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P58883

- PYRF_THETN

UniProt

P58883 - PYRF_THETN

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (24 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei106 – 1061Proton donorBy similarity

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciCSUB273068:GJEB-2765-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMP decarboxylase
    Short name:
    OMPDCase
    Short name:
    OMPdecase
    Gene namesi
    Name:pyrF
    Ordered Locus Names:TTE1532
    OrganismiThermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) (Caldanaerobacter subterraneus subsp. tengcongensis)
    Taxonomic identifieri273068 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacteraceaeCaldanaerobacter
    ProteomesiUP000000555: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Orotidine 5'-phosphate decarboxylasePRO_0000134636Add
    BLAST

    Proteomic databases

    PRIDEiP58883.

    Interactioni

    Protein-protein interaction databases

    STRINGi273068.TTE1532.

    Structurei

    3D structure databases

    ProteinModelPortaliP58883.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000245747.
    KOiK01591.
    OMAiHIHARHP.
    OrthoDBiEOG6DZF33.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01215. OMPdecase_type2.
    InterProiIPR013785. Aldolase_TIM.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P58883-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFVDRLIESV KAKKTPVVVG LDPRIEMIPD FIKEEAFRRK GNGVEGIAEA    50
    MYLFNKGIID AVYDLIPAVK IQVAFYEAYG IEGFKAFFRT AEYAKSLGLI 100
    VIADVKRGDI QDVAKMYSKA YLQNPLFDAI TVNPYMGEDS MVPYLEDVEK 150
    FGKGIFVLVK TSNRSSKDVQ DIETKKGGYV YQEVAKMISR LSKVIVGKYG 200
    YSSIGAVVGA TYPFEAKILR EEMPRCYFLV PGYGAQGATA EDVVNCFDEE 250
    GYGAIINSSR GVIYAYRSDF WKEAYSEYEY GQAAREEVIL MTGMINNALV 300
    KRKYIAS 307
    Length:307
    Mass (Da):34,399
    Last modified:June 24, 2002 - v1
    Checksum:iF1D89D49BDFEFE01
    GO

    Sequence cautioni

    The sequence AAM24743.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008691 Genomic DNA. Translation: AAM24743.1. Different initiation.
    RefSeqiNP_623139.1. NC_003869.1.

    Genome annotation databases

    EnsemblBacteriaiAAM24743; AAM24743; TTE1532.
    GeneIDi996047.
    KEGGitte:TTE1532.
    PATRICi23897768. VBITheTen82880_1534.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008691 Genomic DNA. Translation: AAM24743.1 . Different initiation.
    RefSeqi NP_623139.1. NC_003869.1.

    3D structure databases

    ProteinModelPortali P58883.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273068.TTE1532.

    Proteomic databases

    PRIDEi P58883.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM24743 ; AAM24743 ; TTE1532 .
    GeneIDi 996047.
    KEGGi tte:TTE1532.
    PATRICi 23897768. VBITheTen82880_1534.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000245747.
    KOi K01591.
    OMAi HIHARHP.
    OrthoDBi EOG6DZF33.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci CSUB273068:GJEB-2765-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01215. OMPdecase_type2.
    InterProi IPR013785. Aldolase_TIM.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 15242 / JCM 11007 / NBRC 100824 / MB4.

    Entry informationi

    Entry nameiPYRF_THETN
    AccessioniPrimary (citable) accession number: P58883
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 24, 2002
    Last sequence update: June 24, 2002
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3