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P58875

- S14L2_BOVIN

UniProt

P58875 - S14L2_BOVIN

Protein

SEC14-like protein 2

Gene

SEC14L2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell By similarity.By similarity

    GO - Molecular functioni

    1. lipid binding Source: UniProtKB-KW
    2. transporter activity Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SEC14-like protein 2
    Alternative name(s):
    Alpha-tocopherol-associated protein
    Short name:
    TAP
    Short name:
    bTAP
    Gene namesi
    Name:SEC14L2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 17

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. integral component of membrane Source: InterPro
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 403403SEC14-like protein 2PRO_0000210754Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei11 – 111N6-succinyllysineBy similarity
    Modified residuei51 – 511N6-succinyllysineBy similarity
    Modified residuei253 – 2531N6-succinyllysineBy similarity
    Modified residuei257 – 2571N6-succinyllysineBy similarity
    Modified residuei393 – 3931N6-succinyllysineBy similarity

    Post-translational modificationi

    The N-terminus is blocked.

    Proteomic databases

    PaxDbiP58875.
    PRIDEiP58875.

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    3D structure databases

    ProteinModelPortaliP58875.
    SMRiP58875. Positions 1-396.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini76 – 249174CRAL-TRIOPROSITE-ProRule annotationAdd
    BLAST
    Domaini275 – 383109GOLDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
    Contains 1 GOLD domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG309458.
    GeneTreeiENSGT00550000074580.
    HOGENOMiHOG000232201.
    HOVERGENiHBG055336.
    OrthoDBiEOG7N8ZVD.
    TreeFamiTF313988.

    Family and domain databases

    Gene3Di3.40.525.10. 1 hit.
    InterProiIPR001071. CRAL-bd_toc_tran.
    IPR001251. CRAL-TRIO_dom.
    IPR011074. CRAL/TRIO_N_dom.
    IPR009038. GOLD.
    [Graphical view]
    PfamiPF00650. CRAL_TRIO. 1 hit.
    PF03765. CRAL_TRIO_N. 1 hit.
    [Graphical view]
    PRINTSiPR00180. CRETINALDHBP.
    SMARTiSM01100. CRAL_TRIO_N. 1 hit.
    SM00516. SEC14. 1 hit.
    [Graphical view]
    SUPFAMiSSF101576. SSF101576. 1 hit.
    SSF46938. SSF46938. 1 hit.
    SSF52087. SSF52087. 1 hit.
    PROSITEiPS50191. CRAL_TRIO. 1 hit.
    PS50866. GOLD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P58875-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGRVGDLSP KQKEALAKFR ENVQDVLPAL PNPDDYFLLR WLRARNFNLQ    50
    KSEAMLRKHV EFRKQKDIDN IMSWQPPEVV QQYLSGGMCG YDLEGSPIWY 100
    DIIGPLDAKG LLLSASKQDL FKTKMRDCEL LLQECVRQTE KMGKKIEATT 150
    LIYDCEGLGL KHLWKPAVEA YGEFLCMFEE NYPETLKRLF IVKAPKLFPV 200
    AYNLVKPFLS EDTRKKIQVL GANWKEVLLK YISPDQLPVE YGGTMTDPDG 250
    NPKCKSKINY GGDIPKKYYV RDQVKQQYEH SVQISRGSSH QVEYEILFPG 300
    CVLRWQFMSD GSDIGFGIFL KTKVGERQRA GEMREVLPSQ RYNAHLVPED 350
    GSLTCSDPGI YVLRFDNTYS FIHAKKVSFT VEVLLPDKAL EEKMQQLGAV 400
    TPK 403
    Length:403
    Mass (Da):46,200
    Last modified:June 13, 2006 - v2
    Checksum:i67C28EFC173E1CD9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti193 – 1931K → G AA sequence (PubMed:10829015)Curated
    Sequence conflicti343 – 3431N → S in AAL90886. 1 PublicationCurated
    Sequence conflicti382 – 3821E → D in AAL90886. 1 PublicationCurated
    Sequence conflicti390 – 3901L → S in AAI09892. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF432353 mRNA. Translation: AAO31942.1.
    BC109891 mRNA. Translation: AAI09892.1.
    AF487977 mRNA. Translation: AAL90886.1.
    RefSeqiNP_808812.2. NM_177943.2.
    UniGeneiBt.44611.

    Genome annotation databases

    EnsembliENSBTAT00000056675; ENSBTAP00000051657; ENSBTAG00000017404.
    GeneIDi282469.
    KEGGibta:282469.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF432353 mRNA. Translation: AAO31942.1 .
    BC109891 mRNA. Translation: AAI09892.1 .
    AF487977 mRNA. Translation: AAL90886.1 .
    RefSeqi NP_808812.2. NM_177943.2.
    UniGenei Bt.44611.

    3D structure databases

    ProteinModelPortali P58875.
    SMRi P58875. Positions 1-396.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P58875.
    PRIDEi P58875.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000056675 ; ENSBTAP00000051657 ; ENSBTAG00000017404 .
    GeneIDi 282469.
    KEGGi bta:282469.

    Organism-specific databases

    CTDi 23541.

    Phylogenomic databases

    eggNOGi NOG309458.
    GeneTreei ENSGT00550000074580.
    HOGENOMi HOG000232201.
    HOVERGENi HBG055336.
    OrthoDBi EOG7N8ZVD.
    TreeFami TF313988.

    Miscellaneous databases

    NextBioi 20806234.

    Family and domain databases

    Gene3Di 3.40.525.10. 1 hit.
    InterProi IPR001071. CRAL-bd_toc_tran.
    IPR001251. CRAL-TRIO_dom.
    IPR011074. CRAL/TRIO_N_dom.
    IPR009038. GOLD.
    [Graphical view ]
    Pfami PF00650. CRAL_TRIO. 1 hit.
    PF03765. CRAL_TRIO_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00180. CRETINALDHBP.
    SMARTi SM01100. CRAL_TRIO_N. 1 hit.
    SM00516. SEC14. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101576. SSF101576. 1 hit.
    SSF46938. SSF46938. 1 hit.
    SSF52087. SSF52087. 1 hit.
    PROSITEi PS50191. CRAL_TRIO. 1 hit.
    PS50866. GOLD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization."
      Zimmer S., Stocker A., Sarbolouki M.N., Spycher S.E., Sassoon J., Azzi A.
      J. Biol. Chem. 275:25672-25680(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 178-195 AND 335-353.
      Tissue: Liver.
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.
    3. "Induction of hepatic tocopherol associated protein (TAP) mRNA but not alpha-tocopherol transfer protein (TTP) mRNA in cattle fed increasing levels of vitamin E."
      Meadus J., MacInnis R., Dubeski P., Hidiroglou N., Madere R.
      Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-387.
      Tissue: Liver.

    Entry informationi

    Entry nameiS14L2_BOVIN
    AccessioniPrimary (citable) accession number: P58875
    Secondary accession number(s): Q32KW6, Q867A0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2002
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3