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Protein

182 kDa tankyrase-1-binding protein

Gene

Tnks1bp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Names & Taxonomyi

Protein namesi
Recommended name:
182 kDa tankyrase-1-binding protein
Gene namesi
Name:Tnks1bp1
Synonyms:Kiaa1741, Tab182
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2446193 Tnks1bp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724381 – 1720182 kDa tankyrase-1-binding proteinAdd BLAST1720

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei131PhosphothreonineBy similarity1
Modified residuei178PhosphoserineBy similarity1
Modified residuei220PhosphoserineBy similarity1
Modified residuei238PhosphothreonineBy similarity1
Modified residuei286PhosphoserineBy similarity1
Modified residuei300PhosphoserineCombined sources1
Modified residuei429PhosphoserineCombined sources1
Modified residuei437PhosphoserineBy similarity1
Modified residuei496PhosphoserineCombined sources1
Modified residuei500PhosphoserineCombined sources1
Modified residuei503PhosphothreonineCombined sources1
Modified residuei533PhosphothreonineCombined sources1
Modified residuei539PhosphoserineCombined sources1
Modified residuei568PhosphoserineCombined sources1
Modified residuei602PhosphoserineBy similarity1
Modified residuei673PhosphoserineBy similarity1
Modified residuei692PhosphoserineBy similarity1
Modified residuei713PhosphoserineCombined sources1
Modified residuei763PhosphoserineBy similarity1
Modified residuei796PhosphoserineCombined sources1
Modified residuei807PhosphoserineBy similarity1
Modified residuei845PhosphoserineBy similarity1
Modified residuei866PhosphoserineBy similarity1
Modified residuei871PhosphoserineBy similarity1
Modified residuei876PhosphoserineBy similarity1
Modified residuei887PhosphoserineCombined sources1
Modified residuei912PhosphoserineBy similarity1
Modified residuei976PhosphoserineBy similarity1
Modified residuei980PhosphoserineBy similarity1
Modified residuei1006PhosphoserineBy similarity1
Modified residuei1017PhosphoserineBy similarity1
Modified residuei1022PhosphoserineCombined sources1
Modified residuei1047PhosphoserineBy similarity1
Modified residuei1063PhosphoserineCombined sources1
Modified residuei1084PhosphoserineBy similarity1
Modified residuei1096PhosphoserineBy similarity1
Modified residuei1126PhosphoserineBy similarity1
Modified residuei1131PhosphoserineCombined sources1
Modified residuei1171PhosphoserineBy similarity1
Modified residuei1212PhosphoserineCombined sources1
Modified residuei1241PhosphoserineBy similarity1
Modified residuei1246PhosphoserineCombined sources1
Modified residuei1275PhosphothreonineCombined sources1
Modified residuei1290PhosphoserineCombined sources1
Modified residuei1321PhosphoserineBy similarity1
Modified residuei1324PhosphoserineBy similarity1
Modified residuei1373PhosphoserineCombined sources1
Modified residuei1375PhosphoserineCombined sources1
Modified residuei1425PhosphoserineBy similarity1
Modified residuei1429PhosphoserineBy similarity1
Modified residuei1437PhosphoserineCombined sources1
Modified residuei1440PhosphoserineBy similarity1
Modified residuei1442PhosphoserineCombined sources1
Modified residuei1463PhosphoserineBy similarity1
Modified residuei1466PhosphoserineBy similarity1
Modified residuei1496PhosphoserineBy similarity1
Modified residuei1549PhosphoserineBy similarity1
Modified residuei1554PhosphothreonineBy similarity1
Modified residuei1611PhosphoserineCombined sources1
Modified residuei1612PhosphoserineCombined sources1
Modified residuei1622PhosphoserineBy similarity1
Modified residuei1635N6-methyllysineBy similarity1
Modified residuei1643PhosphoserineBy similarity1
Modified residuei1657PhosphoserineCombined sources1
Modified residuei1706PhosphoserineBy similarity1

