Reviewed, UniProtKB/Swiss-Prot P58890 (PDAD2_METMA)

Names and origin

Protein names

Recommended name:
    Pyruvoyl-dependent arginine decarboxylase 2
      Short name=PvlArgDC 2
    EC=4.1.1.19
Cleaved into the following 2 chains:
    1- Recommended name:
            Pyruvoyl-dependent arginine decarboxylase 2 subunit beta
    2- Recommended name:
            Pyruvoyl-dependent arginine decarboxylase 2 subunit alpha

Gene names

Name:	pdaD2
Ordered Locus Names:	MM_2595

Organism

Methanosarcina mazei (Methanosarcina frisia) [Complete proteome] [HAMAP]

Taxonomic identifier

2209 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	183 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-arginine = agmatine + CO2. HAMAP MF_01404
Cofactor	Pyruvoyl group By similarity.
Sequence similarities	Belongs to the pdaD family.

Ontologies

Keywords
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 40	40	Pyruvoyl-dependent arginine decarboxylase 2 subunit beta By similarity		PRO_0000023320
	Chain	41 – 183	143	Pyruvoyl-dependent arginine decarboxylase 2 subunit alpha By similarity		PRO_0000023321
Sites
	Site	40 – 41	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	41	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P58890-1 [UniParc]. Last modified July 11, 2002. Version 1. Checksum: EC848E8E644A2360	FASTA	183	20,211
	10 20 30 40 50 60 MIPRKAFLTK GTGVHKDRLA SFELALRDAK IEKYNLVSVS SILPPNCKLV PREEGLAELK 70 80 90 100 110 120 PGAIVHCVLA RNDTNEPHRL MASAIGTAVP VNEENYGYIS EHHSFGEEEI IAGEYAEDLA 130 140 150 160 170 180 ATMLATTLGI EFDAEMAWHE REQVYKASGH IFDTFHMCQT AKGDKDGKWT TTVAAMVFVT SKC

References

[1]

"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea." Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G. J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed: 12125824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008384 Genomic DNA. Translation: AAM32291.1.
RefSeq	NP_634619.1.
3D structure databases
HSSP	HSSP built from PDB template 1N2M based on UniProtKB Q57764.
ModBase	Search...
Genome annotation databases
GeneID	1480937.
GenomeReviews	Gene locus MM_2595 in contig AE008384_GR.
KEGG	mma:MM_2595.
NMPDR	fig|192952.1.peg.2595.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P58890.
OMA	YKMSGKI.
Enzyme and pathway databases
BioCyc	MMAZ192952:MM2595-MON.
BRENDA	4.1.1.19. 261165.
Family and domain databases
HAMAP	MF_01404. [Tree]
InterPro	IPR016105. Pyr-dep_his/arg-deCO2ase_sand. IPR002724. Pyruvoyl-dep_arg_deCO2ase. [Graphical view]
Gene3D	G3DSA:3.50.20.10. Pyr-dep_his/arg-deCO2ase_sand. 1 hit.
Pfam	PF01862. PvlArgDC. 1 hit. [Graphical view]
PIRSF	PIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDom	PD010449. DUF44. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00286. PvlArgDC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDAD2_METMA

Accession

Primary (citable) accession number: P58890

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	July 11, 2002
Last modified:	November 3, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)