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P58932

- BCSA_XANAC

UniProt

P58932 - BCSA_XANAC

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Protein
Cellulose synthase catalytic subunit [UDP-forming]
Gene
bcsA, XAC3518
Organism
Xanthomonas axonopodis pv. citri (strain 306)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose, which is produced as an extracellular component for mechanical and chemical protection By similarity.

Catalytic activityi

UDP-glucose + (1,4-beta-D-glucosyl)(n) = UDP + (1,4-beta-D-glucosyl)(n+1).

Cofactori

Magnesium By similarity.

Enzyme regulationi

Activated by bis-(3'-5') cyclic diguanylic acid (c-di-GMP) By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei193 – 1931 Reviewed prediction
Binding sitei240 – 2401Substrate Reviewed prediction
Binding sitei242 – 2421Substrate Reviewed prediction
Active sitei337 – 3371 Reviewed prediction

GO - Molecular functioni

  1. cellulose synthase (UDP-forming) activity Source: UniProtKB-EC
  2. cyclic-di-GMP binding Source: InterPro

GO - Biological processi

  1. UDP-glucose metabolic process Source: InterPro
  2. cellulose biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cellulose biosynthesis

Keywords - Ligandi

c-di-GMP

Enzyme and pathway databases

BioCyciXAXO190486:GH55-3518-MONOMER.
UniPathwayiUPA00694.

Names & Taxonomyi

Protein namesi
Recommended name:
Cellulose synthase catalytic subunit [UDP-forming] (EC:2.4.1.12)
Gene namesi
Name:bcsA
Ordered Locus Names:XAC3518
OrganismiXanthomonas axonopodis pv. citri (strain 306)
Taxonomic identifieri190486 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000000576: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021Helical; Reviewed prediction
Add
BLAST
Transmembranei110 – 13021Helical; Reviewed prediction
Add
BLAST
Transmembranei171 – 19121Helical; Reviewed prediction
Add
BLAST
Transmembranei405 – 42521Helical; Reviewed prediction
Add
BLAST
Transmembranei427 – 44721Helical; Reviewed prediction
Add
BLAST
Transmembranei520 – 54021Helical; Reviewed prediction
Add
BLAST
Transmembranei549 – 56921Helical; Reviewed prediction
Add
BLAST
Transmembranei610 – 63021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 729729Cellulose synthase catalytic subunit [UDP-forming]
PRO_0000059272Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi190486.XAC3518.

Structurei

3D structure databases

ProteinModelPortaliP58932.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini575 – 67197PilZ
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni151 – 24494Catalytic subdomain A
Add
BLAST
Regioni321 – 38161Catalytic subdomain B
Add
BLAST

Domaini

There are two conserved domains in the globular part of the protein: the N-terminal domain (domain A) contains the conserved DXD motif and is possibly involved in catalysis and substrate binding. The C-terminal domain (domain B) contains the QXXRW motif and is present only in processive glycosyl transferases. It could be involved in the processivity function of the enzyme, possibly required for holding the growing glycan chain in the active site.

Sequence similaritiesi

Contains 1 PilZ domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1215.
HOGENOMiHOG000259144.
KOiK00694.
OMAiQLTMGWF.
OrthoDBiEOG66TG3C.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR003919. Cell_synth_A.
IPR029044. Nucleotide-diphossugar_trans.
IPR009875. PilZ_domain.
[Graphical view]
PfamiPF07238. PilZ. 1 hit.
[Graphical view]
PRINTSiPR01439. CELLSNTHASEA.
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03030. CelA. 1 hit.

Sequencei

Sequence statusi: Complete.

