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P58875 (S14L2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SEC14-like protein 2
Alternative name(s):
Alpha-tocopherol-associated protein
Short name=TAP
Short name=bTAP
Gene names
Name:SEC14L2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell By similarity.

Subunit structure

Monomer.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol By similarity.

Post-translational modification

The N-terminus is blocked.

Sequence similarities

Contains 1 CRAL-TRIO domain.

Contains 1 GOLD domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 403403SEC14-like protein 2
PRO_0000210754

Regions

Domain76 – 249174CRAL-TRIO
Domain275 – 383109GOLD

Amino acid modifications

Modified residue111N6-succinyllysine By similarity
Modified residue511N6-succinyllysine By similarity
Modified residue2531N6-succinyllysine By similarity
Modified residue2571N6-succinyllysine By similarity
Modified residue3931N6-succinyllysine By similarity

Experimental info

Sequence conflict1931K → G AA sequence Ref.1
Sequence conflict3431N → S in AAL90886. Ref.3
Sequence conflict3821E → D in AAL90886. Ref.3
Sequence conflict3901L → S in AAI09892. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P58875 [UniParc].

Last modified June 13, 2006. Version 2.
Checksum: 67C28EFC173E1CD9

FASTA40346,200
        10         20         30         40         50         60 
MSGRVGDLSP KQKEALAKFR ENVQDVLPAL PNPDDYFLLR WLRARNFNLQ KSEAMLRKHV 

        70         80         90        100        110        120 
EFRKQKDIDN IMSWQPPEVV QQYLSGGMCG YDLEGSPIWY DIIGPLDAKG LLLSASKQDL 

       130        140        150        160        170        180 
FKTKMRDCEL LLQECVRQTE KMGKKIEATT LIYDCEGLGL KHLWKPAVEA YGEFLCMFEE 

       190        200        210        220        230        240 
NYPETLKRLF IVKAPKLFPV AYNLVKPFLS EDTRKKIQVL GANWKEVLLK YISPDQLPVE 

       250        260        270        280        290        300 
YGGTMTDPDG NPKCKSKINY GGDIPKKYYV RDQVKQQYEH SVQISRGSSH QVEYEILFPG 

       310        320        330        340        350        360 
CVLRWQFMSD GSDIGFGIFL KTKVGERQRA GEMREVLPSQ RYNAHLVPED GSLTCSDPGI 

       370        380        390        400 
YVLRFDNTYS FIHAKKVSFT VEVLLPDKAL EEKMQQLGAV TPK 

« Hide

References

« Hide 'large scale' references
[1]"A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization."
Zimmer S., Stocker A., Sarbolouki M.N., Spycher S.E., Sassoon J., Azzi A.
J. Biol. Chem. 275:25672-25680(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 178-195 AND 335-353.
Tissue: Liver.
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.
[3]"Induction of hepatic tocopherol associated protein (TAP) mRNA but not alpha-tocopherol transfer protein (TTP) mRNA in cattle fed increasing levels of vitamin E."
Meadus J., MacInnis R., Dubeski P., Hidiroglou N., Madere R.
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-387.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF432353 mRNA. Translation: AAO31942.1.
BC109891 mRNA. Translation: AAI09892.1.
AF487977 mRNA. Translation: AAL90886.1.
RefSeqNP_808812.2. NM_177943.2.
UniGeneBt.44611.

3D structure databases

ProteinModelPortalP58875.
SMRP58875. Positions 1-396.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP58875.
PRIDEP58875.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000056675; ENSBTAP00000051657; ENSBTAG00000017404.
GeneID282469.
KEGGbta:282469.

Organism-specific databases

CTD23541.

Phylogenomic databases

eggNOGNOG309458.
GeneTreeENSGT00550000074580.
HOGENOMHOG000232201.
HOVERGENHBG055336.
OrthoDBEOG7N8ZVD.
TreeFamTF313988.

Family and domain databases

Gene3D3.40.525.10. 1 hit.
InterProIPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
IPR009038. GOLD.
[Graphical view]
PfamPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
PRINTSPR00180. CRETINALDHBP.
SMARTSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMSSF101576. SSF101576. 1 hit.
SSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEPS50191. CRAL_TRIO. 1 hit.
PS50866. GOLD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806234.

Entry information

Entry nameS14L2_BOVIN
AccessionPrimary (citable) accession number: P58875
Secondary accession number(s): Q32KW6, Q867A0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 13, 2006
Last modified: March 19, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families