFamiTF330744.

Miscellaneous databases

PROiP59017.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009112.
CleanExiMM_BCL2L13.
ExpressionAtlasiP59017. baseline and differential.
GenevisibleiP59017. MM.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
[Graphical view]
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2L13_MOUSE
AccessioniPrimary (citable) accession number: P59017
Secondary accession number(s): Q543S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.