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Protein

Gamma-tubulin complex component 3

Gene

Tubgcp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-380320. Recruitment of NuMA to mitotic centrosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-tubulin complex component 3
Short name:
GCP-3
Gene namesi
Name:Tubgcp3
Synonyms:Gcp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2183752. Tubgcp3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000781192 – 905Gamma-tubulin complex component 3Add BLAST904

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei113PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP58854.
MaxQBiP58854.
PaxDbiP58854.
PeptideAtlasiP58854.
PRIDEiP58854.

PTM databases

iPTMnetiP58854.
PhosphoSitePlusiP58854.

Expressioni

Gene expression databases

BgeeiENSMUSG00000000759.
CleanExiMM_TUBGCP3.
ExpressionAtlasiP58854. baseline and differential.
GenevisibleiP58854. MM.

Interactioni

Subunit structurei

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBTUBGCP3 and CDK5RAP2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi234417. 15 interactors.
IntActiP58854. 12 interactors.
STRINGi10090.ENSMUSP00000000776.

Structurei

3D structure databases

ProteinModelPortaliP58854.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi823 – 827Poly-Glu5

Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

eggNOGiKOG2000. Eukaryota.
ENOG410XQ5B. LUCA.
GeneTreeiENSGT00850000132278.
HOGENOMiHOG000007959.
HOVERGENiHBG031568.
InParanoidiP58854.
KOiK16570.
OMAiSEIMHFI.
OrthoDBiEOG091G01V2.
PhylomeDBiP58854.
TreeFamiTF300705.

Family and domain databases

InterProiIPR007259. GCP.
[Graphical view]
PANTHERiPTHR19302. PTHR19302. 3 hits.
PfamiPF04130. Spc97_Spc98. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P58854-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPDQKSPN VLLQNLCCRI LGRSEADVAQ QFQFAVRVIG SNFAPTVERD
60 70 80 90 100
EFLVAEKIKK ELIRQRREAD AALFSELHRK LHSQGVLKNK WSILYLLLNL
110 120 130 140 150
SEDPRKQASK VTSYASLFAQ ALPRDAHSTP YYYARPQTLP LNYQDRSTQA
160 170 180 190 200
QSSGSLGSSG ISSIGMCGLS GPTPVQPFLP GQSHQAPGVG DGLRQQLGPR
210 220 230 240 250
LAWTLTGNQP SSQTPTSKGF PNALSRNLTR SRREGDPGGT LEVTEAALVR
260 270 280 290 300
DILYVFQGID GKNIKMSSTE NCYKVEAKAN LNKSLRDTAV RLAELGWLHN
310 320 330 340 350
KIRKYADQRS LDRSFGLVGQ SFCAALHQEL KEYYRLLSVL HSQLQLEDDQ
360 370 380 390 400
GVNLGLESSL TLRRLLVWTY DPKIRLKTLA ALVDHCQGRK GGELASAVHA
410 420 430 440 450
YTKTGDPYMK SLVQHILSLV SHPVLSFLYR WIYDGELEDT YHEFFVASDP
460 470 480 490 500
TVKTDRLWHD KYTLRKSMIP SFITMDQSRK VLLIGKSINF LHQVCHDQTP
510 520 530 540 550
TTKMIAVTKS AESPRDAADL FTDLENAFQG KIDAAYFETS KYLLDVLNKK
560 570 580 590 600
YSLLEHMQAM RRYLLLGQGD FIRHLMDLLK PELVRPATTL YQHNLTGILE
610 620 630 640 650
TAVRATNAQF DSPEILKRLD VRLLEVSPGD TGWDVFSLDY HVDGPIATVF
660 670 680 690 700
TRECMSHYLR VFNFLWRAKR MEYILTDIRK GHMCNAKLLR NMPEFSGVLH
710 720 730 740 750
QCHILASEMV HFIHQMQYYI TFEVLECSWD ELWNRVQQAQ DLDHIIAAHE
760 770 780 790 800
AFLNTITSRC LLDSNSRVLL NQLRAVFDQI IELQNAQDVM YRAALEELQR
810 820 830 840 850
RLQFEEKKKQ REIEGQWGVT AAEEEEENKR IREFQDSIPK MCSQLRILTH
860 870 880 890 900
FYQGVVQQFL VLLTTSSDES LQFLSFRLDF NEHYKAREPR LRVSLGSRGR

RSSHT
Length:905
Mass (Da):103,469
Last modified:October 11, 2005 - v2
Checksum:i7140808D349A471E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229 – 232TRSR → HASG in AAH25647 (PubMed:15489334).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150149 mRNA. Translation: BAE29343.1.
BC025647 mRNA. Translation: AAH25647.1.
BC058566 mRNA. Translation: AAH58566.1.
CCDSiCCDS22103.1.
RefSeqiNP_932148.1. NM_198031.1.
UniGeneiMm.142095.
Mm.246402.

Genome annotation databases

EnsembliENSMUST00000000776; ENSMUSP00000000776; ENSMUSG00000000759.
GeneIDi259279.
KEGGimmu:259279.
UCSCiuc009kwd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150149 mRNA. Translation: BAE29343.1.
BC025647 mRNA. Translation: AAH25647.1.
BC058566 mRNA. Translation: AAH58566.1.
CCDSiCCDS22103.1.
RefSeqiNP_932148.1. NM_198031.1.
UniGeneiMm.142095.
Mm.246402.

3D structure databases

ProteinModelPortaliP58854.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234417. 15 interactors.
IntActiP58854. 12 interactors.
STRINGi10090.ENSMUSP00000000776.

PTM databases

iPTMnetiP58854.
PhosphoSitePlusiP58854.

Proteomic databases

EPDiP58854.
MaxQBiP58854.
PaxDbiP58854.
PeptideAtlasiP58854.
PRIDEiP58854.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000776; ENSMUSP00000000776; ENSMUSG00000000759.
GeneIDi259279.
KEGGimmu:259279.
UCSCiuc009kwd.1. mouse.

Organism-specific databases

CTDi10426.
MGIiMGI:2183752. Tubgcp3.

Phylogenomic databases

eggNOGiKOG2000. Eukaryota.
ENOG410XQ5B. LUCA.
GeneTreeiENSGT00850000132278.
HOGENOMiHOG000007959.
HOVERGENiHBG031568.
InParanoidiP58854.
KOiK16570.
OMAiSEIMHFI.
OrthoDBiEOG091G01V2.
PhylomeDBiP58854.
TreeFamiTF300705.

Enzyme and pathway databases

ReactomeiR-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-380320. Recruitment of NuMA to mitotic centrosomes.

Miscellaneous databases

ChiTaRSiTubgcp3. mouse.
PROiP58854.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000759.
CleanExiMM_TUBGCP3.
ExpressionAtlasiP58854. baseline and differential.
GenevisibleiP58854. MM.

Family and domain databases

InterProiIPR007259. GCP.
[Graphical view]
PANTHERiPTHR19302. PTHR19302. 3 hits.
PfamiPF04130. Spc97_Spc98. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGCP3_MOUSE
AccessioniPrimary (citable) accession number: P58854
Secondary accession number(s): Q6PDQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 11, 2005
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.