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P58883

- PYRF_THETN

UniProt

P58883 - PYRF_THETN

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Protein

Orotidine 5'-phosphate decarboxylase

Gene
pyrF, TTE1532
Organism
Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei106 – 1061Proton donor By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciCSUB273068:GJEB-2765-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:TTE1532
OrganismiThermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Taxonomic identifieri273068 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
ProteomesiUP000000555: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Orotidine 5'-phosphate decarboxylaseUniRule annotationPRO_0000134636Add
BLAST

Proteomic databases

PRIDEiP58883.

Interactioni

Protein-protein interaction databases

STRINGi273068.TTE1532.

Structurei

3D structure databases

ProteinModelPortaliP58883.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000245747.
KOiK01591.
OMAiHIHARHP.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.

Sequencei

Sequence statusi: Complete.

P58883-1 [UniParc]FASTAAdd to Basket

« Hide

MFVDRLIESV KAKKTPVVVG LDPRIEMIPD FIKEEAFRRK GNGVEGIAEA    50
MYLFNKGIID AVYDLIPAVK IQVAFYEAYG IEGFKAFFRT AEYAKSLGLI 100
VIADVKRGDI QDVAKMYSKA YLQNPLFDAI TVNPYMGEDS MVPYLEDVEK 150
FGKGIFVLVK TSNRSSKDVQ DIETKKGGYV YQEVAKMISR LSKVIVGKYG 200
YSSIGAVVGA TYPFEAKILR EEMPRCYFLV PGYGAQGATA EDVVNCFDEE 250
GYGAIINSSR GVIYAYRSDF WKEAYSEYEY GQAAREEVIL MTGMINNALV 300
KRKYIAS 307
Length:307
Mass (Da):34,399
Last modified:June 24, 2002 - v1
Checksum:iF1D89D49BDFEFE01
GO

Sequence cautioni

The sequence AAM24743.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM24743.1. Different initiation.
RefSeqiNP_623139.1. NC_003869.1.

Genome annotation databases

EnsemblBacteriaiAAM24743; AAM24743; TTE1532.
GeneIDi996047.
KEGGitte:TTE1532.
PATRICi23897768. VBITheTen82880_1534.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008691 Genomic DNA. Translation: AAM24743.1 . Different initiation.
RefSeqi NP_623139.1. NC_003869.1.

3D structure databases

ProteinModelPortali P58883.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273068.TTE1532.

Proteomic databases

PRIDEi P58883.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM24743 ; AAM24743 ; TTE1532 .
GeneIDi 996047.
KEGGi tte:TTE1532.
PATRICi 23897768. VBITheTen82880_1534.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000245747.
KOi K01591.
OMAi HIHARHP.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci CSUB273068:GJEB-2765-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Entry informationi

Entry nameiPYRF_THETN
AccessioniPrimary (citable) accession number: P58883
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 24, 2002
Last sequence update: June 24, 2002
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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