SEC14-like protein 2 - Bos taurus (Bovine)

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P58875 (S14L2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 83. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
SEC14-like protein 2

Alternative name(s):
Alpha-tocopherol-associated protein
Short name=TAP
Short name=bTAP

Gene names

Name:

SEC14L2

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	403 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell By similarity.
Subunit structure	Monomer.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Note: Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol By similarity.
Post-translational modification	The N-terminus is blocked.
Sequence similarities	Contains 1 CRAL-TRIO domain. Contains 1 GOLD domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Transport
Cellular component	Cytoplasm Nucleus
Ligand	Lipid-binding
Molecular function	Activator
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lipid binding Inferred from electronic annotation. Source: UniProtKB-KW transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 403

403

SEC14-like protein 2

PRO_0000210754

Regions

Domain

76 – 249

174

CRAL-TRIO

Domain

275 – 383

109

GOLD

Experimental info

Sequence conflict

193

K → G AA sequence Ref.1

Sequence conflict

343

N → S in AAL90886. Ref.3

Sequence conflict

382

E → D in AAL90886. Ref.3

Sequence conflict

390

L → S in AAI09892. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P58875 [UniParc].

Last modified June 13, 2006. Version 2.
Checksum: 67C28EFC173E1CD9
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FASTA

403

46,200

        10         20         30         40         50         60 
MSGRVGDLSP KQKEALAKFR ENVQDVLPAL PNPDDYFLLR WLRARNFNLQ KSEAMLRKHV 

        70         80         90        100        110        120 
EFRKQKDIDN IMSWQPPEVV QQYLSGGMCG YDLEGSPIWY DIIGPLDAKG LLLSASKQDL 

       130        140        150        160        170        180 
FKTKMRDCEL LLQECVRQTE KMGKKIEATT LIYDCEGLGL KHLWKPAVEA YGEFLCMFEE 

       190        200        210        220        230        240 
NYPETLKRLF IVKAPKLFPV AYNLVKPFLS EDTRKKIQVL GANWKEVLLK YISPDQLPVE 

       250        260        270        280        290        300 
YGGTMTDPDG NPKCKSKINY GGDIPKKYYV RDQVKQQYEH SVQISRGSSH QVEYEILFPG 

       310        320        330        340        350        360 
CVLRWQFMSD GSDIGFGIFL KTKVGERQRA GEMREVLPSQ RYNAHLVPED GSLTCSDPGI 

       370        380        390        400 
YVLRFDNTYS FIHAKKVSFT VEVLLPDKAL EEKMQQLGAV TPK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization." Zimmer S., Stocker A., Sarbolouki M.N., Spycher S.E., Sassoon J., Azzi A. J. Biol. Chem. 275:25672-25680(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 178-195 AND 335-353. Tissue: Liver.
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.
[3]	"Induction of hepatic tocopherol associated protein (TAP) mRNA but not alpha-tocopherol transfer protein (TTP) mRNA in cattle fed increasing levels of vitamin E." Meadus J., MacInnis R., Dubeski P., Hidiroglou N., Madere R. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-387. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF432353 mRNA. Translation: AAO31942.1. BC109891 mRNA. Translation: AAI09892.1. AF487977 mRNA. Translation: AAL90886.1.
IPI	IPI00716793.
RefSeq	NP_808812.2. NM_177943.2.
UniGene	Bt.44611.
3D structure databases
ProteinModelPortal	P58875.
SMR	P58875. Positions 1-396.
ModBase	Search...
Proteomic databases
PaxDb	P58875.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000056675; ENSBTAP00000051657; ENSBTAG00000017404.
GeneID	282469.
KEGG	bta:282469.
Organism-specific databases
CTD	23541.
Phylogenomic databases
eggNOG	NOG309458.
GeneTree	ENSGT00550000074580.
HOGENOM	HOG000232201.
HOVERGEN	HBG055336.
Family and domain databases
Gene3D	3.40.525.10. 1 hit.
InterPro	IPR001071. CRAL-bd_toc_tran. IPR001251. CRAL-TRIO_dom. IPR011074. CRAL/TRIO_N_dom. IPR009038. GOLD. [Graphical view]
Pfam	PF00650. CRAL_TRIO. 1 hit. PF03765. CRAL_TRIO_N. 1 hit. [Graphical view]
PRINTS	PR00180. CRETINALDHBP.
SMART	SM01100. CRAL_TRIO_N. 1 hit. SM00516. SEC14. 1 hit. [Graphical view]
SUPFAM	SSF52087. CRAL_TRIO_C. 1 hit. SSF101576. GOLD. 1 hit. SSF46938. Sec14p_like_N. 1 hit.
PROSITE	PS50191. CRAL_TRIO. 1 hit. PS50866. GOLD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20806234.

Entry information

Entry name

S14L2_BOVIN

Accession

Primary (citable) accession number: P58875
Secondary accession number(s): Q32KW6, Q867A0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
Last sequence update:	June 13, 2006
Last modified:	April 3, 2013
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents