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Protein

Conotoxin TVIIA

Gene
N/A
Organism
Conus tulipa (Fish-hunting cone snail) (Tulip cone)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

By structural similarity with conotoxin GS, may inhibit the sodium channel (Nav). No effect was observed upon intracranial injections into mice and intraperitoneal injections into goldfish (25 µg).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin TVIIA
OrganismiConus tulipa (Fish-hunting cone snail) (Tulip cone)
Taxonomic identifieri6495 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri1405. TVIIA.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000444881 – 30Conotoxin TVIIAAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 14
Disulfide bondi9 ↔ 19
Modified residuei104-hydroxyproline1 Publication1
Modified residuei114-hydroxyproline1 Publication1
Disulfide bondi13 ↔ 24

Post-translational modificationi

Three different forms of TVIIA exist. Pro-10 and Pro-11 of conotoxin TVIIA are hydroxylated in TVIIA, whereas Pro-10 is not hydroxylated in [Pro10]TVIIA and neither Pro-10 nor Pro-11 are hydroxylated in [Pro10,11]TVIIA.1 Publication

Keywords - PTMi

Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

Secondary structure

130
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 13Combined sources4
Beta strandi20 – 23Combined sources4
Turni27 – 29Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EYONMR-A1-30[»]
ProteinModelPortaliP58923.
SMRiP58923.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP58923.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
The cysteine framework is VI/VII (C-C-CC-C-C).

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR012629. Conotoxin_TVIIAGS.
PfamiView protein in Pfam
PF08094. Toxin_24. 1 hit.

Sequencei

Sequence statusi: Complete.

P58923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30
SCSGRDSRCP PVCCMGLMCS RGKCVSIYGE
Length:30
Mass (Da):3,186
Last modified:July 26, 2002 - v1
Checksum:iD9419BC6F0DB7A30
GO

Mass spectrometryi

Molecular mass is 3212.4 Da from positions 1 - 30. Determined by ESI. TVIIA with hydroxyPro-10 and hydroxyPro-11.1 Publication
Molecular mass is 3196.0 Da from positions 1 - 30. Determined by ESI. [Pro10]TVIIA with hydroxyPro-11.1 Publication
Molecular mass is 3180.0 Da from positions 1 - 30. Determined by ESI. [Pro10,Pro11]TVIIA.1 Publication

Entry informationi

Entry nameiC7A_CONTU
AccessioniPrimary (citable) accession number: P58923
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: July 26, 2002
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references