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Protein

Omega-conotoxin-like CnVIIH

Gene
N/A
Organism
Conus consors (Singed cone)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin blocks N-type calcium channels (Cav2.2/CACNA1B), but unexpectedly, does not show any blocking activity at amphibian neuromuscular junction. Causes shaking activity, and, at higher doses, causes mild tremors when injected intracerebroventricularly into mice. Causes paralysis, and, at higher doses, causes death when injected intramuscularly into fish.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei13Essential for calcium channel bindingBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-conotoxin-like CnVIIH
Cleaved into the following chain:
OrganismiConus consors (Singed cone)
Taxonomic identifieri101297 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri1632. CnVIIA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00004198281 – 28Omega-conotoxin-like CnVIIHAdd BLAST28
PeptideiPRO_00000444811 – 27Omega-conotoxin CnVIIAAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi1 ↔ 16By similarity
Modified residuei74-hydroxyproline; partial1 Publication1
Disulfide bondi8 ↔ 20By similarity
Modified residuei12Methionine sulfoxide1 Publication1
Disulfide bondi15 ↔ 27By similarity
Modified residuei27Cysteine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond, Hydroxylation, Oxidation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
The cysteine framework is VI/VII (C-C-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin O1 superfamily.Curated

Keywords - Domaini

Knottin

Family and domain databases

InterProiIPR012321. Conotoxin_omega-typ_CS.
[Graphical view]
PROSITEiPS60004. OMEGA_CONOTOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58916-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
CKGKGAPCTR LMYDCCHGSC SSSKGRCG
Length:28
Mass (Da):2,896
Last modified:October 31, 2012 - v2
Checksum:i0A49DEFD1491F2CB
GO

Mass spectrometryi

Molecular mass is 2847.74 Da from positions 1 - 27. Determined by ESI. 1 Publication
Molecular mass is 2904.17 Da from positions 1 - 28. Determined by ESI. CnVIIH.1 Publication
Molecular mass is 2846.14 Da from positions 1 - 27. Determined by ESI. [Hyp7]-CnVIIA and [Pro7, oxMet12]-CnVIIA.1 Publication
Molecular mass is 2830.19 Da from positions 1 - 27. Determined by ESI. [Pro7]CnVIIA.1 Publication

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1632. CnVIIA.

Family and domain databases

InterProiIPR012321. Conotoxin_omega-typ_CS.
[Graphical view]
PROSITEiPS60004. OMEGA_CONOTOXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCO7A_CONCN
AccessioniPrimary (citable) accession number: P58916
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: October 31, 2012
Last modified: July 22, 2015
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

Found in injectable (milked) (IV) venom.1 Publication

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.