Post-translational modificationi

ADP-ribosylated by TNKS1.By similarity

Keywords - PTMi

ADP-ribosylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP58871
MaxQBiP58871
PaxDbiP58871
PeptideAtlasiP58871
PRIDEiP58871

PTM databases

iPTMnetiP58871
PhosphoSitePlusiP58871

Expressioni

Gene expression databases

BgeeiENSMUSG00000033955
CleanExiMM_TNKS1BP1
ExpressionAtlasiP58871 baseline and differential
GenevisibleiP58871 MM

Interactioni

Subunit structurei

Binds to the ANK repeat domain of TNKS1 and TNKS2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230718, 11 interactors
IntActiP58871, 13 interactors
MINTiP58871
STRINGi10090.ENSMUSP00000107232

Structurei

3D structure databases

ProteinModelPortaliP58871
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni209 – 1563AcidicAdd BLAST1355
Regioni1440 – 1532Tankyrase-bindingBy similarityAdd BLAST93

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1620 – 1626Nuclear localization signalSequence analysis7
Motifi1714 – 1719Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1003 – 1333Gly-richAdd BLAST331
Compositional biasi1566 – 1720Arg/Glu/Lys-rich (charged)Add BLAST155

Phylogenomic databases

eggNOGiENOG410IK8U Eukaryota
ENOG410ZTHW LUCA
GeneTreeiENSGT00910000144328
HOGENOMiHOG000001569
HOVERGENiHBG080593
InParanoidiP58871
OMAiFEWTFPT
OrthoDBiEOG091G01HQ
PhylomeDBiP58871
TreeFamiTF336029

Family and domain databases

InterProiView protein in InterPro
IPR032764 Tankyrase-bd_C
PfamiView protein in Pfam
PF15327 Tankyrase_bdg_C, 1 hit
SMARTiView protein in SMART
SM01319 Tankyrase_bdg_C, 1 hit

Sequencei

Sequence statusi: Complete.

