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P58883 (PYRF_THETN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:TTE1532
OrganismThermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis) [Complete proteome] [HAMAP]
Taxonomic identifier273068 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01215

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01215

Sequence similarities

Belongs to the OMP decarboxylase family. Type 2 subfamily.

Sequence caution

The sequence AAM24743.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' UMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

'de novo' pyrimidine nucleobase biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionorotidine-5'-phosphate decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01215
PRO_0000134636

Sites

Active site1061Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
P58883 [UniParc].

Last modified June 24, 2002. Version 1.
Checksum: F1D89D49BDFEFE01

FASTA30734,399
        10         20         30         40         50         60 
MFVDRLIESV KAKKTPVVVG LDPRIEMIPD FIKEEAFRRK GNGVEGIAEA MYLFNKGIID 

        70         80         90        100        110        120 
AVYDLIPAVK IQVAFYEAYG IEGFKAFFRT AEYAKSLGLI VIADVKRGDI QDVAKMYSKA 

       130        140        150        160        170        180 
YLQNPLFDAI TVNPYMGEDS MVPYLEDVEK FGKGIFVLVK TSNRSSKDVQ DIETKKGGYV 

       190        200        210        220        230        240 
YQEVAKMISR LSKVIVGKYG YSSIGAVVGA TYPFEAKILR EEMPRCYFLV PGYGAQGATA 

       250        260        270        280        290        300 
EDVVNCFDEE GYGAIINSSR GVIYAYRSDF WKEAYSEYEY GQAAREEVIL MTGMINNALV 


KRKYIAS 

« Hide

References

[1]"A complete sequence of the T. tengcongensis genome."
Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y., Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R. expand/collapse author list , Wang J., Yu J., Yang H.
Genome Res. 12:689-700(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008691 Genomic DNA. Translation: AAM24743.1. Different initiation.
RefSeqNP_623139.1. NC_003869.1.

3D structure databases

ProteinModelPortalP58883.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273068.TTE1532.

Proteomic databases

PRIDEP58883.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM24743; AAM24743; TTE1532.
GeneID996047.
KEGGtte:TTE1532.
PATRIC23897768. VBITheTen82880_1534.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000245747.
KOK01591.
OMAHIHARHP.
OrthoDBEOG6DZF33.

Enzyme and pathway databases

BioCycCSUB273068:GJEB-2765-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01215. OMPdecase_type2.
InterProIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR02127. pyrF_sub2. 1 hit.
ProtoNetSearch...

Entry information

Entry namePYRF_THETN
AccessionPrimary (citable) accession number: P58883
Entry history
Integrated into UniProtKB/Swiss-Prot: June 24, 2002
Last sequence update: June 24, 2002
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways