Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

182 kDa tankyrase-1-binding protein

Gene

Tnks1bp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-MMU-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.

Names & Taxonomyi

Protein namesi
Recommended name:
182 kDa tankyrase-1-binding protein
Gene namesi
Name:Tnks1bp1
Synonyms:Kiaa1741, Tab182
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2446193. Tnks1bp1.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasmcytoskeleton By similarity
  • Chromosome By similarity

  • Note: Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17201720182 kDa tankyrase-1-binding proteinPRO_0000072438Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141PhosphoserineBy similarity
Modified residuei131 – 1311PhosphothreonineBy similarity
Modified residuei178 – 1781PhosphoserineBy similarity
Modified residuei220 – 2201PhosphoserineBy similarity
Modified residuei238 – 2381PhosphothreonineBy similarity
Modified residuei286 – 2861PhosphoserineBy similarity
Modified residuei300 – 3001PhosphoserineCombined sources
Modified residuei429 – 4291PhosphoserineCombined sources
Modified residuei437 – 4371PhosphoserineBy similarity
Modified residuei496 – 4961PhosphoserineCombined sources
Modified residuei500 – 5001PhosphoserineCombined sources
Modified residuei503 – 5031PhosphothreonineCombined sources
Modified residuei533 – 5331PhosphothreonineCombined sources
Modified residuei539 – 5391PhosphoserineCombined sources
Modified residuei568 – 5681PhosphoserineCombined sources
Modified residuei602 – 6021PhosphoserineBy similarity
Modified residuei673 – 6731PhosphoserineBy similarity
Modified residuei692 – 6921PhosphoserineBy similarity
Modified residuei713 – 7131PhosphoserineCombined sources
Modified residuei763 – 7631PhosphoserineBy similarity
Modified residuei796 – 7961PhosphoserineCombined sources
Modified residuei807 – 8071PhosphoserineBy similarity
Modified residuei845 – 8451PhosphoserineBy similarity
Modified residuei866 – 8661PhosphoserineBy similarity
Modified residuei871 – 8711PhosphoserineBy similarity
Modified residuei876 – 8761PhosphoserineBy similarity
Modified residuei887 – 8871PhosphoserineCombined sources
Modified residuei912 – 9121PhosphoserineBy similarity
Modified residuei976 – 9761PhosphoserineBy similarity
Modified residuei980 – 9801PhosphoserineBy similarity
Modified residuei1006 – 10061PhosphoserineBy similarity
Modified residuei1017 – 10171PhosphoserineBy similarity
Modified residuei1022 – 10221PhosphoserineCombined sources
Modified residuei1047 – 10471PhosphoserineBy similarity
Modified residuei1063 – 10631PhosphoserineCombined sources
Modified residuei1084 – 10841PhosphoserineBy similarity
Modified residuei1096 – 10961PhosphoserineBy similarity
Modified residuei1126 – 11261PhosphoserineBy similarity
Modified residuei1131 – 11311PhosphoserineCombined sources
Modified residuei1171 – 11711PhosphoserineBy similarity
Modified residuei1212 – 12121PhosphoserineCombined sources
Modified residuei1241 – 12411PhosphoserineBy similarity
Modified residuei1246 – 12461PhosphoserineCombined sources
Modified residuei1275 – 12751PhosphothreonineCombined sources
Modified residuei1290 – 12901PhosphoserineCombined sources
Modified residuei1321 – 13211PhosphoserineBy similarity
Modified residuei1324 – 13241PhosphoserineBy similarity
Modified residuei1373 – 13731PhosphoserineCombined sources
Modified residuei1375 – 13751PhosphoserineCombined sources
Modified residuei1425 – 14251PhosphoserineBy similarity
Modified residuei1429 – 14291PhosphoserineBy similarity
Modified residuei1437 – 14371PhosphoserineCombined sources
Modified residuei1440 – 14401PhosphoserineBy similarity
Modified residuei1442 – 14421PhosphoserineCombined sources
Modified residuei1463 – 14631PhosphoserineBy similarity
Modified residuei1466 – 14661PhosphoserineBy similarity
Modified residuei1496 – 14961PhosphoserineBy similarity
Modified residuei1549 – 15491PhosphoserineBy similarity
Modified residuei1554 – 15541PhosphothreonineBy similarity
Modified residuei1611 – 16111PhosphoserineCombined sources
Modified residuei1612 – 16121PhosphoserineCombined sources
Modified residuei1622 – 16221PhosphoserineBy similarity
Modified residuei1643 – 16431PhosphoserineBy similarity
Modified residuei1657 – 16571PhosphoserineCombined sources
Modified residuei1706 – 17061PhosphoserineBy similarity

Post-translational modificationi

ADP-ribosylated by TNKS1.By similarity

Keywords - PTMi

ADP-ribosylation, Phosphoprotein

Proteomic databases

EPDiP58871.
MaxQBiP58871.
PaxDbiP58871.
PeptideAtlasiP58871.
PRIDEiP58871.

PTM databases

iPTMnetiP58871.
PhosphoSiteiP58871.

Expressioni

Gene expression databases

BgeeiP58871.
CleanExiMM_TNKS1BP1.
ExpressionAtlasiP58871. baseline and differential.
GenevisibleiP58871. MM.

Interactioni

Subunit structurei

Binds to the ANK repeat domain of TNKS1 and TNKS2.By similarity

Protein-protein interaction databases

BioGridi230718. 11 interactions.
IntActiP58871. 13 interactions.
MINTiMINT-4137005.
STRINGi10090.ENSMUSP00000107232.

Structurei

3D structure databases

ProteinModelPortaliP58871.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni209 – 15631355AcidicAdd
BLAST
Regioni1440 – 153293Tankyrase-bindingBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1620 – 16267Nuclear localization signalSequence analysis
Motifi1714 – 17196Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1003 – 1333331Gly-richAdd
BLAST
Compositional biasi1566 – 1720155Arg/Glu/Lys-rich (charged)Add
BLAST

Phylogenomic databases

eggNOGiENOG410IK8U. Eukaryota.
ENOG410ZTHW. LUCA.
GeneTreeiENSGT00730000111391.
HOGENOMiHOG000001569.
HOVERGENiHBG080593.
InParanoidiP58871.
OMAiPDQPCVL.
OrthoDBiEOG7DC23N.
PhylomeDBiP58871.
TreeFamiTF336029.

