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Protein

Omega-conotoxin RVIA

Gene
N/A
Organism
Conus radiatus (Rayed cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).

GO - Molecular functioni

Keywordsi

Molecular functionCalcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-conotoxin RVIA
OrganismiConus radiatus (Rayed cone)
Taxonomic identifieri61198 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConusPhasmoconus

Organism-specific databases

ConoServeri1728 RVIA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000444781 – 27Omega-conotoxin RVIAAdd BLAST27

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi1 ↔ 16
Modified residuei44-hydroxyproline1 Publication1
Modified residuei74-hydroxyproline1 Publication1
Disulfide bondi8 ↔ 19
Disulfide bondi15 ↔ 26

Keywords - PTMi

Disulfide bond, Hydroxylation

Proteomic databases

PRIDEiP58914

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiP58914
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
The cysteine framework is VI/VII (C-C-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin O1 superfamily.Curated

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR012321 Conotoxin_omega-typ_CS
PROSITEiView protein in PROSITE
PS60004 OMEGA_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

P58914-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
CKPPGSPCRV SSYNCCSSCK SYNKKCG
Length:27
Mass (Da):2,887
Last modified:July 26, 2002 - v1
Checksum:iF554C1F8A01A88AF
GO

Similar proteinsi

Entry informationi

Entry nameiCO6A_CONRA
AccessioniPrimary (citable) accession number: P58914
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: July 26, 2002
Last modified: May 23, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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