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P58928 (CEX_CONCN) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Conotoxin CcTx
Alternative name(s):
Excitotoxin CcTx
OrganismConus consors (Singed cone)
Taxonomic identifier101297 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Protein attributes

Sequence length30 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May specifically activate neuronal voltage-gated sodium channels (Nav) at the resting membrane potential. Causes a marked contraction and extension of the caudal and dorsal fins in fish and noticeable spontaneous contractions of isolated frog neuromuscular preparations.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom duct.

Domain

The cysteine framework is IV (CC-C-C-C-C).

Post-translational modification

Contains 3 disulfide bonds. They are not added, since framework IV presents two different connectivities (I-V, II-III, IV-VI and I-III, II-V, IV-VI).

Miscellaneous

Found in both injectable (milked) (IV) and dissected venom (DV) (Ref.2).

Mass spectrometry

Molecular mass is 4156 Da from positions 1 - 30. Determined by ESI. Ref.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 3030Conotoxin CcTx
PRO_0000044514

Amino acid modifications

Modified residue214-hydroxyproline
Modified residue1714-hydroxyproline
Modified residue2214-hydroxyproline
Glycosylation71O-linked (HexNAc...) Ref.2

Secondary structure

... 30
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P58928 [UniParc].

Last modified March 23, 2010. Version 2.
Checksum: AD8E9CC5ABB0E065

FASTA303,184
        10         20         30 
APWLVPSQIT TCCGYNPGTM CPSCMCTNTC 

« Hide

References

[1]"A new conotoxin isolated from Conus consors venom acting selectively on axons and motor nerve terminals through a Na+-dependent mechanism."
Le Gall F., Favreau P., Benoit E., Mattei C., Bouet F., Menou J.-L., Menez A., Letourneux Y., Molgo J.
Eur. J. Neurosci. 11:3134-3142(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY.
Tissue: Venom.
[2]"Comparative proteomic study of the venom of the piscivorous cone snail Conus consors."
Biass D., Dutertre S., Gerbault A., Menou J.L., Offord R., Favreau P., Stocklin R.
J. Proteomics 72:210-218(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO 7, GLYCOSYLATION AT SER-7.
[3]"Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach."
Violette A., Biass D., Dutertre S., Koua D., Piquemal D., Pierrat F., Stocklin R., Favreau P.
J. Proteomics 75:5215-5225(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY OF GLYCOSYLATED AND NON-GLYCOSYLATED FORMS.
Tissue: Venom.
+Additional computationally mapped references.

Cross-references

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4B1QNMR-P1-30[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ConoServer1510. CcTx.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameCEX_CONCN
AccessionPrimary (citable) accession number: P58928
Entry history
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: March 23, 2010
Last modified: October 16, 2013
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references