P58889 (PDAD1_METMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyruvoyl-dependent arginine decarboxylase 1
Short name=PvlArgDC 1
EC=4.1.1.19

Cleaved into the following 2 chains:

1. Pyruvoyl-dependent arginine decarboxylase 1 subunit beta
2. Pyruvoyl-dependent arginine decarboxylase 1 subunit alpha

Gene names

Name:	pdaD1
Ordered Locus Names:	MM_0286

Organism

Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) [Complete proteome] [HAMAP]

Taxonomic identifier

192952 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-arginine = agmatine + CO2. HAMAP MF_01404
Cofactor	Pyruvoyl group By similarity. HAMAP MF_01404
Sequence similarities	Belongs to the pdaD family.

Ontologies

Keywords
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 44	44	Pyruvoyl-dependent arginine decarboxylase 1 subunit beta By similarity		PRO_0000023318
	Chain	45 – 165	121	Pyruvoyl-dependent arginine decarboxylase 1 subunit alpha By similarity		PRO_0000023319
Sites
	Site	44 – 45	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	45	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P58889 [UniParc]. Last modified July 11, 2002. Version 1. Checksum: 5F56185DBD942D92	FASTA	165	17,992
	10 20 30 40 50 60 MITKLIPKKV FFTSGAGTHP EKLESFEAAL RDACIEKFNL VTVSSILPPR CEIVTKEEGL 70 80 90 100 110 120 KELSPGEIVF CVMSRISSND PGKTLTSSVG CALPVDISKH GYISEYHAYE ESAQDAGAHA 130 140 150 160 VKLAESMYST WTKEEPLKTF SIPRSSTVKD SGDWMTVISA AVFVI

References

[1]

"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea." Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G. J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed: 12125824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008384 Genomic DNA. Translation: AAM29982.1.
RefSeq	NP_632310.1. NC_003901.1.
3D structure databases
ProteinModelPortal	P58889.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1478628.
GenomeReviews	Gene locus MM_0286 in contig AE008384_GR.
KEGG	mma:MM_0286.
NMPDR	fig|192952.1.peg.286.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG539680.
OMA	YISEYHA.
ProtClustDB	PRK12398.
Enzyme and pathway databases
BioCyc	MMAZ192952:MM0286-MONOMER.
Family and domain databases
HAMAP	MF_01404. PvlArgDC. [Tree]
InterPro	IPR016104. Pyr-dep_his/arg-deCO2ase. IPR016105. Pyr-dep_his/arg-deCO2ase_sand. IPR002724. Pyruvoyl-dep_arg_deCO2ase. [Graphical view]
Gene3D	G3DSA:3.50.20.10. Pyr-dep_his/arg-deCO2ase_sand. 1 hit.
KO	K02626.
Pfam	PF01862. PvlArgDC. 1 hit. [Graphical view]
PIRSF	PIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDom	PD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF56271. His_carbxylase. 1 hit.
TIGRFAMs	TIGR00286. TIGR00286. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDAD1_METMA

Accession

Primary (citable) accession number: P58889

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	July 11, 2002
Last modified:	November 16, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program