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P58989 (CRA1_HOMGA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Crustacyanin-A1 subunit
OrganismHomarus gammarus (European lobster) (Homarus vulgaris)
Taxonomic identifier6707 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAstacideaNephropoideaNephropidaeHomarus

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds the carotenoid astaxanthin (AXT) which provides the blue coloration to the carapace of the lobster.

Subunit structure

Oligomer; Can form dimers (beta-crustacyanin); or complexes of 16 subunits (alpha-crustacyanin). There are five types of subunits: A1, A2, A3, C1 and C2.

Subcellular location

Secretedextracellular space.

Tissue specificity

Found in the carapace.

Sequence similarities

Belongs to the calycin superfamily. Lipocalin family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentSecreted
   LigandChromophore
Pigment
   PTMDisulfide bond
   Technical term3D-structure
Gene Ontology (GO)
   Biological_processprotein-chromophore linkage

Inferred from electronic annotation. Source: UniProtKB-KW

transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpigment binding

Inferred from electronic annotation. Source: UniProtKB-KW

small molecule binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 181181Crustacyanin-A1 subunit
PRO_0000201009

Amino acid modifications

Disulfide bond12 ↔ 121
Disulfide bond51 ↔ 173
Disulfide bond117 ↔ 150

Secondary structure

................................. 181
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P58989 [UniParc].

Last modified August 13, 2002. Version 1.
Checksum: 285EADC1A4F2E353

FASTA18120,652
        10         20         30         40         50         60 
DKIPNFVVPG KCASVDRNKL WAEQTPNRNS YAGVWYQFAL TNNPYQLIEK CVRNEYSFDG 

        70         80         90        100        110        120 
KQFVIKSTGI AYDGNLLKRN GKLYPNPFGE PHLSIDYENS FAAPLVILET DYSNYACLYS 

       130        140        150        160        170        180 
CIDYNFGYHS DFSFIFSRSA NLADQYVKKC EAAFKNINVD TTRFVKTVQG SSCPYDTQKT 


V 

« Hide

References

[1]"Structure of lobster apocrustacyanin A1 using softer X-rays."
Cianci M., Rizkallah P.J., Olczak A., Raftery J., Chayen N.E., Zagalsky P.F., Helliwell J.R.
Acta Crystallogr. D 57:1219-1229(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.15 ANGSTROMS) OF HOMODIMER.
[2]"The molecular basis of the coloration mechanism in lobster shell: beta-crustacyanin at 3.2-A resolution."
Cianci M., Rizkallah P.J., Olczak A., Raftery J., Chayen N.E., Zagalsky P.F., Helliwell J.R.
Proc. Natl. Acad. Sci. U.S.A. 99:9795-9800(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF HETERODIMER OF A1 AND A3 IN COMPLEX WITH ASTAXANTHIN.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Squeeze me - Issue 26 of September 2002

Cross-references

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1GKAX-ray3.23A2-181[»]
1S44X-ray1.60A/B2-181[»]
ProteinModelPortalP58989.
SMRP58989. Positions 2-181.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-242140.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.40.128.20. 1 hit.
InterProIPR012674. Calycin.
IPR011038. Calycin-like.
IPR003057. Invtbrt_color.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFPIRSF036893. Lipocalin_ApoD. 1 hit.
PRINTSPR01273. INVTBRTCOLOR.
PR00179. LIPOCALIN.
SUPFAMSSF50814. SSF50814. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP58989.

Entry information

Entry nameCRA1_HOMGA
AccessionPrimary (citable) accession number: P58989
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: August 13, 2002
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references