Family and domain databases

InterProiIPR032764. Tankyrase-bd_C.
[Graphical view]
PfamiPF15327. Tankyrase_bdg_C. 1 hit.
[Graphical view]
SMARTiSM01319. Tankyrase_bdg_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P58871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGSTLREGT AMASPLPQDM EEELAPVGSE PGDPRAKPPV KPKPRGLPSK
60 70 80 90 100
PALPAKPSLL VPVGPRPPRG PLAELPSARK MNMLAGPQPY GVSKRPLPFA
110 120 130 140 150
PRPSAEATAG GDVTQESGKE DAGKEDLPPL TPPARCAALG GVRKAPAPFR
160 170 180 190 200
PSSERFAACT VEEILAKMEQ PRKEILASPD RLWGSRLTFN HDGSSRYGPR
210 220 230 240 250
TYGAPCPREE DSKSPAKGRS QEGTAEIPAE CQEEHSKTPE ERNLTSSPAM
260 270 280 290 300
NGDLAKLACS EAPTDVSKTW VTSSADPVSE HGGSTSAVRL ANISVPASES
310 320 330 340 350
PRLSSRPSSP CHSQLSETQS PAASEASSIC LPVTPASPSA VLPAEPPGHS
360 370 380 390 400
PSSELPAEAA PETLSPNSSP VETVSGHHSP EQPPVLLPQL LTEGAELPDI
410 420 430 440 450
TRTFPCGEEA AARGHTESRP SSLAQRRFSE GVLQPPSQDQ EKLGGSLATL
460 470 480 490 500
PQGQGSQSAL DRPFGSGTES NWSLSQSFEW TFPTRPSGLG VWRLDSPPPS
510 520 530 540 550
PITEASEAAE AAEADSWAVS GRGEGVSQVG PGTPPAPESP RKPISGVQGN
560 570 580 590 600
DPGISLPQRD DGESQPRSPA LLPSTVEGPP GAPLLQAKEN YEDQEPLVGH
610 620 630 640 650
ESPITLAARE AALPVLEPAL GQQQPTPSDQ PCILFVDVPD PEQALSTEED
660 670 680 690 700
VVTLGWAETT LPMTEAQEPC SVSPEPTGPE SSSRWLDDLL ASPPPNSGSA
710 720 730 740 750
RRAAGAELKD RQSPSTCSEG LLGWAQKDLQ SEFGVATDSH HSSFGSSSWS
760 770 780 790 800
QDTSQNYSLG GRSPVGDTGL GKRDWSSKCG QGSGEGSTRE WASRHSLGQE
810 820 830 840 850
VIGIGGSQDE SEVPVRERAV GRPAQLGAQG LEADAQQWEF GKRESQDPHS
860 870 880 890 900
IHDKELQDQE FGKRDSLGSF STRDASLQDW EFGKRASVST NQDTDENDQE
910 920 930 940 950
LGMKNLSRGY SSQDAEEQDR EFEKRDSVLD IHGSRATAQQ NQEFGKSAWF
960 970 980 990 1000
QDYSSGGGGS RVLGSQERGF GIRSLSSGFS PEEAQQQDEE FEKKTPVGED
1010 1020 1030 1040 1050
RFCEASRDVG HLEEGASGGL LSPSTPHSRD GAARPKDEGS WQDGDSSQEI
1060 1070 1080 1090 1100
TRLQGRMQAE SQSPTNVDLE DKEREQRGWA GEFSLGVAAQ SEAAFSPGRQ
1110 1120 1130 1140 1150
DWSRDVCVEA SESSYQFGII GNDRVSGAGL SPSRKSGGGH FVPPGETKAG
1160 1170 1180 1190 1200
AVDWTDQLGL RNLEVSSCVS SEGPSEAREN VVGQMGWSDS LGLNNGDLAR
1210 1220 1230 1240 1250
RLGTGESEEP RSLGVGEKDW TSSVEARNRD LPGQAEVGRH SQARESGVGE
1260 1270 1280 1290 1300
PDWSGAEAGE FLKSRERGVG QADWTPDLGL RNMAPGAGCS PGEPRELGVG
1310 1320 1330 1340 1350
QVDWGDDLGL RNLEVSCDLE SGGSRGCGVG QMDWAQDLGL RNLRLCGAPS
1360 1370 1380 1390 1400
EVRECGVGRV GPDLELDPKS SGSLSPGLET EDPLEARELG VGEISGPETQ
1410 1420 1430 1440 1450
GEDSSSPSFE TPSEDTGMDT GEAPSLGASP SSCLTRSPPS GSQSLLEGIM
1460 1470 1480 1490 1500
TASSSKGAPQ RESAASGSRV LLEEEGLAAG AGQGEPQEPS RAPLPSSRPQ
1510 1520 1530 1540 1550
PDGEASQVEE VDGTWSLTGA ARQNEQASAP PPRRPPRGLL PSCPSEDFSF
1560 1570 1580 1590 1600
IEDTEILDSA MYRSRANLGR KRGHRAPAIR PGGTLGLSET ADSDTRLFQD
1610 1620 1630 1640 1650
STEPRASRVP SSDEEVVEEP QSRRTRMSLG TKGLKVNLFP GLSPSALKAK
1660 1670 1680 1690 1700
LRSRNRSAEE GEVTESKSSQ KESSVQRSKS CKVPGLGKPL TLPPKPEKSS
1710 1720
GSEGSSPNWL QALKLKKKKI
Length:1,720
Mass (Da):181,825
Last modified:May 29, 2007 - v2
Checksum:i7CFF0046559B923D
GO

