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Protein

Bcl-2-like protein 13

Gene

Bcl2l13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May promote the activation of caspase-3 and apoptosis.

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 13
Short name:
Bcl2-L-13
Alternative name(s):
Bcl-rambo
Protein Mil1
Gene namesi
Name:Bcl2l13
Synonyms:Mil1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2136959 Bcl2l13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001430741 – 434Bcl-2-like protein 13Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35PhosphoserineBy similarity1
Modified residuei256PhosphoserineBy similarity1
Modified residuei258PhosphoserineBy similarity1
Modified residuei300PhosphoserineBy similarity1
Modified residuei343PhosphoserineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei377PhosphoserineBy similarity1
Modified residuei387PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP59017
MaxQBiP59017
PaxDbiP59017
PeptideAtlasiP59017
PRIDEiP59017
TopDownProteomicsiP59017

PTM databases

iPTMnetiP59017
PhosphoSitePlusiP59017
SwissPalmiP59017

Expressioni

Gene expression databases

BgeeiENSMUSG00000009112
CleanExiMM_BCL2L13
ExpressionAtlasiP59017 baseline and differential
GenevisibleiP59017 MM

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

BioGridi220423, 1 interactor
IntActiP59017, 2 interactors
MINTiP59017
STRINGi10090.ENSMUSP00000009256

Structurei

3D structure databases

ProteinModelPortaliP59017
SMRiP59017
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati243 – 253AAdd BLAST11
Repeati258 – 268A; approximateAdd BLAST11

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi14 – 30BH4Add BLAST17
Motifi97 – 113BH3Add BLAST17
Motifi144 – 154BH1Add BLAST11
Motifi190 – 203BH2Add BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi204 – 209Poly-Glu6
Compositional biasi308 – 379Glu-richAdd BLAST72

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK4J Eukaryota
ENOG410XT6A LUCA
GeneTreeiENSGT00390000015552
HOGENOMiHOG000059276
HOVERGENiHBG050648
InParanoidiP59017
KOiK15485
OMAiTYLEDYA
OrthoDBiEOG091G1AZK
TreeFamiTF330744

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR002475 Bcl2-like
IPR036834 Blc2-like_sf
IPR026298 Blc2_fam
PfamiView protein in Pfam
PF00452 Bcl-2, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit

Sequencei

Sequence statusi: Complete.

P59017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSTTASLG FHYETKYVVL SYLGLLSQEK QQGPSPPGVQ LDVAPQSLNP
60 70 80 90 100
EVLLKLKSEI EEELKTLDKE VSEAFTSTGF DCHTSPVFSP ANPESSIEDC
110 120 130 140 150
LAHLGERVSQ DLKEPLQKAL QTILSQPVTY EAYRECTVET AVHASGWNKL
160 170 180 190 200
LVPLVLLQHL LLELTRRGQE PLRMLLQFGV MYLEEHAAEF IIQQGGWGSV
210 220 230 240 250
FSLEPEEEEY PGIIAEDSND IYILPSDNSG QVSPPESPTV TTSWQSESLP
260 270 280 290 300
VSLSASQSWH TESLPVSLGP ESWQQIAMDP EEVKSLDSSG AGEKSENNSS
310 320 330 340 350
NSDIVHVEKE EVPEEAFPGA AAPLLTQVPT VEAPEMMRAE KTSPTPSVFV
360 370 380 390 400
ELGEEELEAV TARPEAVERA EGAAQLSEER AGSRKKSHTG EAAAVRGAKS
410 420 430
GLPAEGKAVL LFGGAAAVAI LAVAVGVALA LRRK
Length:434
Mass (Da):46,719
Last modified:July 27, 2011 - v2
Checksum:iE84790F7CBCE9B67
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8S → P in AAH27307 (PubMed:15489334).Curated1
Sequence conflicti66T → A in AAH27307 (PubMed:15489334).Curated1
Sequence conflicti326T → A in AAH27307 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047223 mRNA Translation: BAC32999.1
AK132774 mRNA Translation: BAE21351.1
AK168833 mRNA Translation: BAE40657.1
CH466523 Genomic DNA Translation: EDK99647.1
BC027307 mRNA Translation: AAH27307.1
BC029016 mRNA Translation: AAH29016.1
CCDSiCCDS20485.1
RefSeqiNP_705736.1, NM_153516.2
UniGeneiMm.27990

Genome annotation databases

EnsembliENSMUST00000009256; ENSMUSP00000009256; ENSMUSG00000009112
GeneIDi94044
KEGGimmu:94044
UCSCiuc009dnt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiB2L13_MOUSE
AccessioniPrimary (citable) accession number: P59017
Secondary accession number(s): Q543S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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