P58871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGSTLREGT AMASPLPQDM EEELAPVGSE PGDPRAKPPV KPKPRGLPSK
60 70 80 90 100
PALPAKPSLL VPVGPRPPRG PLAELPSARK MNMLAGPQPY GVSKRPLPFA
110 120 130 140 150
PRPSAEATAG GDVTQESGKE DAGKEDLPPL TPPARCAALG GVRKAPAPFR
160 170 180 190 200
PSSERFAACT VEEILAKMEQ PRKEILASPD RLWGSRLTFN HDGSSRYGPR
210 220 230 240 250
TYGAPCPREE DSKSPAKGRS QEGTAEIPAE CQEEHSKTPE ERNLTSSPAM
260 270 280 290 300
NGDLAKLACS EAPTDVSKTW VTSSADPVSE HGGSTSAVRL ANISVPASES
310 320 330 340 350
PRLSSRPSSP CHSQLSETQS PAASEASSIC LPVTPASPSA VLPAEPPGHS
360 370 380 390 400
PSSELPAEAA PETLSPNSSP VETVSGHHSP EQPPVLLPQL LTEGAELPDI
410 420 430 440 450
TRTFPCGEEA AARGHTESRP SSLAQRRFSE GVLQPPSQDQ EKLGGSLATL
460 470 480 490 500
PQGQGSQSAL DRPFGSGTES NWSLSQSFEW TFPTRPSGLG VWRLDSPPPS
510 520 530 540 550
PITEASEAAE AAEADSWAVS GRGEGVSQVG PGTPPAPESP RKPISGVQGN
560 570 580 590 600
DPGISLPQRD DGESQPRSPA LLPSTVEGPP GAPLLQAKEN YEDQEPLVGH
610 620 630 640 650
ESPITLAARE AALPVLEPAL GQQQPTPSDQ PCILFVDVPD PEQALSTEED
660 670 680 690 700
VVTLGWAETT LPMTEAQEPC SVSPEPTGPE SSSRWLDDLL ASPPPNSGSA
710 720 730 740 750
RRAAGAELKD RQSPSTCSEG LLGWAQKDLQ SEFGVATDSH HSSFGSSSWS
760 770 780 790 800
QDTSQNYSLG GRSPVGDTGL GKRDWSSKCG QGSGEGSTRE WASRHSLGQE
810 820 830 840 850
VIGIGGSQDE SEVPVRERAV GRPAQLGAQG LEADAQQWEF GKRESQDPHS
860 870 880 890 900
IHDKELQDQE FGKRDSLGSF STRDASLQDW EFGKRASVST NQDTDENDQE
910 920 930 940 950
LGMKNLSRGY SSQDAEEQDR EFEKRDSVLD IHGSRATAQQ NQEFGKSAWF
960 970 980 990 1000
QDYSSGGGGS RVLGSQERGF GIRSLSSGFS PEEAQQQDEE FEKKTPVGED
1010 1020 1030 1040 1050
RFCEASRDVG HLEEGASGGL LSPSTPHSRD GAARPKDEGS WQDGDSSQEI
1060 1070 1080 1090 1100
TRLQGRMQAE SQSPTNVDLE DKEREQRGWA GEFSLGVAAQ SEAAFSPGRQ
1110 1120 1130 1140 1150
DWSRDVCVEA SESSYQFGII GNDRVSGAGL SPSRKSGGGH FVPPGETKAG
1160 1170 1180 1190 1200
AVDWTDQLGL RNLEVSSCVS SEGPSEAREN VVGQMGWSDS LGLNNGDLAR
1210 1220 1230 1240 1250
RLGTGESEEP RSLGVGEKDW TSSVEARNRD LPGQAEVGRH SQARESGVGE
1260 1270 1280 1290 1300
PDWSGAEAGE FLKSRERGVG QADWTPDLGL RNMAPGAGCS PGEPRELGVG
1310 1320 1330 1340 1350
QVDWGDDLGL RNLEVSCDLE SGGSRGCGVG QMDWAQDLGL RNLRLCGAPS
1360 1370 1380 1390 1400
EVRECGVGRV GPDLELDPKS SGSLSPGLET EDPLEARELG VGEISGPETQ
1410 1420 1430 1440 1450
GEDSSSPSFE TPSEDTGMDT GEAPSLGASP SSCLTRSPPS GSQSLLEGIM
1460 1470 1480 1490 1500
TASSSKGAPQ RESAASGSRV LLEEEGLAAG AGQGEPQEPS RAPLPSSRPQ
1510 1520 1530 1540 1550
PDGEASQVEE VDGTWSLTGA ARQNEQASAP PPRRPPRGLL PSCPSEDFSF
1560 1570 1580 1590 1600
IEDTEILDSA MYRSRANLGR KRGHRAPAIR PGGTLGLSET ADSDTRLFQD
1610 1620 1630 1640 1650
STEPRASRVP SSDEEVVEEP QSRRTRMSLG TKGLKVNLFP GLSPSALKAK
1660 1670 1680 1690 1700
LRSRNRSAEE GEVTESKSSQ KESSVQRSKS CKVPGLGKPL TLPPKPEKSS
1710 1720
GSEGSSPNWL QALKLKKKKI
Length:1,720
Mass (Da):181,825
Last modified:May 29, 2007 - v2
Checksum:i7CFF0046559B923D
GO

Sequence cautioni

The sequence CAM22340 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti941N → D in BAC98246 (PubMed:14621295).Curated1
Sequence conflicti941N → D in AAH25943 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX546441 Genomic DNA Translation: CAM22340.1 Sequence problems.
AK129436 mRNA Translation: BAC98246.1
BC024499 mRNA Translation: AAH24499.1
BC025943 mRNA Translation: AAH25943.1
CCDSiCCDS38166.1
RefSeqiNP_001074729.1, NM_001081260.2
XP_017173105.1, XM_017317616.1
UniGeneiMm.23606

Genome annotation databases

EnsembliENSMUST00000111605; ENSMUSP00000107232; ENSMUSG00000033955
GeneIDi228140
KEGGimmu:228140
UCSCiuc012byp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTB182_MOUSE
AccessioniPrimary (citable) accession number: P58871
Secondary accession number(s): A2BH84, Q6ZPI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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