Sequence cautioni

The sequence CAM22340.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti941 – 9411N → D in BAC98246 (PubMed:14621295).Curated
Sequence conflicti941 – 9411N → D in AAH25943 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX546441 Genomic DNA. Translation: CAM22340.1. Sequence problems.
AK129436 mRNA. Translation: BAC98246.1.
BC024499 mRNA. Translation: AAH24499.1.
BC025943 mRNA. Translation: AAH25943.1.
CCDSiCCDS38166.1.
RefSeqiNP_001074729.1. NM_001081260.2.
UniGeneiMm.23606.

Genome annotation databases

EnsembliENSMUST00000111605; ENSMUSP00000107232; ENSMUSG00000033955.
GeneIDi228140.
KEGGimmu:228140.
UCSCiuc012byp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX546441 Genomic DNA. Translation: CAM22340.1. Sequence problems.
AK129436 mRNA. Translation: BAC98246.1.
BC024499 mRNA. Translation: AAH24499.1.
BC025943 mRNA. Translation: AAH25943.1.
CCDSiCCDS38166.1.
RefSeqiNP_001074729.1. NM_001081260.2.
UniGeneiMm.23606.

3D structure databases

ProteinModelPortaliP58871.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230718. 11 interactions.
IntActiP58871. 13 interactions.
MINTiMINT-4137005.
STRINGi10090.ENSMUSP00000107232.

PTM databases

iPTMnetiP58871.
PhosphoSiteiP58871.

Proteomic databases

EPDiP58871.
MaxQBiP58871.
PaxDbiP58871.
PeptideAtlasiP58871.
PRIDEiP58871.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111605; ENSMUSP00000107232; ENSMUSG00000033955.
GeneIDi228140.
KEGGimmu:228140.
UCSCiuc012byp.1. mouse.

Organism-specific databases

CTDi85456.
MGIiMGI:2446193. Tnks1bp1.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IK8U. Eukaryota.
ENOG410ZTHW. LUCA.
GeneTreeiENSGT00730000111391.
HOGENOMiHOG000001569.
HOVERGENiHBG080593.
InParanoidiP58871.
OMAiPDQPCVL.
OrthoDBiEOG7DC23N.
PhylomeDBiP58871.
TreeFamiTF336029.

Enzyme and pathway databases

ReactomeiR-MMU-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.

Miscellaneous databases

PROiP58871.
SOURCEiSearch...

Gene expression databases

BgeeiP58871.
CleanExiMM_TNKS1BP1.
ExpressionAtlasiP58871. baseline and differential.
GenevisibleiP58871. MM.

Family and domain databases

InterProiIPR032764. Tankyrase-bd_C.
[Graphical view]
PfamiPF15327. Tankyrase_bdg_C. 1 hit.
[Graphical view]
SMARTiSM01319. Tankyrase_bdg_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 397-1720.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 812-1720.
    Tissue: Colon and Liver.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-533; SER-539; SER-568; SER-796; SER-887; SER-1131; SER-1212; SER-1290; SER-1375; SER-1611 AND SER-1612, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1611 AND SER-1612, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-300; SER-429; SER-496; SER-500; THR-503; THR-533; SER-539; SER-568; SER-713; SER-796; SER-887; SER-1022; SER-1063; SER-1131; SER-1212; SER-1246; THR-1275; SER-1290; SER-1373; SER-1375; SER-1437; SER-1442; SER-1611; SER-1612 AND SER-1657, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTB182_MOUSE
AccessioniPrimary (citable) accession number: P58871
Secondary accession number(s): A2BH84, Q6ZPI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: May 29, 2007
Last modified: July 6, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.