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P58989

- CRA1_HOMGA

UniProt

P58989 - CRA1_HOMGA

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Protein

Crustacyanin-A1 subunit

Gene
N/A
Organism
Homarus gammarus (European lobster) (Homarus vulgaris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Binds the carotenoid astaxanthin (AXT) which provides the blue coloration to the carapace of the lobster.

GO - Molecular functioni

  1. pigment binding Source: UniProtKB-KW
  2. small molecule binding Source: InterPro

GO - Biological processi

  1. protein-chromophore linkage Source: UniProtKB-KW
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Chromophore, Pigment

Names & Taxonomyi

Protein namesi
Recommended name:
Crustacyanin-A1 subunit
OrganismiHomarus gammarus (European lobster) (Homarus vulgaris)
Taxonomic identifieri6707 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAstacideaNephropoideaNephropidaeHomarus

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Crustacyanin-A1 subunitPRO_0000201009Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi12 ↔ 121
Disulfide bondi51 ↔ 173
Disulfide bondi117 ↔ 150

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Found in the carapace.

Interactioni

Subunit structurei

Oligomer; Can form dimers (beta-crustacyanin); or complexes of 16 subunits (alpha-crustacyanin). There are five types of subunits: A1, A2, A3, C1 and C2.

Protein-protein interaction databases

MINTiMINT-242140.

Structurei

Secondary structure

1
181
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 115
Helixi17 – 248
Helixi25 – 273
Helixi28 – 314
Beta strandi33 – 419
Beta strandi48 – 5811
Beta strandi63 – 719
Beta strandi74 – 8512
Beta strandi91 – 977
Beta strandi98 – 1003
Beta strandi102 – 1109
Beta strandi112 – 12312
Beta strandi127 – 14115
Helixi144 – 15613
Helixi161 – 1633
Beta strandi164 – 1663
Beta strandi170 – 1734
Helixi175 – 1784

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GKAX-ray3.23A2-181[»]
1S44X-ray1.60A/B2-181[»]
ProteinModelPortaliP58989.
SMRiP58989. Positions 2-181.

Miscellaneous databases

EvolutionaryTraceiP58989.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR003057. Invtbrt_color.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
PRINTSiPR01273. INVTBRTCOLOR.
PR00179. LIPOCALIN.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

P58989-1 [UniParc]FASTAAdd to Basket

« Hide

DKIPNFVVPG KCASVDRNKL WAEQTPNRNS YAGVWYQFAL TNNPYQLIEK    50
CVRNEYSFDG KQFVIKSTGI AYDGNLLKRN GKLYPNPFGE PHLSIDYENS 100
FAAPLVILET DYSNYACLYS CIDYNFGYHS DFSFIFSRSA NLADQYVKKC 150
EAAFKNINVD TTRFVKTVQG SSCPYDTQKT V 181
Length:181
Mass (Da):20,652
Last modified:August 13, 2002 - v1
Checksum:i285EADC1A4F2E353
GO

Cross-referencesi

Web resourcesi

Protein Spotlight

Squeeze me - Issue 26 of September 2002

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1GKA X-ray 3.23 A 2-181 [» ]
1S44 X-ray 1.60 A/B 2-181 [» ]
ProteinModelPortali P58989.
SMRi P58989. Positions 2-181.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-242140.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P58989.

Family and domain databases

Gene3Di 2.40.128.20. 1 hit.
InterProi IPR012674. Calycin.
IPR011038. Calycin-like.
IPR003057. Invtbrt_color.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view ]
Pfami PF00061. Lipocalin. 1 hit.
[Graphical view ]
PIRSFi PIRSF036893. Lipocalin_ApoD. 1 hit.
PRINTSi PR01273. INVTBRTCOLOR.
PR00179. LIPOCALIN.
SUPFAMi SSF50814. SSF50814. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: X-RAY CRYSTALLOGRAPHY (1.15 ANGSTROMS) OF HOMODIMER.
  2. "The molecular basis of the coloration mechanism in lobster shell: beta-crustacyanin at 3.2-A resolution."
    Cianci M., Rizkallah P.J., Olczak A., Raftery J., Chayen N.E., Zagalsky P.F., Helliwell J.R.
    Proc. Natl. Acad. Sci. U.S.A. 99:9795-9800(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF HETERODIMER OF A1 AND A3 IN COMPLEX WITH ASTAXANTHIN.

Entry informationi

Entry nameiCRA1_HOMGA
AccessioniPrimary (citable) accession number: P58989
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: August 13, 2002
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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