P58932-1 [UniParc]FASTAAdd to Basket

« Hide

MPLVVPHAAM PEGRLMTAAS RRSASPLPTL ATWALWLLGA LLLVFVVAVP    50
MDVTQQLVFS GVLFAVALAV RNRGGRVVIL MMMGMSLAVS CRYIWWRMTQ 100
TMGVGSAVDF ILGLGLLGAE LYAFVILVLG YFQVLWPLNR KPVPLPADQR 150
LWPSVDVFIP TYNEPLSVVR TTVLAASVID WPAGKITIHL LDDGRRDEFR 200
AFCAEVGINY VTRTNNAHAK AGNINAALKK CSGDYVAIFD CDHIPTRSFL 250
QVAMGWFLHD TKLALVQMPH YFFSPDPFER NLDTHGKVPN EGELFYGLLQ 300
DGNDQWNATF FCGSCAVIKR TALEEVGGVA VETVTEDAHT ALKLQRRGYR 350
TAYLAVPQAA GLATESLSGH VAQRIRWARG MAQIARIDNP LLGRGLKLSQ 400
RLCYLNAMLH FFYGVPRIIY LTAPLAYLFF GAHVIQASAL MILAYALPHI 450
LQANLTNLRV QSRFRHLLWN EVYETTLAWY IFRPTLVALL NPKLGKFNVT 500
PKGGLVARSY FDAQIAKPYL FLLLLNVVGM VAGVLRLIYV GGSGEQQTIW 550
FNLAWTLYNM VLLGATIATA SETRQVRSAH RVPLDVPVTL YLPDGDVLPS 600
RSVNFSTGGM AIMLAQPQPI EPGLPVQIGL SHRGVEQTLP AVVRQDRDGQ 650
VSIQFTQMSM EQERWLVAST FARADIWLSQ WGQHDRDAFW RSMGQVLEAS 700
ARGFGRLGGH IVDSARQGFR PRRAVDLES 729
Length:729
Mass (Da):80,915
Last modified:July 26, 2002 - v1
Checksum:iB9C08BB995E795B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008923 Genomic DNA. Translation: AAM38361.1.
RefSeqiNP_643825.2. NC_003919.1.

Genome annotation databases

EnsemblBacteriaiAAM38361; AAM38361; XAC3518.
GeneIDi1157589.
KEGGixac:XAC3518.
PATRICi24059178. VBIXanAxo33670_3640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008923 Genomic DNA. Translation: AAM38361.1 .
RefSeqi NP_643825.2. NC_003919.1.

3D structure databases

ProteinModelPortali P58932.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 190486.XAC3518.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM38361 ; AAM38361 ; XAC3518 .
GeneIDi 1157589.
KEGGi xac:XAC3518.
PATRICi 24059178. VBIXanAxo33670_3640.

Phylogenomic databases

eggNOGi COG1215.
HOGENOMi HOG000259144.
KOi K00694.
OMAi QLTMGWF.
OrthoDBi EOG66TG3C.

Enzyme and pathway databases

UniPathwayi UPA00694 .
BioCyci XAXO190486:GH55-3518-MONOMER.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR003919. Cell_synth_A.
IPR029044. Nucleotide-diphossugar_trans.
IPR009875. PilZ_domain.
[Graphical view ]
Pfami PF07238. PilZ. 1 hit.
[Graphical view ]
PRINTSi PR01439. CELLSNTHASEA.
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR03030. CelA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparison of the genomes of two Xanthomonas pathogens with differing host specificities."
    da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R., Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., Almeida N.F. Jr., Alves L.M.C., do Amaral A.M., Bertolini M.C., Camargo L.E.A., Camarotte G., Cannavan F., Cardozo J., Chambergo F., Ciapina L.P.
    , Cicarelli R.M.B., Coutinho L.L., Cursino-Santos J.R., El-Dorry H., Faria J.B., Ferreira A.J.S., Ferreira R.C.C., Ferro M.I.T., Formighieri E.F., Franco M.C., Greggio C.C., Gruber A., Katsuyama A.M., Kishi L.T., Leite R.P., Lemos E.G.M., Lemos M.V.F., Locali E.C., Machado M.A., Madeira A.M.B.N., Martinez-Rossi N.M., Martins E.C., Meidanis J., Menck C.F.M., Miyaki C.Y., Moon D.H., Moreira L.M., Novo M.T.M., Okura V.K., Oliveira M.C., Oliveira V.R., Pereira H.A., Rossi A., Sena J.A.D., Silva C., de Souza R.F., Spinola L.A.F., Takita M.A., Tamura R.E., Teixeira E.C., Tezza R.I.D., Trindade dos Santos M., Truffi D., Tsai S.M., White F.F., Setubal J.C., Kitajima J.P.
    Nature 417:459-463(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 306.

Entry informationi

Entry nameiBCSA_XANAC
AccessioniPrimary (citable) accession number: P58932
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: July 26, 2002
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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