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Protein

Pyruvoyl-dependent arginine decarboxylase 2

Gene

pdaD2

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-arginine = agmatine + CO2.

Cofactori

pyruvateBy similarityNote: Binds 1 pyruvoyl group covalently per subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandPyruvate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvoyl-dependent arginine decarboxylase 2 (EC:4.1.1.19)
Short name:
PvlArgDC 2
Cleaved into the following 2 chains:
Gene namesi
Name:pdaD2
Ordered Locus Names:MM_2595
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000000595 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000233201 – 40Pyruvoyl-dependent arginine decarboxylase 2 subunit betaBy similarityAdd BLAST40
ChainiPRO_000002332141 – 183Pyruvoyl-dependent arginine decarboxylase 2 subunit alphaBy similarityAdd BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41Pyruvic acid (Ser)By similarity1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei40 – 41Cleavage (non-hydrolytic)By similarity2

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_2595.

Structurei

3D structure databases

ProteinModelPortaliP58890.
SMRiP58890.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdaD family.Curated

Phylogenomic databases

eggNOGiarCOG04490. Archaea.
COG1945. LUCA.
HOGENOMiHOG000012204.
KOiK02626.
OMAiSEHHSFG.
OrthoDBiPOG093Z0D0B.

Family and domain databases

Gene3Di3.50.20.10. 1 hit.
HAMAPiMF_01404. PvlArgDC. 1 hit.
InterProiView protein in InterPro
IPR016104. Pyr-dep_his/arg-deCO2ase.
IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
IPR002724. Pyruvoyl-dep_arg_deCO2ase.
PANTHERiPTHR40438:SF2. PTHR40438:SF2. 1 hit.
PfamiView protein in Pfam
PF01862. PvlArgDC. 1 hit.
PIRSFiPIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
SFLDiSFLDG01170. Pyruvoyl-dependent_arginine_de. 1 hit.
SUPFAMiSSF56271. SSF56271. 1 hit.
TIGRFAMsiTIGR00286. TIGR00286. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58890-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPRKAFLTK GTGVHKDRLA SFELALRDAK IEKYNLVSVS SILPPNCKLV
60 70 80 90 100
PREEGLAELK PGAIVHCVLA RNDTNEPHRL MASAIGTAVP VNEENYGYIS
110 120 130 140 150
EHHSFGEEEI IAGEYAEDLA ATMLATTLGI EFDAEMAWHE REQVYKASGH
160 170 180
IFDTFHMCQT AKGDKDGKWT TTVAAMVFVT SKC
Length:183
Mass (Da):20,211
Last modified:July 11, 2002 - v1
Checksum:iEC848E8E644A2360
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA. Translation: AAM32291.1.
RefSeqiWP_011034508.1. NC_003901.1.

Genome annotation databases

EnsemblBacteriaiAAM32291; AAM32291; MM_2595.
GeneIDi24880900.
KEGGimma:MM_2595.
PATRICifig|192952.21.peg.2981.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPDAD2_METMA
AccessioniPrimary (citable) accession number: P58890
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: July 11, 2002
Last modified: June 7, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families