Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bcl-2-like protein 13

Gene

Bcl2l13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May promote the activation of caspase-3 and apoptosis.

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. regulation of apoptotic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 13
Short name:
Bcl2-L-13
Alternative name(s):
Bcl-rambo
Protein Mil1
Gene namesi
Name:Bcl2l13
Synonyms:Mil1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2136959. Bcl2l13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei409 – 42921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. mitochondrial membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Bcl-2-like protein 13PRO_0000143074Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351PhosphoserineBy similarity
Modified residuei256 – 2561PhosphoserineBy similarity
Modified residuei258 – 2581PhosphoserineBy similarity
Modified residuei343 – 3431Phosphoserine1 Publication
Modified residuei377 – 3771PhosphoserineBy similarity
Modified residuei387 – 3871PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP59017.
PaxDbiP59017.
PRIDEiP59017.

PTM databases

PhosphoSiteiP59017.

Expressioni

Gene expression databases

BgeeiP59017.
CleanExiMM_BCL2L13.
GenevestigatoriP59017.

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

IntActiP59017. 1 interaction.
MINTiMINT-4088925.

Structurei

3D structure databases

ProteinModelPortaliP59017.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati243 – 25311AAdd
BLAST
Repeati258 – 26811A; approximateAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi14 – 3017BH4Add
BLAST
Motifi97 – 11317BH3Add
BLAST
Motifi144 – 15411BH1Add
BLAST
Motifi190 – 20314BH2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi204 – 2096Poly-Glu
Compositional biasi308 – 37972Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44929.
GeneTreeiENSGT00390000015552.
HOGENOMiHOG000059276.
HOVERGENiHBG050648.
InParanoidiP59017.
KOiK15485.
OMAiSQPVTYQ.
OrthoDBiEOG77M8PW.
TreeFamiTF330744.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
[Graphical view]
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSTTASLG FHYETKYVVL SYLGLLSQEK QQGPSPPGVQ LDVAPQSLNP
60 70 80 90 100
EVLLKLKSEI EEELKTLDKE VSEAFTSTGF DCHTSPVFSP ANPESSIEDC
110 120 130 140 150
LAHLGERVSQ DLKEPLQKAL QTILSQPVTY EAYRECTVET AVHASGWNKL
160 170 180 190 200
LVPLVLLQHL LLELTRRGQE PLRMLLQFGV MYLEEHAAEF IIQQGGWGSV
210 220 230 240 250
FSLEPEEEEY PGIIAEDSND IYILPSDNSG QVSPPESPTV TTSWQSESLP
260 270 280 290 300
VSLSASQSWH TESLPVSLGP ESWQQIAMDP EEVKSLDSSG AGEKSENNSS
310 320 330 340 350
NSDIVHVEKE EVPEEAFPGA AAPLLTQVPT VEAPEMMRAE KTSPTPSVFV
360 370 380 390 400
ELGEEELEAV TARPEAVERA EGAAQLSEER AGSRKKSHTG EAAAVRGAKS
410 420 430
GLPAEGKAVL LFGGAAAVAI LAVAVGVALA LRRK
Length:434
Mass (Da):46,719
Last modified:July 27, 2011 - v2
Checksum:iE84790F7CBCE9B67
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81S → P in AAH27307 (PubMed:15489334).Curated
Sequence conflicti66 – 661T → A in AAH27307 (PubMed:15489334).Curated
Sequence conflicti326 – 3261T → A in AAH27307 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047223 mRNA. Translation: BAC32999.1.
AK132774 mRNA. Translation: BAE21351.1.
AK168833 mRNA. Translation: BAE40657.1.
CH466523 Genomic DNA. Translation: EDK99647.1.
BC027307 mRNA. Translation: AAH27307.1.
BC029016 mRNA. Translation: AAH29016.1.
CCDSiCCDS20485.1.
RefSeqiNP_705736.1. NM_153516.2.
UniGeneiMm.27990.

Genome annotation databases

EnsembliENSMUST00000009256; ENSMUSP00000009256; ENSMUSG00000009112.
GeneIDi94044.
KEGGimmu:94044.
UCSCiuc009dnt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047223 mRNA. Translation: BAC32999.1.
AK132774 mRNA. Translation: BAE21351.1.
AK168833 mRNA. Translation: BAE40657.1.
CH466523 Genomic DNA. Translation: EDK99647.1.
BC027307 mRNA. Translation: AAH27307.1.
BC029016 mRNA. Translation: AAH29016.1.
CCDSiCCDS20485.1.
RefSeqiNP_705736.1. NM_153516.2.
UniGeneiMm.27990.

3D structure databases

ProteinModelPortaliP59017.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP59017. 1 interaction.
MINTiMINT-4088925.

PTM databases

PhosphoSiteiP59017.

Proteomic databases

MaxQBiP59017.
PaxDbiP59017.
PRIDEiP59017.

Protocols and materials databases

DNASUi94044.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009256; ENSMUSP00000009256; ENSMUSG00000009112.
GeneIDi94044.
KEGGimmu:94044.
UCSCiuc009dnt.1. mouse.

Organism-specific databases

CTDi23786.
MGIiMGI:2136959. Bcl2l13.

Phylogenomic databases

eggNOGiNOG44929.
GeneTreeiENSGT00390000015552.
HOGENOMiHOG000059276.
HOVERGENiHBG050648.
InParanoidiP59017.
KOiK15485.
OMAiSQPVTYQ.
OrthoDBiEOG77M8PW.
TreeFamiTF330744.

Miscellaneous databases

NextBioi351999.
PROiP59017.
SOURCEiSearch...

Gene expression databases

BgeeiP59017.
CleanExiMM_BCL2L13.
GenevestigatoriP59017.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
[Graphical view]
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Liver and Testis.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye and Mammary tumor.
  4. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiB2L13_MOUSE
AccessioniPrimary (citable) accession number: P59017
Secondary accession number(s): Q543S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 27, 2011
Last modified: March 4, 2015
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.