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P59017

- B2L13_MOUSE

UniProt

P59017 - B2L13_MOUSE

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Protein
Bcl-2-like protein 13
Gene
Bcl2l13, Mil1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May promote the activation of caspase-3 and apoptosis.

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. regulation of apoptotic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 13
Short name:
Bcl2-L-13
Alternative name(s):
Bcl-rambo
Protein Mil1
Gene namesi
Name:Bcl2l13
Synonyms:Mil1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2136959. Bcl2l13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei409 – 42921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. mitochondrial membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Bcl-2-like protein 13
PRO_0000143074Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351Phosphoserine By similarity
Modified residuei343 – 3431Phosphoserine1 Publication
Modified residuei387 – 3871Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP59017.
PaxDbiP59017.
PRIDEiP59017.

PTM databases

PhosphoSiteiP59017.

Expressioni

Gene expression databases

BgeeiP59017.
CleanExiMM_BCL2L13.
GenevestigatoriP59017.

Interactioni

Subunit structurei

Monomer Inferred.

Protein-protein interaction databases

IntActiP59017. 1 interaction.
MINTiMINT-4088925.

Structurei

3D structure databases

ProteinModelPortaliP59017.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati243 – 25311A
Add
BLAST
Repeati258 – 26811A; approximate
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi14 – 3017BH4
Add
BLAST
Motifi97 – 11317BH3
Add
BLAST
Motifi144 – 15411BH1
Add
BLAST
Motifi190 – 20314BH2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi204 – 2096Poly-Glu
Compositional biasi308 – 37972Glu-rich
Add
BLAST

Sequence similaritiesi

Belongs to the Bcl-2 family.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44929.
GeneTreeiENSGT00390000015552.
HOGENOMiHOG000059276.
HOVERGENiHBG050648.
InParanoidiQ543S1.
KOiK15485.
OMAiSQPVTYQ.
OrthoDBiEOG77M8PW.
TreeFamiTF330744.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
[Graphical view]
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P59017-1 [UniParc]FASTAAdd to Basket

« Hide

MASSTTASLG FHYETKYVVL SYLGLLSQEK QQGPSPPGVQ LDVAPQSLNP    50
EVLLKLKSEI EEELKTLDKE VSEAFTSTGF DCHTSPVFSP ANPESSIEDC 100
LAHLGERVSQ DLKEPLQKAL QTILSQPVTY EAYRECTVET AVHASGWNKL 150
LVPLVLLQHL LLELTRRGQE PLRMLLQFGV MYLEEHAAEF IIQQGGWGSV 200
FSLEPEEEEY PGIIAEDSND IYILPSDNSG QVSPPESPTV TTSWQSESLP 250
VSLSASQSWH TESLPVSLGP ESWQQIAMDP EEVKSLDSSG AGEKSENNSS 300
NSDIVHVEKE EVPEEAFPGA AAPLLTQVPT VEAPEMMRAE KTSPTPSVFV 350
ELGEEELEAV TARPEAVERA EGAAQLSEER AGSRKKSHTG EAAAVRGAKS 400
GLPAEGKAVL LFGGAAAVAI LAVAVGVALA LRRK 434
Length:434
Mass (Da):46,719
Last modified:July 27, 2011 - v2
Checksum:iE84790F7CBCE9B67
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81S → P in AAH27307. 1 Publication
Sequence conflicti66 – 661T → A in AAH27307. 1 Publication
Sequence conflicti326 – 3261T → A in AAH27307. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK047223 mRNA. Translation: BAC32999.1.
AK132774 mRNA. Translation: BAE21351.1.
AK168833 mRNA. Translation: BAE40657.1.
CH466523 Genomic DNA. Translation: EDK99647.1.
BC027307 mRNA. Translation: AAH27307.1.
BC029016 mRNA. Translation: AAH29016.1.
CCDSiCCDS20485.1.
RefSeqiNP_705736.1. NM_153516.2.
UniGeneiMm.27990.

Genome annotation databases

EnsembliENSMUST00000009256; ENSMUSP00000009256; ENSMUSG00000009112.
GeneIDi94044.
KEGGimmu:94044.
UCSCiuc009dnt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK047223 mRNA. Translation: BAC32999.1 .
AK132774 mRNA. Translation: BAE21351.1 .
AK168833 mRNA. Translation: BAE40657.1 .
CH466523 Genomic DNA. Translation: EDK99647.1 .
BC027307 mRNA. Translation: AAH27307.1 .
BC029016 mRNA. Translation: AAH29016.1 .
CCDSi CCDS20485.1.
RefSeqi NP_705736.1. NM_153516.2.
UniGenei Mm.27990.

3D structure databases

ProteinModelPortali P59017.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P59017. 1 interaction.
MINTi MINT-4088925.

PTM databases

PhosphoSitei P59017.

Proteomic databases

MaxQBi P59017.
PaxDbi P59017.
PRIDEi P59017.

Protocols and materials databases

DNASUi 94044.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000009256 ; ENSMUSP00000009256 ; ENSMUSG00000009112 .
GeneIDi 94044.
KEGGi mmu:94044.
UCSCi uc009dnt.1. mouse.

Organism-specific databases

CTDi 23786.
MGIi MGI:2136959. Bcl2l13.

Phylogenomic databases

eggNOGi NOG44929.
GeneTreei ENSGT00390000015552.
HOGENOMi HOG000059276.
HOVERGENi HBG050648.
InParanoidi Q543S1.
KOi K15485.
OMAi SQPVTYQ.
OrthoDBi EOG77M8PW.
TreeFami TF330744.

Miscellaneous databases

NextBioi 351999.
PROi P59017.
SOURCEi Search...

Gene expression databases

Bgeei P59017.
CleanExi MM_BCL2L13.
Genevestigatori P59017.

Family and domain databases

InterProi IPR002475. Bcl2-like.
IPR026298. Blc2_fam.
[Graphical view ]
Pfami PF00452. Bcl-2. 1 hit.
[Graphical view ]
PROSITEi PS50062. BCL2_FAMILY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Liver and Testis.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Eye and Mammary tumor.
  4. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiB2L13_MOUSE
AccessioniPrimary (citable) accession number: P59017
Secondary accession number(s): Q543S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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