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P58839 (G3P_METKA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glyceraldehyde-3-phosphate dehydrogenase

Short name=GAPDH
EC=1.2.1.59
Alternative name(s):
NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase
Gene names
Name:gap
Synonyms:gapA
Ordered Locus Names:MK0618
OrganismMethanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Taxonomic identifier190192 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanopyriMethanopyralesMethanopyraceaeMethanopyrus

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H. HAMAP MF_00559

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. HAMAP MF_00559

Subunit structure

Homotetramer By similarity. HAMAP MF_00559

Subcellular location

Cytoplasm By similarity HAMAP MF_00559.

Sequence similarities

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandNAD
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNAD binding

Inferred from electronic annotation. Source: InterPro

NADP binding

Inferred from electronic annotation. Source: InterPro

glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Glyceraldehyde-3-phosphate dehydrogenase HAMAP MF_00559
PRO_0000145724

Regions

Nucleotide binding13 – 142NAD By similarity
Region147 – 1493Glyceraldehyde 3-phosphate binding By similarity
Region202 – 2032Glyceraldehyde 3-phosphate binding By similarity

Sites

Active site1481Nucleophile By similarity
Binding site1181NAD; via amide nitrogen By similarity
Binding site1761NAD By similarity
Binding site3091NAD; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
P58839 [UniParc].

Last modified May 27, 2002. Version 1.
Checksum: F9BCB72702E22E02

FASTA35038,367
        10         20         30         40         50         60 
MADVSVLING YGTIGKRVAD AVDAQRDMEV LGVVKTSPDY LARLAVEEYG YPLFVPEDRV 

        70         80         90        100        110        120 
ERFEDAGIET EGTVEDVVLN AEDYGLDVVV DCTPEGIGAR NKETLYEKAG VKAIFQGGEE 

       130        140        150        160        170        180 
AEVAEVSFVA QCNYEEALGA DYVRCVSCNT TALCRTLGTL KEEFELGRVY VTIVRRAADP 

       190        200        210        220        230        240 
HQVKKGPINA IAPNPVTVPS HHGPDVKTVM PDIDITTAAV KVPTTLMHMH VVRVELKEEV 

       250        260        270        280        290        300 
TSDDVIDAFE EARRIWVVPH GEGLGSTAEL IELGRDLGRK RYDLYEILVW EESINVEDGV 

       310        320        330        340        350 
LYYMQAVHQE ADVVPENVDA IRAMTELEED PEASMDATDS ALGVLNSPPL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009439 Genomic DNA. Translation: AAM01833.1.
RefSeqNP_613903.1. NC_003551.1.

3D structure databases

ProteinModelPortalP58839.
SMRP58839. Positions 5-345.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1476719.
GenomeReviewsGene locus MK0618 in contig AE009439_GR.
KEGGmka:MK0618.
NMPDRfig|190192.1.peg.616.

Phylogenomic databases

HOGENOMHBG392099.
OMAVPSHHGP.
ProtClustDBPRK04207.

Enzyme and pathway databases

BioCycMKAN190192:MK0618-MONOMER.

Family and domain databases

HAMAPMF_00559. G3P_dehdrog_arch.
[Tree]
InterProIPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR006436. Glyceraldehyde-3-P_DH_2_arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00150.
PfamPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000149. GAP_DH. 1 hit.
SMARTSM00846. Gp_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01546. GAPDH-II_archae. 1 hit.
PROSITEPS00071. GAPDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG3P_METKA
AccessionPrimary (citable) accession number: P58839
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: November 16, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families